MX2019002328A - Adenovirus armado con captador biespecífico de linfocitos t (bite). - Google Patents

Adenovirus armado con captador biespecífico de linfocitos t (bite).

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Publication number
MX2019002328A
MX2019002328A MX2019002328A MX2019002328A MX2019002328A MX 2019002328 A MX2019002328 A MX 2019002328A MX 2019002328 A MX2019002328 A MX 2019002328A MX 2019002328 A MX2019002328 A MX 2019002328A MX 2019002328 A MX2019002328 A MX 2019002328A
Authority
MX
Mexico
Prior art keywords
bispecific
bite
virus
cell engager
armed
Prior art date
Application number
MX2019002328A
Other languages
English (en)
Inventor
Robert Champion Brian
Claire Noel Bromley Alice
David Freedman Joshua
David Fisher Kerry
William Seymour Leonard
Original Assignee
Psioxus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1614607.8A external-priority patent/GB201614607D0/en
Priority claimed from GBGB1700663.6A external-priority patent/GB201700663D0/en
Priority claimed from GBGB1706219.1A external-priority patent/GB201706219D0/en
Priority claimed from GBGB1713765.4A external-priority patent/GB201713765D0/en
Application filed by Psioxus Therapeutics Ltd filed Critical Psioxus Therapeutics Ltd
Publication of MX2019002328A publication Critical patent/MX2019002328A/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

Un adenovirus modificado, en particular Enadenotucirev (EnAd), armado con un captador biespecífico de linfocitos T (BiTE) que comprende al menos dos dominios de fijación, en donde al menos uno de los dominios es específico para un antígeno de superficie en un linfocito T de interés. También se proporciona una composición, tal como una formulación farmacéutica que comprende el virus, el uso del virus y las formulaciones de virus para el tratamiento, tal como en el tratamiento contra el cáncer. La divulgación también se extiende a procesos para preparar el virus.
MX2019002328A 2016-08-29 2017-08-29 Adenovirus armado con captador biespecífico de linfocitos t (bite). MX2019002328A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1614607.8A GB201614607D0 (en) 2016-08-29 2016-08-29 Modified adenovirus
GBGB1700663.6A GB201700663D0 (en) 2017-01-13 2017-01-13 Modified adenovirus
GBGB1706219.1A GB201706219D0 (en) 2017-04-19 2017-04-19 Modified adenovirus
GBGB1713765.4A GB201713765D0 (en) 2017-08-28 2017-08-28 Modified adenovirus
PCT/EP2017/071674 WO2018041838A1 (en) 2016-08-29 2017-08-29 Adenovirus armed with bispecific t cell engager (bite)

Publications (1)

Publication Number Publication Date
MX2019002328A true MX2019002328A (es) 2019-07-04

Family

ID=59923381

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019002328A MX2019002328A (es) 2016-08-29 2017-08-29 Adenovirus armado con captador biespecífico de linfocitos t (bite).
MX2023008779A MX2023008779A (es) 2016-08-29 2019-02-26 Adenovirus armado con un activador biespecifico de linfocitos t.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023008779A MX2023008779A (es) 2016-08-29 2019-02-26 Adenovirus armado con un activador biespecifico de linfocitos t.

Country Status (17)

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US (2) US20190194690A1 (es)
EP (3) EP3503918B1 (es)
JP (3) JP2019532621A (es)
KR (2) KR102427563B1 (es)
CN (2) CN109862912A (es)
AU (1) AU2017320776A1 (es)
BR (1) BR112019003866A2 (es)
CA (2) CA3034517A1 (es)
CL (1) CL2019000510A1 (es)
CO (1) CO2019002371A2 (es)
IL (2) IL303187A (es)
MX (2) MX2019002328A (es)
MY (1) MY197324A (es)
PH (1) PH12019500436A1 (es)
SG (2) SG11201901716TA (es)
WO (2) WO2018041838A1 (es)
ZA (1) ZA201900644B (es)

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US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
EP3831398A1 (en) 2013-10-25 2021-06-09 PsiOxus Therapeutics Limited Oncolytic adenoviruses armed with heterologous genes
PL3122781T3 (pl) 2014-03-28 2020-06-15 Xencor, Inc. Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3
EA037065B1 (ru) 2014-11-26 2021-02-01 Ксенкор, Инк. Гетеродимерные антитела, связывающие cd3 и cd38
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
BR112017011092A2 (pt) 2014-11-26 2017-12-26 Xencor Inc anticorpos heterodiméricos que ligam cd3 e antígenos de tumor
KR20240032177A (ko) 2015-04-30 2024-03-08 싸이오서스 테라퓨틱스 엘티디. B7 단백질을 암호화하는 종양세포붕괴 아데노바이러스
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BR112018012180A2 (pt) 2015-12-17 2018-12-04 Psioxus Therapeutics Ltd vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr
KR20230054508A (ko) 2016-06-14 2023-04-24 젠코어 인코포레이티드 이중특이적 체크포인트 억제제 항체
KR20190020341A (ko) 2016-06-28 2019-02-28 젠코어 인코포레이티드 소마토스타틴 수용체 2에 결합하는 이종이량체 항체
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
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