JP2019534036A5 - - Google Patents

Download PDF

Info

Publication number
JP2019534036A5
JP2019534036A5 JP2019532192A JP2019532192A JP2019534036A5 JP 2019534036 A5 JP2019534036 A5 JP 2019534036A5 JP 2019532192 A JP2019532192 A JP 2019532192A JP 2019532192 A JP2019532192 A JP 2019532192A JP 2019534036 A5 JP2019534036 A5 JP 2019534036A5
Authority
JP
Japan
Prior art keywords
adenovirus
oncolytic adenovirus
bite
oncolytic
adenovirus according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019532192A
Other languages
English (en)
Japanese (ja)
Other versions
JP7212620B2 (ja
JP2019534036A (ja
Filing date
Publication date
Priority claimed from GBGB1614607.8A external-priority patent/GB201614607D0/en
Priority claimed from GBGB1700663.6A external-priority patent/GB201700663D0/en
Priority claimed from GBGB1706219.1A external-priority patent/GB201706219D0/en
Priority claimed from GBGB1713765.4A external-priority patent/GB201713765D0/en
Priority claimed from PCT/EP2017/071674 external-priority patent/WO2018041838A1/en
Application filed filed Critical
Publication of JP2019534036A publication Critical patent/JP2019534036A/ja
Publication of JP2019534036A5 publication Critical patent/JP2019534036A5/ja
Priority to JP2022130173A priority Critical patent/JP7525558B2/ja
Publication of JP7212620B2 publication Critical patent/JP7212620B2/ja
Application granted granted Critical
Priority to JP2024114614A priority patent/JP2024147722A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019532192A 2016-08-29 2017-08-29 二重特異性t細胞アクチベーターで武装したアデノウイルス Active JP7212620B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022130173A JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2024114614A JP2024147722A (ja) 2016-08-29 2024-07-18 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB1614607.8 2016-08-29
GBGB1614607.8A GB201614607D0 (en) 2016-08-29 2016-08-29 Modified adenovirus
GBGB1700663.6A GB201700663D0 (en) 2017-01-13 2017-01-13 Modified adenovirus
GB1700663.6 2017-01-13
GBGB1706219.1A GB201706219D0 (en) 2017-04-19 2017-04-19 Modified adenovirus
GB1706219.1 2017-04-19
GB1713765.4 2017-08-28
GBGB1713765.4A GB201713765D0 (en) 2017-08-28 2017-08-28 Modified adenovirus
PCT/EP2017/071674 WO2018041838A1 (en) 2016-08-29 2017-08-29 Adenovirus armed with bispecific t cell engager (bite)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022130173A Division JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス

Publications (3)

Publication Number Publication Date
JP2019534036A JP2019534036A (ja) 2019-11-28
JP2019534036A5 true JP2019534036A5 (enExample) 2020-10-08
JP7212620B2 JP7212620B2 (ja) 2023-01-25

Family

ID=59923381

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019532192A Active JP7212620B2 (ja) 2016-08-29 2017-08-29 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2019507924A Pending JP2019532621A (ja) 2016-08-29 2017-08-29 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス
JP2022130173A Active JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2024114614A Pending JP2024147722A (ja) 2016-08-29 2024-07-18 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019507924A Pending JP2019532621A (ja) 2016-08-29 2017-08-29 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス
JP2022130173A Active JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2024114614A Pending JP2024147722A (ja) 2016-08-29 2024-07-18 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス

Country Status (18)

