JP2019526582A5 - - Google Patents

Download PDF

Info

Publication number
JP2019526582A5
JP2019526582A5 JP2019512205A JP2019512205A JP2019526582A5 JP 2019526582 A5 JP2019526582 A5 JP 2019526582A5 JP 2019512205 A JP2019512205 A JP 2019512205A JP 2019512205 A JP2019512205 A JP 2019512205A JP 2019526582 A5 JP2019526582 A5 JP 2019526582A5
Authority
JP
Japan
Prior art keywords
disease
independently
disorder
substituted
pulmonary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019512205A
Other languages
English (en)
Japanese (ja)
Other versions
JP7050759B2 (ja
JP2019526582A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/049834 external-priority patent/WO2018045276A1/en
Publication of JP2019526582A publication Critical patent/JP2019526582A/ja
Publication of JP2019526582A5 publication Critical patent/JP2019526582A5/ja
Priority to JP2022050708A priority Critical patent/JP7628096B2/ja
Application granted granted Critical
Publication of JP7050759B2 publication Critical patent/JP7050759B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019512205A 2016-09-02 2017-09-01 縮合二環式sgc刺激剤 Active JP7050759B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022050708A JP7628096B2 (ja) 2016-09-02 2022-03-25 縮合二環式sgc刺激剤

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662382942P 2016-09-02 2016-09-02
US62/382,942 2016-09-02
US201662423445P 2016-11-17 2016-11-17
US62/423,445 2016-11-17
US201762468598P 2017-03-08 2017-03-08
US62/468,598 2017-03-08
US201762482486P 2017-04-06 2017-04-06
US62/482,486 2017-04-06
PCT/US2017/049834 WO2018045276A1 (en) 2016-09-02 2017-09-01 Fused bicyclic sgc stimulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022050708A Division JP7628096B2 (ja) 2016-09-02 2022-03-25 縮合二環式sgc刺激剤

Publications (3)

Publication Number Publication Date
JP2019526582A JP2019526582A (ja) 2019-09-19
JP2019526582A5 true JP2019526582A5 (enExample) 2020-10-15
JP7050759B2 JP7050759B2 (ja) 2022-04-08

Family

ID=59887396

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019512205A Active JP7050759B2 (ja) 2016-09-02 2017-09-01 縮合二環式sgc刺激剤
JP2022050708A Active JP7628096B2 (ja) 2016-09-02 2022-03-25 縮合二環式sgc刺激剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022050708A Active JP7628096B2 (ja) 2016-09-02 2022-03-25 縮合二環式sgc刺激剤

Country Status (29)

