JP2023093495A5 - - Google Patents
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- JP2023093495A5 JP2023093495A5 JP2023054891A JP2023054891A JP2023093495A5 JP 2023093495 A5 JP2023093495 A5 JP 2023093495A5 JP 2023054891 A JP2023054891 A JP 2023054891A JP 2023054891 A JP2023054891 A JP 2023054891A JP 2023093495 A5 JP2023093495 A5 JP 2023093495A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- sequence
- phosphoinositide
- lymphoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 9
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 9
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 8
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 8
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 229960003445 idelalisib Drugs 0.000 claims 1
- YKLIKGKUANLGSB-HNNXBMFYSA-N idelalisib Chemical group C1([C@@H](NC=2[C]3N=CN=C3N=CN=2)CC)=NC2=CC=CC(F)=C2C(=O)N1C1=CC=CC=C1 YKLIKGKUANLGSB-HNNXBMFYSA-N 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 1
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025093012A JP2025131697A (ja) | 2015-08-21 | 2025-06-04 | 組み合わせおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15181925.7 | 2015-08-21 | ||
| EP15181925 | 2015-08-21 | ||
| JP2021059383A JP2021113194A (ja) | 2015-08-21 | 2021-03-31 | 組み合わせおよびその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021059383A Division JP2021113194A (ja) | 2015-08-21 | 2021-03-31 | 組み合わせおよびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025093012A Division JP2025131697A (ja) | 2015-08-21 | 2025-06-04 | 組み合わせおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023093495A JP2023093495A (ja) | 2023-07-04 |
| JP2023093495A5 true JP2023093495A5 (enExample) | 2023-11-22 |
Family
ID=54010888
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508728A Active JP6862422B2 (ja) | 2015-08-21 | 2016-08-18 | 組み合わせおよびその使用 |
| JP2021059383A Pending JP2021113194A (ja) | 2015-08-21 | 2021-03-31 | 組み合わせおよびその使用 |
| JP2023054891A Pending JP2023093495A (ja) | 2015-08-21 | 2023-03-30 | 組み合わせおよびその使用 |
| JP2025093012A Pending JP2025131697A (ja) | 2015-08-21 | 2025-06-04 | 組み合わせおよびその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508728A Active JP6862422B2 (ja) | 2015-08-21 | 2016-08-18 | 組み合わせおよびその使用 |
| JP2021059383A Pending JP2021113194A (ja) | 2015-08-21 | 2021-03-31 | 組み合わせおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025093012A Pending JP2025131697A (ja) | 2015-08-21 | 2025-06-04 | 組み合わせおよびその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US11224654B2 (enExample) |
| EP (2) | EP3954388A1 (enExample) |
| JP (4) | JP6862422B2 (enExample) |
| KR (2) | KR102786010B1 (enExample) |
| CN (2) | CN107921129B (enExample) |
| AU (3) | AU2016311136B2 (enExample) |
| CA (1) | CA2995738A1 (enExample) |
| CY (1) | CY1124706T1 (enExample) |
| DK (1) | DK3337506T3 (enExample) |
| ES (1) | ES2891336T3 (enExample) |
| HR (1) | HRP20211291T1 (enExample) |
| HU (1) | HUE056408T2 (enExample) |
| IL (2) | IL257345B2 (enExample) |
| LT (1) | LT3337506T (enExample) |
| MX (2) | MX392561B (enExample) |
| PL (1) | PL3337506T3 (enExample) |
| PT (1) | PT3337506T (enExample) |
| RS (1) | RS62260B1 (enExample) |
| RU (1) | RU2767063C2 (enExample) |
| SI (1) | SI3337506T1 (enExample) |
| SM (1) | SMT202100541T1 (enExample) |
| WO (1) | WO2017032679A1 (enExample) |
| ZA (1) | ZA201801052B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017032679A1 (en) | 2015-08-21 | 2017-03-02 | Morphosys Ag | Combinations and uses thereof |
| AU2017348624B2 (en) | 2016-10-28 | 2024-09-26 | Incyte Corporation | Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof |
| BR112019025034A2 (pt) | 2017-05-31 | 2020-06-30 | Morphosys Ag | combinação |
| JP7279011B2 (ja) | 2017-07-10 | 2023-05-22 | インターナショナル－ドラッグ－ディベロップメント－バイオテック | 抗ｃｄ２０抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗ｃｄ１９抗体を用いるｂ細胞悪性の治療 |
