AU2016324479B2 - Immunogenic antigen identification from a pathogen and correlation to clinical efficacy - Google Patents

Immunogenic antigen identification from a pathogen and correlation to clinical efficacy Download PDF

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AU2016324479B2
AU2016324479B2 AU2016324479A AU2016324479A AU2016324479B2 AU 2016324479 B2 AU2016324479 B2 AU 2016324479B2 AU 2016324479 A AU2016324479 A AU 2016324479A AU 2016324479 A AU2016324479 A AU 2016324479A AU 2016324479 B2 AU2016324479 B2 AU 2016324479B2
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cells
virus
antigen
cancer
antigens
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AU2016324479A1 (en
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Pailbel AGUAYO-HIRALDO
Ann Marie Leen
Ifigeneia TZANNOU
Juan F. Valdes Vera
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Baylor College of Medicine
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    • A61K39/12Viral antigens
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AU2016324479A 2015-09-18 2016-09-19 Immunogenic antigen identification from a pathogen and correlation to clinical efficacy Active AU2016324479B2 (en)

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US201562220884P 2015-09-18 2015-09-18
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PCT/US2016/052487 WO2017049291A1 (en) 2015-09-18 2016-09-19 Immunogenic antigen identification from a pathogen and correlation to clinical efficacy

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EP (2) EP3350600A4 (enExample)
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CN (3) CN113943703A (enExample)
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CA (1) CA2998649A1 (enExample)
HK (1) HK1258649A1 (enExample)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2953434T3 (es) 2009-08-24 2023-11-13 Baylor College Medicine Generación de líneas de CTL con especificidad frente a múltiples antígenos tumorales o múltiples virus
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
EP2812431B1 (en) 2012-02-09 2019-07-17 Baylor College Of Medicine Pepmixes to generate multiviral ctls with broad specificity
HK1258649A1 (zh) 2015-09-18 2019-11-15 Baylor College Of Medicine 来自病原体的免疫原性抗原鉴定以及与临床效力的相关性
CN113811328A (zh) * 2019-03-25 2021-12-17 贝勒医学院 多呼吸道病毒抗原特异性t细胞及其制备方法和治疗上的使用方法
EP3976068A4 (en) * 2019-05-31 2023-08-09 Children's National Medical Center CYTOKINE COCKTAILS FOR SELECTIVE T-LYMPHOCYTE SUBSET EXPANSION
CA3151356A1 (en) 2019-08-16 2021-02-25 Baylor College Of Medicine Third party virus-specific t cell compositions, and methods of making and using the same in anti-viral prophylaxis
WO2021119293A2 (en) * 2019-12-10 2021-06-17 Children's National Medical Center T-cell epitopes of human parainfluenza virus 3 for adoptive t-cell immunotherapy
US20230028788A1 (en) * 2019-12-23 2023-01-26 Baylor College Of Medicine T cell performance assay as a prognostic factor for clinical outcome
WO2022192402A1 (en) * 2021-03-10 2022-09-15 Avail Bio, Inc. Methods, compositions, and systems for b-cell isolation sequencing

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015110397A2 (en) * 2014-01-21 2015-07-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for testing t cell priming efficacy in a subject

