JP2019525915A5 - - Google Patents

Download PDF

Info

Publication number
JP2019525915A5
JP2019525915A5 JP2019500509A JP2019500509A JP2019525915A5 JP 2019525915 A5 JP2019525915 A5 JP 2019525915A5 JP 2019500509 A JP2019500509 A JP 2019500509A JP 2019500509 A JP2019500509 A JP 2019500509A JP 2019525915 A5 JP2019525915 A5 JP 2019525915A5
Authority
JP
Japan
Prior art keywords
disease
pulmonary
hypertension
disorders
syndrome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019500509A
Other languages
English (en)
Japanese (ja)
Other versions
JP7016853B2 (ja
JP2019525915A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/040809 external-priority patent/WO2018009596A1/en
Publication of JP2019525915A publication Critical patent/JP2019525915A/ja
Publication of JP2019525915A5 publication Critical patent/JP2019525915A5/ja
Priority to JP2022010212A priority Critical patent/JP7368516B2/ja
Application granted granted Critical
Publication of JP7016853B2 publication Critical patent/JP7016853B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019500509A 2016-07-07 2017-07-06 sGC刺激剤のリンプロドラッグ Active JP7016853B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022010212A JP7368516B2 (ja) 2016-07-07 2022-01-26 sGC刺激剤のリンプロドラッグ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
US62/359,419 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022010212A Division JP7368516B2 (ja) 2016-07-07 2022-01-26 sGC刺激剤のリンプロドラッグ

Publications (3)

Publication Number Publication Date
JP2019525915A JP2019525915A (ja) 2019-09-12
JP2019525915A5 true JP2019525915A5 (enExample) 2020-08-13
JP7016853B2 JP7016853B2 (ja) 2022-02-07

Family

ID=59351139

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019500509A Active JP7016853B2 (ja) 2016-07-07 2017-07-06 sGC刺激剤のリンプロドラッグ
JP2022010212A Active JP7368516B2 (ja) 2016-07-07 2022-01-26 sGC刺激剤のリンプロドラッグ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022010212A Active JP7368516B2 (ja) 2016-07-07 2022-01-26 sGC刺激剤のリンプロドラッグ

Country Status (13)

