JP2019533682A5 - - Google Patents
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- Publication number
- JP2019533682A5 JP2019533682A5 JP2019522273A JP2019522273A JP2019533682A5 JP 2019533682 A5 JP2019533682 A5 JP 2019533682A5 JP 2019522273 A JP2019522273 A JP 2019522273A JP 2019522273 A JP2019522273 A JP 2019522273A JP 2019533682 A5 JP2019533682 A5 JP 2019533682A5
- Authority
- JP
- Japan
- Prior art keywords
- lymphoma
- combination according
- combination
- hodgkin
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 10
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 6
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 6
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 2
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 2
- 229960001183 venetoclax Drugs 0.000 claims 2
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 1
- 201000003791 MALT lymphoma Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022100006A JP2022137089A (ja) | 2016-10-28 | 2022-06-22 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
| JP2024125584A JP2024167208A (ja) | 2016-10-28 | 2024-08-01 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196184.2 | 2016-10-28 | ||
| EP16196184 | 2016-10-28 | ||
| PCT/EP2017/077654 WO2018078123A1 (en) | 2016-10-28 | 2017-10-27 | Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022100006A Division JP2022137089A (ja) | 2016-10-28 | 2022-06-22 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019533682A JP2019533682A (ja) | 2019-11-21 |
| JP2019533682A5 true JP2019533682A5 (enExample) | 2020-12-03 |
| JP7094950B2 JP7094950B2 (ja) | 2022-07-04 |
Family
ID=57218739
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522273A Active JP7094950B2 (ja) | 2016-10-28 | 2017-10-27 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
| JP2022100006A Pending JP2022137089A (ja) | 2016-10-28 | 2022-06-22 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
| JP2024125584A Pending JP2024167208A (ja) | 2016-10-28 | 2024-08-01 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022100006A Pending JP2022137089A (ja) | 2016-10-28 | 2022-06-22 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
| JP2024125584A Pending JP2024167208A (ja) | 2016-10-28 | 2024-08-01 | 抗ｃｄ１９抗体とｂｃｌ－２阻害剤との組み合わせおよびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US12358983B2 (enExample) |
| EP (2) | EP3903821A1 (enExample) |
| JP (3) | JP7094950B2 (enExample) |
| KR (2) | KR102500868B1 (enExample) |
| CN (2) | CN109890418B (enExample) |
| AU (2) | AU2017348624B2 (enExample) |
| BR (1) | BR112019008244A2 (enExample) |
| CA (1) | CA3037246A1 (enExample) |
| CY (1) | CY1124648T1 (enExample) |
| DK (1) | DK3532098T3 (enExample) |
| ES (1) | ES2871574T3 (enExample) |
| HR (1) | HRP20210838T1 (enExample) |
| HU (1) | HUE054496T2 (enExample) |
| IL (3) | IL301786B2 (enExample) |
| LT (1) | LT3532098T (enExample) |
| MX (2) | MX2019004942A (enExample) |
| NZ (1) | NZ751414A (enExample) |
| PL (1) | PL3532098T3 (enExample) |
| PT (1) | PT3532098T (enExample) |
| RS (1) | RS62036B1 (enExample) |
| RU (1) | RU2756405C2 (enExample) |
| SG (1) | SG10202104036QA (enExample) |
| SI (1) | SI3532098T1 (enExample) |
| SM (1) | SMT202100347T1 (enExample) |
| WO (1) | WO2018078123A1 (enExample) |
| ZA (1) | ZA201903302B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL257345B2 (en) | 2015-08-21 | 2023-03-01 | Morphosys Ag | Combinations and their uses |
| RU2756405C2 (ru) | 2016-10-28 | 2021-09-30 | МорфоСис АГ | Комбинация антитела CD19 с ингибитором BCL-2 и пути ее применения |
| LT3630177T (lt) | 2017-05-31 | 2023-10-25 | Morphosys Ag | Gydymo paradigma, skirta kompleksiniam gydymui anti-cd19 antikūnu ir venetoklaksu |
| GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| UA128954C2 (uk) * | 2018-08-31 | 2024-12-11 | Ейдісі Терапьютікс Са | Комбінована терапія |
| KR20200030337A (ko) | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| JP7704748B2 (ja) * | 2019-10-31 | 2025-07-08 | インサイト・コーポレイション | 逐次抗ｃｄ１９治療 |