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
WO1994002156A1 (en) 1992-07-16 1994-02-03 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate t cells
US6821778B1 (en) 1993-12-01 2004-11-23 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
CA2185027A1 (en) 1994-03-08 1995-09-14 Vassiliki A. Boussiotis Methods for modulating t cell unresponsiveness
AUPM446594A0 (en) 1994-03-16 1994-04-14 Csl Limited Cytotoxic t-cell epitopes identified within epstein-barr virus
DK0772624T3 (da) 1994-04-06 2000-11-13 Immunex Corp Interleukin-15
PT804210E (pt) 1994-05-16 2003-04-30 Roche Diagnostics Gmbh Processo de imunomodelacao por transferencia adoptiva de linfocitos t citotoxicos especificos de um antigenio
US6300090B1 (en) 1994-07-29 2001-10-09 The Rockefeller University Methods of use of viral vectors to deliver antigen to dendritic cells
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
DE69618080T2 (de) 1995-06-06 2002-06-13 Organon Teknika B.V., Boxtel Epstein-Barr Viruspeptide, und Antikörper gegen diese Peptide
FR2745185B1 (fr) 1996-02-28 1998-05-15 Sanofi Sa Utilisation de l'il-7 dans le traitement des maladies auto-immunes, en particulier le diabete mellitus insulinodependant
US6699477B2 (en) 1996-05-24 2004-03-02 The Council Of The Queensland Institute Of Medical Research EBV CTL epitopes
US5962318A (en) 1996-11-15 1999-10-05 St. Jude Children's Research Hospital Cytotoxic T lymphocyte-mediated immunotherapy
JP2001509677A (ja) 1997-01-31 2001-07-24 エピミューン,インコーポレイティド Ctlを活性化するためのペプチドおよびペプチド担持抗原提示細胞
AU7256498A (en) 1997-04-25 1998-11-24 Wistar Institute Of Anatomy And Biology, The Cytolytic t-cell clones against colorectal carcinoma and methods of use thereof
US7951383B2 (en) * 1997-05-23 2011-05-31 The United States Of America As Represented By The Department Of Health And Human Services Attenuated parainfluenza virus (PIV) vaccines
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
ATE428769T1 (de) 1997-10-27 2009-05-15 Univ Rockefeller Methode und zusammensetzung zur herstellung von reifen dendritischen zellen
US20020155108A1 (en) 1998-05-04 2002-10-24 Biocrystal, Ltd. Method for ex vivo loading of antigen presenting cells with antigen, and a vaccine comprising the loaded cells
AU3373300A (en) 1999-02-24 2000-09-14 Wistar Institute Of Anatomy And Biology, The Method of modifying cytotoxic cells and uses thereof
US6828147B1 (en) 1999-02-24 2004-12-07 The Wistar Institute Of Anatomy And Biology Method of modifying cytotoxic cells and uses thereof
US7005131B1 (en) 1999-08-13 2006-02-28 The Rockefeller University Protective antigen of Epstein Barr Virus
US20150037297A1 (en) 1999-08-30 2015-02-05 David S Terman Sickled Erythrocytes and Progenitors Target Cytotoxics to Tumors
AU2425801A (en) 1999-11-24 2001-06-04 Ernest G. Hope Anti-angiogenic cellular agent for cancer therapy
DE10009341A1 (de) 2000-02-22 2001-09-06 Florian Kern Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten
US20020155127A1 (en) 2000-06-02 2002-10-24 Danher Wang Genetic vaccine against human immunodeficiency virus
JP5184732B2 (ja) 2000-06-19 2013-04-17 ベス イスラエル デアコネス メディカル センター T細胞亜集団に特異的なモノクローナル抗体およびポリクローナル抗体の組成物および使用方法
EP1326961B1 (en) 2000-09-15 2007-08-22 Ortho-McNeil Pharmaceutical, Inc. Compositions and methods for inducing specific cytolytic t cell responses
EP1229043A1 (en) 2001-01-30 2002-08-07 Cyto-Barr B.V. Peptides derived from Epstein Barr virus (EBV) proteins LMP1, LMP2 and BARF1 antibody reagents reactive therewith
GB0107628D0 (en) 2001-03-27 2001-05-16 Avidex Ltd Substances
US20040022761A1 (en) 2001-05-11 2004-02-05 Banchereau Jacques F Compositions and methods for producing antigen-presenting cells
