AU2017348624B2 - Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof - Google Patents

Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof Download PDF

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Publication number
AU2017348624B2
AU2017348624B2 AU2017348624A AU2017348624A AU2017348624B2 AU 2017348624 B2 AU2017348624 B2 AU 2017348624B2 AU 2017348624 A AU2017348624 A AU 2017348624A AU 2017348624 A AU2017348624 A AU 2017348624A AU 2017348624 B2 AU2017348624 B2 AU 2017348624B2
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leu
val
pro
thr
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AU2017348624A1 (en
Inventor
Rainer Boxhammer
Jan Endell
Peter Kelemen
Konstantin PETROPOULOS
Markus Rückert
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Incyte Corp
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Incyte Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2017348624A 2016-10-28 2017-10-27 Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof Active AU2017348624B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024287178A AU2024287178A1 (en) 2016-10-28 2024-12-23 Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16196184.2 2016-10-28
EP16196184 2016-10-28
PCT/EP2017/077654 WO2018078123A1 (en) 2016-10-28 2017-10-27 Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof

Related Child Applications (1)

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AU2024287178A Division AU2024287178A1 (en) 2016-10-28 2024-12-23 Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof

Publications (2)

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AU2017348624A1 AU2017348624A1 (en) 2019-03-28
AU2017348624B2 true AU2017348624B2 (en) 2024-09-26

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AU2017348624A Active AU2017348624B2 (en) 2016-10-28 2017-10-27 Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof
AU2024287178A Pending AU2024287178A1 (en) 2016-10-28 2024-12-23 Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof

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AU2024287178A Pending AU2024287178A1 (en) 2016-10-28 2024-12-23 Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof

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US (1) US12358983B2 (enExample)
EP (2) EP3903821A1 (enExample)
JP (3) JP7094950B2 (enExample)
KR (2) KR102500868B1 (enExample)
CN (2) CN109890418B (enExample)
AU (2) AU2017348624B2 (enExample)
BR (1) BR112019008244A2 (enExample)
CA (1) CA3037246A1 (enExample)
CY (1) CY1124648T1 (enExample)
DK (1) DK3532098T3 (enExample)
ES (1) ES2871574T3 (enExample)
HR (1) HRP20210838T1 (enExample)
HU (1) HUE054496T2 (enExample)
IL (3) IL301786B2 (enExample)
LT (1) LT3532098T (enExample)
MX (2) MX2019004942A (enExample)
NZ (1) NZ751414A (enExample)
PL (1) PL3532098T3 (enExample)
PT (1) PT3532098T (enExample)
RS (1) RS62036B1 (enExample)
RU (1) RU2756405C2 (enExample)
SG (1) SG10202104036QA (enExample)
SI (1) SI3532098T1 (enExample)
SM (1) SMT202100347T1 (enExample)
WO (1) WO2018078123A1 (enExample)
ZA (1) ZA201903302B (enExample)

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GB201809746D0 (en) * 2018-06-14 2018-08-01 Berlin Chemie Ag Pharmaceutical combinations
UA128954C2 (uk) * 2018-08-31 2024-12-11 Ейдісі Терапьютікс Са Комбінована терапія
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
JP7704748B2 (ja) * 2019-10-31 2025-07-08 インサイト・コーポレイション 逐次抗ｃｄ１９治療
US20220389104A1 (en) * 2021-05-28 2022-12-08 Ose Immunotherapeutics Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent

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Also Published As

Publication number Publication date
IL301786A (en) 2023-05-01
KR102500868B1 (ko) 2023-02-16
AU2017348624A1 (en) 2019-03-28
DK3532098T3 (da) 2021-05-25
CY1124648T1 (el) 2022-07-22
US12358983B2 (en) 2025-07-15
BR112019008244A2 (pt) 2019-07-16
IL266216B2 (en) 2023-09-01
IL266216A (en) 2019-06-30
ZA201903302B (en) 2021-04-28
PT3532098T (pt) 2021-06-17
CA3037246A1 (en) 2018-05-03
HUE054496T2 (hu) 2021-09-28
SMT202100347T1 (it) 2021-07-12
JP2022137089A (ja) 2022-09-21
LT3532098T (lt) 2021-06-25
IL320372A (en) 2025-06-01
AU2024287178A1 (en) 2025-01-23
CN109890418A (zh) 2019-06-14
NZ751414A (en) 2025-10-31
KR20190075942A (ko) 2019-07-01
MX2022016270A (es) 2023-02-15
EP3532098B1 (en) 2021-04-07
IL301786B2 (en) 2025-09-01
US20190241656A1 (en) 2019-08-08
CN109890418B (zh) 2024-03-08
ES2871574T3 (es) 2021-10-29
PL3532098T3 (pl) 2022-01-31
RU2019113370A (ru) 2020-11-30
KR20230028571A (ko) 2023-02-28
JP2024167208A (ja) 2024-12-03
RU2756405C2 (ru) 2021-09-30
EP3532098A1 (en) 2019-09-04
IL266216B1 (en) 2023-05-01
EP3903821A1 (en) 2021-11-03
MX2019004942A (es) 2019-08-12
IL301786B1 (en) 2025-05-01
RS62036B1 (sr) 2021-07-30
SG10202104036QA (en) 2021-05-28
RU2019113370A3 (enExample) 2021-03-01
JP2019533682A (ja) 2019-11-21
HRP20210838T1 (hr) 2021-08-06
JP7094950B2 (ja) 2022-07-04
WO2018078123A1 (en) 2018-05-03
SI3532098T1 (sl) 2021-12-31
CN118045175A (zh) 2024-05-17

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