JP2019536757A5 - - Google Patents
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- Publication number
- JP2019536757A5 JP2019536757A5 JP2019520150A JP2019520150A JP2019536757A5 JP 2019536757 A5 JP2019536757 A5 JP 2019536757A5 JP 2019520150 A JP2019520150 A JP 2019520150A JP 2019520150 A JP2019520150 A JP 2019520150A JP 2019536757 A5 JP2019536757 A5 JP 2019536757A5
- Authority
- JP
- Japan
- Prior art keywords
- muscle
- trans
- thiazole
- carboxamide
- yloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *=C(*C(CC1)CC1Oc1c2nc[s]c2cc(F)c1)NC(CC1)CCN1c(nc1)ncc1F Chemical compound *=C(*C(CC1)CC1Oc1c2nc[s]c2cc(F)c1)NC(CC1)CCN1c(nc1)ncc1F 0.000 description 1
- HEGBXROZTLMDLF-UHFFFAOYSA-N O=C(NC(C1)CN1c(cc1)ncc1F)N(C1)CC1Oc1c2nc[s]c2cc(F)c1 Chemical compound O=C(NC(C1)CN1c(cc1)ncc1F)N(C1)CC1Oc1c2nc[s]c2cc(F)c1 HEGBXROZTLMDLF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662407634P | 2016-10-13 | 2016-10-13 | |
| US62/407,634 | 2016-10-13 | ||
| PCT/IB2017/056320 WO2018069863A1 (en) | 2016-10-13 | 2017-10-12 | 1,3 di-substituted cyclobutane or azetidine derivatives as hematopoietic prostaglandin d synthase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536757A JP2019536757A (ja) | 2019-12-19 |
| JP2019536757A5 true JP2019536757A5 (OSRAM) | 2020-12-24 |
| JP6938628B2 JP6938628B2 (ja) | 2021-09-22 |
Family
ID=60320926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520150A Expired - Fee Related JP6938628B2 (ja) | 2016-10-13 | 2017-10-12 | 造血器型プロスタグランジンｄシンターゼ阻害剤としての１，３二置換シクロブタンまたはアゼチジン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11053234B2 (OSRAM) |
| EP (1) | EP3526206A1 (OSRAM) |
| JP (1) | JP6938628B2 (OSRAM) |
| KR (1) | KR20190072565A (OSRAM) |
| CN (1) | CN110072857A (OSRAM) |
| AR (1) | AR109931A1 (OSRAM) |
| AU (1) | AU2017342156B2 (OSRAM) |
| BR (1) | BR112019007609A2 (OSRAM) |
| CA (1) | CA3038756A1 (OSRAM) |
| CL (1) | CL2019000986A1 (OSRAM) |
| CO (1) | CO2019003482A2 (OSRAM) |
| CR (1) | CR20190174A (OSRAM) |
| DO (1) | DOP2019000087A (OSRAM) |
| EA (1) | EA201990904A1 (OSRAM) |
| IL (1) | IL265597A (OSRAM) |
| JO (1) | JOP20190072A1 (OSRAM) |
| MA (1) | MA46531A (OSRAM) |
| MX (1) | MX2019004320A (OSRAM) |
| PE (1) | PE20191020A1 (OSRAM) |
| PH (1) | PH12019500811A1 (OSRAM) |
| TW (1) | TW201827412A (OSRAM) |
| UY (1) | UY37440A (OSRAM) |
| WO (1) | WO2018069863A1 (OSRAM) |
| ZA (1) | ZA201901848B (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| EP3638672A1 (en) * | 2017-06-13 | 2020-04-22 | GlaxoSmithKline Intellectual Property Development Limited | Chemical compounds as h-pgds inhibitors |
| CR20200054A (es) | 2017-08-09 | 2020-03-21 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
| HUE062446T2 (hu) | 2017-09-01 | 2023-11-28 | Denali Therapeutics Inc | Vegyületek, készítmények és eljárások |
| EP3923935A4 (en) | 2019-02-13 | 2022-10-26 | Denali Therapeutics Inc. | COMPOUNDS, COMPOSITIONS AND METHODS |
| MA54959A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| WO2021152113A1 (en) | 2020-01-31 | 2021-08-05 | Bayer Aktiengesellschaft | Substituted 2,3-benzodiazepines derivatives |
| WO2021207310A1 (en) | 2020-04-08 | 2021-10-14 | Agios Pharmaceuticals, Inc. | Menin inhibitors and methods of use for treating cancer |
| CN113582880B (zh) * | 2020-04-30 | 2023-11-17 | 南京药石科技股份有限公司 | 一种（3-氨基二环[1.1.1]戊烷-1-基）氨基甲酸叔丁酯的制备方法 |
| CN111574473A (zh) * | 2020-06-04 | 2020-08-25 | 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） | 一种氨基噻唑类化合物的合成方法 |
| CN115916776A (zh) * | 2020-06-09 | 2023-04-04 | 艾尼莫生物科技公司 | 胶原蛋白1翻译抑制剂及其使用方法 |
| CN111549000B (zh) * | 2020-06-18 | 2022-07-29 | 中国医学科学院整形外科医院 | 一种过表达Hpgds的重组脂肪干细胞、制备方法及其应用 |
| US20230339937A1 (en) | 2020-06-19 | 2023-10-26 | Sato Pharmaceutical Co., Ltd. | Condensed ring compounds that inhibit h-pgds |
