JP2019534036A5 - - Google Patents

Download PDF

Info

Publication number
JP2019534036A5
JP2019534036A5 JP2019532192A JP2019532192A JP2019534036A5 JP 2019534036 A5 JP2019534036 A5 JP 2019534036A5 JP 2019532192 A JP2019532192 A JP 2019532192A JP 2019532192 A JP2019532192 A JP 2019532192A JP 2019534036 A5 JP2019534036 A5 JP 2019534036A5
Authority
JP
Japan
Prior art keywords
adenovirus
oncolytic adenovirus
bite
oncolytic
adenovirus according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019532192A
Other languages
English (en)
Japanese (ja)
Other versions
JP7212620B2 (ja
JP2019534036A (ja
Filing date
Publication date
Priority claimed from GBGB1614607.8A external-priority patent/GB201614607D0/en
Priority claimed from GBGB1700663.6A external-priority patent/GB201700663D0/en
Priority claimed from GBGB1706219.1A external-priority patent/GB201706219D0/en
Priority claimed from GBGB1713765.4A external-priority patent/GB201713765D0/en
Priority claimed from PCT/EP2017/071674 external-priority patent/WO2018041838A1/en
Application filed filed Critical
Publication of JP2019534036A publication Critical patent/JP2019534036A/ja
Publication of JP2019534036A5 publication Critical patent/JP2019534036A5/ja
Priority to JP2022130173A priority Critical patent/JP7525558B2/ja
Publication of JP7212620B2 publication Critical patent/JP7212620B2/ja
Application granted granted Critical
Priority to JP2024114614A priority patent/JP2024147722A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019532192A 2016-08-29 2017-08-29 二重特異性t細胞アクチベーターで武装したアデノウイルス Active JP7212620B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022130173A JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2024114614A JP2024147722A (ja) 2016-08-29 2024-07-18 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB1614607.8 2016-08-29
GBGB1614607.8A GB201614607D0 (en) 2016-08-29 2016-08-29 Modified adenovirus
GBGB1700663.6A GB201700663D0 (en) 2017-01-13 2017-01-13 Modified adenovirus
GB1700663.6 2017-01-13
GB1706219.1 2017-04-19
GBGB1706219.1A GB201706219D0 (en) 2017-04-19 2017-04-19 Modified adenovirus
GB1713765.4 2017-08-28
GBGB1713765.4A GB201713765D0 (en) 2017-08-28 2017-08-28 Modified adenovirus
PCT/EP2017/071674 WO2018041838A1 (en) 2016-08-29 2017-08-29 Adenovirus armed with bispecific t cell engager (bite)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022130173A Division JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス

Publications (3)

Publication Number Publication Date
JP2019534036A JP2019534036A (ja) 2019-11-28
JP2019534036A5 true JP2019534036A5 (enExample) 2020-10-08
JP7212620B2 JP7212620B2 (ja) 2023-01-25

Family

ID=59923381

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019532192A Active JP7212620B2 (ja) 2016-08-29 2017-08-29 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2019507924A Pending JP2019532621A (ja) 2016-08-29 2017-08-29 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス
JP2022130173A Active JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2024114614A Pending JP2024147722A (ja) 2016-08-29 2024-07-18 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019507924A Pending JP2019532621A (ja) 2016-08-29 2017-08-29 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス
JP2022130173A Active JP7525558B2 (ja) 2016-08-29 2022-08-17 二重特異性t細胞アクチベーターで武装したアデノウイルス
JP2024114614A Pending JP2024147722A (ja) 2016-08-29 2024-07-18 二重特異性T細胞エンゲージャー(BiTE)で武装したアデノウイルス

Country Status (18)

