MX2023008779A - Adenovirus armado con un activador biespecifico de linfocitos t. - Google Patents

Adenovirus armado con un activador biespecifico de linfocitos t.

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Publication number
MX2023008779A
MX2023008779A MX2023008779A MX2023008779A MX2023008779A MX 2023008779 A MX2023008779 A MX 2023008779A MX 2023008779 A MX2023008779 A MX 2023008779A MX 2023008779 A MX2023008779 A MX 2023008779A MX 2023008779 A MX2023008779 A MX 2023008779A
Authority
MX
Mexico
Prior art keywords
bispecific
bite
virus
cell engager
armed
Prior art date
Application number
MX2023008779A
Other languages
English (en)
Inventor
Brian Robert Champion
Joshua David Freedman
Kerry David Fisher
Leonard William Seymour
Alice Claire Noel Bromley
Original Assignee
Akamis Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1614607.8A external-priority patent/GB201614607D0/en
Priority claimed from GBGB1700663.6A external-priority patent/GB201700663D0/en
Priority claimed from GBGB1706219.1A external-priority patent/GB201706219D0/en
Priority claimed from GBGB1713765.4A external-priority patent/GB201713765D0/en
Application filed by Akamis Bio Ltd filed Critical Akamis Bio Ltd
Publication of MX2023008779A publication Critical patent/MX2023008779A/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K14/521—Chemokines
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • C12N2840/00—Vectors comprising a special translation-regulating system
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Abstract

Un adenovirus modificado, en particular Enadenotucirev (EnAd), armado con un Activador biespecífico de linfocitos T que comprende al menos dos dominios de fijación, en donde al menos uno de los dominios es específico para un antígeno de superficie en un linfocito T de interés. También se proporciona una composición, tal como una formulación farmacéutica que comprende el virus, el uso del virus y las formulaciones de virus para el tratamiento, tal como en el tratamiento contra el cáncer. La divulgación también se extiende a procesos para preparar el virus.
MX2023008779A 2016-08-29 2019-02-26 Adenovirus armado con un activador biespecifico de linfocitos t. MX2023008779A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1614607.8A GB201614607D0 (en) 2016-08-29 2016-08-29 Modified adenovirus
GBGB1700663.6A GB201700663D0 (en) 2017-01-13 2017-01-13 Modified adenovirus
GBGB1706219.1A GB201706219D0 (en) 2017-04-19 2017-04-19 Modified adenovirus
GBGB1713765.4A GB201713765D0 (en) 2017-08-28 2017-08-28 Modified adenovirus

Publications (1)

Publication Number Publication Date
MX2023008779A true MX2023008779A (es) 2023-08-04

Family

ID=59923381

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019002328A MX2019002328A (es) 2016-08-29 2017-08-29 Adenovirus armado con captador biespecífico de linfocitos t (bite).
MX2023008779A MX2023008779A (es) 2016-08-29 2019-02-26 Adenovirus armado con un activador biespecifico de linfocitos t.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019002328A MX2019002328A (es) 2016-08-29 2017-08-29 Adenovirus armado con captador biespecífico de linfocitos t (bite).

Country Status (17)