Country Link
US (5) US10472363B2 (enExample)
EP (2) EP3507291B1 (enExample)
JP (2) JP7050759B2 (enExample)
KR (2) KR102568384B1 (enExample)
CN (2) CN117105939B (enExample)
AU (2) AU2017321810B2 (enExample)
CA (1) CA3035210A1 (enExample)
CL (1) CL2019000486A1 (enExample)
CO (1) CO2019001760A2 (enExample)
CR (2) CR20220309A (enExample)
CY (1) CY1124612T1 (enExample)
DK (1) DK3507291T3 (enExample)
ES (2) ES2885003T3 (enExample)
HR (1) HRP20211355T1 (enExample)
HU (1) HUE056051T2 (enExample)
IL (2) IL292968B2 (enExample)
LT (1) LT3507291T (enExample)
MA (1) MA53999A (enExample)
MX (3) MX394958B (enExample)
MY (1) MY199759A (enExample)
PE (1) PE20190607A1 (enExample)
PH (1) PH12019500461B1 (enExample)
PL (1) PL3507291T3 (enExample)
PT (1) PT3507291T (enExample)
RS (1) RS62256B1 (enExample)
SG (1) SG11201901729YA (enExample)
SI (1) SI3507291T1 (enExample)
TW (2) TWI813078B (enExample)
WO (1) WO2018045276A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100467946B1 (ko) * 1997-01-24 2005-01-24 로무 가부시키가이샤 반도체 칩의 제조방법
MX2017003518A (es) * 2014-09-17 2017-07-28 Ironwood Pharmaceuticals Inc Estimuladores de guanilato ciclasa soluble (sgc).
CA3015172A1 (en) 2016-02-18 2017-08-24 Privo Technologies, Inc. Two-stage microparticle-based therapeutic delivery system and method
MY199759A (en) 2016-09-02 2023-11-21 Tisento Therapeutics Inc Fused bicyclic sgc stimulators
SG10202104865UA (en) * 2016-11-08 2021-06-29 Cyclerion Therapeutics Inc Treatment of cns diseases with sgc stimulators
WO2018151849A1 (en) 2017-02-17 2018-08-23 Privo Technologies, Inc. Particle-based multi-layer therapeutic delivery device and method
US10478403B1 (en) 2017-05-03 2019-11-19 Privo Technologies, Inc. Intraoperative topically-applied non-implantable rapid release patch
US20190292188A1 (en) 2018-02-27 2019-09-26 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
AU2019231721B2 (en) 2018-03-07 2024-06-27 Tisento Therapeutics Inc. Process for preparing soluble guanylate cyclase stimulators
AU2019231724B2 (en) * 2018-03-07 2024-06-27 Tisento Therapeutics Inc. Crystalline forms of an sGC stimulator
WO2019211081A1 (en) * 2018-04-30 2019-11-07 Bayer Aktiengesellschaft The use of sgc activators and sgc stimulators for the treatment of cognitive impairment
MA52940A (fr) 2018-05-18 2021-04-28 Incyte Corp Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
CN113166153B (zh) 2018-07-05 2024-11-01 因赛特公司 作为a2a/a2b抑制剂的稠合吡嗪衍生物
SG11202100092QA (en) 2018-07-11 2021-02-25 Cyclerion Therapeutics Inc USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONRIAL DISORDERS
GB201811695D0 (en) * 2018-07-17 2018-08-29 Salvensis Compounds for use in the treatment of fascioliasis
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
AU2019389263B2 (en) * 2018-11-28 2025-05-22 Topadur Pharma Ag Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CN110305125B (zh) * 2019-06-06 2021-09-03 山东新华制药股份有限公司 5-嘧啶-6-氧-吡唑并吡啶类衍生物及其制备方法和应用
CN114980899A (zh) * 2019-11-26 2022-08-30 普拉西斯精密医药公司 离子通道调节剂
WO2021195403A1 (en) 2020-03-26 2021-09-30 Cyclerion Therapeutics, Inc. Deuterated sgc stimulators
TW202228697A (zh) 2020-10-13 2022-08-01 美商賽克瑞恩醫療公司 以CNS穿透性sGC刺激劑治療認知損傷
CN117957228A (zh) * 2021-04-20 2024-04-30 帝善多制药公司 sGC刺激剂
AU2022261862A1 (en) 2021-04-20 2023-11-30 Tisento Therapeutics Inc. Sgc stimulators
TW202308634A (zh) 2021-04-20 2023-03-01 美商賽克瑞恩醫療公司 使用sGC刺激劑之CNS疾病治療
US20240099979A1 (en) * 2021-06-01 2024-03-28 Privo Technologies, Inc. Enhanced two-stage microparticle-based localized therapeutic delivery system
WO2023148203A1 (en) 2022-02-01 2023-08-10 Charité - Universitätsmedizin Berlin A soluble guanylat cyclase activator for treating chronic vascular dysfunction
US20230277521A1 (en) * 2022-03-07 2023-09-07 Harrow Ip, Llc Extended-release pharmaceutical compositions for treating eye conditions
EP4605080A1 (en) 2022-10-18 2025-08-27 Tisento Therapeutics Inc. Treatment of mitochondrial diseases with sgc stimulators
CN119285629A (zh) * 2024-09-03 2025-01-10 中南大学 5-[1,2,4-噁二唑]-6-氧-吡唑并吡啶类衍生物及其制备方法和应用
CN119185590B (zh) * 2024-11-28 2025-02-25 华润双鹤利民药业(济南)有限公司 羟丙基-β-环糊精在制备维立西呱固体制剂中的应用、固体制剂及制备方法