Country Link
US (3) US12258417B2 (enExample)
EP (3) EP4273252A3 (enExample)
JP (4) JP7212620B2 (enExample)
KR (2) KR102491752B1 (enExample)
CN (4) CN109862912B (enExample)
AU (2) AU2017320776B2 (enExample)
BR (1) BR112019003866A2 (enExample)
CA (2) CA3033267A1 (enExample)
CL (1) CL2019000510A1 (enExample)
CO (1) CO2019002371A2 (enExample)
ES (1) ES2983916T3 (enExample)
IL (2) IL303187A (enExample)
MX (2) MX2019002328A (enExample)
MY (1) MY197324A (enExample)
PH (1) PH12019500436A1 (enExample)
SG (2) SG11201901715UA (enExample)
WO (2) WO2018041827A1 (enExample)
ZA (1) ZA201900644B (enExample)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
KR102391731B1 (ko) 2013-01-14 2022-04-27 젠코어 인코포레이티드 신규한 이형이량체 단백질
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
KR102272932B1 (ko) 2013-10-25 2021-07-05 싸이오서스 테라퓨틱스 엘티디. 이종 유전자로 무장된 종양살상 아데노바이러스
PL3122781T3 (pl) 2014-03-28 2020-06-15 Xencor, Inc. Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
HK1245171A1 (zh) 2014-11-26 2018-08-24 Xencor, Inc. 结合cd3和cd38的异二聚体抗体
JP6696982B2 (ja) 2014-11-26 2020-05-20 ゼンコー・インコーポレイテッドXencor、 Inc. Cd3および腫瘍抗原に結合するヘテロ二量体抗体
DK3288573T3 (da) 2015-04-30 2020-03-16 Psioxus Therapeutics Ltd Onkolytisk adenovirus, der koder for et b7-protein
EP3387013B1 (en) 2015-12-07 2022-06-08 Xencor, Inc. Heterodimeric antibodies that bind cd3 and psma
US11155622B2 (en) 2015-12-17 2021-10-26 Psioxus Therapeutics Limited Virus encoding an anti-TCR-complex antibody or fragment
CA3026151A1 (en) 2016-06-14 2017-12-21 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
RU2019102008A (ru) 2016-06-28 2020-07-28 Ксенкор, Инк. Гетеродимерные антитела, которые связывают рецептор соматостатина 2-го типа
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
KR102491752B1 (ko) 2016-08-29 2023-01-26 싸이오서스 테라퓨틱스 엘티디. 이중특이성 T 세포 세포 관여자(BiTE)가 보강된 아데노바이러스
MX2020000993A (es) * 2017-07-26 2020-07-22 Oncorus Inc Vectores virales oncolíticos y usos de estos.
AU2018366199A1 (en) 2017-11-08 2020-05-28 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
JP7765181B2 (ja) 2017-12-19 2025-11-06 ゼンコア インコーポレイテッド 改変されたil-2 fc融合タンパク質
WO2019133847A1 (en) * 2017-12-29 2019-07-04 Oncorus, Inc. Oncolytic viral delivery of therapeutic polypeptides
CN112469477A (zh) * 2018-04-04 2021-03-09 Xencor股份有限公司 与成纤维细胞活化蛋白结合的异源二聚体抗体
WO2019200013A1 (en) * 2018-04-11 2019-10-17 Cancer Targeting Systems, Inc. Therapeutic constructs for treating cancer
CA3097593A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
KR20210003814A (ko) 2018-04-18 2021-01-12 젠코어 인코포레이티드 IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질
EP3847186A4 (en) * 2018-09-05 2022-05-18 Memorial Sloan Kettering Cancer Center Pleural effusion-based methods for assessing immunoresponsive cell activity
