JP2019502691A5 - - Google Patents
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- Publication number
- JP2019502691A5 JP2019502691A5 JP2018531378A JP2018531378A JP2019502691A5 JP 2019502691 A5 JP2019502691 A5 JP 2019502691A5 JP 2018531378 A JP2018531378 A JP 2018531378A JP 2018531378 A JP2018531378 A JP 2018531378A JP 2019502691 A5 JP2019502691 A5 JP 2019502691A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- quinoline
- difluoromethoxy
- trans
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268630P | 2015-12-17 | 2015-12-17 | |
| US62/268,630 | 2015-12-17 | ||
| PCT/IB2016/057676 WO2017103851A1 (en) | 2015-12-17 | 2016-12-15 | Quinoline-3-carboxamides as h-pgds inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019502691A JP2019502691A (ja) | 2019-01-31 |
| JP2019502691A5 true JP2019502691A5 (OSRAM) | 2020-02-06 |
Family
ID=57589094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531378A Pending JP2019502691A (ja) | 2015-12-17 | 2016-12-15 | Ｈ−ｐｇｄｓ阻害剤としてのキノリン−３−カルボキサミド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210238162A1 (OSRAM) |
| EP (1) | EP3390384B1 (OSRAM) |
| JP (1) | JP2019502691A (OSRAM) |
| KR (1) | KR20180095580A (OSRAM) |
| CN (1) | CN108430992A (OSRAM) |
| AR (1) | AR107044A1 (OSRAM) |
| AU (1) | AU2016370779B2 (OSRAM) |
| BR (1) | BR112018012469B1 (OSRAM) |
| CA (1) | CA3008358A1 (OSRAM) |
| RU (1) | RU2018126105A (OSRAM) |
| TW (1) | TW201733988A (OSRAM) |
| UY (1) | UY37028A (OSRAM) |
| WO (1) | WO2017103851A1 (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI788830B (zh) | 2015-07-02 | 2023-01-01 | 瑞士商赫孚孟拉羅股份公司 | 雙環內醯胺及其使用方法 |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| EP3526219B1 (en) | 2016-10-17 | 2021-12-15 | F. Hoffmann-La Roche AG | Bicyclic pyridone lactams and methods of use thereof |
| CN109890793B (zh) | 2016-11-11 | 2022-11-18 | 拜耳动物保健有限责任公司 | 新的抗蠕虫药喹啉-3-甲酰胺衍生物 |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| US11738009B2 (en) | 2017-04-18 | 2023-08-29 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
| EP3638672A1 (en) | 2017-06-13 | 2020-04-22 | GlaxoSmithKline Intellectual Property Development Limited | Chemical compounds as h-pgds inhibitors |
| MX2020001403A (es) | 2017-08-04 | 2020-03-09 | Bayer Animal Health Gmbh | Nuevos derivados de quinolina. |
| HUE062446T2 (hu) | 2017-09-01 | 2023-11-28 | Denali Therapeutics Inc | Vegyületek, készítmények és eljárások |
| EP3724197A1 (en) * | 2017-12-13 | 2020-10-21 | GlaxoSmithKline Intellectual Property Development Ltd | Fused pyridines which act as inhibitors of h-pgds |
| UY38009A (es) | 2017-12-15 | 2019-07-31 | Bayer Animal Health Gmbh | Proceso para la preparación de derivados de quinolina |
| SG11202010153WA (en) | 2018-04-17 | 2020-11-27 | Tempest Therapeutics Inc | Bicyclic carboxamides and methods of use thereof |
| JP7398391B2 (ja) * | 2018-04-20 | 2023-12-14 | エフ． ホフマン－ラ ロシュ アーゲー | Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物 |
| JP7403472B2 (ja) | 2018-05-09 | 2023-12-22 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規キノリン誘導体 |
| WO2020181247A1 (en) * | 2019-03-06 | 2020-09-10 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| JP2023521342A (ja) | 2020-04-09 | 2023-05-24 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 駆虫性化合物としての置換縮合アジン類 |
| CN111549000B (zh) * | 2020-06-18 | 2022-07-29 | 中国医学科学院整形外科医院 | 一种过表达Hpgds的重组脂肪干细胞、制备方法及其应用 |
| US20230339937A1 (en) | 2020-06-19 | 2023-10-26 | Sato Pharmaceutical Co., Ltd. | Condensed ring compounds that inhibit h-pgds |
| WO2022055926A1 (en) * | 2020-09-11 | 2022-03-17 | The Regents Of The University Of California | Compositions and methods for treating muscular dystrophies |
