JP2018529339A5 - - Google Patents

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JP2018529339A5
JP2018529339A5 JP2018514333A JP2018514333A JP2018529339A5 JP 2018529339 A5 JP2018529339 A5 JP 2018529339A5 JP 2018514333 A JP2018514333 A JP 2018514333A JP 2018514333 A JP2018514333 A JP 2018514333A JP 2018529339 A5 JP2018529339 A5 JP 2018529339A5
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antigen
cell
pathogen
cells
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JP2018514333A 2015-09-18 2016-09-19 病原体からの免疫原性抗原同定および臨床的有効性との相関 Active JP6999941B2 (ja)

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Application Number Priority Date Filing Date Title
JP2021139714A JP7429051B2 (ja) 2015-09-18 2021-08-30 病原体からの免疫原性抗原同定および臨床的有効性との相関
JP2024006928A JP2024045272A (ja) 2015-09-18 2024-01-19 病原体からの免疫原性抗原同定および臨床的有効性との相関

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US201562220884P 2015-09-18 2015-09-18
US62/220,884 2015-09-18
PCT/US2016/052487 WO2017049291A1 (en) 2015-09-18 2016-09-19 Immunogenic antigen identification from a pathogen and correlation to clinical efficacy

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JP2018529339A JP2018529339A (ja) 2018-10-11
JP2018529339A5 true JP2018529339A5 (enExample) 2019-11-07
JP6999941B2 JP6999941B2 (ja) 2022-02-10

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JP2018514333A Active JP6999941B2 (ja) 2015-09-18 2016-09-19 病原体からの免疫原性抗原同定および臨床的有効性との相関
JP2021139714A Active JP7429051B2 (ja) 2015-09-18 2021-08-30 病原体からの免疫原性抗原同定および臨床的有効性との相関
JP2024006928A Pending JP2024045272A (ja) 2015-09-18 2024-01-19 病原体からの免疫原性抗原同定および臨床的有効性との相関

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JP2024006928A Pending JP2024045272A (ja) 2015-09-18 2024-01-19 病原体からの免疫原性抗原同定および臨床的有効性との相関

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US (3) US11167024B2 (enExample)
EP (2) EP4290238A3 (enExample)
JP (3) JP6999941B2 (enExample)
CN (3) CN113791213A (enExample)
AU (2) AU2016324479B2 (enExample)
CA (1) CA2998649A1 (enExample)
HK (1) HK1258649A1 (enExample)
IL (2) IL298359B2 (enExample)
SG (1) SG10202112047TA (enExample)
WO (1) WO2017049291A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120059581A (ko) 2009-08-24 2012-06-08 윌슨 울프 매뉴팩처링 다중 종양 항원 또는 다중 바이러스에 대해 특이성을 갖는 ctl주의 생성
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
EP2812431B1 (en) 2012-02-09 2019-07-17 Baylor College Of Medicine Pepmixes to generate multiviral ctls with broad specificity
IL298359B2 (en) 2015-09-18 2025-12-01 Baylor College Medicine Immunogenic antigen identification from a pathogen and correlation to clinical efficacy
MX2021011622A (es) * 2019-03-25 2022-01-04 Baylor College Medicine Células t específicas de antígeno de multiples virus respiratorios y métodos para elaborar y usar las mismas de manera terapéutica.
WO2020243729A1 (en) * 2019-05-31 2020-12-03 Children's National Medical Center Cytokine cocktails for selective expansion of t cell subsets
US20220288119A1 (en) 2019-08-16 2022-09-15 Baylor College Of Medicine Third party virus-specific t cell compositions, and methods of making and using the same in anti-viral prophylaxis
WO2021119293A2 (en) * 2019-12-10 2021-06-17 Children's National Medical Center T-cell epitopes of human parainfluenza virus 3 for adoptive t-cell immunotherapy
US20230028788A1 (en) * 2019-12-23 2023-01-26 Baylor College Of Medicine T cell performance assay as a prognostic factor for clinical outcome
WO2022192402A1 (en) * 2021-03-10 2022-09-15 Avail Bio, Inc. Methods, compositions, and systems for b-cell isolation sequencing

