JP2019524640A5 - - Google Patents

Info

Publication number

JP2019524640A5

JP2019524640A5 JP2018559715A JP2018559715A JP2019524640A5 JP 2019524640 A5 JP2019524640 A5 JP 2019524640A5 JP 2018559715 A JP2018559715 A JP 2018559715A JP 2018559715 A JP2018559715 A JP 2018559715A JP 2019524640 A5 JP2019524640 A5 JP 2019524640A5

Authority

JP

Japan

Prior art keywords

antibody

seq

polypeptide

variable region

chain variable

Prior art date

2017-05-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 26
• 229920001184 polypeptide Polymers 0.000 claims description 25
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 25
• 229910052727 yttrium Inorganic materials 0.000 claims description 23
• 229910052731 fluorine Inorganic materials 0.000 claims description 20
• 229910052799 carbon Inorganic materials 0.000 claims description 15
• 229910052739 hydrogen Inorganic materials 0.000 claims description 11
• 229910052717 sulfur Inorganic materials 0.000 claims description 11
• 229910052698 phosphorus Inorganic materials 0.000 claims description 9
• 229910052757 nitrogen Inorganic materials 0.000 claims description 8
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 7
• 102000004169 proteins and genes Human genes 0.000 claims description 5
• 108090000623 proteins and genes Proteins 0.000 claims description 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 11
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 229940127121 immunoconjugate Drugs 0.000 claims 8
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 230000035772 mutation Effects 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 229910052720 vanadium Inorganic materials 0.000 claims 2
• 101710188315 Protein X Proteins 0.000 claims 1
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 108010044540 auristatin Proteins 0.000 claims 1
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
• 229930195731 calicheamicin Natural products 0.000 claims 1
• 239000000824 cytostatic agent Substances 0.000 claims 1
• 230000001085 cytostatic effect Effects 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 claims 1
• 229930188854 dolastatin Natural products 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 description 2
• 102000049622 human ROR2 Human genes 0.000 description 2