Country Link
US (3) US12049513B2 (enExample)
EP (3) EP4273252A3 (enExample)
JP (4) JP7212620B2 (enExample)
KR (2) KR102491752B1 (enExample)
CN (4) CN110214025B (enExample)
AU (2) AU2017320776B2 (enExample)
BR (1) BR112019003866A2 (enExample)
CA (2) CA3033267A1 (enExample)
CL (1) CL2019000510A1 (enExample)
CO (1) CO2019002371A2 (enExample)
ES (1) ES2983916T3 (enExample)
IL (2) IL264902B2 (enExample)
MX (2) MX2019002328A (enExample)
MY (1) MY197324A (enExample)
PH (1) PH12019500436A1 (enExample)
SG (2) SG11201901716TA (enExample)
WO (2) WO2018041838A1 (enExample)
ZA (1) ZA201900644B (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
CA3211863A1 (en) 2013-01-14 2014-07-17 Xencor, Inc. Novel heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
SI3021859T1 (en) 2013-10-25 2018-04-30 Psioxus Therapeutics Limited Oncolytic adenoviruses equipped with heterologous genes
BR112016022385A2 (pt) 2014-03-28 2018-06-19 Xencor, Inc anticorpos específicos que se ligam a cd38 e cd3
SG11201704274QA (en) 2014-11-26 2017-06-29 Xencor Inc Heterodimeric antibodies that bind cd3 and cd38
WO2016086189A2 (en) 2014-11-26 2016-06-02 Xencor, Inc. Heterodimeric antibodies that bind cd3 and tumor antigens
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
KR102854512B1 (ko) 2015-04-30 2025-09-04 아카미스 바이오 리미티드 B7 단백질을 암호화하는 종양세포붕괴 아데노바이러스
CA3007030A1 (en) 2015-12-07 2017-06-15 Xencor, Inc. Heterodimeric antibodies that bind cd3 and psma
KR20180108590A (ko) 2015-12-17 2018-10-04 싸이오서스 테라퓨틱스 엘티디. 항-tcr-복합체 항체 또는 단편을 암호화하는 바이러스
CA3026151A1 (en) 2016-06-14 2017-12-21 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
KR20190020341A (ko) 2016-06-28 2019-02-28 젠코어 인코포레이티드 소마토스타틴 수용체 2에 결합하는 이종이량체 항체
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
CN110214025B (zh) 2016-08-29 2024-08-02 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
RU2771110C2 (ru) * 2017-07-26 2022-04-26 Онкорус, Инк. Онколитические вирусные векторы и их применение
US11312770B2 (en) 2017-11-08 2022-04-26 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
WO2019125732A1 (en) 2017-12-19 2019-06-27 Xencor, Inc. Engineered il-2 fc fusion proteins
EP3731850A4 (en) * 2017-12-29 2021-12-01 Oncorus, Inc. ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES
WO2019195623A2 (en) * 2018-04-04 2019-10-10 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
EP3781130A4 (en) * 2018-04-11 2022-01-26 Precision Molecular Inc. THERAPEUTIC CONSTRUCTS FOR TREATMENT OF CANCER
CN112867734A (zh) 2018-04-18 2021-05-28 Xencor股份有限公司 包含IL-15/IL-15Ra Fc融合蛋白和PD-1抗原结合结构域的靶向PD-1的异源二聚体融合蛋白及其用途
US11505595B2 (en) 2018-04-18 2022-11-22 Xencor, Inc. TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15RA Fc-fusion proteins and TIM-3 antigen binding domains
EP3847186A4 (en) * 2018-09-05 2022-05-18 Memorial Sloan Kettering Cancer Center Pleural effusion-based methods for assessing immunoresponsive cell activity
EP3861016A2 (en) 2018-10-03 2021-08-11 Xencor, Inc. Il-12 heterodimeric fc-fusion proteins
CN109709341B (zh) * 2019-01-17 2020-12-15 浙江大学 骨关节炎第二亚型的生物标记物以及用途
CN113646334B (zh) * 2019-02-20 2025-09-16 国家儿童医院研究所 癌症靶向的、病毒编码的、可调节的t细胞(catvert)或nk细胞(catvern)接头
AU2020232605A1 (en) 2019-03-01 2021-10-21 Xencor, Inc. Heterodimeric antibodies that bind ENPP3 and CD3
KR102503349B1 (ko) 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
US11919956B2 (en) 2020-05-14 2024-03-05 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
WO2021252917A2 (en) 2020-06-11 2021-12-16 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
CN116322728A (zh) * 2020-08-14 2023-06-23 上海行深生物科技有限公司 水疱性口炎病毒及其治疗用途
KR20230166150A (ko) 2020-08-19 2023-12-06 젠코어 인코포레이티드 항-cd28 조성물
TW202229546A (zh) * 2020-09-27 2022-08-01 美商建南德克公司 高通量多參數免疫細胞接合物篩選測定
EP4247850A1 (en) 2020-11-20 2023-09-27 Simcere Innovation, Inc. Armed dual car-t compositions and methods for cancer immunotherapy
WO2022148736A1 (en) * 2021-01-05 2022-07-14 Transgene Vectorization of muc1 t cell engager
GB202102049D0 (en) 2021-02-13 2021-03-31 Psioxus Therapeutics Ltd Viruses
CA3212665A1 (en) 2021-03-09 2022-09-15 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
WO2022192586A1 (en) 2021-03-10 2022-09-15 Xencor, Inc. Heterodimeric antibodies that bind cd3 and gpc3
CN115161293B (zh) * 2021-04-01 2024-11-15 南京惟亚德生物医药有限公司 一种编码双特异性t细胞衔接子的溶瘤痘苗病毒及其制备方法和应用
US20250163157A1 (en) 2022-02-27 2025-05-22 Boehringer Ingelheim International Gmbh Bispecific antibodies against cd277 and a tumor-antigen
EP4562028A1 (en) 2022-07-28 2025-06-04 Akamis Bio Limited Virus encoding transgenes to complement cellular therapy
WO2024047114A1 (en) 2022-08-31 2024-03-07 Universität Zürich Adenoviral-based in situ delivery of bispecific t cell engagers