Country Link
US (4) US10927136B2 (enExample)
EP (1) EP3481837B1 (enExample)
JP (2) JP7016853B2 (enExample)
KR (1) KR102513343B1 (enExample)
CN (2) CN109476686B (enExample)
AU (2) AU2017291826B2 (enExample)
BR (1) BR112019000290B1 (enExample)
CA (1) CA3029374A1 (enExample)
EA (1) EA039683B1 (enExample)
IL (1) IL263993B2 (enExample)
MA (1) MA45592A (enExample)
MX (2) MX391896B (enExample)
WO (1) WO2018009596A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109476686B (zh) * 2016-07-07 2022-01-18 赛克里翁治疗有限公司 sGC刺激剂的磷前药
KR20210031931A (ko) 2018-07-11 2021-03-23 사이클리온 테라퓨틱스, 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
CN120584098A (zh) * 2022-11-07 2025-09-02 弗吉尼亚联邦大学 用于治疗镰状细胞病的具有直接聚合物失稳效应的苯甲醛化合物
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721365A (en) 1989-09-15 1998-02-24 Us Health N-substituted piperazine NONOates
US5155137A (en) 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
EP0605622B1 (en) 1991-09-24 1997-11-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5405919A (en) 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
AU685178B2 (en) 1993-10-08 1998-01-15 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 1−(置換ベンジル)−3−(置換アリール)縮合ピラゾール類、その製造法及びその用途
US5700830A (en) 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
DK0837052T3 (da) 1995-06-21 2007-01-02 Shionogi & Co Bicykliske aminoderivater og PGD2-antagonist indeholdende disse
US5714511A (en) 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
WO1998025915A1 (en) 1996-12-12 1998-06-18 Shionogi & Co., Ltd. Fused heterocyclic benzenecarboxylic acid amide derivatives and pgd2 antagonists containing the same
EP0944614B1 (en) 1996-12-13 2002-09-11 Shionogi & Co., Ltd. Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
HU228111B1 (en) 1998-07-08 2012-11-28 Sanofi Aventis Deutschland Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
WO2003022814A1 (en) 2001-09-07 2003-03-20 Ono Pharmaceutical Co., Ltd. Indole derivatives
DE60115411D1 (de) 2000-04-12 2006-01-05 Merck Frosst Canada & Co Kirkl Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US20010051624A1 (en) 2000-04-12 2001-12-13 Jones Thomas R. Method and compositions for the treatment of allergic conditions using PGD2 receptor antagonists
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
TWI241190B (en) 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
MY136316A (en) 2001-02-13 2008-09-30 Sanofi Aventis Deutschland Acylated 6,7,8,9-tetrahydro-5h-benzocycloheptenyl amines and their use as pharmaceutical.
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
US6511911B1 (en) 2001-04-03 2003-01-28 Advanced Micro Devices, Inc. Metal gate stack with etch stop layer
WO2003022813A1 (en) 2001-09-07 2003-03-20 Ono Pharmaceutical Co., Ltd. Indole derivatives, process for producing the same and drugs containing the same as the active ingredient
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
WO2003097042A1 (en) 2002-05-16 2003-11-27 Shionogi & Co., Ltd. Pgd2 receptor antagonist
US7534897B2 (en) 2002-05-16 2009-05-19 Shionogi & Co., Ltd. Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
KR20050055747A (ko) 2002-10-04 2005-06-13 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료용의 pgd2 수용체 길항제
EP1585511B1 (en) 2002-12-20 2013-01-23 Amgen Inc. Asthma and allergic inflammation modulators
US8309608B2 (en) 2003-11-06 2012-11-13 Sanofi-Aventis Deutschland Gmbh Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases
AU2006330277B2 (en) * 2005-12-27 2011-10-06 Otsuka Pharmaceutical Co., Ltd. Water-soluble benzoazepine compound and its pharmaceutical composition
DE102007036075A1 (de) * 2007-08-01 2009-02-05 Bayer Healthcare Ag Prodrugs und ihre Verwendung
BRPI0816382A2 (pt) 2007-09-06 2015-02-24 Merck Sharp & Dohme Composto, composição, e, métodos para ativar a guanilato ciclase solúvel e para tratar ou previnir doenças
JP2011510082A (ja) 2008-01-24 2011-03-31 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンii受容体拮抗薬
CN101735267A (zh) * 2008-11-17 2010-06-16 上海阳帆医药科技有限公司 水溶性(r)-(-)-比卡鲁胺前药、其制备方法及用途
AU2009322836B2 (en) 2008-11-25 2013-04-04 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
AU2010218224B2 (en) 2009-02-26 2013-06-27 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
US9284301B2 (en) 2010-03-25 2016-03-15 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
EA023254B1 (ru) 2010-05-27 2016-05-31 Мерк Шарп Энд Домэ Корп. Активаторы растворимой гуанилатциклазы
EP2632551B1 (en) 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
JP6085829B2 (ja) * 2011-01-14 2017-03-01 スペロ トリネム, インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼiv阻害剤
CN103288809B (zh) * 2012-02-24 2015-09-23 深圳市健元医药科技有限公司 葛根素单磷酸盐或单磺酸盐衍生物及其制备方法
EP2970243B1 (en) * 2013-03-15 2019-11-27 Cyclerion Therapeutics, Inc. Sgc stimulators
WO2014154168A1 (zh) * 2013-03-29 2014-10-02 山东轩竹医药科技有限公司 双环取代的嘧啶类pde-5抑制剂的前药
US20160324856A1 (en) 2014-01-13 2016-11-10 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of neuromuscular disorders
CN109476686B (zh) * 2016-07-07 2022-01-18 赛克里翁治疗有限公司 sGC刺激剂的磷前药

Similar Documents

Publication Publication Date Title
JP2019525915A5 (enExample)
JP2019524710A5 (enExample)
JP2016540017A5 (enExample)
HRP20200276T1 (hr) Stimulatori sgc
JP2016517432A5 (enExample)
JP6823095B2 (ja) 噴霧乾燥製剤
HRP20211355T1 (hr) Fuzionirani biciklični sgc stimulatori
JP5599457B2 (ja) リゾリン脂質受容体の多環式アンタゴニスト
CN107406421A (zh) sGC刺激物
JP2019526582A5 (enExample)
JP2017527604A5 (enExample)
US20190255042A1 (en) Application of hedgehog pathway inhibitor in treating fibrosis diseases
JP2012532112A5 (enExample)
JP2016530210A (ja) ヘテロ環式ビニルオートタキシン阻害剤化合物
CN102050888B (zh) 一种依诺肝素钠的制备方法
TWI272263B (en) PGD2/TXA2 two receptors antagonistic pharmaceutical composition having [2,2,1] and [3,1,1] bicyclo skeleton
CN105085428B (zh) 芳杂环类衍生物及其在药物上的应用
JP2023504415A (ja) 線維性疾患の治療に使用するためのアゼチジンlpa1受容体アンタゴニストのピルフェニドン及び/又はニンテダニブとの合剤
JP2014525427A5 (enExample)
TWI439464B (zh) 二胺衍生物之製造方法
CN103596947A (zh) 用于治疗纤维化、疼痛、癌症和呼吸、过敏性、神经系统疾病或心血管疾病的基于3-或5-联苯-4-基异噁唑的化合物
JP2019526589A5 (enExample)
CN113260616B (zh) 用于治疗呼吸系统疾病的新型化合物
RS61999B1 (sr) Jedinjenja
WO2025011664A1 (zh) Glp-1r激动剂的制剂及其制备方法