MX391896B - Profármacos de fósforo de estimuladores de guanilato ciclasa soluble (sgc). - Google Patents
Profármacos de fósforo de estimuladores de guanilato ciclasa soluble (sgc).Info
- Publication number
- MX391896B MX391896B MX2019000103A MX2019000103A MX391896B MX 391896 B MX391896 B MX 391896B MX 2019000103 A MX2019000103 A MX 2019000103A MX 2019000103 A MX2019000103 A MX 2019000103A MX 391896 B MX391896 B MX 391896B
- Authority
- MX
- Mexico
- Prior art keywords
- sgc
- stimulators
- guanylate cyclase
- soluble guanylate
- phosphorus prodrugs
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359419P | 2016-07-07 | 2016-07-07 | |
| PCT/US2017/040809 WO2018009596A1 (en) | 2016-07-07 | 2017-07-06 | Phosphorus prodrugs of sgc stimulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019000103A MX2019000103A (es) | 2019-04-22 |
| MX391896B true MX391896B (es) | 2025-03-21 |
Family
ID=59351139
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000103A MX391896B (es) | 2016-07-07 | 2017-07-06 | Profármacos de fósforo de estimuladores de guanilato ciclasa soluble (sgc). |
| MX2022005024A MX2022005024A (es) | 2016-07-07 | 2019-01-07 | Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc). |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022005024A MX2022005024A (es) | 2016-07-07 | 2019-01-07 | Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc). |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10927136B2 (enExample) |
| EP (1) | EP3481837B1 (enExample) |
| JP (2) | JP7016853B2 (enExample) |
| KR (1) | KR102513343B1 (enExample) |
| CN (2) | CN114736240A (enExample) |
| AU (2) | AU2017291826B2 (enExample) |
| BR (1) | BR112019000290B1 (enExample) |
| CA (1) | CA3029374A1 (enExample) |
| EA (1) | EA039683B1 (enExample) |
| IL (1) | IL263993B2 (enExample) |
| MA (1) | MA45592A (enExample) |
| MX (2) | MX391896B (enExample) |
| WO (1) | WO2018009596A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102513343B1 (ko) * | 2016-07-07 | 2023-03-22 | 사이클리온 테라퓨틱스, 인크. | sGC 자극제의 인 전구약물 |
| JP7542518B2 (ja) | 2018-07-11 | 2024-08-30 | ティセント セラピューティクス インコーポレーテッド | ミトコンドリア（ｍｉｔｏｃｈｏｎｒｉａｌ）障害の処置のためのｓＧＣ刺激剤の使用 |
| CN114377149B (zh) * | 2021-12-14 | 2023-11-10 | 西北工业大学 | 一种Mn基可降解MOF纳米反应器及其制备方法和应用 |
| CN120584098A (zh) * | 2022-11-07 | 2025-09-02 | 弗吉尼亚联邦大学 | 用于治疗镰状细胞病的具有直接聚合物失稳效应的苯甲醛化合物 |
| CN116478309B (zh) * | 2023-05-19 | 2024-05-17 | 青海大学 | 锁阳精多糖、锁阳多糖化合物及制备方法和应用 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721365A (en) | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
| US5155137A (en) | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
| AU668107B2 (en) | 1991-09-24 | 1996-04-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
| US5814666A (en) | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
| US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5691423A (en) | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
| US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| US5910316A (en) | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
| EP0722320B1 (en) | 1993-10-08 | 2000-07-19 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Use of nitric oxide-releasing compounds as medicaments for hypoxic cell radiation sensitization |
| JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| US5700830A (en) | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
| ATE337294T1 (de) | 1995-06-21 | 2006-09-15 | Shionogi & Co | Bizyklische aminoderivate und enthaltende pgd2- antagonisten |
| US5714511A (en) | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| JP4120993B2 (ja) | 1996-12-12 | 2008-07-16 | 塩野義製薬株式会社 | ヘテロ環縮合ベンゼンカルボン酸アミド誘導体およびそれを含有するｐｇｄ２拮抗剤 |
| CA2274591C (en) | 1996-12-13 | 2005-06-14 | Shionogi & Co., Ltd. | Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them |