| KR20200030337A (ko) * | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| PH12022551021A1 (en) * | 2019-10-31 | 2023-03-06 | Morphosys Ag | Sequential anti-cd19 therapy |
| WO2022115762A1 (en) * | 2020-11-30 | 2022-06-02 | Incyte Corporation | Combination therapy with an anti-cd19 antibody and parsaclisib |
| US20230357392A1 (en) * | 2021-12-22 | 2023-11-09 | Morphosys Ag | Treatment Paradigm for an Anti-CD19 Antibody Therapy |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
| US5686072A (en) | 1992-06-17 | 1997-11-11 | Board Of Regents, The University Of Texas | Epitope-specific monoclonal antibodies and immunotoxins and uses thereof |
| KR100785363B1 (ko) | 2000-04-25 | 2007-12-18 | 이코스 코포레이션 | 인간 포스파티딜-이노시톨 3-키나제 델타의 억제제 |
| WO2002022212A2 (en) | 2000-09-18 | 2002-03-21 | Idec Pharmaceuticals Corporation | Combination therapy for treatment of autoimmune diseases using b cell depleting/immunoregulatory antibody combination |
| US7771951B2 (en) | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| US20080152649A1 (en) * | 2002-03-01 | 2008-06-26 | Xencor, Inc. | Optimized igf-1r antibodies and methods of using the same |
| US7109304B2 (en) | 2003-07-31 | 2006-09-19 | Immunomedics, Inc. | Humanized anti-CD19 antibodies |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| ES2873875T3 (es) | 2004-05-13 | 2021-11-04 | Icos Corp | Quinazolinonas como inhibidores de fosfatidilinositol 3-quinasa delta humano |
| JP5215180B2 (ja) | 2005-06-20 | 2013-06-19 | メダレックス インコーポレーティッド | Ｃｄ１９抗体およびその使用法 |
| ATE509954T1 (de) | 2005-12-30 | 2011-06-15 | Merck Patent Gmbh | Anti-cd19-antikörper mit reduzierter immunogenität |
| ES2402591T3 (es) | 2006-08-14 | 2013-05-07 | Xencor Inc. | Anticuerpos optimizados que seleccionan como diana CD19 |
| US8323653B2 (en) | 2006-09-08 | 2012-12-04 | Medimmune, Llc | Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| ES2659517T3 (es) | 2007-05-30 | 2018-03-16 | Xencor, Inc. | Métodos y composiciones para inhibir células que expresan CD32B |
| SI2211904T1 (sl) | 2007-10-19 | 2016-12-30 | Seattle Genetics, Inc. | CD19 vezavna sredstva in njihove uporabe |
| CN102421800A (zh) | 2009-02-23 | 2012-04-18 | 格兰马克药品股份有限公司 | 结合cd19的人源化抗体及其用途 |
| AU2010263272C1 (en) | 2009-06-24 | 2016-02-11 | The Feinstein Institute For Medical Research | Method for treating chronic lymphocytic leukemia |
| US8840888B2 (en) * | 2009-10-27 | 2014-09-23 | Micromet Ag | Dosage regimen for administering a CD19XCD3 bispecific antibody |
| WO2011147834A1 (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof |
| EP2409712A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| US9272052B2 (en) * | 2010-10-22 | 2016-03-01 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway |
| EP2524929A1 (en) | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| PT2744826T (pt) | 2011-08-16 | 2022-05-19 | Morphosys Ag | Terapia de combinação com um anticorpo anti-cd19 e um análogo de purina |
| KR20140064873A (ko) | 2011-08-16 | 2014-05-28 | 모르포시스 아게 | 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법 |
| MD20140100A2 (ro) | 2012-03-05 | 2015-01-31 | Gilead Calistoga Llc | Forme polimorfe ale (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilchinazolin-4(3H)-onei |
| CA2890105C (en) | 2012-11-01 | 2023-03-21 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| MX356112B (es) | 2013-02-15 | 2018-05-15 | 3M Innovative Properties Co | Sistema y metodo para elaborar medios de filtracion plegados. |
| US20170137516A1 (en) | 2014-06-16 | 2017-05-18 | Xencor, Inc. | Treatment for chronic lymphocytic leukemia (cll) |
| SMT201900647T1 (it) | 2015-05-26 | 2020-01-14 | Morphosys Ag | Combinazione di un anticorpo anti-cd19 e un inibitore della tirosina chinasi di bruton e suoi usi |
| WO2017032679A1 (en) | 2015-08-21 | 2017-03-02 | Morphosys Ag | Combinations and uses thereof |