| US20220389104A1 (en) * | 2021-05-28 | 2022-12-08 | Ose Immunotherapeutics | Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US5686072A (en) | 1992-06-17 | 1997-11-11 | Board Of Regents, The University Of Texas | Epitope-specific monoclonal antibodies and immunotoxins and uses thereof |
| US20020058029A1 (en) | 2000-09-18 | 2002-05-16 | Nabil Hanna | Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination |
| ES2307832T3 (es) | 2001-12-03 | 2008-12-01 | Amgen Fremont Inc. | Clasificacion de anticuerpos basada en las caracteristicas de union. |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| EP1648512A4 (en) | 2003-07-31 | 2009-01-21 | Immunomedics Inc | ANTI-CD19 ANTIBODIES |
| MX2007015944A (es) | 2005-06-20 | 2008-03-07 | Medarex Inc | Anticuerpos cd19 y sus usos. |
| ES2426468T3 (es) | 2005-12-30 | 2013-10-23 | Merck Patent Gmbh | Anticuerpos anti-CD19 con inmunogenicidad reducida |
| DK2059536T3 (da) | 2006-08-14 | 2014-04-14 | Xencor Inc | Optimerede antistoffer, der er rettet mod cd19 |
| US7798471B2 (en) | 2006-08-15 | 2010-09-21 | Hydralift Amclyde, Inc. | Direct acting single sheave active/passive heave compensator |
| ES2383710T3 (es) | 2006-09-08 | 2012-06-25 | Medimmune, Llc | Anticuerpos anti-CD19 humanizados y su uso en el tratamiento de tumores, trasplantes y enfermedades autoinmunes |
| SI2529622T1 (en) | 2006-09-22 | 2018-06-29 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| AU2008260498B2 (en) | 2007-05-30 | 2012-11-29 | Xencor, Inc. | Methods and compositions for inhibiting CD32b expressing cells |
| PT2211904T (pt) | 2007-10-19 | 2016-11-02 | Seattle Genetics Inc | Agentes de ligação a cd19 e seus usos |
| US20100128586A1 (en) | 2008-11-25 | 2010-05-27 | Mediatek Inc. | Method and apparatus for accessing data from disc with linking area |
| CN102421800A (zh) | 2009-02-23 | 2012-04-18 | 格兰马克药品股份有限公司 | 结合cd19的人源化抗体及其用途 |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| EP2445530B1 (en) | 2009-06-24 | 2016-09-07 | The Feinstein Institute for Medical Research | Method for treating chronic lymphocytic leukemia |
| WO2011147834A1 (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof |
| NZ753024A (en) | 2010-06-03 | 2020-08-28 | Pharmacyclics Llc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| EP2409712A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| US8543911B2 (en) | 2011-01-18 | 2013-09-24 | Apple Inc. | Ordering document content based on reading flow |
| EP2524929A1 (en) | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| EP2744515B1 (en) | 2011-08-16 | 2022-02-09 | MorphoSys AG | Combination therapy with an anti-cd19 antibody and a nitrogen mustard |
| CN103703027B (zh) * | 2011-08-16 | 2018-01-12 | 莫佛塞斯公司 | 使用抗cd‑19抗体和嘌呤类似物的联合治疗 |
| CN105793251B (zh) * | 2013-12-05 | 2018-10-12 | 豪夫迈·罗氏有限公司 | 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物 |
| EP3110509B1 (en) * | 2014-02-28 | 2020-08-19 | Merck Sharp & Dohme Corp. | Treating cancer with a combination comprising dinaciclib |
| LT3129470T (lt) * | 2014-04-07 | 2021-07-12 | Novartis Ag | Vėžio gydymas naudojant anti-cd19 chimerinį antigeno receptorių |
| JP2017519757A (ja) | 2014-06-16 | 2017-07-20 | ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． | 慢性リンパ球性白血病（ｃｌｌ）の処置 |
| EP3209690B1 (en) | 2014-10-20 | 2021-05-05 | Juno Therapeutics, Inc. | Methods and compositions for dosing in adoptive cell therapy |
| JP2018506533A (ja) * | 2015-02-12 | 2018-03-08 | シアトル ジェネティックス， インコーポレイテッド | Ｃｄ１９−ａｄｃ及びビンクリスチンを使用する組み合わせ療法 |
| NZ736727A (en) | 2015-05-26 | 2022-09-30 | Hoffmann La Roche | Combination therapy of an anti cd20 antibody with a bcl-2 inhibitor and a mdm2 inhibitor |
| CN107660151B (zh) | 2015-05-26 | 2022-03-11 | 莫佛塞斯公司 | 抗-cd19抗体和布鲁顿酪氨酸激酶抑制剂的组合及其用途 |
| AU2016288246A1 (en) | 2015-07-02 | 2018-02-01 | Celgene Corporation | Combination therapy for treatment of hematological cancers and solid tumors |
