JP2019524134A5 - - Google Patents
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- Publication number
- JP2019524134A5 JP2019524134A5 JP2019507224A JP2019507224A JP2019524134A5 JP 2019524134 A5 JP2019524134 A5 JP 2019524134A5 JP 2019507224 A JP2019507224 A JP 2019507224A JP 2019507224 A JP2019507224 A JP 2019507224A JP 2019524134 A5 JP2019524134 A5 JP 2019524134A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- udp glycosyltransferase
- host cell
- loop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 62
- 102000051366 Glycosyltransferases Human genes 0.000 claims 41
- 108700023372 Glycosyltransferases Proteins 0.000 claims 41
- 235000001014 amino acid Nutrition 0.000 claims 32
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 241000954177 Bangana ariza Species 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
- 239000004383 Steviol glycoside Substances 0.000 claims 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- RPYRMTHVSUWHSV-CUZJHZIBSA-N rebaudioside D Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RPYRMTHVSUWHSV-CUZJHZIBSA-N 0.000 claims 4
- 229930182488 steviol glycoside Natural products 0.000 claims 4
- 235000019411 steviol glycoside Nutrition 0.000 claims 4
- 235000019202 steviosides Nutrition 0.000 claims 4
- 239000004474 valine Substances 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 230000037361 pathway Effects 0.000 claims 3
- 150000008144 steviol glycosides Chemical class 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 229960000310 isoleucine Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002864 sequence alignment Methods 0.000 claims 2
- ONVABDHFQKWOSV-UHFFFAOYSA-N 16-Phyllocladene Natural products C1CC(C2)C(=C)CC32CCC2C(C)(C)CCCC2(C)C31 ONVABDHFQKWOSV-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000007317 Farnesyltranstransferase Human genes 0.000 claims 1
- 108010007508 Farnesyltranstransferase Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 1
- 108010045510 NADPH-Ferrihemoprotein Reductase Proteins 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 101100427140 Stevia rebaudiana UGT74G1 gene Proteins 0.000 claims 1
- 101100262416 Stevia rebaudiana UGT76G1 gene Proteins 0.000 claims 1
- 101100048059 Stevia rebaudiana UGT85C2 gene Proteins 0.000 claims 1
- QFVOYBUQQBFCRH-UHFFFAOYSA-N Steviol Natural products C1CC2(C3)CC(=C)C3(O)CCC2C2(C)C1C(C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-UHFFFAOYSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- QFVOYBUQQBFCRH-VQSWZGCSSA-N steviol Chemical compound C([C@@]1(O)C(=C)C[C@@]2(C1)CC1)C[C@H]2[C@@]2(C)[C@H]1[C@](C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-VQSWZGCSSA-N 0.000 claims 1
- 229940032084 steviol Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022097959A JP2022137061A (ja) | 2016-08-12 | 2022-06-17 | レバウジオシドの高効率の産生のためのｕｄｐ依存性グリコシルトランスフェラーゼ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374408P | 2016-08-12 | 2016-08-12 | |
| US62/374,408 | 2016-08-12 | ||
| PCT/US2017/046637 WO2018031955A2 (en) | 2016-08-12 | 2017-08-11 | Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022097959A Division JP2022137061A (ja) | 2016-08-12 | 2022-06-17 | レバウジオシドの高効率の産生のためのｕｄｐ依存性グリコシルトランスフェラーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524134A JP2019524134A (ja) | 2019-09-05 |
| JP2019524134A5 true JP2019524134A5 (cg-RX-API-DMAC7.html) | 2020-09-17 |
| JP7404068B2 JP7404068B2 (ja) | 2023-12-25 |
Family
ID=59700219
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507224A Active JP7404068B2 (ja) | 2016-08-12 | 2017-08-11 | レバウジオシドの高効率の産生のためのｕｄｐ依存性グリコシルトランスフェラーゼ |
