MX391896B - Profármacos de fósforo de estimuladores de guanilato ciclasa soluble (sgc). - Google Patents
Profármacos de fósforo de estimuladores de guanilato ciclasa soluble (sgc).Info
- Publication number
- MX391896B MX391896B MX2019000103A MX2019000103A MX391896B MX 391896 B MX391896 B MX 391896B MX 2019000103 A MX2019000103 A MX 2019000103A MX 2019000103 A MX2019000103 A MX 2019000103A MX 391896 B MX391896 B MX 391896B
- Authority
- MX
- Mexico
- Prior art keywords
- sgc
- stimulators
- guanylate cyclase
- soluble guanylate
- phosphorus prodrugs
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/08—Bronchodilators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359419P | 2016-07-07 | 2016-07-07 | |
| PCT/US2017/040809 WO2018009596A1 (en) | 2016-07-07 | 2017-07-06 | Phosphorus prodrugs of sgc stimulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019000103A MX2019000103A (es) | 2019-04-22 |
| MX391896B true MX391896B (es) | 2025-03-21 |
Family
ID=59351139
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000103A MX391896B (es) | 2016-07-07 | 2017-07-06 | Profármacos de fósforo de estimuladores de guanilato ciclasa soluble (sgc). |
| MX2022005024A MX2022005024A (es) | 2016-07-07 | 2019-01-07 | Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc). |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022005024A MX2022005024A (es) | 2016-07-07 | 2019-01-07 | Profarmacos de fosforo de estimuladores de guanilato ciclasa soluble (sgc). |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10927136B2 (enExample) |
| EP (1) | EP3481837B1 (enExample) |
| JP (2) | JP7016853B2 (enExample) |
| KR (1) | KR102513343B1 (enExample) |
| CN (2) | CN109476686B (enExample) |
| AU (2) | AU2017291826B2 (enExample) |
| BR (1) | BR112019000290B1 (enExample) |
| CA (1) | CA3029374A1 (enExample) |
| EA (1) | EA039683B1 (enExample) |
| IL (1) | IL263993B2 (enExample) |
| MA (1) | MA45592A (enExample) |
| MX (2) | MX391896B (enExample) |
| WO (1) | WO2018009596A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109476686B (zh) * | 2016-07-07 | 2022-01-18 | 赛克里翁治疗有限公司 | sGC刺激剂的磷前药 |
| BR112021000358A2 (pt) | 2018-07-11 | 2021-04-06 | Cyclerion Therapeutics, Inc. | Uso de estimulantes de sgc para o tratamento de distúrbios mitocondriais |
| CN114377149B (zh) * | 2021-12-14 | 2023-11-10 | 西北工业大学 | 一种Mn基可降解MOF纳米反应器及其制备方法和应用 |
| CN120584098A (zh) * | 2022-11-07 | 2025-09-02 | 弗吉尼亚联邦大学 | 用于治疗镰状细胞病的具有直接聚合物失稳效应的苯甲醛化合物 |
| CN116478309B (zh) * | 2023-05-19 | 2024-05-17 | 青海大学 | 锁阳精多糖、锁阳多糖化合物及制备方法和应用 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721365A (en) | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
| US5155137A (en) | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
| AU668107B2 (en) | 1991-09-24 | 1996-04-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
| US5814666A (en) | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
| US5691423A (en) | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
| US5910316A (en) | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
| US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| WO1995010267A1 (en) | 1993-10-08 | 1995-04-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers |
| JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| US5700830A (en) | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
| PL185107B1 (pl) | 1995-06-21 | 2003-02-28 | Shionogi & Co | Bicykliczne związki aminowe, kompozycja farmaceutyczna i jej stosowanie |
| US5714511A (en) | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| ATE295360T1 (de) | 1996-12-12 | 2005-05-15 | Shionogi & Co | Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten |
| CZ297324B6 (cs) | 1996-12-13 | 2006-11-15 | Shionogi & Co., Ltd. | Benzothiofenkarboxamidové deriváty a antagonisty PGD2, které je obsahují |