EP1407004B1 (en) 2001-05-15 2009-08-05 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Ex-vivo priming for generating cd40-ligand specific cytotoxic t lymphocytes to treat autoimmune and allergic disease
EP1429597B1 (de) 2001-09-28 2005-12-14 Heinrich-Günter Schumacher Mähmesser mit einer aus teilschienen zusammengesetzten messerschiene
JP2005536982A (ja) 2001-11-07 2005-12-08 麒麟麦酒株式会社 インビトロにおけるt細胞増幅および増幅されたt細胞集団
US20030148982A1 (en) 2001-11-13 2003-08-07 Brenner Malcolm K. Bi-spcific chimeric T cells
RU2313365C2 (ru) 2001-11-29 2007-12-27 Дандрит Байотек А/С Фармацевтическая композиция для индукции иммунной реакции у человека
US20040096457A1 (en) 2001-12-11 2004-05-20 Huber Brigitte T Treatment and prevention of ebv infection and ebv-associated disorders
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US7670781B2 (en) 2002-01-03 2010-03-02 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an agent that provides a primary activation signal and another agent that provides a co-stimulatory signal
TW200416043A (en) 2002-11-07 2004-09-01 Queensland Inst Med Res Epstein barr virus peptide epitopes, polyepitopes and delivery system therefor
AU2002953238A0 (en) 2002-12-09 2003-01-02 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland In vitro immunization
IL158140A0 (en) 2003-09-25 2004-03-28 Hadasit Med Res Service Multiepitope polypeptides for cancer immunotherapy
AU2004280623B2 (en) 2003-10-08 2010-12-02 Wilson Wolf Manufacturing, LLC Cell culture methods and devices utilizing gas permeable materials
US20050221481A1 (en) 2004-03-30 2005-10-06 Istituto Superiore Di Sanita' Amplification of T cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2
US7785806B2 (en) * 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
WO2005118788A2 (en) 2004-05-27 2005-12-15 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
US7785875B2 (en) 2004-07-03 2010-08-31 Mogam Biotechnology Research Institute Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same
US20060045883A1 (en) 2004-08-26 2006-03-02 Jeffrey Molldrem Anti-cancer vaccines
JP4731867B2 (ja) 2004-10-01 2011-07-27 国立大学法人三重大学 Cd8陽性の細胞傷害性tリンパ球の誘導方法
US20060204509A1 (en) 2005-03-14 2006-09-14 Harty John T Accelerated CD8+ T-cell memory after dendritic cell vaccination
EP1712615A1 (en) 2005-04-15 2006-10-18 Txcell In vitro production of a cell population using feeder cells
DE602006010934D1 (de) * 2005-04-20 2010-01-21 Hoffmann La Roche Verfahren zur Identifizierung von Epitopen in Zusammenhang mit Immunogenität bei Biopharmazeutika
JP2008539758A (ja) 2005-05-11 2008-11-20 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 抗原特異的t−細胞の急速な増大のための方法
US20070003531A1 (en) 2005-06-30 2007-01-04 University Of Connecticut Methods for improving immunotherapy by enhancing survival of antigen-specific cytotoxic T lymphocytes
US20100035282A1 (en) 2005-08-03 2010-02-11 Maria Chiara Bonini Use of common gamma chain cytokines for the visualization, isolation and genetic modification of memory t lymphocytes
JP4824389B2 (ja) 2005-10-28 2011-11-30 株式会社医学生物学研究所 エプスタイン−バールウイルス感染細胞を特異的に攻撃する細胞傷害性t細胞エピトープペプチド及びその用途
AU2006338570B2 (en) 2005-11-18 2013-07-11 The Ohio State University Research Foundation Viral gene products and methods for vaccination to prevent viral associated diseases
GB0604170D0 (en) * 2006-03-02 2006-04-12 Antitope Ltd T cell assays
EP1989544B1 (en) 2006-03-02 2011-06-22 Antitope Limited T cell assays
US20070243549A1 (en) 2006-04-12 2007-10-18 Biocept, Inc. Enrichment of circulating fetal dna
