JP2018529339A5 - - Google Patents
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- JP2018529339A5 JP2018529339A5 JP2018514333A JP2018514333A JP2018529339A5 JP 2018529339 A5 JP2018529339 A5 JP 2018529339A5 JP 2018514333 A JP2018514333 A JP 2018514333A JP 2018514333 A JP2018514333 A JP 2018514333A JP 2018529339 A5 JP2018529339 A5 JP 2018529339A5
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- 238000000034 method Methods 0.000 claims 75
- 239000000427 antigen Substances 0.000 claims 53
- 108091007433 antigens Proteins 0.000 claims 53
- 102000036639 antigens Human genes 0.000 claims 53
- 244000052769 pathogen Species 0.000 claims 28
- 230000001717 pathogenic effect Effects 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 27
- 210000001744 T-lymphocyte Anatomy 0.000 claims 26
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 14
- 238000005259 measurement Methods 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 8
- 102000004127 Cytokines Human genes 0.000 claims 6
- 108090000695 Cytokines Proteins 0.000 claims 6
- 230000004071 biological effect Effects 0.000 claims 6
- 108010002350 Interleukin-2 Proteins 0.000 claims 5
- 102000000588 Interleukin-2 Human genes 0.000 claims 5
- 238000004113 cell culture Methods 0.000 claims 5
- 230000000638 stimulation Effects 0.000 claims 5
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 4
- -1 IL-17a Proteins 0.000 claims 4
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- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
- 108010065805 Interleukin-12 Proteins 0.000 claims 3
- 102000013462 Interleukin-12 Human genes 0.000 claims 3
- 108090000172 Interleukin-15 Proteins 0.000 claims 3
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- 102100030704 Interleukin-21 Human genes 0.000 claims 3
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- 238000009169 immunotherapy Methods 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 108010074108 interleukin-21 Proteins 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
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- 102100032937 CD40 ligand Human genes 0.000 claims 2
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- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
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- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 2
- 101000852964 Homo sapiens Interleukin-27 subunit beta Proteins 0.000 claims 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 102000013691 Interleukin-17 Human genes 0.000 claims 2
- 108050003558 Interleukin-17 Proteins 0.000 claims 2
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- 108010066979 Interleukin-27 Proteins 0.000 claims 2
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- 108090001005 Interleukin-6 Proteins 0.000 claims 2
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- 241000351643 Metapneumovirus Species 0.000 claims 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 230000000961 alloantigen Effects 0.000 claims 2
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- 238000004808 supercritical fluid chromatography Methods 0.000 claims 2
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- 108010082808 4-1BB Ligand Proteins 0.000 claims 1
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 1
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- 108010046080 CD27 Ligand Proteins 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
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- 101150089023 FASLG gene Proteins 0.000 claims 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 1
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims 1
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 1
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims 1
- 101001055145 Homo sapiens Interleukin-2 receptor subunit beta Proteins 0.000 claims 1
- 101000853002 Homo sapiens Interleukin-25 Proteins 0.000 claims 1
- 101000853000 Homo sapiens Interleukin-26 Proteins 0.000 claims 1
- 101000998139 Homo sapiens Interleukin-32 Proteins 0.000 claims 1
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims 1
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101001128431 Homo sapiens Myeloid-derived growth factor Proteins 0.000 claims 1
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 claims 1
- 101100207070 Homo sapiens TNFSF8 gene Proteins 0.000 claims 1
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 1
- 241000342334 Human metapneumovirus Species 0.000 claims 1
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 102100020989 Interferon lambda-2 Human genes 0.000 claims 1
- 101710099622 Interferon lambda-2 Proteins 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 101800003050 Interleukin-16 Proteins 0.000 claims 1
- 102100033101 Interleukin-17B Human genes 0.000 claims 1
- 102000003810 Interleukin-18 Human genes 0.000 claims 1
- 108090000171 Interleukin-18 Proteins 0.000 claims 1
- 102100039879 Interleukin-19 Human genes 0.000 claims 1
- 108050009288 Interleukin-19 Proteins 0.000 claims 1
- 102100026879 Interleukin-2 receptor subunit beta Human genes 0.000 claims 1
- 102100030703 Interleukin-22 Human genes 0.000 claims 1
- 108010065637 Interleukin-23 Proteins 0.000 claims 1
- 102000013264 Interleukin-23 Human genes 0.000 claims 1