| LT3916392T (lt) | 2016-05-30 | 2024-08-26 | Incyte Corporation | Pacientų gydymo anti-cd19 terapinės naudos prognozavimo būdai |
| SG10201912369QA (en) | 2016-06-27 | 2020-02-27 | Morphosys Ag | Anti-cd19 antibody formulations |
| AU2017348624B2 (en) | 2016-10-28 | 2024-09-26 | Incyte Corporation | Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof |
| BR112019025034A2 (pt) | 2017-05-31 | 2020-06-30 | Morphosys Ag | combinação |
| KR20200030337A (ko) | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| JP2022532519A (ja) | 2019-05-03 | 2022-07-15 | モルフォシス・アーゲー | 限られた数のｎｋ細胞を有する患者における抗ｃｄ１９療法 |
| PH12022551021A1 (en) | 2019-10-31 | 2023-03-06 | Morphosys Ag | Sequential anti-cd19 therapy |
| IL292181A (en) | 2019-10-31 | 2022-06-01 | Morphosys Ag | Anti-cd19 therapy in combination with lenalidomide for the treatment of leukemia or lymphoma |
| TWI883067B (zh) | 2019-10-31 | 2025-05-11 | 美商英塞特公司 | 包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法 |
| US20230014026A1 (en) | 2020-06-22 | 2023-01-19 | Morphosys Ag | Anti-Tumor Combination Therapy comprising Anti-CD19 Antibody and Polypeptides Blocking the SIRPalpha-CD47 Innate Immune Checkpoint |
| WO2022115762A1 (en) | 2020-11-30 | 2022-06-02 | Incyte Corporation | Combination therapy with an anti-cd19 antibody and parsaclisib |
| IL303384A (en) | 2020-12-04 | 2023-08-01 | Morphosys Ag | Anti-CD19 combination therapy |
| US20230357392A1 (en) | 2021-12-22 | 2023-11-09 | Morphosys Ag | Treatment Paradigm for an Anti-CD19 Antibody Therapy |
-
2016
- 2016-08-18 WO PCT/EP2016/069571 patent/WO2017032679A1/en not_active Ceased
- 2016-08-18 JP JP2018508728A patent/JP6862422B2/ja active Active
- 2016-08-18 US US15/752,009 patent/US11224654B2/en active Active
- 2016-08-18 EP EP21186316.2A patent/EP3954388A1/en active Pending
- 2016-08-18 DK DK16756997.9T patent/DK3337506T3/da active
- 2016-08-18 KR KR1020247011695A patent/KR102786010B1/ko active Active
- 2016-08-18 KR KR1020187007728A patent/KR20180042335A/ko not_active Ceased
- 2016-08-18 PL PL16756997T patent/PL3337506T3/pl unknown
- 2016-08-18 RS RS20211009A patent/RS62260B1/sr unknown
- 2016-08-18 SM SM20210541T patent/SMT202100541T1/it unknown
- 2016-08-18 RU RU2018107929A patent/RU2767063C2/ru active
- 2016-08-18 CA CA2995738A patent/CA2995738A1/en active Pending
- 2016-08-18 SI SI201631293T patent/SI3337506T1/sl unknown
- 2016-08-18 ES ES16756997T patent/ES2891336T3/es active Active
- 2016-08-18 HR HRP20211291TT patent/HRP20211291T1/hr unknown
- 2016-08-18 MX MX2018002241A patent/MX392561B/es unknown
- 2016-08-18 CN CN201680048061.2A patent/CN107921129B/zh active Active
- 2016-08-18 PT PT167569979T patent/PT3337506T/pt unknown
- 2016-08-18 CN CN202210502807.XA patent/CN115054697B/zh active Active
- 2016-08-18 HU HUE16756997A patent/HUE056408T2/hu unknown
- 2016-08-18 LT LTEPPCT/EP2016/069571T patent/LT3337506T/lt unknown
- 2016-08-18 IL IL257345A patent/IL257345B2/en unknown
- 2016-08-18 AU AU2016311136A patent/AU2016311136B2/en active Active
- 2016-08-18 EP EP16756997.9A patent/EP3337506B1/en active Active
-
2018
- 2018-02-15 ZA ZA2018/01052A patent/ZA201801052B/en unknown
- 2018-02-20 MX MX2022006154A patent/MX2022006154A/es unknown
-
2021
- 2021-03-31 JP JP2021059383A patent/JP2021113194A/ja active Pending
- 2021-09-17 CY CY20211100817T patent/CY1124706T1/el unknown
- 2021-12-08 US US17/545,274 patent/US12194095B2/en active Active
-
2022
- 2022-04-28 AU AU2022202800A patent/AU2022202800B2/en active Active
- 2022-10-03 IL IL297057A patent/IL297057B2/en unknown
-
2023
- 2023-03-30 JP JP2023054891A patent/JP2023093495A/ja active Pending
-
2024
- 2024-04-02 AU AU2024202109A patent/AU2024202109A1/en active Pending
- 2024-12-02 US US18/965,167 patent/US20250195646A1/en active Pending
-
2025
- 2025-06-04 JP JP2025093012A patent/JP2025131697A/ja active Pending
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