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US4203440A (en) 1978-10-23 1980-05-20 Alza Corporation Device having variable volume chamber for dispensing useful agent
US4627850A (en) 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
EP0192963B1 (de) 1985-02-27 1988-07-20 Werkzeugmaschinenfabrik Oerlikon-Bührle AG Schwingungsmesseinrichtung für ein Spiralkegelradgetriebe auf einer Zahnradprüfmaschine
IL92966A (en) 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 1−(置換ベンジル)−3−(置換アリール)縮合ピラゾール類、その製造法及びその用途
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
PL199236B1 (pl) 1998-07-08 2008-08-29 Sanofi Aventis Deutschland N-Aryloamidy kwasów sulfonyloaminokarboksylowych podstawionych siarką, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie N-aryloamidów kwasów sulfonyloaminokarboksylowych podstawionych siarką
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
MXPA01006108A (es) 1998-12-17 2002-09-18 Alza Corp Conversion de capsulas de gelatina rellenas de liquido en sistemas de liberacion controlada mediante multiples recubrimientos.
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6720317B1 (en) 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
AU2001250783A1 (en) 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
WO2003059346A1 (en) 2002-01-18 2003-07-24 The Genetics Company Inc. Beta-secretase inhibitors
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
MXPA06001506A (es) 2003-08-04 2006-05-15 Pfizer Prod Inc Formas de dosificacion de inhibidores de la proteina de transferencia de colesteril ester e inhibidores de la hmg-coa reductasa.
CA2536954C (en) 2003-08-29 2012-11-27 Exelixis, Inc. C-kit modulators and methods of use
DE102006020327A1 (de) * 2006-04-27 2007-12-27 Bayer Healthcare Ag Heterocyclisch substituierte, anellierte Pyrazol-Derivate und ihre Verwendung
CN101939053A (zh) 2007-09-06 2011-01-05 默沙东公司 可溶性的鸟苷酸环化酶活化剂
WO2009094242A1 (en) 2008-01-24 2009-07-30 Merck & Co., Inc. Angiotensin ii receptor antagonists
WO2010065275A1 (en) 2008-11-25 2010-06-10 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
GB0822981D0 (en) 2008-12-17 2009-01-21 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
EP2401265B1 (en) 2009-02-26 2016-09-14 Merck Sharp & Dohme Corp. Derivatives of 1-pyri(mid)in-2-yl-pyrazole-4-carboxylic acid which are useful for therapy or prophylaxis of cardiovascular diseases
HRP20150345T1 (hr) 2009-09-24 2015-05-08 F. Hoffmann-La Roche Ag Derivati imidazopiridina ili imidazopirimidina kao inhibitori fosfodiesteraze 10a
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
EP2549875B1 (en) 2010-03-25 2015-05-13 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
EP2575473B1 (en) 2010-05-27 2016-01-20 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
EA026692B1 (ru) 2010-06-30 2017-05-31 Айронвуд Фармасьютикелз, Инк. Стимуляторы sgc
EP2632551B1 (en) 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
WO2012064559A1 (en) * 2010-11-09 2012-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
JP5937102B2 (ja) 2010-12-14 2016-06-22 エレクトロフォレティクス リミテッド カゼインキナーゼ1デルタ(ck1デルタ)阻害剤
EP2797915B1 (en) 2011-12-27 2016-07-13 Ironwood Pharmaceuticals, Inc. 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure
DE102012200349A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung
WO2014047111A1 (en) * 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US9624214B2 (en) 2012-11-05 2017-04-18 Bayer Pharma Aktiengesellschaft Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
RS63108B1 (sr) * 2013-03-15 2022-04-29 Cyclerion Therapeutics Inc Sgc stimulatori
US20160311826A1 (en) 2013-12-11 2016-10-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP3152214B1 (en) 2014-06-04 2020-01-29 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
MX2017003518A (es) * 2014-09-17 2017-07-28 Ironwood Pharmaceuticals Inc Estimuladores de guanilato ciclasa soluble (sgc).
TW201625635A (zh) 2014-11-21 2016-07-16 默沙東藥廠 作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物
EP3227286B1 (de) * 2014-12-02 2018-12-26 Bayer Pharma Aktiengesellschaft Substituierte pyrazolo[1,5-a]pyridine und imidazo[1,2-a]pyrazine und ihre verwendung
EP3303342B1 (en) 2015-05-27 2021-03-17 Merck Sharp & Dohme Corp. Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators
WO2016191335A1 (en) 2015-05-28 2016-12-01 Merck Sharp & Dohme Corp. Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators
WO2017002120A1 (en) 2015-07-02 2017-01-05 Yeda Research And Development Co. Ltd. Selective inhibitors of senescent cells and uses thereof
WO2017108441A1 (en) 2015-12-22 2017-06-29 Universiteit Maastricht Treatment of cognitive impairment with cgc stimulator
TN2018000198A1 (en) 2015-12-29 2019-10-04 Pfizer Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
GB201614934D0 (en) 2016-09-02 2016-10-19 Glaxosmithkline Intellectual Property (No 2) Ltd Chemical compounds
MY199759A (en) * 2016-09-02 2023-11-21 Tisento Therapeutics Inc Fused bicyclic sgc stimulators
TWI886480B (zh) 2017-04-06 2025-06-11 美商富曼西公司 殺真菌之噁二唑
EP3606922A4 (en) 2017-04-06 2021-03-03 Hangzhou Dac Biotech Co., Ltd CONJUGATION OF A CYTOSTATIC WITH BIS CONNECTION