| JP2022097959A Pending JP2022137061A (ja) | 2016-08-12 | 2022-06-17 | レバウジオシドの高効率の産生のためのｕｄｐ依存性グリコシルトランスフェラーゼ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022097959A Pending JP2022137061A (ja) | 2016-08-12 | 2022-06-17 | レバウジオシドの高効率の産生のためのｕｄｐ依存性グリコシルトランスフェラーゼ |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11091743B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3497222B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7404068B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102331018B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109804073B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017308143B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018074999A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3031162A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2906310T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2019001631A (cg-RX-API-DMAC7.html) |
| MY (1) | MY194280A (cg-RX-API-DMAC7.html) |
| PT (1) | PT3497222T (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201900930UA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018031955A2 (cg-RX-API-DMAC7.html) |
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| SG10202112698PA (en) * | 2017-05-15 | 2021-12-30 | Purecircle Usa Inc | High-purity steviol glycosides |
| CN111868252B (zh) * | 2018-03-12 | 2025-06-03 | 科纳根公司 | 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产 |
| US11608364B2 (en) | 2018-04-30 | 2023-03-21 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| JP7584401B2 (ja) | 2018-07-30 | 2024-11-15 | テイト アンド ライル ソリューションズ ユー・エス・エー エル・エル・シー | 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法 |
| EP3867370A1 (en) | 2018-10-15 | 2021-08-25 | Amyris, Inc. | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| SG11202107656TA (en) | 2019-01-24 | 2021-08-30 | Amyris Inc | Abc transporters for the high efficiency production of rebaudiosides |
| SG11202111698SA (en) | 2019-05-03 | 2021-11-29 | Amyris Inc | Kaurenoic acid 13-hydroxylase (kah) variants and uses thereof |
| MX2022011329A (es) * | 2020-03-13 | 2022-10-07 | Amyris Inc | Composiciones edulcorantes de rebaudiosido m. |
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| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
| JP2024540897A (ja) * | 2021-10-19 | 2024-11-06 | シージェイ チェイルジェダン コーポレーション | レバウジオシドｄ及びレバウジオシドｍを製造する方法 |
| CN114045273B (zh) * | 2021-11-15 | 2022-07-22 | 四川大学 | 糖基转移酶OsUGT91C1突变体及其应用 |
| JP2025500510A (ja) * | 2021-12-24 | 2025-01-09 | サムヤン コーポレイション | 糖転移酵素変異体、およびこれを利用したステビオール配糖体の製造方法 |
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| WO2024042405A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the synthesis of bio-based polymers |
| WO2024042486A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the production of polyurethanes |
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| WO2025159542A1 (ko) * | 2024-01-24 | 2025-07-31 | 씨제이제일제당 (주) | 신규한 변이형 당전이 효소 폴리펩티드 및 이를 이용한 스테비올배당체 생산 방법 |
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2017
- 2017-08-11 ES ES17757641T patent/ES2906310T3/es active Active
- 2017-08-11 MX MX2019001631A patent/MX2019001631A/es unknown
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- 2017-08-11 MY MYPI2019000757A patent/MY194280A/en unknown
- 2017-08-11 PT PT177576410T patent/PT3497222T/pt unknown
- 2017-08-11 WO PCT/US2017/046637 patent/WO2018031955A2/en not_active Ceased
- 2017-08-11 BR BR112018074999-0A patent/BR112018074999A2/pt not_active Application Discontinuation
- 2017-08-11 EP EP17757641.0A patent/EP3497222B1/en active Active
- 2017-08-11 AU AU2017308143A patent/AU2017308143B2/en active Active
- 2017-08-11 US US16/323,756 patent/US11091743B2/en active Active
- 2017-08-11 JP JP2019507224A patent/JP7404068B2/ja active Active
- 2017-08-11 KR KR1020197006546A patent/KR102331018B1/ko not_active Expired - Fee Related
- 2017-08-11 CN CN201780049312.3A patent/CN109804073B/zh active Active
- 2017-08-11 CA CA3031162A patent/CA3031162A1/en active Pending
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2021
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2022
- 2022-06-17 JP JP2022097959A patent/JP2022137061A/ja active Pending
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2023
- 2023-11-30 US US18/525,234 patent/US12371677B2/en active Active
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