KR102884523B1 (ko) 2018-10-03 2025-11-10 젠코어 인코포레이티드 IL-12 이종이량체 Fc-융합 단백질
CN109709341B (zh) * 2019-01-17 2020-12-15 浙江大学 骨关节炎第二亚型的生物标记物以及用途
WO2020172259A1 (en) * 2019-02-20 2020-08-27 Research Institute At Nationwide Children's Hospital Cancer-targeted, virus-encoded, regulatable t (catvert) or nk cell (catvern) linkers
EP3930850A1 (en) 2019-03-01 2022-01-05 Xencor, Inc. Heterodimeric antibodies that bind enpp3 and cd3
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を予防するための方法および組成物
EP3901168A1 (en) * 2020-04-21 2021-10-27 Universität Duisburg-Essen Interferon alpha 2 variants and uses thereof
EP4149632A1 (en) 2020-05-14 2023-03-22 Xencor, Inc. Heterodimeric antibodies that bind msln and cd3
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
CN116322728B (zh) * 2020-08-14 2026-07-31 上海行深生物科技有限公司 水疱性口炎病毒及其治疗用途
US11919958B2 (en) 2020-08-19 2024-03-05 Xencor, Inc. Anti-CD28 compositions
CN116420076A (zh) * 2020-09-27 2023-07-11 基因泰克公司 高通量多参数免疫细胞接合物筛选测定
JP2023550148A (ja) 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重car-t組成物及び方法
WO2022148736A1 (en) * 2021-01-05 2022-07-14 Transgene Vectorization of muc1 t cell engager
GB202102049D0 (en) 2021-02-13 2021-03-31 Psioxus Therapeutics Ltd Viruses
EP4305067A1 (en) 2021-03-09 2024-01-17 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
US11859012B2 (en) 2021-03-10 2024-01-02 Xencor, Inc. Heterodimeric antibodies that bind CD3 and GPC3
WO2022204724A1 (en) * 2021-03-25 2022-09-29 Dynamicure Biotechnology Llc Anti-igfbp7 constructs and uses thereof
CN115161293B (zh) * 2021-04-01 2024-11-15 南京惟亚德生物医药有限公司 一种编码双特异性t细胞衔接子的溶瘤痘苗病毒及其制备方法和应用
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
CA3238406A1 (en) * 2021-11-19 2023-05-25 Wuhan Yzy Biopharma Co., Ltd. Bispecific antibody and use thereof
IL314678A (en) 2022-02-27 2024-10-01 Boehringer Ingelheim Int Bispecific antibodies against cd277 and a tumor-antigen
EP4562028A1 (en) 2022-07-28 2025-06-04 Akamis Bio Limited Virus encoding transgenes to complement cellular therapy
EP4581055A1 (en) 2022-08-31 2025-07-09 Universität Zürich Adenoviral-based in situ delivery of bispecific t cell engagers
AU2024277678A1 (en) 2023-05-25 2025-11-27 Dispatch Biotherapeutics, Inc. Synthetic cancer antigens as targets for treating cancers
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses
WO2026117756A2 (en) 2024-11-27 2026-06-04 Dispatch Biotherapeutics, Inc. Systems and methods for expression of synthetic cancer antigens and cytokine receptors
WO2026117753A1 (en) 2024-11-27 2026-06-04 Dispatch Biotherapeutics, Inc. Viral vectors for expression of synthetic cancer antigens and chemokine and related methods and uses