Similar Documents

Publication Publication Date Title
JP2019526582A5 (enExample)
HRP20211355T1 (hr) Fuzionirani biciklični sgc stimulatori
DE60124577T2 (de) Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
JP6043935B2 (ja) ピペラジノトリアゾール化合物及びその製造方法と製薬用途
JP3335362B2 (ja) キノレイン−2(1h)−オン誘導体セロトニンアンタゴニスト
EP2802589B1 (en) Fused pyrroles as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
JP2020506899A5 (enExample)
TWI439464B (zh) 二胺衍生物之製造方法
JP2016517432A5 (enExample)
JPH06501941A (ja) アリールピリダジノン
TW201326127A (zh) 新穎菸鹼醯胺衍生物或其鹽
JPS59501409A (ja) ピリドン化合物
JP2016505063A (ja) ソルチリン阻害剤としてのn置換された5置換フタルアミド酸
JP2024153885A (ja) 新規なピラゾール誘導体
JP2019534310A (ja) 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩
TW201619133A (zh) 新穎亞氨腈(iminonitrile)衍生物
JP5274012B2 (ja) ピリドンカルボン酸抗菌薬の調製
JP7025555B2 (ja) 一過性受容体電位a1イオンチャネルの阻害
AU2019300106A1 (en) Phenyl/pyridyl-n-phenyl/pyridyl derivatives for treating a RNA virus infection
JP2010517958A (ja) PDE5インヒビターとして有用な6−ベンジル−2,3,4,7−テトラヒドロ−インドロ[2,3−c]キノリン化合物
JP2660016B2 (ja) 治療用薬剤
JP6667507B2 (ja) ピラゾロ[3,4−c]ピリジン誘導体
JP6007339B2 (ja) イミダゾピリジン誘導体
CN112996513B (zh) 新颖哒嗪
CN116514728A (zh) 一种喹唑啉衍生物及其用途