AU2024277678A1 (en) 2023-05-25 2025-11-27 Dispatch Biotherapeutics, Inc. Synthetic cancer antigens as targets for treating cancers
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170269A3 (en) 1984-08-02 1987-09-23 Kao Corporation Medicated cosmetic compositions
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
US5358866A (en) 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
FR2705361B1 (fr) 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
PT667912E (pt) 1993-07-13 2008-10-15 Centelion Vectores adenovirais deficientes e utilização em terapia génica
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5830686A (en) 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
US5677170A (en) 1994-03-02 1997-10-14 The Johns Hopkins University In vitro transposition of artificial transposons
US5587299A (en) 1994-04-20 1996-12-24 Memorial Sloan-Kettering Cancer Center Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof
DE19648650C2 (de) 1996-01-29 1998-07-02 Schering Ag Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US5877011A (en) 1996-11-20 1999-03-02 Genzyme Corporation Chimeric adenoviral vectors
CN1242051A (zh) 1996-12-31 2000-01-19 昂尼克斯药物公司 用于肿瘤治疗和预防的致细胞病变病毒
ATE374821T1 (de) 1997-02-20 2007-10-15 Univ Johns Hopkins Med Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
HUP0003911A3 (en) 1997-10-09 2007-11-28 Pro Virus Treatment of neoplasms with viruses
US6291214B1 (en) 1998-05-11 2001-09-18 Glaxo Wellcome Inc. System for generating recombinant viruses
US20020019051A1 (en) 1998-05-27 2002-02-14 Monika Lusky Chimeric adenoviral vectors
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
CN1110553C (zh) 1998-07-15 2003-06-04 杭州赛狮生物技术开发有限公司 基因工程腺病毒及其用途
AU767975B2 (en) 1998-09-11 2003-11-27 Genvec, Inc. Alternatively targeted adenovirus
ATE361988T1 (de) 1998-12-09 2007-06-15 Us Gov Health & Human Serv Recombinanter vector, welcher mehrere kostimulatorische moleküle exprimiert und dessen verwenden
AU774437B2 (en) 1999-02-22 2004-06-24 Transgene S.A. Method for obtaining a purified viral preparation
HK1045716A1 (zh) 1999-04-09 2002-12-06 阿文蒂斯药物股份有限公司 用於保存感染性重組腺病毒的組合物
NZ515582A (en) 1999-05-17 2003-11-28 Crucell Holland B Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35
ATE291633T1 (de) 1999-06-01 2005-04-15 Univ Washington Rekombinante adenovirale vektoren, die chimäre fiberproteine exprimieren, für die zellspezifische infektion und genomische integration
CA2379166C (en) 1999-08-09 2013-03-26 Targeted Genetics Corporation Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs
US7396679B2 (en) 1999-11-15 2008-07-08 Onyx Pharmaceuticals, Inc. Oncolytic adenovirus
BRPI0107736B8 (pt) 2000-01-21 2021-05-25 Biovex Ltd cepa hsv1 js1, composição farmacêutica, e, uso de uma cepa hsv1 js1
US7456009B2 (en) 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
JP2003534806A (ja) 2000-05-31 2003-11-25 ジェンベク、インコーポレイティッド アデノウイルスベクターのターゲティングの方法および組成物
JP2004500863A (ja) 2000-06-06 2004-01-15 ブリストル−マイヤーズ スクイブ カンパニー 免疫調節に有用なb7関連核酸およびポリペプチド
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
EP1348030B1 (en) 2001-01-04 2009-11-25 Wadell, Göran Viral vector for gene therapy
US20050175589A1 (en) 2001-07-13 2005-08-11 Btg International Limited Anti-neoplastic viral agents
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
EP1327688A1 (en) 2002-01-14 2003-07-16 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Adenoviruses with enhanced lytic potency
US20030219410A1 (en) 2002-02-01 2003-11-27 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated to PODs
US20060147420A1 (en) 2004-03-10 2006-07-06 Juan Fueyo Oncolytic adenovirus armed with therapeutic genes
WO2003092594A2 (en) 2002-04-30 2003-11-13 Duke University Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use
US20040167088A1 (en) 2003-02-25 2004-08-26 Genvec, Inc. Method of using adenoviral vectors with increased persistence in vivo
WO2004087930A1 (en) 2003-03-28 2004-10-14 Saint Louis University Adenovirus replication-competent vectors expressing trail
US20050136035A1 (en) 2003-06-03 2005-06-23 Derek Ko Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site
CA2527020A1 (en) 2003-07-01 2005-01-13 Celltech R & D Limited Modified antibody fab fragments
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
EP1646717A4 (en) 2003-07-18 2006-12-20 Onyx Pharma Inc ADENOVIRAL VECTORS OF SUB-GROUP B FOR THE TREATMENT OF DISEASES
PL1673398T3 (pl) * 2003-10-16 2011-05-31 Amgen Res Munich Gmbh Multispecyficzne deimmunizowane cząsteczki wiążące CD3
US20080292592A1 (en) 2004-04-30 2008-11-27 Sunil Chada Oncolytic Adenovirus Armed with Therapeutic Genes
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
