CY1124706T1 - Συνδυασμοι και χρησεις αυτων - Google Patents

Συνδυασμοι και χρησεις αυτων

Info

Publication number
CY1124706T1
CY1124706T1 CY20211100817T CY211100817T CY1124706T1 CY 1124706 T1 CY1124706 T1 CY 1124706T1 CY 20211100817 T CY20211100817 T CY 20211100817T CY 211100817 T CY211100817 T CY 211100817T CY 1124706 T1 CY1124706 T1 CY 1124706T1
Authority
CY
Cyprus
Prior art keywords
combinations
phosphoinositide
hodgkin
lymphoma
antibody
Prior art date
Application number
CY20211100817T
Other languages
Greek (el)
English (en)
Inventor
Jan Endell
Mark Winderlich
Rainer Boxhammer
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of CY1124706T1 publication Critical patent/CY1124706T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CY20211100817T 2015-08-21 2021-09-17 Συνδυασμοι και χρησεις αυτων CY1124706T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15181925 2015-08-21
PCT/EP2016/069571 WO2017032679A1 (en) 2015-08-21 2016-08-18 Combinations and uses thereof

Publications (1)

Publication Number Publication Date
CY1124706T1 true CY1124706T1 (el) 2022-07-22

Family

ID=54010888

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100817T CY1124706T1 (el) 2015-08-21 2021-09-17 Συνδυασμοι και χρησεις αυτων

Country Status (23)

Country Link
US (3) US11224654B2 (enExample)
EP (2) EP3337506B1 (enExample)
JP (4) JP6862422B2 (enExample)
KR (2) KR102786010B1 (enExample)
CN (2) CN115054697B (enExample)
AU (3) AU2016311136B2 (enExample)
CA (1) CA2995738A1 (enExample)
CY (1) CY1124706T1 (enExample)
DK (1) DK3337506T3 (enExample)
ES (1) ES2891336T3 (enExample)
HR (1) HRP20211291T1 (enExample)
HU (1) HUE056408T2 (enExample)
IL (2) IL257345B2 (enExample)
LT (1) LT3337506T (enExample)
MX (2) MX392561B (enExample)
PL (1) PL3337506T3 (enExample)
PT (1) PT3337506T (enExample)
RS (1) RS62260B1 (enExample)
RU (1) RU2767063C2 (enExample)
SI (1) SI3337506T1 (enExample)
SM (1) SMT202100541T1 (enExample)
WO (1) WO2017032679A1 (enExample)
ZA (1) ZA201801052B (enExample)

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PT3532098T (pt) 2016-10-28 2021-06-17 Morphosys Ag Combinação de anticorpo anti cd19 com um inibidor bcl-2 e suas utilizações
SMT202300338T1 (it) 2017-05-31 2023-11-13 Morphosys Ag Paradigma di trattamento per un trattamento combinato di anticorpo anti-cd19 e venetoclax
JP7279011B2 (ja) 2017-07-10 2023-05-22 インターナショナル－ドラッグ－ディベロップメント－バイオテック 抗ｃｄ２０抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗ｃｄ１９抗体を用いるｂ細胞悪性の治療
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
TW202131950A (zh) * 2019-10-31 2021-09-01 德商莫菲西斯公司 依序抗ｃｄ１９療法
TW202241436A (zh) * 2020-11-30 2022-11-01 美商英塞特公司 抗ｃｄ１９抗體及帕薩昔布（ｐａｒｓａｃｌｉｓｉｂ）之組合療法
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KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
KR20220007087A (ko) 2019-05-03 2022-01-18 모르포시스 아게 제한된 수의 nk 세포를 갖는 환자에서의 항-cd19 치료제
TW202131950A (zh) 2019-10-31 2021-09-01 德商莫菲西斯公司 依序抗ｃｄ１９療法
DK4051710T3 (da) 2019-10-31 2025-12-15 Incyte Corp Antitumor-kombinationsterapi bestående af anti-cd19-antistof og gamma-delta-t-celler
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TW202241436A (zh) 2020-11-30 2022-11-01 美商英塞特公司 抗ｃｄ１９抗體及帕薩昔布（ｐａｒｓａｃｌｉｓｉｂ）之組合療法
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AU2022419233A1 (en) 2021-12-22 2024-07-04 Incyte Corporation Treatment paradigm for an anti-cd19 antibody therapy

Also Published As

Publication number Publication date
HK1247122A1 (zh) 2018-09-21
MX392561B (es) 2025-03-24
CN107921129A (zh) 2018-04-17
IL297057B2 (en) 2025-11-01
US11224654B2 (en) 2022-01-18
IL257345A (en) 2018-03-29
RU2767063C2 (ru) 2022-03-16
CN115054697B (zh) 2024-06-11
DK3337506T3 (da) 2021-09-06
US20180228893A1 (en) 2018-08-16
ZA201801052B (en) 2021-05-26
IL257345B (en) 2022-11-01
JP6862422B2 (ja) 2021-04-21
JP2025131697A (ja) 2025-09-09
EP3954388A1 (en) 2022-02-16
WO2017032679A1 (en) 2017-03-02
HRP20211291T1 (hr) 2021-12-10
SMT202100541T1 (it) 2021-11-12
EP3337506A1 (en) 2018-06-27
EP3337506B1 (en) 2021-07-21
ES2891336T3 (es) 2022-01-27
KR20240052084A (ko) 2024-04-22
AU2022202800A1 (en) 2022-05-19
IL257345B2 (en) 2023-03-01
KR20180042335A (ko) 2018-04-25
CN115054697A (zh) 2022-09-16
CA2995738A1 (en) 2017-03-02
NZ739706A (en) 2025-02-28
MX2022006154A (es) 2022-10-07
RU2018107929A (ru) 2019-09-23
AU2016311136B2 (en) 2022-02-17
RS62260B1 (sr) 2021-09-30
PL3337506T3 (pl) 2022-01-03
JP2021113194A (ja) 2021-08-05
RU2018107929A3 (enExample) 2020-01-14
HUE056408T2 (hu) 2022-02-28
IL297057B1 (en) 2025-07-01
LT3337506T (lt) 2021-10-11
US12194095B2 (en) 2025-01-14
AU2016311136A1 (en) 2018-03-01
JP2018523685A (ja) 2018-08-23
MX2018002241A (es) 2018-03-23
KR102786010B1 (ko) 2025-03-26
CN107921129B (zh) 2022-05-27
AU2022202800B2 (en) 2024-01-04
PT3337506T (pt) 2021-09-24
IL297057A (en) 2022-12-01
SI3337506T1 (sl) 2021-12-31
US20220088197A1 (en) 2022-03-24
JP2023093495A (ja) 2023-07-04
AU2024202109A1 (en) 2024-05-02
US20250195646A1 (en) 2025-06-19
BR112018003263A2 (pt) 2018-09-25

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