| DE19744026A1 (de) | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| DE19830430A1 (de) | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| KR100720844B1 (ko) | 1998-07-08 | 2007-05-25 | 사노피-아벤티스 도이칠란트 게엠베하 | 황 치환된 설포닐아미노카복실산 ｎ-아릴아미드, 이의 제조방법, 및 이를 함유하는 약제학적 제제 |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| GB9824310D0 (en) | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
| DE19942809A1 (de) | 1999-09-08 | 2001-03-15 | Bayer Ag | Verfahren zur Herstellung substituierter Pyrimidinderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| US20010051624A1 (en) | 2000-04-12 | 2001-12-13 | Jones Thomas R. | Method and compositions for the treatment of allergic conditions using PGD2 receptor antagonists |
| ATE311200T1 (de) | 2000-04-12 | 2005-12-15 | Merck Frosst Canada Inc | Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
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-
2017
- 2017-07-06 KR KR1020197003458A patent/KR102513343B1/ko active Active
- 2017-07-06 MA MA045592A patent/MA45592A/fr unknown
- 2017-07-06 US US16/315,210 patent/US10927136B2/en active Active
- 2017-07-06 EP EP17740237.7A patent/EP3481837B1/en active Active
- 2017-07-06 MX MX2019000103A patent/MX391896B/es unknown
- 2017-07-06 CN CN202111570967.XA patent/CN114736240A/zh active Pending
- 2017-07-06 CN CN201780045937.2A patent/CN109476686B/zh active Active
- 2017-07-06 AU AU2017291826A patent/AU2017291826B2/en active Active
- 2017-07-06 EA EA201990238A patent/EA039683B1/ru unknown
- 2017-07-06 BR BR112019000290-1A patent/BR112019000290B1/pt active IP Right Grant
- 2017-07-06 JP JP2019500509A patent/JP7016853B2/ja active Active
- 2017-07-06 CA CA3029374A patent/CA3029374A1/en active Pending
- 2017-07-06 WO PCT/US2017/040809 patent/WO2018009596A1/en not_active Ceased
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2018
- 2018-12-27 IL IL263993A patent/IL263993B2/en unknown
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2019
- 2019-01-07 MX MX2022005024A patent/MX2022005024A/es unknown
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2022
- 2022-01-19 AU AU2022200331A patent/AU2022200331B2/en active Active
- 2022-01-26 JP JP2022010212A patent/JP7368516B2/ja active Active
-
2023
- 2023-09-01 US US18/241,630 patent/US20240228520A9/en not_active Abandoned
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2024
- 2024-01-12 US US18/411,480 patent/US20240360164A1/en not_active Abandoned
- 2024-11-14 US US18/947,131 patent/US20250243228A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022062115A (ja) | 2022-04-19 |
| AU2017291826A1 (en) | 2019-01-24 |
| JP7368516B2 (ja) | 2023-10-24 |
| EP3481837A1 (en) | 2019-05-15 |
| KR20190026841A (ko) | 2019-03-13 |
| BR112019000290B1 (pt) | 2022-10-18 |
| AU2022200331A1 (en) | 2022-02-17 |
| IL263993A (en) | 2019-02-28 |
| BR112019000290A2 (pt) | 2019-04-16 |
| US20190300555A1 (en) | 2019-10-03 |
| IL263993B2 (en) | 2023-06-01 |
| MX2022005024A (es) | 2022-05-16 |
| AU2017291826B2 (en) | 2021-10-21 |
| EP3481837B1 (en) | 2023-12-06 |
| EA201990238A1 (ru) | 2019-07-31 |
| US20240132528A1 (en) | 2024-04-25 |
| KR102513343B1 (ko) | 2023-03-22 |
| MX2019000103A (es) | 2019-04-22 |
| US20240228520A9 (en) | 2024-07-11 |
| CN109476686B (zh) | 2022-01-18 |
| MA45592A (fr) | 2019-05-15 |
| JP7016853B2 (ja) | 2022-02-07 |
| CN114736240A (zh) | 2022-07-12 |
| CA3029374A1 (en) | 2018-01-11 |
| JP2019525915A (ja) | 2019-09-12 |
| US20250243228A1 (en) | 2025-07-31 |
| CN109476686A (zh) | 2019-03-15 |
| AU2022200331B2 (en) | 2023-12-07 |
| EA039683B1 (ru) | 2022-02-28 |
| US20240360164A1 (en) | 2024-10-31 |
| WO2018009596A1 (en) | 2018-01-11 |
| US10927136B2 (en) | 2021-02-23 |
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