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
WO1994002156A1 (en) 1992-07-16 1994-02-03 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate t cells
US6821778B1 (en) 1993-12-01 2004-11-23 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
ES2153895T3 (es) 1994-03-08 2001-03-16 Dana Farber Cancer Inst Inc Metodos para modular la insensibilidad de celulas t.
AUPM446594A0 (en) 1994-03-16 1994-04-14 Csl Limited Cytotoxic t-cell epitopes identified within epstein-barr virus
PT772624E (pt) 1994-04-06 2001-03-30 Immunex Corp Interleucina-15
ES2186686T3 (es) 1994-05-16 2003-05-16 Roche Diagnostics Gmbh Metodo de inmunomodulacion por medio de transferencia adoptiva de linfocitos t-citotoxicos especificos de antigenos.
US6300090B1 (en) 1994-07-29 2001-10-09 The Rockefeller University Methods of use of viral vectors to deliver antigen to dendritic cells
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
PT747481E (pt) 1995-06-06 2002-05-31 Organon Teknika Bv Peptidos do virus de epstein-barr e anticorpos contra estes peptidos
FR2745185B1 (fr) 1996-02-28 1998-05-15 Sanofi Sa Utilisation de l'il-7 dans le traitement des maladies auto-immunes, en particulier le diabete mellitus insulinodependant
US6703024B2 (en) 1996-05-24 2004-03-09 The Council Of The Queensland Institute Of Medical Research EBV CTL epitopes
US5962318A (en) 1996-11-15 1999-10-05 St. Jude Children's Research Hospital Cytotoxic T lymphocyte-mediated immunotherapy
JP2001509677A (ja) 1997-01-31 2001-07-24 エピミューン,インコーポレイティド Ctlを活性化するためのペプチドおよびペプチド担持抗原提示細胞
WO1998049270A1 (en) 1997-04-25 1998-11-05 The Wistar Institute Of Anatomy And Biology Cytolytic t-cell clones against colorectal carcinoma and methods of use thereof
US7951383B2 (en) * 1997-05-23 2011-05-31 The United States Of America As Represented By The Department Of Health And Human Services Attenuated parainfluenza virus (PIV) vaccines
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
DE69840739D1 (de) 1997-10-27 2009-05-28 Merix Bioscience Inc Methode und Zusammensetzung zur Herstellung von reifen dendritischen Zellen
US20020155108A1 (en) 1998-05-04 2002-10-24 Biocrystal, Ltd. Method for ex vivo loading of antigen presenting cells with antigen, and a vaccine comprising the loaded cells
WO2000050569A1 (en) * 1999-02-24 2000-08-31 The Wistar Institute Of Anatomy And Biology Method of modifying cytotoxic cells and uses thereof
US6828147B1 (en) 1999-02-24 2004-12-07 The Wistar Institute Of Anatomy And Biology Method of modifying cytotoxic cells and uses thereof
US7005131B1 (en) 1999-08-13 2006-02-28 The Rockefeller University Protective antigen of Epstein Barr Virus
US20150037297A1 (en) 1999-08-30 2015-02-05 David S Terman Sickled Erythrocytes and Progenitors Target Cytotoxics to Tumors
DK1231840T3 (da) 1999-11-24 2009-11-23 Red Cliff Holding Anti-angiogent cellulært middel til cancerterapi
DE10009341A1 (de) 2000-02-22 2001-09-06 Florian Kern Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten
US20020155127A1 (en) 2000-06-02 2002-10-24 Danher Wang Genetic vaccine against human immunodeficiency virus
DK1297017T3 (da) 2000-06-19 2012-09-17 Dana Farber Cancer Inst Inc Sammensætninger og fremgangsmåder med monoklonale og polyklonale antistoffer, der er specifikke for T-cellesubpopulationer
DK1326961T3 (da) 2000-09-15 2008-01-07 Ortho Mcneil Pharm Inc Sammensætninger og fremgangsmåder tl inducering af specifikke cytolytiske T-cellereaktioner