- 102100036679 Interleukin-26 Human genes 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 101710181613 Interleukin-31 Proteins 0.000 claims 1
- 108010067003 Interleukin-33 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 102000000704 Interleukin-7 Human genes 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims 1
- 108010002335 Interleukin-9 Proteins 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 102100039564 Leukosialin Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 101100207071 Mus musculus Tnfsf8 gene Proteins 0.000 claims 1
- 102100031789 Myeloid-derived growth factor Human genes 0.000 claims 1
- 108010042215 OX40 Ligand Proteins 0.000 claims 1
- 108010067902 Peptide Library Proteins 0.000 claims 1
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 1
- 108700012411 TNFSF10 Proteins 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims 1
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 claims 1
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 claims 1
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 1
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims 1
- 238000011467 adoptive cell therapy Methods 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 239000002458 cell surface marker Substances 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000006867 granzyme B production Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 108090000681 interleukin 20 Proteins 0.000 claims 1
- 108010074109 interleukin-22 Proteins 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 229930192851 perforin Natural products 0.000 claims 1
- 238000012958 reprocessing Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021139714A JP7429051B2 (ja) | 2015-09-18 | 2021-08-30 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
| JP2024006928A JP2024045272A (ja) | 2015-09-18 | 2024-01-19 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220884P | 2015-09-18 | 2015-09-18 | |
| US62/220,884 | 2015-09-18 | ||
| PCT/US2016/052487 WO2017049291A1 (en) | 2015-09-18 | 2016-09-19 | Immunogenic antigen identification from a pathogen and correlation to clinical efficacy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139714A Division JP7429051B2 (ja) | 2015-09-18 | 2021-08-30 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529339A JP2018529339A (ja) | 2018-10-11 |
| JP2018529339A5 true JP2018529339A5 (enExample) | 2019-11-07 |
| JP6999941B2 JP6999941B2 (ja) | 2022-02-10 |
Family
ID=58289728
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514333A Active JP6999941B2 (ja) | 2015-09-18 | 2016-09-19 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
| JP2021139714A Active JP7429051B2 (ja) | 2015-09-18 | 2021-08-30 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
| JP2024006928A Pending JP2024045272A (ja) | 2015-09-18 | 2024-01-19 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139714A Active JP7429051B2 (ja) | 2015-09-18 | 2021-08-30 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
| JP2024006928A Pending JP2024045272A (ja) | 2015-09-18 | 2024-01-19 | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11167024B2 (enExample) |
| EP (2) | EP3350600A4 (enExample) |
| JP (3) | JP6999941B2 (enExample) |
| CN (3) | CN113943703A (enExample) |
| AU (2) | AU2016324479B2 (enExample) |
| CA (1) | CA2998649A1 (enExample) |
| HK (1) | HK1258649A1 (enExample) |
| IL (2) | IL258090B2 (enExample) |
| SG (1) | SG10202112047TA (enExample) |
| WO (1) | WO2017049291A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2953434T3 (es) | 2009-08-24 | 2023-11-13 | Baylor College Medicine | Generación de líneas de CTL con especificidad frente a múltiples antígenos tumorales o múltiples virus |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| EP2812431B1 (en) | 2012-02-09 | 2019-07-17 | Baylor College Of Medicine | Pepmixes to generate multiviral ctls with broad specificity |
| HK1258649A1 (zh) | 2015-09-18 | 2019-11-15 | Baylor College Of Medicine | 来自病原体的免疫原性抗原鉴定以及与临床效力的相关性 |
| CN113811328A (zh) * | 2019-03-25 | 2021-12-17 | 贝勒医学院 | 多呼吸道病毒抗原特异性t细胞及其制备方法和治疗上的使用方法 |
| EP3976068A4 (en) * | 2019-05-31 | 2023-08-09 | Children's National Medical Center | CYTOKINE COCKTAILS FOR SELECTIVE T-LYMPHOCYTE SUBSET EXPANSION |
| CA3151356A1 (en) | 2019-08-16 | 2021-02-25 | Baylor College Of Medicine | Third party virus-specific t cell compositions, and methods of making and using the same in anti-viral prophylaxis |
| WO2021119293A2 (en) * | 2019-12-10 | 2021-06-17 | Children's National Medical Center | T-cell epitopes of human parainfluenza virus 3 for adoptive t-cell immunotherapy |
| US20230028788A1 (en) * | 2019-12-23 | 2023-01-26 | Baylor College Of Medicine | T cell performance assay as a prognostic factor for clinical outcome |
| WO2022192402A1 (en) * | 2021-03-10 | 2022-09-15 | Avail Bio, Inc. | Methods, compositions, and systems for b-cell isolation sequencing |
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2016
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- 2016-09-19 EP EP16847545.7A patent/EP3350600A4/en active Pending
- 2016-09-19 WO PCT/US2016/052487 patent/WO2017049291A1/en not_active Ceased
- 2016-09-19 AU AU2016324479A patent/AU2016324479B2/en active Active
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