JP2020506903A5 - - Google Patents

Download PDF

Info

Publication number
JP2020506903A5
JP2020506903A5 JP2019538585A JP2019538585A JP2020506903A5 JP 2020506903 A5 JP2020506903 A5 JP 2020506903A5 JP 2019538585 A JP2019538585 A JP 2019538585A JP 2019538585 A JP2019538585 A JP 2019538585A JP 2020506903 A5 JP2020506903 A5 JP 2020506903A5
Authority
JP
Japan
Prior art keywords
alkyl
disease
pain
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2019538585A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020506903A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2018/050128 external-priority patent/WO2018134698A1/en
Publication of JP2020506903A publication Critical patent/JP2020506903A/ja
Publication of JP2020506903A5 publication Critical patent/JP2020506903A5/ja
Withdrawn legal-status Critical Current

Links

JP2019538585A 2017-01-23 2018-01-09 Magl阻害薬としての複素環式スピロ化合物 Withdrawn JP2020506903A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449242P 2017-01-23 2017-01-23
US62/449,242 2017-01-23
PCT/IB2018/050128 WO2018134698A1 (en) 2017-01-23 2018-01-09 Heterocyclic spiro compounds as magl inhibitors

Publications (2)

Publication Number Publication Date
JP2020506903A JP2020506903A (ja) 2020-03-05
JP2020506903A5 true JP2020506903A5 (cg-RX-API-DMAC7.html) 2021-02-12

Family

ID=61028112

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019538585A Withdrawn JP2020506903A (ja) 2017-01-23 2018-01-09 Magl阻害薬としての複素環式スピロ化合物

Country Status (14)

