JP2019521986A5 - - Google Patents
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- JP2019521986A5 JP2019521986A5 JP2018565786A JP2018565786A JP2019521986A5 JP 2019521986 A5 JP2019521986 A5 JP 2019521986A5 JP 2018565786 A JP2018565786 A JP 2018565786A JP 2018565786 A JP2018565786 A JP 2018565786A JP 2019521986 A5 JP2019521986 A5 JP 2019521986A5
- Authority
- JP
- Japan
- Prior art keywords
- chromatography
- antibody
- mixed mode
- anion exchange
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022117433A JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
| JP2024102664A JP2024156655A (ja) | 2016-06-17 | 2024-06-26 | 多重特異性抗体の精製 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662351908P | 2016-06-17 | 2016-06-17 | |
| US62/351,908 | 2016-06-17 | ||
| PCT/US2017/038007 WO2017218977A2 (en) | 2016-06-17 | 2017-06-16 | Purification of multispecific antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022117433A Division JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019521986A JP2019521986A (ja) | 2019-08-08 |
| JP2019521986A5 true JP2019521986A5 (enExample) | 2020-08-06 |
Family
ID=59593150
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565786A Pending JP2019521986A (ja) | 2016-06-17 | 2017-06-16 | 多重特異性抗体の精製 |
| JP2022117433A Active JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
| JP2024102664A Pending JP2024156655A (ja) | 2016-06-17 | 2024-06-26 | 多重特異性抗体の精製 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022117433A Active JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
| JP2024102664A Pending JP2024156655A (ja) | 2016-06-17 | 2024-06-26 | 多重特異性抗体の精製 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20190256556A1 (enExample) |
| EP (2) | EP3472177B1 (enExample) |
| JP (3) | JP2019521986A (enExample) |
| KR (3) | KR20250107275A (enExample) |
| CN (1) | CN109563124A (enExample) |
| AR (1) | AR108800A1 (enExample) |
| AU (2) | AU2017286676B2 (enExample) |
| BR (1) | BR112018075516A2 (enExample) |
| CA (1) | CA3026518A1 (enExample) |
| ES (1) | ES2988363T3 (enExample) |
| HR (1) | HRP20241323T1 (enExample) |
| HU (1) | HUE068564T2 (enExample) |
| IL (1) | IL263690B2 (enExample) |
| MX (2) | MX2018015173A (enExample) |
| PL (1) | PL3472177T3 (enExample) |
| SG (1) | SG11201810777WA (enExample) |
| TW (1) | TWI798179B (enExample) |
| WO (1) | WO2017218977A2 (enExample) |
Families Citing this family (45)
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| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| EP3676280B1 (en) * | 2017-08-30 | 2025-03-19 | Fresenius Kabi Deutschland GmbH | Method for purifying anti-il-6 receptor antibodies |
| CN111491951B (zh) * | 2017-12-22 | 2024-05-24 | 豪夫迈·罗氏有限公司 | 通过疏水相互作用色谱法耗尽轻链错配的抗体变体 |
| WO2019149693A1 (en) * | 2018-01-30 | 2019-08-08 | Univercells S.A. | Protein purification process and platform |
| US20210040146A1 (en) * | 2018-01-30 | 2021-02-11 | Exothera S.A. | Protein purification process |
| WO2019154776A1 (en) * | 2018-02-06 | 2019-08-15 | F. Hoffmann-La Roche Ag | Treatment of ophthalmologic diseases |