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170269A3 (en) 1984-08-02 1987-09-23 Kao Corporation Medicated cosmetic compositions
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
US5358866A (en) 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
FR2705361B1 (fr) 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
CA2144040A1 (fr) 1993-07-13 1995-01-26 Michel Perricaudet Vecteurs adenoviraux defectifs et utilisation en therapie genique
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5830686A (en) 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
US5677170A (en) 1994-03-02 1997-10-14 The Johns Hopkins University In vitro transposition of artificial transposons
US5587299A (en) 1994-04-20 1996-12-24 Memorial Sloan-Kettering Cancer Center Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof
DE19648650C2 (de) 1996-01-29 1998-07-02 Schering Ag Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US5877011A (en) 1996-11-20 1999-03-02 Genzyme Corporation Chimeric adenoviral vectors
CN1242051A (zh) 1996-12-31 2000-01-19 昂尼克斯药物公司 用于肿瘤治疗和预防的致细胞病变病毒
ATE374821T1 (de) 1997-02-20 2007-10-15 Univ Johns Hopkins Med Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
EP1905304A3 (en) 1997-10-09 2008-08-13 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US6291214B1 (en) 1998-05-11 2001-09-18 Glaxo Wellcome Inc. System for generating recombinant viruses
US20020019051A1 (en) 1998-05-27 2002-02-14 Monika Lusky Chimeric adenoviral vectors
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
CN1110553C (zh) 1998-07-15 2003-06-04 杭州赛狮生物技术开发有限公司 基因工程腺病毒及其用途
AU767975B2 (en) 1998-09-11 2003-11-27 Genvec, Inc. Alternatively targeted adenovirus
AU774076C (en) 1998-12-09 2005-04-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The A recombinant vector expressing multiple costimulatory molecules and uses thereof
CA2364934C (fr) 1999-02-22 2011-10-18 Transgene S.A. Procede d'obtention d'une preparation virale purifiee
WO2000061726A1 (fr) 1999-04-09 2000-10-19 Aventis Pharma S.A. Composition destinee a la conservation d'adenovirus recombinants infectieux
ATE519854T1 (de) 1999-05-17 2011-08-15 Crucell Holland Bv Rekombinantes adenovirus auf basis von serotyp 48 (ad48).
ATE291633T1 (de) 1999-06-01 2005-04-15 Univ Washington Rekombinante adenovirale vektoren, die chimäre fiberproteine exprimieren, für die zellspezifische infektion und genomische integration
US6596535B1 (en) 1999-08-09 2003-07-22 Targeted Genetics Corporation Metabolically activated recombinant viral vectors and methods for the preparation and use
US7396679B2 (en) 1999-11-15 2008-07-08 Onyx Pharmaceuticals, Inc. Oncolytic adenovirus
JP4810042B2 (ja) 2000-01-21 2011-11-09 バイオヴェックス リミテッド ヘルペスウイルス株
US7456009B2 (en) 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
EP1301612A2 (en) 2000-05-31 2003-04-16 Genvec, Inc. Method and composition for targeting an adenoviral vector
US6965018B2 (en) 2000-06-06 2005-11-15 Bristol-Myers Squibb Company Antibodies directed to B7-related polypeptide, BSL-2
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
ATE449859T1 (de) 2001-01-04 2009-12-15 Goeran Wadell Virusvektor zur gentherapie
US20050175589A1 (en) 2001-07-13 2005-08-11 Btg International Limited Anti-neoplastic viral agents
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
EP1327688A1 (en) 2002-01-14 2003-07-16 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Adenoviruses with enhanced lytic potency
EP1470233A1 (en) 2002-02-01 2004-10-27 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated with pods
US20060147420A1 (en) 2004-03-10 2006-07-06 Juan Fueyo Oncolytic adenovirus armed with therapeutic genes
US7858367B2 (en) 2002-04-30 2010-12-28 Duke University Viral vectors and methods for producing and using the same
US20040167088A1 (en) 2003-02-25 2004-08-26 Genvec, Inc. Method of using adenoviral vectors with increased persistence in vivo
US20040213764A1 (en) 2003-03-28 2004-10-28 William Wold Adenovirus replication-competent vectors expressing trail
US20050136035A1 (en) 2003-06-03 2005-06-23 Derek Ko Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site
PT1644412E (pt) 2003-07-01 2015-12-23 Ucb Biopharma Sprl Fragmentos de anticorpos fab modificados
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
EP1646717A4 (en) 2003-07-18 2006-12-20 Onyx Pharma Inc ADENOVIRAL VECTORS OF SUB-GROUP B FOR THE TREATMENT OF DISEASES
US8076459B2 (en) 2003-10-16 2011-12-13 Micromet Ag Multispecfic deimmunized CD3-binders
WO2005107474A2 (en) 2004-04-30 2005-11-17 Introgen Therapeutics, Inc. Oncolytic adenovirus armed with therapeutic genes
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