WO2008025992A2 (en) 2006-09-01 2008-03-06 Cambridge Enterprise Limited Methods of expanding non-effector cd8 t-cell populations
CA2670107A1 (en) 2006-11-22 2008-06-05 The Board Of Trustees Of The University Of Arkansas Multi-epitope peptide-loaded dendritic cell immunotherapy for cancer
EP2092052B1 (en) 2006-12-07 2020-09-23 Wilson Wolf Manufacturing Corporation Highly efficient gas permeable devices for culturing cells
US8105602B2 (en) 2006-12-08 2012-01-31 Tactic Pharma, Llc Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof
DE102006060824B4 (de) * 2006-12-21 2011-06-01 Johannes-Gutenberg-Universität Mainz Nachweis von individuellen T-Zell-Reaktionsmustern gegen Tumor-assoziierte Antigene (TAA) in Tumorpatienten als Basis für die individuelle therapeutische Vakzinierung von Patienten
WO2008148170A1 (en) * 2007-06-08 2008-12-11 The University Of Queensland Human metapneumovirus immunogenic peptides, compositions, and methods of use
US8546137B2 (en) 2007-09-27 2013-10-01 The Board Of Trustees Of The University Of Arkansas Inhibition of dendritic cell-driven regulatory T cell activation and potentiation of tumor antigen-specific T cell responses by interleukin-15 and MAP kinase inhibitor
EP2060583A1 (en) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
EP2207875A1 (en) 2007-10-24 2010-07-21 Anne Letsch Antigen-specific t-cell preparations from bone marrow
EP3085707B1 (en) 2007-11-01 2019-02-27 Mayo Foundation for Medical Education and Research Hla-dr binding peptides and their uses
EP2065462A1 (en) 2007-11-27 2009-06-03 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Ex vivo method for producing a preparation containing CD4+ T cells specific for EBV structural antigens
WO2010030947A1 (en) 2008-09-11 2010-03-18 University Of Florida Research Foundation, Inc. System and method for producing t cells
CN101824400B (zh) 2009-03-05 2012-08-08 中国科学院微生物研究所 一种放大增殖抗原特异性t细胞的方法
ES2953434T3 (es) * 2009-08-24 2023-11-13 Baylor College Medicine Generación de líneas de CTL con especificidad frente a múltiples antígenos tumorales o múltiples virus
JP5833443B2 (ja) 2009-08-29 2015-12-16 株式会社バイオメッドコア 抗原特異的t細胞誘導能測定法
GB0917090D0 (en) 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
SG181559A1 (en) 2009-12-08 2012-07-30 Wolf Wilson Mfg Corp Improved methods of cell culture for adoptive cell therapy
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
US20130115617A1 (en) 2009-12-08 2013-05-09 John R. Wilson Methods of cell culture for adoptive cell therapy
BR112012029066A2 (pt) * 2010-05-14 2020-09-01 The General Hospital Corporation composições e processos de identificação de neoantígenos específicos de tumor.
WO2011146473A1 (en) 2010-05-17 2011-11-24 Duke University Methods of treatment using ex vivo expansion of cord blood t cells
US20130129713A1 (en) 2010-08-04 2013-05-23 Ieo - Istituto Europeo Di Oncologia S.R.L. Method of antigen loading for immunotherapy
WO2012054792A2 (en) 2010-10-22 2012-04-26 Virginia Commonwealth University Composition and method for immunological treatment of cancer, prevention of cancer recurrence and metastasis, and overcoming immune suppressor cells
EP2453243A1 (en) 2010-11-11 2012-05-16 Cosmo S.p.A. Method for the diagnosis and/or follow up of the evolution of a tumor
US20130045491A1 (en) 2011-07-19 2013-02-21 Derya Unutmaz Methods for activating t cells
MX351226B (es) 2011-09-08 2017-10-05 Yeda Res & Dev Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades.
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
US10351824B2 (en) 2011-12-12 2019-07-16 Cell Medica Limited Process of expanding T cells
