PT3497222T - Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos - Google Patents
Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeosInfo
- Publication number
- PT3497222T PT3497222T PT177576410T PT17757641T PT3497222T PT 3497222 T PT3497222 T PT 3497222T PT 177576410 T PT177576410 T PT 177576410T PT 17757641 T PT17757641 T PT 17757641T PT 3497222 T PT3497222 T PT 3497222T
- Authority
- PT
- Portugal
- Prior art keywords
- rebaudiosides
- udp
- high efficiency
- efficiency production
- dependent glycosyltransferase
- Prior art date
Links
- 102000051366 Glycosyltransferases Human genes 0.000 title 1
- 108700023372 Glycosyltransferases Proteins 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 229930188195 rebaudioside Natural products 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/24—Non-sugar sweeteners
- A23V2250/262—Stevioside
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374408P | 2016-08-12 | 2016-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3497222T true PT3497222T (pt) | 2022-02-09 |
Family
ID=59700219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177576410T PT3497222T (pt) | 2016-08-12 | 2017-08-11 | Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11091743B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3497222B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7404068B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102331018B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109804073B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017308143B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018074999A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3031162A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2906310T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2019001631A (cg-RX-API-DMAC7.html) |
| MY (1) | MY194280A (cg-RX-API-DMAC7.html) |
| PT (1) | PT3497222T (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201900930UA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018031955A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017005656A2 (pt) | 2014-09-19 | 2018-07-31 | Purecircle Sdn Bhd | glicosídeos de esteviol de alta pureza |
| ES2906310T3 (es) * | 2016-08-12 | 2022-04-18 | Amyris Inc | Glicosiltransferasa dependiente de UDP para la producción de alta eficiencia de rebaudiósidos |
| CN110914445B (zh) | 2017-02-03 | 2024-08-27 | 泰莱解决方案美国有限责任公司 | 工程化糖基转移酶和甜菊醇糖苷葡糖基化方法 |
| SG10202112698PA (en) * | 2017-05-15 | 2021-12-30 | Purecircle Usa Inc | High-purity steviol glycosides |
| CN111868252B (zh) * | 2018-03-12 | 2025-06-03 | 科纳根公司 | 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产 |
| US11608364B2 (en) | 2018-04-30 | 2023-03-21 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| JP7584401B2 (ja) | 2018-07-30 | 2024-11-15 | テイト アンド ライル ソリューションズ ユー・エス・エー エル・エル・シー | 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法 |
| EP3867370A1 (en) | 2018-10-15 | 2021-08-25 | Amyris, Inc. | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| SG11202107656TA (en) | 2019-01-24 | 2021-08-30 | Amyris Inc | Abc transporters for the high efficiency production of rebaudiosides |
| SG11202111698SA (en) | 2019-05-03 | 2021-11-29 | Amyris Inc | Kaurenoic acid 13-hydroxylase (kah) variants and uses thereof |
| MX2022011329A (es) * | 2020-03-13 | 2022-10-07 | Amyris Inc | Composiciones edulcorantes de rebaudiosido m. |
| CN111518782B (zh) * | 2020-03-24 | 2022-09-02 | 广东广业清怡食品科技股份有限公司 | 一种糖基转移酶ugtzj1突变体及其应用 |
| CN111424065B (zh) * | 2020-03-24 | 2022-08-16 | 金禾益康(北京)生物科技有限公司 | 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法 |
| EP4269573A4 (en) * | 2020-12-23 | 2025-07-23 | Samyang Corp | GLYCOSYLTRANSFERASE AND METHOD FOR PREPARING STEVIOL GLUCOSIDE USING SAME |
| WO2022216922A1 (en) * | 2021-04-08 | 2022-10-13 | Conagen Inc. | Biosynthetic production of steviol glycosides |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
| JP2024540897A (ja) * | 2021-10-19 | 2024-11-06 | シージェイ チェイルジェダン コーポレーション | レバウジオシドｄ及びレバウジオシドｍを製造する方法 |
| CN114045273B (zh) * | 2021-11-15 | 2022-07-22 | 四川大学 | 糖基转移酶OsUGT91C1突变体及其应用 |
| JP2025500510A (ja) * | 2021-12-24 | 2025-01-09 | サムヤン コーポレイション | 糖転移酵素変異体、およびこれを利用したステビオール配糖体の製造方法 |
| US20250320538A1 (en) * | 2022-05-19 | 2025-10-16 | Amyris, Inc. | Compositions and methods for improved production of steviol glycosides |
| WO2024042405A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the synthesis of bio-based polymers |
