CN114736240A - sGC刺激剂的磷前药 - Google Patents

sGC刺激剂的磷前药 Download PDF

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Publication number
CN114736240A
CN114736240A CN202111570967.XA CN202111570967A CN114736240A CN 114736240 A CN114736240 A CN 114736240A CN 202111570967 A CN202111570967 A CN 202111570967A CN 114736240 A CN114736240 A CN 114736240A
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China
Prior art keywords
compound
formula
disease
pharmaceutically acceptable
hydrogen
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Pending
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CN202111570967.XA
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English (en)
Chinese (zh)
Inventor
J·E·史派克
P·A·伦豪
A·莫尔梅里安
T·C·巴登
G·R·伦尼
R·R·延加
T·中井
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Cyclone Therapy Co ltd
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Cyclone Therapy Co ltd
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Publication of CN114736240A publication Critical patent/CN114736240A/zh
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
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  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
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CN202111570967.XA 2016-07-07 2017-07-06 sGC刺激剂的磷前药 Pending CN114736240A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
US62/359,419 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators
CN201780045937.2A CN109476686B (zh) 2016-07-07 2017-07-06 sGC刺激剂的磷前药

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780045937.2A Division CN109476686B (zh) 2016-07-07 2017-07-06 sGC刺激剂的磷前药

Publications (1)

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CN114736240A true CN114736240A (zh) 2022-07-12

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Application Number Title Priority Date Filing Date
CN202111570967.XA Pending CN114736240A (zh) 2016-07-07 2017-07-06 sGC刺激剂的磷前药
CN201780045937.2A Active CN109476686B (zh) 2016-07-07 2017-07-06 sGC刺激剂的磷前药

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US (4) US10927136B2 (enExample)
EP (1) EP3481837B1 (enExample)
JP (2) JP7016853B2 (enExample)
KR (1) KR102513343B1 (enExample)
CN (2) CN114736240A (enExample)
AU (2) AU2017291826B2 (enExample)
BR (1) BR112019000290B1 (enExample)
CA (1) CA3029374A1 (enExample)
EA (1) EA039683B1 (enExample)
IL (1) IL263993B2 (enExample)
MA (1) MA45592A (enExample)
MX (2) MX391896B (enExample)
WO (1) WO2018009596A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7016853B2 (ja) * 2016-07-07 2022-02-07 サイクレリオン・セラピューティクス，インコーポレーテッド ｓＧＣ刺激剤のリンプロドラッグ
CA3103676A1 (en) 2018-07-11 2020-01-16 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of mitochonrial disorders
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
CA3273101A1 (en) * 2022-11-07 2024-05-16 Illexcor Holdings, Llc. Benzaldehyde compounds with direct polymer destabilizing effects for the treatment of sickle cell disease
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101735267A (zh) * 2008-11-17 2010-06-16 上海阳帆医药科技有限公司 水溶性(r)-(-)-比卡鲁胺前药、其制备方法及用途
WO2014144100A2 (en) * 2013-03-15 2014-09-18 Takashi Nakai Sgc stimulators

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