| BR112023024807A2 (pt) * | 2021-05-28 | 2024-02-15 | Merck Sharp & Dohme Llc | Síntese de inibidor de btk e intermediários do mesmo |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| EP4450502A4 (en) | 2021-12-17 | 2025-06-11 | Sato Pharmaceutical Co., Ltd. | AZAINDOLE DERIVATIVE INHIBITING H-PGDS |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5569450A (en) | 1993-03-17 | 1996-10-29 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid |
| US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| CN1361768A (zh) * | 1999-06-02 | 2002-07-31 | Nps药物有限公司 | 代谢移变的谷氨酸盐受体拮抗剂和它们治疗中枢神经系统疾病的用途 |
| US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| WO2005094805A1 (ja) * | 2004-04-01 | 2005-10-13 | Institute Of Medicinal Molecular Design. Inc. | イミン誘導体及びアミド誘導体 |
| TW200720255A (en) | 2005-07-13 | 2007-06-01 | Taiho Pharmaceutical Co Ltd | Benzoimidazole compound capable of inhibiting prostaglandin d synthetase |
| JP2007051121A (ja) | 2005-07-22 | 2007-03-01 | Taiho Yakuhin Kogyo Kk | プロスタグランジンｄ合成酵素を阻害するピリミジン化合物 |
| PE20110118A1 (es) | 2005-10-04 | 2011-03-08 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| JP2010513458A (ja) * | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用 |
| DK2142516T3 (da) | 2007-03-30 | 2013-04-15 | Sanofi Sa | Pyrimidinhydrazidforbindelser i ders egenskab af pgds-inhibitorer |
| GB0706793D0 (en) | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
| ES2553340T3 (es) * | 2007-12-12 | 2015-12-07 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
| US20110306597A1 (en) | 2008-06-18 | 2011-12-15 | James Michael Crawforth | Nicotinamide Derivatives |
| WO2009153720A1 (en) | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
| BRPI0919004A2 (pt) | 2008-09-22 | 2019-09-24 | Cayman Chem Co | composto de multiheteroarila como inibidores de h-pgds e sua utilização para o tratamento de doenças mediadas por prostaglandina d2 |
| AU2010222122B2 (en) | 2009-03-09 | 2013-06-27 | Taiho Pharmaceutical Co., Ltd. | Piperazine compound capable of inhibiting prostaglandin D synthase |
| EP2487175A1 (en) | 2009-10-06 | 2012-08-15 | Kyowa Hakko Kirin Co., Ltd. | Pharmaceutical product containing aromatic heterocyclic compound |
| BR112012007635B1 (pt) | 2009-10-08 | 2019-07-09 | Sanofi | Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação |
| EP2527340B1 (en) | 2010-01-22 | 2016-08-17 | Taiho Pharmaceutical Co., Ltd. | Piperazine compound having a pgds inhibitory effect |
| WO2014012050A2 (en) * | 2012-07-13 | 2014-01-16 | Indiana University Research & Technology Corporation | Compounds for treatment of spinal muscular atrophy |
-
2016
- 2016-12-15 CN CN201680074158.0A patent/CN108430992A/zh active Pending
- 2016-12-15 TW TW105141512A patent/TW201733988A/zh unknown
- 2016-12-15 WO PCT/IB2016/057676 patent/WO2017103851A1/en not_active Ceased
- 2016-12-15 BR BR112018012469-9A patent/BR112018012469B1/pt not_active IP Right Cessation
- 2016-12-15 EP EP16815960.6A patent/EP3390384B1/en active Active
- 2016-12-15 AR ARP160103847A patent/AR107044A1/es unknown
- 2016-12-15 KR KR1020187019904A patent/KR20180095580A/ko not_active Withdrawn
- 2016-12-15 JP JP2018531378A patent/JP2019502691A/ja active Pending
- 2016-12-15 AU AU2016370779A patent/AU2016370779B2/en not_active Expired - Fee Related
- 2016-12-15 US US16/062,223 patent/US20210238162A1/en not_active Abandoned
- 2016-12-15 RU RU2018126105A patent/RU2018126105A/ru not_active Application Discontinuation
- 2016-12-15 CA CA3008358A patent/CA3008358A1/en not_active Abandoned
- 2016-12-15 UY UY0001037028A patent/UY37028A/es unknown
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