| US12071476B2 (en) | 2018-03-02 | 2024-08-27 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
| US20230182041A1 (en) * | 2018-04-25 | 2023-06-15 | Medimmune, Llc | Purification of antibodies |
| SG11202103064YA (en) | 2018-10-29 | 2021-05-28 | Hoffmann La Roche | Antibody formulation |
| CN111423512B (zh) * | 2019-01-10 | 2024-01-05 | 北京比洋生物技术有限公司 | 阻断血管内皮细胞生长且活化t细胞的多靶向融合蛋白和包含其的药物组合物 |
| TWI871300B (zh) * | 2019-01-28 | 2025-02-01 | 美商安進公司 | 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程 |
| WO2020160118A1 (en) | 2019-01-29 | 2020-08-06 | Shire-Nps Pharmaceuticals, Inc. | Parathyroid hormone variants |
| CN114981286B (zh) * | 2019-05-03 | 2026-02-13 | 豪夫迈·罗氏有限公司 | 降低从纯化平台获得的组合物中酶水解活性速率的方法 |
| CN114026108B (zh) * | 2019-06-28 | 2024-09-10 | 夏尔巴生物技术(苏州)有限公司 | 无缝连续流层析方法 |
| AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| KR20220092958A (ko) * | 2019-11-07 | 2022-07-04 | 암젠 인크 | 산물-관련 불순물을 제거하기 위한 양이온 교환 크로마토그래피 동안의 고염 세척 |
| EP4061825A1 (en) * | 2019-11-22 | 2022-09-28 | MorphoSys AG | Method to increase antibody yield during ion exchange chromatography |
| EP4090666A1 (en) * | 2020-01-15 | 2022-11-23 | F. Hoffmann-La Roche AG | Methods to decrease impurities from recombinant protein manufacturing processes |
| KR102154952B1 (ko) * | 2020-02-21 | 2020-09-10 | 프레스티지바이오로직스 주식회사 | 아달리무맙의 Non-Protein A 정제방법 |
| CN115066258A (zh) * | 2020-02-28 | 2022-09-16 | 上海药明生物技术有限公司 | 双特异性抗体的纯化 |
| EP4118093A4 (en) * | 2020-03-11 | 2024-04-17 | Dr. Reddy's Laboratories Ltd. | METHOD FOR PURIFYING A FC FUSION PROTEIN |
| CN115734969A (zh) * | 2020-04-13 | 2023-03-03 | 上海药明生物技术有限公司 | 双特异性抗体的纯化 |
| US20230143066A1 (en) * | 2020-04-17 | 2023-05-11 | Ono Pharmaceutical Co., Ltd. | Method for removing color from drug substance of protein preparation |
| CN113563469A (zh) * | 2020-04-28 | 2021-10-29 | 江苏中新医药有限公司 | 高回收率纯化阿达木单抗的方法 |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| AU2021265346A1 (en) * | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of affinity chromatography |
| EP4142905A4 (en) * | 2020-05-01 | 2024-11-13 | Kashiv Biosciences, LLC | IMPROVED PROCESS FOR PURIFICATION OF PROTEIN |
| CN114014906B (zh) * | 2020-06-24 | 2024-01-12 | 夏尔巴生物技术(苏州)有限公司 | 一种利用阳离子交换层析纯化疏水性蛋白的方法 |
| CA3191328A1 (en) * | 2020-09-21 | 2022-03-24 | Genentech, Inc. | Purification of multispecific antibodies |
| CN114539416B (zh) * | 2020-11-26 | 2024-11-08 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体的层析纯化工艺 |
| JP2024500747A (ja) * | 2020-12-18 | 2024-01-10 | キニクサ ファーマシューティカルズ， リミテッド | タンパク質組成物ならびにそれを産生及び使用するための方法 |
| ES3040791T3 (en) | 2020-12-18 | 2025-11-05 | Richter Gedeon Nyrt | Methods for the purification of refolded fc-peptide fusion protein |
| BR112023018268A2 (pt) * | 2021-03-09 | 2023-10-31 | Japan Chem Res | Método para produzir uma proteína de fusão |
| WO2022225060A1 (ja) * | 2021-04-23 | 2022-10-27 | 協和キリン株式会社 | 分解物の産生を抑制する方法 |
| TW202241924A (zh) * | 2021-04-23 | 2022-11-01 | 大陸商和鉑醫藥（上海）有限責任公司 | 一種雙特異性抗體的純化方法 |
