JP7016853B2 - ｓＧＣ刺激剤のリンプロドラッグ - Google Patents

ｓＧＣ刺激剤のリンプロドラッグ Download PDF

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JP7016853B2
JP7016853B2 JP2019500509A JP2019500509A JP7016853B2 JP 7016853 B2 JP7016853 B2 JP 7016853B2 JP 2019500509 A JP2019500509 A JP 2019500509A JP 2019500509 A JP2019500509 A JP 2019500509A JP 7016853 B2 JP7016853 B2 JP 7016853B2
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disease
pulmonary
disorders
hypertension
compound
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JP2019525915A5 (enExample
JP2019525915A (ja
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シェペック，ジェームズ・エドワード
レンハウ，ポール・アラン
マーメリアン，アラ
バーデン，ティモシー・クロード
レニー，グレン・ロバート
アイアンガー，ラジェシュ・アール
崇 中井
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サイクレリオン・セラピューティクス，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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    • C—CHEMISTRY; METALLURGY
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
JP2019500509A 2016-07-07 2017-07-06 ｓＧＣ刺激剤のリンプロドラッグ Active JP7016853B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022010212A JP7368516B2 (ja) 2016-07-07 2022-01-26 ｓＧＣ刺激剤のリンプロドラッグ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
US62/359,419 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators

Related Child Applications (1)

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JP2022010212A Division JP7368516B2 (ja) 2016-07-07 2022-01-26 ｓＧＣ刺激剤のリンプロドラッグ

Publications (3)

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JP2019525915A JP2019525915A (ja) 2019-09-12
JP2019525915A5 JP2019525915A5 (enExample) 2020-08-13
JP7016853B2 true JP7016853B2 (ja) 2022-02-07

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JP2019500509A Active JP7016853B2 (ja) 2016-07-07 2017-07-06 ｓＧＣ刺激剤のリンプロドラッグ
JP2022010212A Active JP7368516B2 (ja) 2016-07-07 2022-01-26 ｓＧＣ刺激剤のリンプロドラッグ

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Country Status (13)

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US (4) US10927136B2 (enExample)
EP (1) EP3481837B1 (enExample)
JP (2) JP7016853B2 (enExample)
KR (1) KR102513343B1 (enExample)
CN (2) CN114736240A (enExample)
AU (2) AU2017291826B2 (enExample)
BR (1) BR112019000290B1 (enExample)
CA (1) CA3029374A1 (enExample)
EA (1) EA039683B1 (enExample)
IL (1) IL263993B2 (enExample)
MA (1) MA45592A (enExample)
MX (2) MX391896B (enExample)
WO (1) WO2018009596A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
KR102513343B1 (ko) * 2016-07-07 2023-03-22 사이클리온 테라퓨틱스, 인크. sGC 자극제의 인 전구약물
JP7542518B2 (ja) 2018-07-11 2024-08-30 ティセント セラピューティクス インコーポレーテッド ミトコンドリア（ｍｉｔｏｃｈｏｎｒｉａｌ）障害の処置のためのｓＧＣ刺激剤の使用
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
CN120584098A (zh) * 2022-11-07 2025-09-02 弗吉尼亚联邦大学 用于治疗镰状细胞病的具有直接聚合物失稳效应的苯甲醛化合物
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

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JP2009521397A (ja) 2005-12-27 2009-06-04 大塚製薬株式会社 水溶性ベンゾアゼピン化合物及び医薬組成物
JP2010534695A (ja) 2007-08-01 2010-11-11 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト ２−アミノ−６−（｛［２−（４−クロロフェニル）−１，３−チアゾール−４−イル］メチル｝チオ）−４−［４−（２−ヒドロキシエトキシ）フェニル］ピリジン−３，５−ジカルボニトリルのプロドラッグ
JP2014503557A (ja) 2011-01-14 2014-02-13 バーテックス ファーマシューティカルズ インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
JP2016516736A (ja) 2013-03-29 2016-06-09 シュエンジュウ・ファーマ・カンパニー・リミテッド 二環式置換ピリミジン型ｐｄｅ−５阻害剤のプロドラッグ
JP2016517432A (ja) 2013-03-15 2016-06-16 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激薬

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