Country Link
US (2) US20180208608A1 (cg-RX-API-DMAC7.html)
EP (1) EP3571202B1 (cg-RX-API-DMAC7.html)
JP (1) JP2020506903A (cg-RX-API-DMAC7.html)
KR (1) KR20190097242A (cg-RX-API-DMAC7.html)
CN (1) CN110198944A (cg-RX-API-DMAC7.html)
AU (1) AU2018208848A1 (cg-RX-API-DMAC7.html)
BR (1) BR112019014099A2 (cg-RX-API-DMAC7.html)
CA (1) CA3050853A1 (cg-RX-API-DMAC7.html)
IL (1) IL267781A (cg-RX-API-DMAC7.html)
MX (1) MX2019008690A (cg-RX-API-DMAC7.html)
RU (1) RU2726631C1 (cg-RX-API-DMAC7.html)
SG (1) SG11201906427QA (cg-RX-API-DMAC7.html)
TW (1) TWI665199B (cg-RX-API-DMAC7.html)
WO (1) WO2018134698A1 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6832914B2 (ja) 2015-07-31 2021-02-24 ファイザー・インク Magl阻害薬としての1,1,1−トリフルオロ−3−ヒドロキシプロパン−2−イルカルバマート誘導体および1,1,1−トリフルオロ−4−ヒドロキシブタン−2−イルカルバマート誘導体
JP7106462B2 (ja) 2016-07-01 2022-07-26 ジー1 セラピューティクス, インコーポレイテッド N-(ヘテロアリール)-ピロロ[3,2-d]ピリミジン-2-アミンの合成
CA3050625C (en) * 2017-01-20 2021-07-20 Pfizer Inc. 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
CA3076477A1 (en) * 2017-09-29 2019-04-04 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10662159B2 (en) * 2017-11-22 2020-05-26 Makscientific, Llc ABHD6 and dual ABHD6/MGL inhibitors and their uses
CN111566105A (zh) 2018-01-08 2020-08-21 豪夫迈·罗氏有限公司 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物
US20210309669A1 (en) * 2018-07-19 2021-10-07 Pfizer Inc. Heterocyclic Spiro Compounds As MAGL Inhibitors
EP3840756B1 (en) 2018-08-24 2025-11-05 Pharmacosmos Holding A/S Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one
EP3856179A1 (en) * 2018-09-28 2021-08-04 Janssen Pharmaceutica N.V. Monoacylglycerol lipase modulators
JP2022509206A (ja) * 2018-11-28 2022-01-20 ハー・ルンドベック・アクチエゼルスカベット Magl阻害剤による疾病の治療方法
CN109485656A (zh) * 2018-12-17 2019-03-19 上海药明康德新药开发有限公司 3-氧亚基-7-氧杂-2,10-二氮杂螺[4.6]十一烷-10-甲酸叔丁酯的制法
MX2021008865A (es) * 2019-01-25 2021-10-26 H Lundbeck As Inhibidores de magl para usarse para tratar enfermedades antecedentes.
CN114096545A (zh) * 2019-07-09 2022-02-25 豪夫迈·罗氏有限公司 新杂环化合物
AU2020358948A1 (en) 2019-09-30 2022-05-26 Janssen Pharmaceutica Nv Radiolabelled MGL PET ligands
KR20220158785A (ko) * 2020-03-26 2022-12-01 얀센 파마슈티카 엔.브이. 모노아실글리세롤 리파아제 조절제로서의 아미노사이클로부탄
WO2021228123A1 (zh) * 2020-05-12 2021-11-18 北京广为医药科技有限公司 调节nmda受体活性的化合物、其药物组合物及用途
ES2997114T3 (en) * 2020-09-22 2025-02-14 Janssen Pharmaceutica Nv Cyclobutyl amide monoacylglycerol lipase modulators
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
US11434222B2 (en) * 2020-11-13 2022-09-06 H. Lundbeck A/S MAGL inhibitors
WO2022135462A1 (zh) * 2020-12-22 2022-06-30 鲁南制药集团股份有限公司 Magl抑制剂的医药用途
KR20240128870A (ko) 2021-12-29 2024-08-27 싸이 테라퓨틱스, 인크. 모노아실글리세롤 리파아제(magl) 억제
AU2023264787A1 (en) * 2022-05-04 2024-10-31 H. Lundbeck A/S Crystalline form of 1,1,1,3,3,3-hexafluoropropan-2-yl (s)-1-(pyridazin-3-ylcarbamoyl)-6 azaspiro[2.5]octane-6-carboxylate as monoacylglycerol lipase inhibitor.
WO2024168426A1 (en) 2023-02-13 2024-08-22 Apogee Pharmaceuticals, Inc. Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273659A1 (en) 1986-12-27 1988-07-06 Takeda Chemical Industries, Ltd. Azaspiro compounds, their production and use
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
AU699272B2 (en) 1994-08-02 1998-11-26 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
CA2369695A1 (en) 1999-04-09 2000-10-19 Manabu Itoh Agent for treating neuropathic pain
WO2001011968A2 (en) 1999-08-13 2001-02-22 Aventis Cropscience Gmbh Heterocyclic spiro compounds as pesticides
US20020151712A1 (en) 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
US6696443B2 (en) 2000-11-20 2004-02-24 Scios, Inc. Piperidine/piperazine-type inhibitors of p38 kinase
DK1390372T3 (da) 2001-05-14 2008-09-15 Hoffmann La Roche 1-oxa-3,9-diaza-spiro '5,5]undecan-2-on-derivater og anvendelse deraf som neurokininreceptorantagonist
GEP20084393B (en) 2003-04-24 2008-06-10 Incyte Corp Aza spiro alkane derivatives as inhibitors of metalloproteases
NZ545748A (en) 2003-08-29 2010-03-26 Ranbaxy Lab Ltd Isoxazoline derivatives as inhibitors of phosphodiesterase type-IV
SE0302811D0 (sv) 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
AR046756A1 (es) 2003-12-12 2005-12-21 Solvay Pharm Gmbh Derivados de hidronopol como agonistas de receptores orl-1 humanos.
JP3912400B2 (ja) 2004-03-30 2007-05-09 株式会社デンソー 圧力センサ
ES2370788T3 (es) 2005-02-07 2011-12-22 Aerocrine Ab Controlar flujo de aliento exhalado durante análisis.
BRPI0611498B1 (pt) 2005-05-25 2015-10-13 Basf Ag composto, processos para a preparação de compostos e de agentes, e para combater vegetação indesejada, agente, e, uso de compostos
EP1888509B1 (de) 2005-05-25 2013-05-15 Basf Se Benzoylsubstituierte serin-amide
BRPI0613505A2 (pt) 2005-06-30 2011-01-11 Prosidion Ltd agonistas de gpcr
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
ES2483866T3 (es) 2006-12-05 2014-08-08 Janssen Pharmaceutica Nv Derivados de diaza-espiro-piridinona sustituidos novedosos para uso en enfermedades mediadas por MCH-1
FR2915198B1 (fr) 2007-04-18 2009-12-18 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
JP2010524940A (ja) 2007-04-20 2010-07-22 シェーリング コーポレイション ピリミジノン誘導体およびそれらの使用方法
EP2058306A1 (en) 2007-11-08 2009-05-13 Schwarz Pharma Ag Heteroaryl-substituted 2-pyridinyl-methylamine derivatives
MX2011000664A (es) 2008-07-16 2011-02-24 Schering Corp Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119.
JP2012506883A (ja) 2008-10-29 2012-03-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換されたスピロアミン
CA2743861A1 (en) 2008-11-14 2010-05-20 The Scripps Research Institute Methods and compositions related to targeting monoacylglycerol lipase
BRPI0923819B1 (pt) * 2008-12-24 2021-11-09 Bial-Portela & Ca, S.A. Compostos inibidores de hidrolase amida de ácidos graxos, composições e usos dos mesmos
US8435977B2 (en) 2009-04-22 2013-05-07 Janssen Pharmaceutica, Nv Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors
TWI465446B (zh) 2009-04-22 2014-12-21 Janssen Pharmaceutica Nv 作為單醯基甘油脂酶抑制劑之吖丁啶基二醯胺類(四)
FR2945531A1 (fr) 2009-05-12 2010-11-19 Sanofi Aventis Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
JPWO2011142359A1 (ja) 2010-05-10 2013-07-22 日産化学工業株式会社 スピロ化合物及びアディポネクチン受容体活性化薬
FR2960875B1 (fr) 2010-06-04 2012-12-28 Sanofi Aventis Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique
JP2013537920A (ja) 2010-09-27 2013-10-07 ヤンセン ファーマシューティカ エヌ.ベー. モノアシルグリセロールリパーゼ阻害剤としてのオキソピペラジン−アゼチジンアミド及びオキソジアゼピン−アゼチジンアミド
US8513423B2 (en) 2010-10-22 2013-08-20 Janssen Pharmaceutica, Nv Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors
US8575363B2 (en) 2010-10-22 2013-11-05 Janssen Pharmaceutica N.V. Amino-pyrrolidine-azetidine diamides as monoacylglycerol lipase inhibitors
ES2618929T3 (es) 2011-03-14 2017-06-22 Vertex Pharmaceuticals Incorporated Morfolina-Spiro piperidina amida cíclica como moduladores del canal iónico
JP2014159376A (ja) 2011-06-17 2014-09-04 Taisho Pharmaceutical Co Ltd アザスピロアルカン化合物
ES2982694T3 (es) * 2012-01-06 2024-10-17 H Lundbeck As Compuestos de carbamato para su uso en tratamiento
WO2013131010A2 (en) 2012-03-02 2013-09-06 Icahn School Of Medicine At Mount Sinai Function of chemokine receptor ccr8 in melanoma metastasis
JP6566867B2 (ja) 2012-07-13 2019-08-28 ペイン セラピューティクス インコーポレイテッド 生きている患者でのアルツハイマー病アッセイ
WO2014074715A1 (en) 2012-11-07 2014-05-15 Genentech, Inc. Cyclopropyl amide derivatives
WO2015104343A1 (en) 2014-01-09 2015-07-16 Proyecto De Biomedicina Cima, S.L. New antifibrinolytic compounds
US9771341B2 (en) * 2015-03-18 2017-09-26 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
JP6832914B2 (ja) 2015-07-31 2021-02-24 ファイザー・インク Magl阻害薬としての1,1,1−トリフルオロ−3−ヒドロキシプロパン−2−イルカルバマート誘導体および1,1,1−トリフルオロ−4−ヒドロキシブタン−2−イルカルバマート誘導体
US10030020B2 (en) * 2016-05-12 2018-07-24 Abide Therapeutics, Inc. Spirocycle compounds and methods of making and using same