EP1229043A1 (en) 2001-01-30 2002-08-07 Cyto-Barr B.V. Peptides derived from Epstein Barr virus (EBV) proteins LMP1, LMP2 and BARF1 antibody reagents reactive therewith
GB0107628D0 (en) 2001-03-27 2001-05-16 Avidex Ltd Substances
US20040022761A1 (en) 2001-05-11 2004-02-05 Banchereau Jacques F Compositions and methods for producing antigen-presenting cells
EP1407004B1 (en) 2001-05-15 2009-08-05 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Ex-vivo priming for generating cd40-ligand specific cytotoxic t lymphocytes to treat autoimmune and allergic disease
ATE312505T1 (de) 2001-09-28 2005-12-15 Heinrich-Guenter Schumacher Mähmesser mit einer aus teilschienen zusammengesetzten messerschiene
EP1444330A1 (en) 2001-11-07 2004-08-11 Kirin Beer Kabushiki Kaisha Expansion of t cells in vitro and expanded t cell populations
US20030148982A1 (en) 2001-11-13 2003-08-07 Brenner Malcolm K. Bi-spcific chimeric T cells
DK1448229T3 (da) 2001-11-29 2010-03-08 Dandrit Biotech As Farmaceutisk sammensætning til at inducere et immunrespons hos et menneske eller et dyr
US20040096457A1 (en) 2001-12-11 2004-05-20 Huber Brigitte T Treatment and prevention of ebv infection and ebv-associated disorders
AU2003202908A1 (en) 2002-01-03 2003-07-24 The Trustees Of The University Of Pennsylvania Activation and expansion of t-cells using an engineered multivalent signaling platform
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
WO2004041849A1 (en) 2002-11-07 2004-05-21 The Council Of The Queensland Institute Of Medical Research Epstein barr virus peptide epitopes, polyepitopes and delivery system therefor
AU2002953238A0 (en) 2002-12-09 2003-01-02 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland In vitro immunization
IL158140A0 (en) 2003-09-25 2004-03-28 Hadasit Med Res Service Multiepitope polypeptides for cancer immunotherapy
CN101120083B (zh) 2003-10-08 2013-03-27 威尔森沃尔夫制造公司 利用透气性材料进行细胞培养的方法及装置
US20050221481A1 (en) 2004-03-30 2005-10-06 Istituto Superiore Di Sanita' Amplification of T cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2
US7785806B2 (en) * 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
CA2568344C (en) * 2004-05-27 2016-01-19 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
US7785875B2 (en) 2004-07-03 2010-08-31 Mogam Biotechnology Research Institute Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same
US20060045883A1 (en) 2004-08-26 2006-03-02 Jeffrey Molldrem Anti-cancer vaccines
JP4731867B2 (ja) 2004-10-01 2011-07-27 国立大学法人三重大学 Cd8陽性の細胞傷害性tリンパ球の誘導方法
US20060204509A1 (en) 2005-03-14 2006-09-14 Harty John T Accelerated CD8+ T-cell memory after dendritic cell vaccination
EP1712615A1 (en) 2005-04-15 2006-10-18 Txcell In vitro production of a cell population using feeder cells
ES2334936T3 (es) 2005-04-20 2010-03-17 F. Hoffmann-La Roche Ag Metodo de identificacion de epitopos relacionados con la inmunogenicidad en biofarmacos.
AU2006247802A1 (en) 2005-05-11 2006-11-23 The Trustees Of The University Of Pennsylvania Methods for the rapid expansion of antigen specific T-cells
US20070003531A1 (en) 2005-06-30 2007-01-04 University Of Connecticut Methods for improving immunotherapy by enhancing survival of antigen-specific cytotoxic T lymphocytes
US20100035282A1 (en) 2005-08-03 2010-02-11 Maria Chiara Bonini Use of common gamma chain cytokines for the visualization, isolation and genetic modification of memory t lymphocytes
JP4824389B2 (ja) 2005-10-28 2011-11-30 株式会社医学生物学研究所 エプスタイン−バールウイルス感染細胞を特異的に攻撃する細胞傷害性t細胞エピトープペプチド及びその用途