| CN114085167A (zh) * | 2021-12-13 | 2022-02-25 | 华中药业股份有限公司 | 一种杂质ts-3a的制备方法 |
| EP4450502A4 (en) | 2021-12-17 | 2025-06-11 | Sato Pharmaceutical Co., Ltd. | AZAINDOLE DERIVATIVE INHIBITING H-PGDS |
| WO2023111996A1 (en) | 2021-12-17 | 2023-06-22 | Reglagene Holding, Inc. | Compositions and methods of making and using small molecules in the treatment of cancer |
| US20250250265A1 (en) * | 2022-04-15 | 2025-08-07 | Vanderbilt University | Benzothiazole-phenylsulfonyl-piperidine analogs as activators of nacylphosphatidylethanolamine hydrolyzing phospholipase d |
| US12215102B2 (en) | 2023-02-28 | 2025-02-04 | Reglagene, Inc. | Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions |
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| US4031221A (en) * | 1974-06-17 | 1977-06-21 | American Hoechst Corporation | Method of treating pain and hypertension |
| US4956359A (en) | 1985-02-28 | 1990-09-11 | A. H. Robins Company, Inc. | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics |
| IE58943B1 (en) | 1985-02-28 | 1993-12-01 | Robins Co Inc A H | 3-Aryloxy-azetidine-carboxamides |
| US6809088B2 (en) * | 1997-03-24 | 2004-10-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
| GB9801501D0 (en) * | 1998-01-23 | 1998-03-18 | Cerebrus Ltd | Chemical compounds - II |
| GB9917385D0 (en) | 1999-07-23 | 1999-09-22 | Cerebrus Ltd | Chemical compounds-I |
| US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
| JP2007522233A (ja) * | 2004-02-11 | 2007-08-09 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療におけるそれらの使用 |
| WO2005094805A1 (ja) | 2004-04-01 | 2005-10-13 | Institute Of Medicinal Molecular Design. Inc. | イミン誘導体及びアミド誘導体 |
| CA2563963A1 (en) * | 2004-04-28 | 2005-11-10 | Pfizer Inc. | 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor |
| AP2007004047A0 (en) * | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| JP2008545008A (ja) | 2005-06-30 | 2008-12-11 | プロシディオン・リミテッド | Ｇｐｃｒアゴニスト |
| GB0514017D0 (en) | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| TW200720255A (en) | 2005-07-13 | 2007-06-01 | Taiho Pharmaceutical Co Ltd | Benzoimidazole compound capable of inhibiting prostaglandin d synthetase |
| JP2007051121A (ja) | 2005-07-22 | 2007-03-01 | Taiho Yakuhin Kogyo Kk | プロスタグランジンｄ合成酵素を阻害するピリミジン化合物 |
| PE20110118A1 (es) | 2005-10-04 | 2011-03-08 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| US20070208426A1 (en) * | 2006-03-03 | 2007-09-06 | Sdgi Holdings, Inc. | Spinal implant with improved surface properties for delivery |
| WO2007106705A1 (en) | 2006-03-10 | 2007-09-20 | Boehringer Ingelheim International Gmbh | Soluble epoxide hydrolase inhibitors and methods of using same |
| WO2008023720A1 (en) | 2006-08-23 | 2008-02-28 | Astellas Pharma Inc. | Urea compound or salt thereof |
| JP2010513458A (ja) * | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用 |
| DK2142516T3 (da) | 2007-03-30 | 2013-04-15 | Sanofi Sa | Pyrimidinhydrazidforbindelser i ders egenskab af pgds-inhibitorer |
| GB0706793D0 (en) | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
| DK2265578T3 (en) | 2008-03-04 | 2015-10-12 | Vernalis R&D Ltd | Azetidin-DERIVATIVES |
| WO2009153720A1 (en) | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
| US20110306597A1 (en) | 2008-06-18 | 2011-12-15 | James Michael Crawforth | Nicotinamide Derivatives |
| WO2010024903A1 (en) * | 2008-08-29 | 2010-03-04 | Yangbo Feng | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS |
| BRPI0919004A2 (pt) | 2008-09-22 | 2019-09-24 | Cayman Chem Co | composto de multiheteroarila como inibidores de h-pgds e sua utilização para o tratamento de doenças mediadas por prostaglandina d2 |
| AU2010222122B2 (en) | 2009-03-09 | 2013-06-27 | Taiho Pharmaceutical Co., Ltd. | Piperazine compound capable of inhibiting prostaglandin D synthase |