Similar Documents

Publication Publication Date Title
JP2020506903A5 (cg-RX-API-DMAC7.html)
JP2020506899A5 (cg-RX-API-DMAC7.html)
US11746091B2 (en) Cannabinoid receptor modulators
JP2019526582A5 (cg-RX-API-DMAC7.html)
RU2726631C1 (ru) Гетероциклические спиросоединения в качестве ингибиторов magl
US9751859B2 (en) Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
JP5843861B2 (ja) Axl阻害剤としての薬学的に活性な化合物
JP6661749B2 (ja) Rorガンマモジュレータとしての新規化合物
JP2022166179A (ja) アミノピリジン誘導体化合物の塩、その結晶形態、及びその調製プロセス
KR102591886B1 (ko) 축합고리 피리미딘계 화합물, 중간체, 이의 제조 방법, 조성물 및 응용
TW201609706A (zh) 胺基嘧啶基化合物
JP2010518026A5 (cg-RX-API-DMAC7.html)
KR20120030447A (ko) Jak 저해물질로서 3-[4-(7h-피롤로[2,3-d]피리미딘-4-일)-1h-피라졸-1-일]옥탄- 또는 헵탄-니트릴
JP2009527562A (ja) ホスホジエステラーゼ10阻害剤としてのシンノリン誘導体
PT2222675E (pt) 5-anilinoimidazopiridinas e métodos de utilização
JP2017500364A (ja) セリン/トレオニンキナーゼ阻害剤
JP2011526926A (ja) 置換二環式ヘテロ環化合物と使用方法
JP2006522035A (ja) 置換ピラゾール
JP2010504302A (ja) 5−ht6アンタゴニストとしてのスルホニルピラゾリンカルボキサミジン誘導体
AU2018229493A1 (en) Therapeutic compounds and uses thereof
KR20170040299A (ko) 이미다조피리다진 화합물
JP4988583B2 (ja) 血管内皮成長因子(vegf)受容体キナーゼインヒビターとしての新規アントラニルアミドピリジンウレア
JP2019520366A (ja) Alk5抑制剤としての新規ピラゾール誘導体およびその用途
JP2022551093A (ja) 四環系ピリミジノン類化合物、その製造方法、その組成物及び使用
JP7043483B2 (ja) 二環式プロリン化合物