CA2630218A1 (en) 2005-11-18 2007-08-30 The Ohio State University Research Foundation Viral gene products and methods for vaccination to prevent viral associated diseases
CA2644540C (en) 2006-03-02 2014-09-30 Antitope Limited T cell assays
GB0604170D0 (en) 2006-03-02 2006-04-12 Antitope Ltd T cell assays
US20070243549A1 (en) 2006-04-12 2007-10-18 Biocept, Inc. Enrichment of circulating fetal dna
WO2008025992A2 (en) 2006-09-01 2008-03-06 Cambridge Enterprise Limited Methods of expanding non-effector cd8 t-cell populations
EP2091961A4 (en) 2006-11-22 2009-12-09 Univ Arkansas IMMUNOTHERAPY AGAINST CANCER WITH MULTIPPITOP-PEPTIDE-LOADED DENDRITIC CELLS
CN101611133A (zh) 2006-12-07 2009-12-23 威尔森沃尔夫制造公司 高效装置及培养细胞的方法
JP2010512324A (ja) 2006-12-08 2010-04-22 アッテヌオン エル エル シー ウロキナーゼ型プラスミノーゲン活性化因子受容体エピトープ、それに由来するモノクローナル抗体及びそれらの使用方法
DE102006060824B4 (de) * 2006-12-21 2011-06-01 Johannes-Gutenberg-Universität Mainz Nachweis von individuellen T-Zell-Reaktionsmustern gegen Tumor-assoziierte Antigene (TAA) in Tumorpatienten als Basis für die individuelle therapeutische Vakzinierung von Patienten
WO2008148170A1 (en) * 2007-06-08 2008-12-11 The University Of Queensland Human metapneumovirus immunogenic peptides, compositions, and methods of use
US8546137B2 (en) 2007-09-27 2013-10-01 The Board Of Trustees Of The University Of Arkansas Inhibition of dendritic cell-driven regulatory T cell activation and potentiation of tumor antigen-specific T cell responses by interleukin-15 and MAP kinase inhibitor
EP2060583A1 (en) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
US20100254958A1 (en) 2007-10-24 2010-10-07 Anne Letsch Antigen-Specific T-Cell Preparations from Bone Marrow
EP2215111B1 (en) 2007-11-01 2016-03-16 Mayo Foundation For Medical Education And Research Hla-dr binding peptides and their uses
EP2065462A1 (en) 2007-11-27 2009-06-03 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Ex vivo method for producing a preparation containing CD4+ T cells specific for EBV structural antigens
CA2736851A1 (en) 2008-09-11 2010-03-18 Lung-Ji Chang System and method for producing t cells
CN101824400B (zh) 2009-03-05 2012-08-08 中国科学院微生物研究所 一种放大增殖抗原特异性t细胞的方法
KR20120059581A (ko) 2009-08-24 2012-06-08 윌슨 울프 매뉴팩처링 다중 종양 항원 또는 다중 바이러스에 대해 특이성을 갖는 ctl주의 생성
WO2011024482A1 (ja) 2009-08-29 2011-03-03 株式会社バイオメッドコア 抗原特異的t細胞誘導能測定法
GB0917090D0 (en) 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
JP2013512694A (ja) 2009-12-08 2013-04-18 ウィルソン ウォルフ マニュファクチャリング コーポレイション 養子細胞療法のための細胞を培養する方法
US20130115617A1 (en) 2009-12-08 2013-05-09 John R. Wilson Methods of cell culture for adoptive cell therapy
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
KR102095670B1 (ko) * 2010-05-14 2020-03-31 더 제너럴 하스피톨 코포레이션 종양 특이적 신생항원을 확인하는 조성물 및 방법
WO2011146473A1 (en) 2010-05-17 2011-11-24 Duke University Methods of treatment using ex vivo expansion of cord blood t cells
WO2012017033A1 (en) 2010-08-04 2012-02-09 Ieo-Istituto Europeo Di Oncologia S.R.L. Method of antigen loading for immunotherapy
US8741642B2 (en) 2010-10-22 2014-06-03 Virginia Commonwealth University Methods for producing autologous immune cells resistant to myeloid-derived suppressor cells effects
EP2453243A1 (en) 2010-11-11 2012-05-16 Cosmo S.p.A. Method for the diagnosis and/or follow up of the evolution of a tumor
US20130045491A1 (en) 2011-07-19 2013-02-21 Derya Unutmaz Methods for activating t cells
BR112014005355B1 (pt) 2011-09-08 2022-03-29 Yeda Research An Development Co., Ltd Células t de memória central anti-terceiro, métodos de produção e uso das mesmas em transplante e tratamento de doença