| EP2487175A1 (en) | 2009-10-06 | 2012-08-15 | Kyowa Hakko Kirin Co., Ltd. | Pharmaceutical product containing aromatic heterocyclic compound |
| BR112012007635B1 (pt) | 2009-10-08 | 2019-07-09 | Sanofi | Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação |
| EP2527340B1 (en) | 2010-01-22 | 2016-08-17 | Taiho Pharmaceutical Co., Ltd. | Piperazine compound having a pgds inhibitory effect |
| JP2013526546A (ja) | 2010-05-13 | 2013-06-24 | アムジエン・インコーポレーテツド | Ｐｄｅ１０阻害剤としてのヘテロアリ−ルオキシヘテロシクリル化合物 |
| JP2013526537A (ja) | 2010-05-13 | 2013-06-24 | アムジエン・インコーポレーテツド | Ｐｄｅ１０阻害剤としてのヘテロアリールオキシカルボシクリル化合物 |
| US9050334B2 (en) * | 2010-07-16 | 2015-06-09 | Innov88 Llc | MIF inhibitors and their uses |
| CA2812081A1 (en) * | 2010-09-13 | 2012-03-22 | Novartis Ag | Triazine-oxadiazoles |
| KR101400192B1 (ko) | 2010-12-31 | 2014-05-27 | 제일모직 주식회사 | 포지티브형 감광성 수지 조성물, 이를 사용하여 제조된 감광성 수지막 및 상기 감광성 수지막을 포함하는 반도체 소자 |
| US9133164B2 (en) | 2011-04-13 | 2015-09-15 | Innov88 Llc | MIF inhibitors and their uses |
| CN103702961A (zh) | 2011-05-23 | 2014-04-02 | 赛诺菲 | 含有n-烷基的氘代化合物的制备方法 |
| WO2013074387A1 (en) | 2011-11-14 | 2013-05-23 | Merck Sharp & Dohme Corp. | Imidazole derivatives |
| US9499533B2 (en) | 2012-03-27 | 2016-11-22 | Shionogi & Co., Ltd. | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity |
| TWI585088B (zh) | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物 |
| EP2956441A4 (en) | 2013-02-18 | 2016-11-02 | Scripps Research Inst | MODULATORS OF VASOPRESSIN RECEPTORS WITH THERAPEUTIC POTENTIAL |
| WO2014179144A1 (en) | 2013-04-29 | 2014-11-06 | E. I. Du Pont De Nemours And Company | Fungicidal heterocyclic compounds |
| MX375153B (es) | 2014-05-19 | 2025-03-06 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelminticos. |
| TWI695831B (zh) * | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
| MY188957A (en) * | 2015-03-30 | 2022-01-14 | Mission Therapeutics Ltd | 1-cyano-pyrrolidine compounds as usp30 inhibitors |
| CN108430992A (zh) | 2015-12-17 | 2018-08-21 | 阿斯特克斯医疗公司 | 作为h-pgds抑制剂的喹啉-3-甲酰胺 |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
-
2017
- 2017-06-16 JO JOP/2019/0072A patent/JOP20190072A1/ar unknown
- 2017-10-11 TW TW106134668A patent/TW201827412A/zh unknown
- 2017-10-11 UY UY0001037440A patent/UY37440A/es unknown
- 2017-10-11 AR ARP170102843A patent/AR109931A1/es unknown
- 2017-10-12 CR CR20190174A patent/CR20190174A/es unknown
- 2017-10-12 JP JP2019520150A patent/JP6938628B2/ja not_active Expired - Fee Related
- 2017-10-12 EP EP17797738.6A patent/EP3526206A1/en not_active Withdrawn
- 2017-10-12 EA EA201990904A patent/EA201990904A1/ru unknown
- 2017-10-12 US US16/341,113 patent/US11053234B2/en not_active Expired - Fee Related
- 2017-10-12 KR KR1020197013195A patent/KR20190072565A/ko not_active Ceased
- 2017-10-12 PE PE2019000741A patent/PE20191020A1/es unknown
- 2017-10-12 MX MX2019004320A patent/MX2019004320A/es unknown
- 2017-10-12 BR BR112019007609A patent/BR112019007609A2/pt not_active Application Discontinuation
- 2017-10-12 MA MA046531A patent/MA46531A/fr unknown
- 2017-10-12 AU AU2017342156A patent/AU2017342156B2/en not_active Ceased
- 2017-10-12 CA CA3038756A patent/CA3038756A1/en not_active Abandoned
- 2017-10-12 CN CN201780075127.1A patent/CN110072857A/zh active Pending
- 2017-10-12 WO PCT/IB2017/056320 patent/WO2018069863A1/en not_active Ceased
-
2019
- 2019-03-25 IL IL265597A patent/IL265597A/en unknown
- 2019-03-26 ZA ZA2019/01848A patent/ZA201901848B/en unknown
- 2019-04-08 DO DO2019000087A patent/DOP2019000087A/es unknown
- 2019-04-08 CO CONC2019/0003482A patent/CO2019003482A2/es unknown
- 2019-04-11 CL CL2019000986A patent/CL2019000986A1/es unknown
- 2019-04-12 PH PH12019500811A patent/PH12019500811A1/en unknown
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