CA3037246A1 - Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof - Google Patents

Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof Download PDF

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Publication number
CA3037246A1
CA3037246A1 CA3037246A CA3037246A CA3037246A1 CA 3037246 A1 CA3037246 A1 CA 3037246A1 CA 3037246 A CA3037246 A CA 3037246A CA 3037246 A CA3037246 A CA 3037246A CA 3037246 A1 CA3037246 A1 CA 3037246A1
Authority
CA
Canada
Prior art keywords
venetoclax
seq
sequence
combination
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3037246A
Other languages
English (en)
French (fr)
Inventor
Jan Endell
Konstantin PETROPOULOS
Peter Kelemen
Rainer Boxhammer
Markus Ruckert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphosys GmbH
Original Assignee
Morphosys GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys GmbH filed Critical Morphosys GmbH
Publication of CA3037246A1 publication Critical patent/CA3037246A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3037246A 2016-10-28 2017-10-27 Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof Pending CA3037246A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16196184 2016-10-28
EP16196184.2 2016-10-28
PCT/EP2017/077654 WO2018078123A1 (en) 2016-10-28 2017-10-27 Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof

Publications (1)

Publication Number Publication Date
CA3037246A1 true CA3037246A1 (en) 2018-05-03

Family

ID=57218739

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3037246A Pending CA3037246A1 (en) 2016-10-28 2017-10-27 Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof

Country Status (25)

Country Link
US (2) US12358983B2 (enExample)
EP (2) EP3532098B1 (enExample)
JP (3) JP7094950B2 (enExample)
KR (2) KR20230028571A (enExample)
CN (2) CN109890418B (enExample)
AU (2) AU2017348624B2 (enExample)
BR (1) BR112019008244A2 (enExample)
CA (1) CA3037246A1 (enExample)
CY (1) CY1124648T1 (enExample)
DK (1) DK3532098T3 (enExample)
ES (1) ES2871574T3 (enExample)
HR (1) HRP20210838T1 (enExample)
HU (1) HUE054496T2 (enExample)
IL (3) IL266216B2 (enExample)
LT (1) LT3532098T (enExample)
MX (2) MX2019004942A (enExample)
PL (1) PL3532098T3 (enExample)
PT (1) PT3532098T (enExample)
RS (1) RS62036B1 (enExample)
RU (1) RU2756405C2 (enExample)
SG (1) SG10202104036QA (enExample)
SI (1) SI3532098T1 (enExample)
SM (1) SMT202100347T1 (enExample)
WO (1) WO2018078123A1 (enExample)
ZA (1) ZA201903302B (enExample)

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AU2016311136B2 (en) 2015-08-21 2022-02-17 Incyte Corporation Combinations and uses thereof
ES2981046T3 (es) 2016-05-30 2024-10-07 Incyte Corp Métodos para predecir el beneficio terapéutico de una terapia anti-CD19 en pacientes
SMT202100317T1 (it) 2016-06-27 2021-07-12 Morphosys Ag Formulazioni di anticorpi anti-cd19
WO2018078123A1 (en) 2016-10-28 2018-05-03 Morphosys Ag Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof
HUE063119T2 (hu) 2017-05-31 2024-01-28 Morphosys Ag Kezelési paradigma anti-CD19 antitest és venetoclax kombinációs kezeléshez
GB201809746D0 (en) * 2018-06-14 2018-08-01 Berlin Chemie Ag Pharmaceutical combinations
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TW202131950A (zh) * 2019-10-31 2021-09-01 德商莫菲西斯公司 依序抗ｃｄ１９療法
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Also Published As

Publication number Publication date
RU2756405C2 (ru) 2021-09-30
IL266216A (en) 2019-06-30
RS62036B1 (sr) 2021-07-30
IL320372A (en) 2025-06-01
JP2019533682A (ja) 2019-11-21
US20190241656A1 (en) 2019-08-08
CN118045175A (zh) 2024-05-17
US12358983B2 (en) 2025-07-15
KR20190075942A (ko) 2019-07-01
IL301786B2 (en) 2025-09-01
IL301786B1 (en) 2025-05-01
MX2022016270A (es) 2023-02-15
HRP20210838T1 (hr) 2021-08-06
MX2019004942A (es) 2019-08-12
DK3532098T3 (da) 2021-05-25
HUE054496T2 (hu) 2021-09-28
JP2022137089A (ja) 2022-09-21
PT3532098T (pt) 2021-06-17
SMT202100347T1 (it) 2021-07-12
EP3532098B1 (en) 2021-04-07
KR102500868B1 (ko) 2023-02-16
JP2024167208A (ja) 2024-12-03
CN109890418A (zh) 2019-06-14
US20260176355A1 (en) 2026-06-25
AU2017348624A1 (en) 2019-03-28
EP3532098A1 (en) 2019-09-04
WO2018078123A1 (en) 2018-05-03
IL301786A (en) 2023-05-01
IL266216B2 (en) 2023-09-01
NZ751414A (en) 2025-10-31
PL3532098T3 (pl) 2022-01-31
CY1124648T1 (el) 2022-07-22
JP7094950B2 (ja) 2022-07-04
ES2871574T3 (es) 2021-10-29
CN109890418B (zh) 2024-03-08
AU2017348624B2 (en) 2024-09-26
KR20230028571A (ko) 2023-02-28
AU2024287178A1 (en) 2025-01-23
RU2019113370A3 (enExample) 2021-03-01
RU2019113370A (ru) 2020-11-30
IL266216B1 (en) 2023-05-01
ZA201903302B (en) 2021-04-28
SI3532098T1 (sl) 2021-12-31
SG10202104036QA (en) 2021-05-28
LT3532098T (lt) 2021-06-25
BR112019008244A2 (pt) 2019-07-16
EP3903821A1 (en) 2021-11-03

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