| IL257345B2 (en) | 2015-08-21 | 2023-03-01 | Morphosys Ag | Combinations and their uses |
| MD3916392T2 (ro) | 2016-05-30 | 2024-10-31 | Incyte Corp | Metode de predicție a beneficiului terapeutic al terapiei anti-CD19 la pacienți |
| CN109415440B (zh) | 2016-06-27 | 2022-12-06 | 莫佛塞斯公司 | 抗-cd19抗体制剂 |
| RU2756405C2 (ru) | 2016-10-28 | 2021-09-30 | МорфоСис АГ | Комбинация антитела CD19 с ингибитором BCL-2 и пути ее применения |
| LT3630177T (lt) | 2017-05-31 | 2023-10-25 | Morphosys Ag | Gydymo paradigma, skirta kompleksiniam gydymui anti-cd19 antikūnu ir venetoklaksu |
| US20210292410A1 (en) | 2017-12-07 | 2021-09-23 | Morphosys Ag | Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment |
| KR20200030337A (ko) | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| US20220242952A1 (en) | 2019-05-03 | 2022-08-04 | Morphosys Ag | Anti-cd19 therapy in patients having a limited number of nk cells |
| JP7704748B2 (ja) | 2019-10-31 | 2025-07-08 | インサイト・コーポレイション | 逐次抗ｃｄ１９治療 |
| JP2023501209A (ja) | 2019-10-31 | 2023-01-18 | モルフォシス・アーゲー | 白血病またはリンパ腫の治療のためのレナリドミドと組み合わせた抗ｃｄ１９療法 |
| IL292213A (en) | 2019-10-31 | 2022-06-01 | Morphosys Ag | Combination anti-tumor therapy including anti-cd19 antibody and gamma delta t cells |
| KR20230030636A (ko) | 2020-06-22 | 2023-03-06 | 모르포시스 아게 | 항-CD19 항체, 및 SIRPα-CD47 선천성 면역 체크포인트를 차단하는 폴리펩티드를 포함하는 항-종양 조합 요법 |
| KR20230131464A (ko) | 2020-12-04 | 2023-09-13 | 모르포시스 아게 | 항-cd19 병용 요법 |
| MX2024007649A (es) | 2021-12-22 | 2024-08-26 | Incyte Corp | Paradigma de tratamiento para una terapia con anticuerpos anti cumulo de diferenciacion (anti-cd19). |
-
2017
- 2017-10-27 RU RU2019113370A patent/RU2756405C2/ru active
- 2017-10-27 SM SM20210347T patent/SMT202100347T1/it unknown
- 2017-10-27 SG SG10202104036QA patent/SG10202104036QA/en unknown
- 2017-10-27 JP JP2019522273A patent/JP7094950B2/ja active Active
- 2017-10-27 HR HRP20210838TT patent/HRP20210838T1/hr unknown
- 2017-10-27 IL IL301786A patent/IL301786B2/en unknown
- 2017-10-27 DK DK17797564.6T patent/DK3532098T3/da active
- 2017-10-27 KR KR1020197012532A patent/KR102500868B1/ko active Active
- 2017-10-27 NZ NZ751414A patent/NZ751414A/en unknown
- 2017-10-27 KR KR1020237005018A patent/KR20230028571A/ko not_active Ceased
- 2017-10-27 IL IL266216A patent/IL266216B2/en unknown
- 2017-10-27 AU AU2017348624A patent/AU2017348624B2/en active Active
- 2017-10-27 RS RS20210792A patent/RS62036B1/sr unknown
- 2017-10-27 EP EP21165598.0A patent/EP3903821A1/en active Pending
- 2017-10-27 WO PCT/EP2017/077654 patent/WO2018078123A1/en not_active Ceased
- 2017-10-27 SI SI201730811T patent/SI3532098T1/sl unknown
- 2017-10-27 CA CA3037246A patent/CA3037246A1/en active Pending
- 2017-10-27 IL IL320372A patent/IL320372A/en unknown
- 2017-10-27 LT LTEP17797564.6T patent/LT3532098T/lt unknown
- 2017-10-27 ES ES17797564T patent/ES2871574T3/es active Active
- 2017-10-27 PL PL17797564T patent/PL3532098T3/pl unknown
- 2017-10-27 HU HUE17797564A patent/HUE054496T2/hu unknown
- 2017-10-27 MX MX2019004942A patent/MX2019004942A/es unknown
- 2017-10-27 US US16/342,645 patent/US12358983B2/en active Active
- 2017-10-27 EP EP17797564.6A patent/EP3532098B1/en active Active
- 2017-10-27 PT PT177975646T patent/PT3532098T/pt unknown
- 2017-10-27 CN CN201780067047.1A patent/CN109890418B/zh active Active
- 2017-10-27 CN CN202410183851.8A patent/CN118045175A/zh active Pending
- 2017-10-27 BR BR112019008244-1A patent/BR112019008244A2/pt unknown
-
2019
- 2019-04-26 MX MX2022016270A patent/MX2022016270A/es unknown
- 2019-05-24 ZA ZA2019/03302A patent/ZA201903302B/en unknown
-
2021
- 2021-06-10 CY CY20211100512T patent/CY1124648T1/el unknown
-
2022
- 2022-06-22 JP JP2022100006A patent/JP2022137089A/ja active Pending
-
2024
- 2024-08-01 JP JP2024125584A patent/JP2024167208A/ja active Pending
- 2024-12-23 AU AU2024287178A patent/AU2024287178A1/en active Pending
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