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US (2) US20190194690A1 (es)
EP (3) EP4273252A3 (es)
JP (3) JP7212620B2 (es)
KR (2) KR102491752B1 (es)
CN (2) CN110214025A (es)
AU (1) AU2017320776A1 (es)
BR (1) BR112019003866A2 (es)
CA (2) CA3033267A1 (es)
CL (1) CL2019000510A1 (es)
CO (1) CO2019002371A2 (es)
IL (2) IL303187A (es)
MX (2) MX2019002328A (es)
MY (1) MY197324A (es)
PH (1) PH12019500436A1 (es)
SG (2) SG11201901716TA (es)
WO (2) WO2018041838A1 (es)
ZA (1) ZA201900644B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
EP2943511B1 (en) 2013-01-14 2019-08-07 Xencor, Inc. Novel heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
AU2014338864C1 (en) 2013-10-25 2020-07-16 Akamis Bio Limited Oncolytic adenoviruses armed with heterologous genes
SG10202008629XA (en) 2014-03-28 2020-10-29 Xencor Inc Bispecific antibodies that bind to cd38 and cd3
JP2017536830A (ja) 2014-11-26 2017-12-14 ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． Ｃｄ３及びｃｄ３８に結合するヘテロ二量体抗体
IL252480B2 (en) 2014-11-26 2023-12-01 Xencor Inc Heterodimeric antibodies that bind CD3 and tumor antigens
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
IL284375B (en) 2015-04-30 2022-07-01 Psioxus Therapeutics Ltd A replication-competent group b oncolytic adenovirus
US11623957B2 (en) 2015-12-07 2023-04-11 Xencor, Inc. Heterodimeric antibodies that bind CD3 and PSMA
BR112018012180A2 (pt) 2015-12-17 2018-12-04 Psioxus Therapeutics Ltd vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr
IL263542B1 (en) 2016-06-14 2024-06-01 Xencor Inc Bispecific antibodies inhibit immunological checkpoint
WO2018005706A1 (en) 2016-06-28 2018-01-04 Xencor, Inc. Heterodimeric antibodies that bind somatostatin receptor 2
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
US11319355B2 (en) 2017-12-19 2022-05-03 Xencor, Inc. Engineered IL-2 Fc fusion proteins
EP3731850A4 (en) * 2017-12-29 2021-12-01 Oncorus, Inc. ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES
US10982006B2 (en) 2018-04-04 2021-04-20 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
EP3781130A4 (en) * 2018-04-11 2022-01-26 Precision Molecular Inc. THERAPEUTIC CONSTRUCTS FOR TREATMENT OF CANCER
US11505595B2 (en) 2018-04-18 2022-11-22 Xencor, Inc. TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15RA Fc-fusion proteins and TIM-3 antigen binding domains
JP2021521784A (ja) 2018-04-18 2021-08-30 ゼンコア インコーポレイテッド ＩＬ−１５／ＩＬ−１５ＲａＦｃ融合タンパク質とＰＤ−１抗原結合ドメインを含むＰＤ−１標的化ヘテロダイマー融合タンパク質およびそれらの使用
WO2020051345A1 (en) * 2018-09-05 2020-03-12 Memorial Sloan-Kettering Cancer Center Pleural effusion-based methods for assessing immunoresponsive cell activity
WO2020072821A2 (en) 2018-10-03 2020-04-09 Xencor, Inc. Il-12 heterodimeric fc-fusion proteins
CN109709341B (zh) * 2019-01-17 2020-12-15 浙江大学 骨关节炎第二亚型的生物标记物以及用途
CA3129506A1 (en) * 2019-02-20 2020-08-27 Research Institute At Nationwide Children's Hospital Cancer-targeted, virus-encoded, regulatable t (catvert) or nk cell (catvern) linkers
SG11202109406TA (en) 2019-03-01 2021-09-29 Xencor Inc Heterodimeric antibodies that bind enpp3 and cd3
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
IL300666A (en) 2020-08-19 2023-04-01 Xencor Inc ANTI–CD28 COMPOSITIONS
CN116420076A (zh) * 2020-09-27 2023-07-11 基因泰克公司 高通量多参数免疫细胞接合物筛选测定
JP2023550148A (ja) 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法
WO2022148736A1 (en) * 2021-01-05 2022-07-14 Transgene Vectorization of muc1 t cell engager
GB202102049D0 (en) 2021-02-13 2021-03-31 Psioxus Therapeutics Ltd Viruses
CN117157319A (zh) 2021-03-09 2023-12-01 Xencor股份有限公司 结合cd3和cldn6的异二聚抗体
JP2024509274A (ja) 2021-03-10 2024-02-29 ゼンコア インコーポレイテッド Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体
CN115161293A (zh) * 2021-04-01 2022-10-11 南京惟亚德生物医药有限公司 一种编码双特异性t细胞衔接子的溶瘤痘苗病毒及其制备方法和应用
WO2023161457A1 (en) 2022-02-27 2023-08-31 Evobright Gmbh Bispecific antibodies against cd277 and a tumor-antigen
WO2024022602A1 (en) 2022-07-28 2024-02-01 Akamis Bio Ltd Virus encoding transgenes to complement cellular therapy
WO2024047114A1 (en) 2022-08-31 2024-03-07 Universität Zürich Adenoviral-based in situ delivery of bispecific t cell engagers

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
US5587299A (en) 1994-04-20 1996-12-24 Memorial Sloan-Kettering Cancer Center Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
US7989594B2 (en) 2003-07-01 2011-08-02 Celltech R & D Limited Modified antibody fab fragments
BRPI0415457A (pt) * 2003-10-16 2006-12-05 Micromet Ag constructo de ligação especìfico de cd3 citotoxicamente ativo, seu processo de produção, composição compreendendo o mesmo, seqüência de ácido nucléico, vetor, hospedeiro, seus usos na preparação de uma composição farmacêutica e kit compreendendo os mesmo
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
ATE491799T1 (de) 2004-05-26 2011-01-15 Bayer Schering Pharma Ag Chimäre adenoviren zur verwendung in der krebsbehandlung
EP1819823A2 (en) 2004-12-01 2007-08-22 Bayer Schering Pharma Aktiengesellschaft Generation of replication competent viruses for therapeutic use
EP2094284A2 (en) 2006-12-22 2009-09-02 Bayer Schering Pharma AG Generation of oncolytic adenoviruses and uses thereof
EP2535349A1 (en) 2007-09-26 2012-12-19 UCB Pharma S.A. Dual specificity antibody fusions
US10407513B2 (en) 2008-09-26 2019-09-10 Ucb Biopharma Sprl Biological products
CA2738545A1 (en) * 2008-10-01 2010-04-08 Micromet Ag Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxcd3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody
CA2776037A1 (en) 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd Anti-fibroblast activation protein antibodies and methods and uses thereof
US20160000842A1 (en) * 2013-03-05 2016-01-07 Baylor College Of Medicine Oncolytic virus
WO2014138414A1 (en) 2013-03-06 2014-09-12 Simon Adam J Form factors for the multi-modal physiological assessment of brain health
AU2014338864C1 (en) 2013-10-25 2020-07-16 Akamis Bio Limited Oncolytic adenoviruses armed with heterologous genes
GB201406608D0 (en) 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
WO2016030489A2 (en) * 2014-08-27 2016-03-03 Psioxus Therapeutics Limited A process for the production of adenovirus
BR112017018111A2 (pt) * 2015-03-17 2018-04-10 Tilt Biotherapeutics Oy adenovírus oncolítico codificando para anticorpos bi-específicos e métodos e usos relacionados ao mesmo

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