| DE19744026A1 (de) | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| DE19830430A1 (de) | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| WO2000002851A1 (en) | 1998-07-08 | 2000-01-20 | Aventis Pharma Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| GB9824310D0 (en) | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
| DE19942809A1 (de) | 1999-09-08 | 2001-03-15 | Bayer Ag | Verfahren zur Herstellung substituierter Pyrimidinderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| ATE311200T1 (de) | 2000-04-12 | 2005-12-15 | Merck Frosst Canada Inc | Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten |
| US20010051624A1 (en) | 2000-04-12 | 2001-12-13 | Jones Thomas R. | Method and compositions for the treatment of allergic conditions using PGD2 receptor antagonists |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| TWI241190B (en) | 2001-02-13 | 2005-10-11 | Aventis Pharma Gmbh | 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical |
| TWI243164B (en) | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
| PE20020870A1 (es) | 2001-02-13 | 2002-11-18 | Aventis Pharma Gmbh | 6,7,8,9-tetrahidro-5h-benzocicloheptenil aminas aciladas |
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-
2017
- 2017-07-06 CN CN201780045937.2A patent/CN109476686B/zh active Active
- 2017-07-06 WO PCT/US2017/040809 patent/WO2018009596A1/en not_active Ceased
- 2017-07-06 AU AU2017291826A patent/AU2017291826B2/en active Active
- 2017-07-06 MX MX2019000103A patent/MX391896B/es unknown
- 2017-07-06 MA MA045592A patent/MA45592A/fr unknown
- 2017-07-06 JP JP2019500509A patent/JP7016853B2/ja active Active
- 2017-07-06 US US16/315,210 patent/US10927136B2/en active Active
- 2017-07-06 CN CN202111570967.XA patent/CN114736240A/zh active Pending
- 2017-07-06 KR KR1020197003458A patent/KR102513343B1/ko active Active
- 2017-07-06 EA EA201990238A patent/EA039683B1/ru unknown
- 2017-07-06 EP EP17740237.7A patent/EP3481837B1/en active Active
- 2017-07-06 CA CA3029374A patent/CA3029374A1/en active Pending
- 2017-07-06 BR BR112019000290-1A patent/BR112019000290B1/pt active IP Right Grant
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2018
- 2018-12-27 IL IL263993A patent/IL263993B2/en unknown
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2019
- 2019-01-07 MX MX2022005024A patent/MX2022005024A/es unknown
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2022
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- 2022-01-26 JP JP2022010212A patent/JP7368516B2/ja active Active
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2023
- 2023-09-01 US US18/241,630 patent/US20240228520A9/en not_active Abandoned
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2024
- 2024-01-12 US US18/411,480 patent/US20240360164A1/en not_active Abandoned
- 2024-11-14 US US18/947,131 patent/US20250243228A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240132528A1 (en) | 2024-04-25 |
| JP2019525915A (ja) | 2019-09-12 |
| CN109476686B (zh) | 2022-01-18 |
| MA45592A (fr) | 2019-05-15 |
| EP3481837B1 (en) | 2023-12-06 |
| CN114736240A (zh) | 2022-07-12 |
| BR112019000290A2 (pt) | 2019-04-16 |
| BR112019000290B1 (pt) | 2022-10-18 |
| JP7016853B2 (ja) | 2022-02-07 |
| US20190300555A1 (en) | 2019-10-03 |
| US20250243228A1 (en) | 2025-07-31 |
| EP3481837A1 (en) | 2019-05-15 |
| WO2018009596A1 (en) | 2018-01-11 |
| KR102513343B1 (ko) | 2023-03-22 |
| MX2019000103A (es) | 2019-04-22 |
| EA201990238A1 (ru) | 2019-07-31 |
| CN109476686A (zh) | 2019-03-15 |
| IL263993A (en) | 2019-02-28 |
| KR20190026841A (ko) | 2019-03-13 |
| JP2022062115A (ja) | 2022-04-19 |
| IL263993B2 (en) | 2023-06-01 |
| JP7368516B2 (ja) | 2023-10-24 |
| US20240360164A1 (en) | 2024-10-31 |
| US10927136B2 (en) | 2021-02-23 |
| MX2022005024A (es) | 2022-05-16 |
| AU2017291826A1 (en) | 2019-01-24 |
| AU2017291826B2 (en) | 2021-10-21 |
| US20240228520A9 (en) | 2024-07-11 |
| AU2022200331A1 (en) | 2022-02-17 |
| CA3029374A1 (en) | 2018-01-11 |
| EA039683B1 (ru) | 2022-02-28 |
| AU2022200331B2 (en) | 2023-12-07 |
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