PT1749098E (pt) 2004-05-26 2011-02-02 Bayer Schering Pharma Ag Adenovírus quimérico para utilização no tratamento do cancro
CN100361710C (zh) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
US20060292682A1 (en) 2004-07-22 2006-12-28 Hawkins Lynda K Addition of transgenes into adenoviral vectors
JP2008511336A (ja) 2004-09-01 2008-04-17 アメリカ合衆国 免疫原性が増加したアデノウイルスベクターをインビボで用いる方法
EP1819823A2 (en) 2004-12-01 2007-08-22 Bayer Schering Pharma Aktiengesellschaft Generation of replication competent viruses for therapeutic use
US20060205080A1 (en) 2005-03-01 2006-09-14 David Frey Formulations for therapeutic viruses having enhanced storage stability
US8765146B2 (en) 2005-08-31 2014-07-01 Genvec, Inc. Adenoviral vector-based malaria vaccines
CN1961961B (zh) 2005-11-11 2010-05-26 深圳市源兴生物医药科技有限公司 一种药物制剂及其制备方法
DE102005055128B4 (de) 2005-11-15 2015-04-02 Universität Rostock Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor
ES2304281B1 (es) 2006-02-01 2009-08-12 Dnatrix Inc. Adenovirus oncoliticos para el tratamiento del cancer.
EP2094284A2 (en) 2006-12-22 2009-09-02 Bayer Schering Pharma AG Generation of oncolytic adenoviruses and uses thereof
CA2700714C (en) 2007-09-26 2018-09-11 Ucb Pharma S.A. Dual specificity antibody fusions
WO2009097443A2 (en) 2008-01-29 2009-08-06 Remedy Pharmaceuticals, Inc. Liquid formulations of compounds active at sulfonylurea receptors
US20110086005A1 (en) 2008-05-27 2011-04-14 Oncolytics Biotech Inc. Modulating interstitial pressure and oncolytic viral delivery and distribution
CA2737241C (en) 2008-09-26 2017-08-29 Ucb Pharma S.A. Multivalent antibody fusion proteins
KR101837053B1 (ko) 2008-10-01 2018-03-12 암젠 리서치 (뮌헨) 게엠베하 종간 특이적 PSCAxCD3, CD19xCD3, c-METxCD3, 엔도시알린xCD3, EpCAMxCD3, IGF-1RxCD3 또는 FAPαxCD3 이중특이적 단일쇄 항체
CN101381742A (zh) 2008-10-23 2009-03-11 浙江理工大学 晚期启动子靶向性调控溶瘤腺病毒pCN305载体及其构建方法与应用
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
US20100297072A1 (en) 2009-05-19 2010-11-25 Depinho Ronald A Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
US8999342B2 (en) 2009-10-02 2015-04-07 Ludwig Institute For Cancer Research, Ltd. Anti-fibroblast activation protein antibodies and methods and uses thereof
UY33492A (es) * 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
KR101721725B1 (ko) 2010-08-16 2017-03-31 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 아데노바이러스 조립 방법
EP3321286B1 (en) 2011-08-23 2021-01-06 Roche Glycart AG Bispecific t cell activating antigen binding molecules
US20140316369A1 (en) 2011-11-14 2014-10-23 Regenerative Sciences, Llc Suspended particle delivery systems and methods
CN102586327B (zh) 2012-01-18 2013-09-11 陕西师范大学 一步法构建携带外源基因的d24纤维蛋白修饰的条件复制型腺病毒载体及其应用
US10633451B2 (en) * 2012-02-03 2020-04-28 Hoffmann-La Roche Inc. Bispecific antibody molecules with antigen-transfected T-cells and their use in medicine
SG10201603896RA (en) 2012-05-04 2016-07-28 Pfizer Prostate-associated antigens and vaccine-based immunotherapy regimens
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US20160000842A1 (en) * 2013-03-05 2016-01-07 Baylor College Of Medicine Oncolytic virus
CN105592788A (zh) 2013-03-06 2016-05-18 塞罗拉公司 用于脑健康的多模态生理评估的形成因素
GB201322851D0 (en) 2013-12-23 2014-02-12 Psioxus Therapeutics Ltd Method
GB201318793D0 (en) 2013-10-24 2013-12-11 Plaquetec Ltd Vascular Biomarkers
SI3021859T1 (en) * 2013-10-25 2018-04-30 Psioxus Therapeutics Limited Oncolytic adenoviruses equipped with heterologous genes
JP2016540505A (ja) 2013-11-22 2016-12-28 ディーエヌエートリックス インコーポレイテッド アデノウイルス発現免疫細胞刺激受容体アゴニスト
CN106459213B (zh) 2014-04-03 2020-12-01 Igm生物科学股份有限公司 修饰的j链
GB201406608D0 (en) 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
WO2016030489A2 (en) * 2014-08-27 2016-03-03 Psioxus Therapeutics Limited A process for the production of adenovirus
GB201503500D0 (en) 2015-03-02 2015-04-15 Ucl Business Plc Cell
US11485791B2 (en) * 2015-03-17 2022-11-01 Tilt Biotherapeutics Oy Oncolytic adenoviruses coding for bi-specific antibodies
KR102854512B1 (ko) 2015-04-30 2025-09-04 아카미스 바이오 리미티드 B7 단백질을 암호화하는 종양세포붕괴 아데노바이러스
KR20180108590A (ko) 2015-12-17 2018-10-04 싸이오서스 테라퓨틱스 엘티디. 항-tcr-복합체 항체 또는 단편을 암호화하는 바이러스
WO2017161360A2 (en) 2016-03-18 2017-09-21 Nant Holdings Ip, Llc Multimodal vector for dendritic cell infection
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
CN110214025B (zh) 2016-08-29 2024-08-02 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
AU2017345764A1 (en) 2016-10-20 2019-05-02 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
WO2018083259A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083257A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083258A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes

Similar Documents

Publication Publication Date Title
JP2019534036A5 (enExample)
JP2024147722A5 (enExample)
Zhao et al. Th17 cells in inflammatory bowel disease: cytokines, plasticity, and therapies
Gallagher et al. Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses
Chang et al. IL-17F: regulation, signaling and function in inflammation
CN112105633A (zh) 新型白介素2及其用途
Savan et al. Cloning, characterization and expression analysis of interleukin‐10 from the common carp, Cyprinus carpio L.
van der Bruggen et al. Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha
Shekhar et al. Interleukins profiling for biosensing applications: possibilities and the future of disease detection
Nishimoto et al. Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation
JP2002524537A5 (enExample)
DiCarlo et al. Cytokine and chemokine patterns across 100 days after hematopoietic stem cell transplantation in children
Cameron et al. Cytokines and chemokines-their receptors and their genes: an overview
B Maschio-Signorini et al. Melatonin regulates angiogenic and inflammatory proteins in MDA-MB-231 cell line and in co-culture with cancer-associated fibroblasts
RU2015148920A (ru) Расширенная адоптивная клеточная терапия
RU2007129263A (ru) Антитела к интерлейкину-17f и другие антагонисты опосредуемой il-17f передачи сигналов и их применение
JP2013516194A5 (enExample)
Tsuboi et al. Serum interleukin-12 and interleukin-18 levels as a tumor marker in patients with esophageal carcinoma
JPWO2021189059A5 (enExample)
Bauer Interleukin-6 and its receptor during homeostasis, inflammation, and tumor growth
Kashfi et al. Interleukin-16 polymorphisms as new promising biomarkers for risk of gastric cancer
Seelige et al. Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection
JP2018529339A5 (enExample)
Lee et al. Interleukin‐4 inhibits the expression of tumour necrosis factors α and β, interleukins‐1 β and‐6 and interferon‐γ
LAI et al. Anti‐DNA autoantibodies stimulate the release of interleukin‐1 and interleukin‐6 from endothelial cells