EP2812431B1 (en) 2012-02-09 2019-07-17 Baylor College Of Medicine Pepmixes to generate multiviral ctls with broad specificity
US20130217122A1 (en) 2012-02-21 2013-08-22 The Trustees Of The University Of Pennsylvania Expansion of Interferon-Gamma-Producing T-Cells Using Glypican-3 Peptide Library
CN104428411B (zh) 2012-05-08 2018-11-23 健康科学西部大学 用于cd4+t细胞群之抗原特异性扩增的标准化离体平台
CA2930784C (en) 2013-11-22 2023-01-31 Cellectis Method for generating batches of allogeneic t cells with averaged potency
WO2016073595A1 (en) 2014-11-05 2016-05-12 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services T cells and dendritic cells for polyomavirus therapy
NZ731321A (en) 2014-11-05 2022-09-30 Memorial Sloan Kettering Cancer Center Methods of selecting t cell line and donor thereof for adoptive cellular therapy
BR112017020058A2 (pt) 2015-03-20 2018-06-05 Childrens Nat Medical Ct processo para produzir uma célula-t específica, composição, banco de células-t específicas, método de tratamento, e, banco ou instalação de armazenamento de células.
CN107921065A (zh) 2015-06-26 2018-04-17 纪念斯隆-凯特林癌症中心 通过t细胞疗法治疗cmv视网膜炎的方法
HK1258649A1 (zh) 2015-09-18 2019-11-15 Baylor College Of Medicine 来自病原体的免疫原性抗原鉴定以及与临床效力的相关性
KR20190030661A (ko) 2016-05-25 2019-03-22 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 동종이계 t 세포를 이용한 자가면역 질환을 치료하는 방법
WO2018052947A1 (en) 2016-09-16 2018-03-22 Baylor College Of Medicine Platform for activation and expansion of virus-specific t-cells
WO2018055191A1 (en) 2016-09-26 2018-03-29 Tessa Therapeutics Pte. Ltd. T cell expansion method
AU2018288386A1 (en) 2017-06-22 2020-02-06 New South Wales Health Pathology Adoptive T cell therapy 2
CA3074734A1 (en) 2017-09-06 2019-03-14 Nant Holdings Ip, Llc Hla tissue matching and methods therefor
GB201808651D0 (en) 2018-05-25 2018-07-11 Rolls Royce Plc Rotor blade arrangement
CN113811328A (zh) 2019-03-25 2021-12-17 贝勒医学院 多呼吸道病毒抗原特异性t细胞及其制备方法和治疗上的使用方法
AR118859A1 (es) 2019-05-08 2021-11-03 Neon Therapeutics Inc Composiciones y métodos de fabricación de células t
AU2020297019A1 (en) 2019-06-20 2022-02-17 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis B virus (HBV) vaccines
US20220257654A1 (en) 2019-07-23 2022-08-18 Baylor College Of Medicine Antigen-specific t cell banks and methods of making and using the same therapeutically
BR112022001596A2 (pt) 2019-07-29 2022-06-07 Baylor College Medicine Bancos de células t específicas para antígeno e métodos para produzir e usar os mesmos terapeuticamente
CA3151356A1 (en) 2019-08-16 2021-02-25 Baylor College Of Medicine Third party virus-specific t cell compositions, and methods of making and using the same in anti-viral prophylaxis
US20230028788A1 (en) 2019-12-23 2023-01-26 Baylor College Of Medicine T cell performance assay as a prognostic factor for clinical outcome
WO2021189084A1 (en) 2020-03-20 2021-09-23 Baylor College Of Medicine Sars-cov2-specific t cell compositions and their use in treating and preventing coronavirus and other respiratory virus infections
EP3974029A1 (en) 2020-09-25 2022-03-30 Universidad Autónoma de Madrid Memory t cells as adoptive cell therapy for viral infections

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015110397A2 (en) * 2014-01-21 2015-07-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for testing t cell priming efficacy in a subject

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEEN A ET AL, "DIFFERENTIAL IMMUNOGENICITY OF EPSTEIN-BARR VIRUS LATENT-CYCLE PROTEINS FOR HUMAN CD4+ T-HELPER 1 RESPONSES", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, 2001, vol. 75, no. 18, pages 8649 - 8659 *

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