| WO2024042486A1 (en) | 2022-08-26 | 2024-02-29 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for the production of polyurethanes |
| WO2024116153A1 (en) | 2022-12-02 | 2024-06-06 | Amyris Bio Products Portugal, Unipessoal, Ltda. | Compositions and methods for using previously cultured cells |
| WO2025159542A1 (ko) * | 2024-01-24 | 2025-07-31 | 씨제이제일제당 (주) | 신규한 변이형 당전이 효소 폴리펩티드 및 이를 이용한 스테비올배당체 생산 방법 |
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| ES2592377T3 (es) | 2008-10-03 | 2016-11-29 | Morita Kagaku Kogyo Co., Ltd. | Nuevos glucósidos de esteviol |
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| US10113154B2 (en) | 2012-03-27 | 2018-10-30 | Suntory Holdings Limited | Method for producing steviol glycoside |
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| TW201402599A (zh) | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
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| WO2014191581A2 (en) | 2013-05-31 | 2014-12-04 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| MX2016000452A (es) | 2013-07-15 | 2016-05-12 | Dsm Ip Assets Bv | Produccion de diterpeno. |
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| WO2017025649A1 (en) | 2015-08-13 | 2017-02-16 | Dsm Ip Assets B.V. | Steviol glycoside transport |
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| JP2019503670A (ja) | 2015-12-10 | 2019-02-14 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | 組換え宿主内でのステビオールグリコシドの産生 |
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| SG11201808856TA (en) | 2016-04-13 | 2018-11-29 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| AU2017267214A1 (en) | 2016-05-16 | 2018-11-15 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3497109A1 (en) | 2016-08-09 | 2019-06-19 | DSM IP Assets B.V. | Crystallization of steviol glycosides |
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| EP3535406A1 (en) | 2016-11-07 | 2019-09-11 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| SG10202112698PA (en) | 2017-05-15 | 2021-12-30 | Purecircle Usa Inc | High-purity steviol glycosides |
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| JP7584401B2 (ja) | 2018-07-30 | 2024-11-15 | テイト アンド ライル ソリューションズ ユー・エス・エー エル・エル・シー | 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法 |
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-
2017
- 2017-08-11 ES ES17757641T patent/ES2906310T3/es active Active
- 2017-08-11 MX MX2019001631A patent/MX2019001631A/es unknown
- 2017-08-11 SG SG11201900930UA patent/SG11201900930UA/en unknown
- 2017-08-11 MY MYPI2019000757A patent/MY194280A/en unknown
- 2017-08-11 PT PT177576410T patent/PT3497222T/pt unknown
- 2017-08-11 WO PCT/US2017/046637 patent/WO2018031955A2/en not_active Ceased
- 2017-08-11 BR BR112018074999-0A patent/BR112018074999A2/pt not_active Application Discontinuation
- 2017-08-11 EP EP17757641.0A patent/EP3497222B1/en active Active
- 2017-08-11 AU AU2017308143A patent/AU2017308143B2/en active Active
- 2017-08-11 US US16/323,756 patent/US11091743B2/en active Active
- 2017-08-11 JP JP2019507224A patent/JP7404068B2/ja active Active
- 2017-08-11 KR KR1020197006546A patent/KR102331018B1/ko not_active Expired - Fee Related
- 2017-08-11 CN CN201780049312.3A patent/CN109804073B/zh active Active
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2023
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Also Published As
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|---|---|
| WO2018031955A3 (en) | 2018-03-15 |
| CA3031162A1 (en) | 2018-02-15 |
| MY194280A (en) | 2022-11-25 |
| US12371677B2 (en) | 2025-07-29 |
| MX2019001631A (es) | 2019-08-05 |
| JP7404068B2 (ja) | 2023-12-25 |
| JP2019524134A (ja) | 2019-09-05 |
| US20240174987A1 (en) | 2024-05-30 |
| US20210355458A1 (en) | 2021-11-18 |
| US20190185826A1 (en) | 2019-06-20 |
| JP2022137061A (ja) | 2022-09-21 |
| SG11201900930UA (en) | 2019-02-27 |
| AU2017308143B2 (en) | 2022-04-07 |
| EP3497222A2 (en) | 2019-06-19 |
| ES2906310T3 (es) | 2022-04-18 |
| US11091743B2 (en) | 2021-08-17 |
| EP3497222B1 (en) | 2021-12-22 |
| KR20190038612A (ko) | 2019-04-08 |
| CN109804073A (zh) | 2019-05-24 |
| BR112018074999A2 (pt) | 2019-03-12 |
| CN109804073B (zh) | 2023-05-16 |
| RU2019104496A3 (cg-RX-API-DMAC7.html) | 2021-04-09 |
| RU2019104496A (ru) | 2020-09-14 |
| KR102331018B1 (ko) | 2021-11-26 |
| WO2018031955A2 (en) | 2018-02-15 |
| US11866738B2 (en) | 2024-01-09 |
| AU2017308143A1 (en) | 2019-02-07 |
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