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
JP6081483B2 (ja) 2011-12-12 2017-02-15 セル・メディカ・リミテッド T細胞を増殖させるプロセス
EP2812431B1 (en) 2012-02-09 2019-07-17 Baylor College Of Medicine Pepmixes to generate multiviral ctls with broad specificity
US20130217122A1 (en) 2012-02-21 2013-08-22 The Trustees Of The University Of Pennsylvania Expansion of Interferon-Gamma-Producing T-Cells Using Glypican-3 Peptide Library
WO2013169922A1 (en) 2012-05-08 2013-11-14 Western University Of Health Sciences Standardized ex vivo platforms for the antigen-specific expansion of cd4+ t cell populations
EP3071686B1 (en) 2013-11-22 2020-07-22 Cellectis SA Method for generating batches of allogeneic t-cells with averaged potency
EP3097416A2 (en) * 2014-01-21 2016-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for testing t cell priming efficacy in a subject
WO2016073595A1 (en) 2014-11-05 2016-05-12 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services T cells and dendritic cells for polyomavirus therapy
TWI673365B (zh) 2014-11-05 2019-10-01 美國紀念斯隆 凱特琳癌症中心 選擇用於過繼性細胞療法之t細胞株及其供體之方法
WO2016154112A1 (en) 2015-03-20 2016-09-29 Children's National Medical Center Generating virus or other antigen-specific t cells from a naive t cell population
EP3313419B1 (en) 2015-06-26 2020-08-19 Memorial Sloan Kettering Cancer Center Methods of treating cmv retinitis by t cell therapy
IL298359B2 (en) 2015-09-18 2025-12-01 Baylor College Medicine Immunogenic antigen identification from a pathogen and correlation to clinical efficacy
MX2018013959A (es) 2016-05-25 2019-08-22 Council Queensland Inst Medical Res Metodos para tratar enfermedad autoinmune usando celulas t alogenicas.
JP7002769B2 (ja) 2016-09-16 2022-02-04 ベイラー カレッジ オブ メディスン ウイルス特異的t細胞の活性化および拡大のためのプラットフォーム
TW201814042A (zh) 2016-09-26 2018-04-16 新加坡商泰莎治療私人有限公司 T細胞擴展方法
EP3641807A4 (en) 2017-06-22 2021-04-21 The Westmead Institute For Medical Research Adoptive t cell therapy 2
AU2018330415A1 (en) 2017-09-06 2020-03-19 Nant Holdings Ip, Llc HLA tissue matching and methods therefor
GB201808651D0 (en) 2018-05-25 2018-07-11 Rolls Royce Plc Rotor blade arrangement
MX2021011622A (es) 2019-03-25 2022-01-04 Baylor College Medicine Células t específicas de antígeno de multiples virus respiratorios y métodos para elaborar y usar las mismas de manera terapéutica.
TWI867324B (zh) 2019-05-08 2024-12-21 美商百歐恩泰美國公司 T細胞製備組合物及方法
MA56534A (fr) 2019-06-20 2022-04-27 Janssen Sciences Ireland Unlimited Co Administration par nanoporteurs glucidiques, de vaccins contre le virus de l'hépatite b (vhb)
US20220257654A1 (en) 2019-07-23 2022-08-18 Baylor College Of Medicine Antigen-specific t cell banks and methods of making and using the same therapeutically
CA3149145A1 (en) 2019-07-29 2021-02-04 Baylor College Of Medicine Antigen-specific t cell banks and methods of making and using the same therapeutically
US20220288119A1 (en) 2019-08-16 2022-09-15 Baylor College Of Medicine Third party virus-specific t cell compositions, and methods of making and using the same in anti-viral prophylaxis
US20230028788A1 (en) 2019-12-23 2023-01-26 Baylor College Of Medicine T cell performance assay as a prognostic factor for clinical outcome
JP2023518792A (ja) 2020-03-20 2023-05-08 ベイラー カレッジ オブ メディスン SARS-CoV2特異的T細胞組成物ならびにコロナウイルスおよび他の呼吸器系ウイルス感染症の処置および予防におけるそれらの使用
EP3974029A1 (en) 2020-09-25 2022-03-30 Universidad Autónoma de Madrid Memory t cells as adoptive cell therapy for viral infections

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