ES2358204T3 (es) 2004-05-26 2011-05-06 Bayer Schering Pharma Aktiengesellschaft Adenovirus quiméricos para uso en el tratamiento del cáncer.
CN100361710C (zh) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
US20060292682A1 (en) 2004-07-22 2006-12-28 Hawkins Lynda K Addition of transgenes into adenoviral vectors
WO2006039045A2 (en) 2004-09-01 2006-04-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenoviral vectors able to transduce apcs, potential use in immune response generation
EP1819823A2 (en) 2004-12-01 2007-08-22 Bayer Schering Pharma Aktiengesellschaft Generation of replication competent viruses for therapeutic use
US20060205080A1 (en) 2005-03-01 2006-09-14 David Frey Formulations for therapeutic viruses having enhanced storage stability
US8765146B2 (en) 2005-08-31 2014-07-01 Genvec, Inc. Adenoviral vector-based malaria vaccines
CN1961961B (zh) 2005-11-11 2010-05-26 深圳市源兴生物医药科技有限公司 一种药物制剂及其制备方法
DE102005055128B4 (de) 2005-11-15 2015-04-02 Universität Rostock Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor
ES2304281B1 (es) 2006-02-01 2009-08-12 Dnatrix Inc. Adenovirus oncoliticos para el tratamiento del cancer.
JP5448840B2 (ja) 2006-12-22 2014-03-19 プシオクサス・セラピューティクス・リミテッド 腫瘍退縮アデノウイルスの作出およびその使用
EP2535350B1 (en) 2007-09-26 2018-01-24 UCB Biopharma SPRL Dual specificity antibody fusions
WO2009097443A2 (en) 2008-01-29 2009-08-06 Remedy Pharmaceuticals, Inc. Liquid formulations of compounds active at sulfonylurea receptors
US20110086005A1 (en) 2008-05-27 2011-04-14 Oncolytics Biotech Inc. Modulating interstitial pressure and oncolytic viral delivery and distribution
US10407513B2 (en) 2008-09-26 2019-09-10 Ucb Biopharma Sprl Biological products
KR101837053B1 (ko) 2008-10-01 2018-03-12 암젠 리서치 (뮌헨) 게엠베하 종간 특이적 PSCAxCD3, CD19xCD3, c-METxCD3, 엔도시알린xCD3, EpCAMxCD3, IGF-1RxCD3 또는 FAPαxCD3 이중특이적 단일쇄 항체
CN101381742A (zh) 2008-10-23 2009-03-11 浙江理工大学 晚期启动子靶向性调控溶瘤腺病毒pCN305载体及其构建方法与应用
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
US20100297072A1 (en) 2009-05-19 2010-11-25 Depinho Ronald A Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
WO2011040972A1 (en) 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd. Anti-fibroblast activation protein antibodies and methods and uses thereof
UY33492A (es) * 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
AU2011292120B2 (en) 2010-08-16 2015-07-30 Salk Institute For Biological Studies Adenoviral assembly method
LT2748201T (lt) 2011-08-23 2018-02-26 Roche Glycart Ag Dvigubai specifinė t ląsteles aktyvinantį antigeną surišanti molekulė
JP2015507604A (ja) 2011-11-14 2015-03-12 リジェネレイティブ サイエンシーズ, エルエルシー 懸濁粒子送達システムおよび方法
CN102586327B (zh) 2012-01-18 2013-09-11 陕西师范大学 一步法构建携带外源基因的d24纤维蛋白修饰的条件复制型腺病毒载体及其应用
WO2013113615A1 (en) * 2012-02-03 2013-08-08 F. Hoffmann-La Roche Ag Bispecific antibody molecules with antigen-transfected t-cells and their use in medicine
PL2844282T3 (pl) 2012-05-04 2019-11-29 Pfizer Antygeny związane z gruczołem krokowym i schematy immunoterapii oparte na szczepionce
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
WO2014138314A1 (en) * 2013-03-05 2014-09-12 Baylor College Of Medicine Oncolytic virus
CN105592788A (zh) * 2013-03-06 2016-05-18 塞罗拉公司 用于脑健康的多模态生理评估的形成因素
GB201322851D0 (en) 2013-12-23 2014-02-12 Psioxus Therapeutics Ltd Method
GB201318793D0 (en) 2013-10-24 2013-12-11 Plaquetec Ltd Vascular Biomarkers
KR102272932B1 (ko) 2013-10-25 2021-07-05 싸이오서스 테라퓨틱스 엘티디. 이종 유전자로 무장된 종양살상 아데노바이러스
CN114317461A (zh) 2013-11-22 2022-04-12 德那翠丝有限公司 表达免疫细胞刺激受体激动剂的腺病毒
EP4011910A1 (en) 2014-04-03 2022-06-15 IGM Biosciences, Inc. Modified j-chain
GB201406608D0 (en) * 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
KR20170044194A (ko) 2014-08-27 2017-04-24 싸이오서스 테라퓨틱스 엘티디. 아데노바이러스의 제조를 위한 공정
GB201503500D0 (en) 2015-03-02 2015-04-15 Ucl Business Plc Cell
WO2016146894A1 (en) * 2015-03-17 2016-09-22 Tilt Biotherapeutics Oy Oncolytic adenoviruses coding for bi-specific antibodies and methods and uses related thereto
DK3288573T3 (da) 2015-04-30 2020-03-16 Psioxus Therapeutics Ltd Onkolytisk adenovirus, der koder for et b7-protein
US11155622B2 (en) 2015-12-17 2021-10-26 Psioxus Therapeutics Limited Virus encoding an anti-TCR-complex antibody or fragment
AU2017233072B2 (en) 2016-03-18 2020-12-24 Nantcell, Inc. Multimodal vector for dendritic cell infection
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
KR102491752B1 (ko) 2016-08-29 2023-01-26 싸이오서스 테라퓨틱스 엘티디. 이중특이성 T 세포 세포 관여자(BiTE)가 보강된 아데노바이러스
EP3872180A1 (en) 2016-10-20 2021-09-01 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
WO2018083259A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083258A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes
WO2018083257A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes

Similar Documents

Publication Publication Date Title
JP2024147722A5 (enExample)
HRP20200439T1 (hr) Onkolitički adenovirus koji kodira protein b7
Shekhar et al. Interleukins profiling for biosensing applications: possibilities and the future of disease detection
Li et al. IL-17 receptor–based signaling and implications for disease
van der Bruggen et al. Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha
Savan et al. Cloning, characterization and expression analysis of interleukin‐10 from the common carp, Cyprinus carpio L.
Kitaya et al. Spatial and temporal expression of ligands for CXCR3 and CXCR4 in human endometrium
Silver et al. gp130 at the nexus of inflammation, autoimmunity, and cancer
DiCarlo et al. Cytokine and chemokine patterns across 100 days after hematopoietic stem cell transplantation in children
JP2002524537A5 (enExample)
Dondeti et al. Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms
FI3461491T3 (fi) Tehostettu adoptiivinen soluterapia
Woo Cytokines and juvenile idiopathic arthritis
Ishibashi et al. Cytokine secretion profile of human keratinocytes exposed to Malassezia yeasts
Tsuboi et al. Serum interleukin-12 and interleukin-18 levels as a tumor marker in patients with esophageal carcinoma
B Maschio-Signorini et al. Melatonin regulates angiogenic and inflammatory proteins in MDA-MB-231 cell line and in co-culture with cancer-associated fibroblasts
Seelige et al. Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection
JP2021073453A5 (enExample)
JP2018529339A5 (enExample)
Gibellini et al. Plasma cytokine atlas reveals the importance of TH2 polarization and interferons in predicting COVID-19 severity and survival
LAI et al. Anti‐DNA autoantibodies stimulate the release of interleukin‐1 and interleukin‐6 from endothelial cells
JP2021532163A5 (enExample)
Hsieh et al. Polymorphisms for interleukin‐4 (IL‐4)–590 promoter, IL‐4 intron3, and tumor necrosis factor alpha–308 promoter: Non‐association with endometriosis
JP2024505564A5 (enExample)
Klein et al. Production of multiple cytokines by Hodgkin's disease derived cell lines