AU2017291826B2 - Phosphorus prodrugs of sGC stimulators - Google Patents

Phosphorus prodrugs of sGC stimulators Download PDF

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Publication number
AU2017291826B2
AU2017291826B2 AU2017291826A AU2017291826A AU2017291826B2 AU 2017291826 B2 AU2017291826 B2 AU 2017291826B2 AU 2017291826 A AU2017291826 A AU 2017291826A AU 2017291826 A AU2017291826 A AU 2017291826A AU 2017291826 B2 AU2017291826 B2 AU 2017291826B2
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disease
pulmonary
hypertension
diseases
syndrome
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AU2017291826A1 (en
Inventor
Timothy Claude Barden
Rajesh R. Iyengar
Ara Mermerian
Takashi Nakai
Paul Allan Renhowe
Glen Robert RENNIE
James Edward SHEPPECK
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Cyclerion Therapeutics Inc
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Cyclerion Therapeutics Inc
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Assigned to CYCLERION THERAPEUTICS, INC. reassignment CYCLERION THERAPEUTICS, INC. Request for Assignment Assignors: IRONWOOD PHARMACEUTICALS, INC.
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Priority to AU2022200331A priority Critical patent/AU2022200331B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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AU2017291826A 2016-07-07 2017-07-06 Phosphorus prodrugs of sGC stimulators Active AU2017291826B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022200331A AU2022200331B2 (en) 2016-07-07 2022-01-19 Phosphorus prodrugs of sGC stimulators

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
US62/359,419 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022200331A Division AU2022200331B2 (en) 2016-07-07 2022-01-19 Phosphorus prodrugs of sGC stimulators

Publications (2)

Publication Number Publication Date
AU2017291826A1 AU2017291826A1 (en) 2019-01-24
AU2017291826B2 true AU2017291826B2 (en) 2021-10-21

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AU2017291826A Active AU2017291826B2 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sGC stimulators
AU2022200331A Active AU2022200331B2 (en) 2016-07-07 2022-01-19 Phosphorus prodrugs of sGC stimulators

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US (4) US10927136B2 (enExample)
EP (1) EP3481837B1 (enExample)
JP (2) JP7016853B2 (enExample)
KR (1) KR102513343B1 (enExample)
CN (2) CN114736240A (enExample)
AU (2) AU2017291826B2 (enExample)
BR (1) BR112019000290B1 (enExample)
CA (1) CA3029374A1 (enExample)
EA (1) EA039683B1 (enExample)
IL (1) IL263993B2 (enExample)
MA (1) MA45592A (enExample)
MX (2) MX391896B (enExample)
WO (1) WO2018009596A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102513343B1 (ko) * 2016-07-07 2023-03-22 사이클리온 테라퓨틱스, 인크. sGC 자극제의 인 전구약물
JP7542518B2 (ja) 2018-07-11 2024-08-30 ティセント セラピューティクス インコーポレーテッド ミトコンドリア（ｍｉｔｏｃｈｏｎｒｉａｌ）障害の処置のためのｓＧＣ刺激剤の使用
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
CN120584098A (zh) * 2022-11-07 2025-09-02 弗吉尼亚联邦大学 用于治疗镰状细胞病的具有直接聚合物失稳效应的苯甲醛化合物
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014144100A2 (en) * 2013-03-15 2014-09-18 Takashi Nakai Sgc stimulators
WO2015106268A1 (en) * 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS

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