| WO2022272119A2 (en) * | 2021-06-25 | 2022-12-29 | The Board Of Trustees Of The University Of Illinois | Synthetic toolkit for plant transformation |
| WO2023068740A1 (ko) * | 2021-10-19 | 2023-04-27 | 주식회사 알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 정제방법 |
| WO2024076990A1 (en) * | 2022-10-03 | 2024-04-11 | Therini Bio, Inc. | Multi-specific antigen binding proteins which bind human fibrin or fibrinogen ?c domain and vascular endothelial growth factor and methods of use |
| CN117990807B (zh) * | 2022-11-07 | 2024-09-24 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp单克隆抗体电荷异质性的检测方法 |
| CN119264256B (zh) * | 2023-07-07 | 2026-01-02 | 齐鲁制药有限公司 | 一种单克隆抗体的纯化方法 |
| CN116769044A (zh) * | 2023-07-11 | 2023-09-19 | 康日百奥生物科技(苏州)有限公司 | 抗cd3和cd19双特异性抗体蛋白及其层析纯化方法 |
| WO2025029614A1 (en) * | 2023-07-28 | 2025-02-06 | Amgen Inc. | A method for equilibrating a chromatography medium |
| WO2025088516A1 (en) * | 2023-10-26 | 2025-05-01 | Pfizer Inc. | Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained |
| WO2025155751A1 (en) * | 2024-01-17 | 2025-07-24 | Nutcracker Therapeutics, Inc. | Improved method for isolating and characterizing proteins |
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2017
- 2017-06-16 TW TW106120122A patent/TWI798179B/zh active
- 2017-06-16 EP EP17751870.1A patent/EP3472177B1/en active Active
- 2017-06-16 KR KR1020257021158A patent/KR20250107275A/ko active Pending
- 2017-06-16 ES ES17751870T patent/ES2988363T3/es active Active
- 2017-06-16 AR ARP170101667A patent/AR108800A1/es active IP Right Grant
- 2017-06-16 CA CA3026518A patent/CA3026518A1/en active Pending
- 2017-06-16 CN CN201780047396.7A patent/CN109563124A/zh active Pending
- 2017-06-16 JP JP2018565786A patent/JP2019521986A/ja active Pending
- 2017-06-16 WO PCT/US2017/038007 patent/WO2017218977A2/en not_active Ceased
- 2017-06-16 HR HRP20241323TT patent/HRP20241323T1/hr unknown
- 2017-06-16 HU HUE17751870A patent/HUE068564T2/hu unknown
- 2017-06-16 AU AU2017286676A patent/AU2017286676B2/en active Active
- 2017-06-16 KR KR1020237025000A patent/KR102826635B1/ko active Active
- 2017-06-16 MX MX2018015173A patent/MX2018015173A/es unknown
- 2017-06-16 KR KR1020197001176A patent/KR20190039929A/ko not_active Ceased
- 2017-06-16 PL PL17751870.1T patent/PL3472177T3/pl unknown
- 2017-06-16 SG SG11201810777WA patent/SG11201810777WA/en unknown
- 2017-06-16 EP EP24193902.4A patent/EP4549463A3/en active Pending
- 2017-06-16 BR BR112018075516-8A patent/BR112018075516A2/pt unknown
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2018
- 2018-12-06 MX MX2024003651A patent/MX2024003651A/es unknown
- 2018-12-13 IL IL263690A patent/IL263690B2/en unknown
- 2018-12-14 US US16/221,369 patent/US20190256556A1/en active Pending
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2022
- 2022-07-22 JP JP2022117433A patent/JP7564843B2/ja active Active
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2024
- 2024-06-26 JP JP2024102664A patent/JP2024156655A/ja active Pending
- 2024-10-23 AU AU2024227572A patent/AU2024227572A1/en active Pending
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