JP2019521986A5 - - Google Patents
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- JP2019521986A5 JP2019521986A5 JP2018565786A JP2018565786A JP2019521986A5 JP 2019521986 A5 JP2019521986 A5 JP 2019521986A5 JP 2018565786 A JP2018565786 A JP 2018565786A JP 2018565786 A JP2018565786 A JP 2018565786A JP 2019521986 A5 JP2019521986 A5 JP 2019521986A5
- Authority
- JP
- Japan
- Prior art keywords
- chromatography
- antibody
- mixed mode
- anion exchange
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022117433A JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
| JP2024102664A JP7881651B2 (ja) | 2016-06-17 | 2024-06-26 | 多重特異性抗体の精製 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662351908P | 2016-06-17 | 2016-06-17 | |
| US62/351,908 | 2016-06-17 | ||
| PCT/US2017/038007 WO2017218977A2 (en) | 2016-06-17 | 2017-06-16 | Purification of multispecific antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022117433A Division JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019521986A JP2019521986A (ja) | 2019-08-08 |
| JP2019521986A5 true JP2019521986A5 (enExample) | 2020-08-06 |
Family
ID=59593150
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565786A Pending JP2019521986A (ja) | 2016-06-17 | 2017-06-16 | 多重特異性抗体の精製 |
| JP2022117433A Active JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
| JP2024102664A Active JP7881651B2 (ja) | 2016-06-17 | 2024-06-26 | 多重特異性抗体の精製 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022117433A Active JP7564843B2 (ja) | 2016-06-17 | 2022-07-22 | 多重特異性抗体の精製 |
| JP2024102664A Active JP7881651B2 (ja) | 2016-06-17 | 2024-06-26 | 多重特異性抗体の精製 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20190256556A1 (enExample) |
| EP (2) | EP4549463A3 (enExample) |
| JP (3) | JP2019521986A (enExample) |
| KR (3) | KR102826635B1 (enExample) |
| CN (1) | CN109563124A (enExample) |
| AR (1) | AR108800A1 (enExample) |
| AU (2) | AU2017286676B2 (enExample) |
| BR (1) | BR112018075516A2 (enExample) |
| CA (1) | CA3026518A1 (enExample) |
| ES (1) | ES2988363T3 (enExample) |
| HR (1) | HRP20241323T1 (enExample) |
| HU (1) | HUE068564T2 (enExample) |
| IL (1) | IL263690B2 (enExample) |
| MX (2) | MX2018015173A (enExample) |
| PL (1) | PL3472177T3 (enExample) |
| SG (1) | SG11201810777WA (enExample) |
| TW (1) | TWI798179B (enExample) |
| WO (1) | WO2017218977A2 (enExample) |
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| WO2015200905A2 (en) | 2014-06-28 | 2015-12-30 | Oligasis, Llc | Dual pdgf/vegf antagonists |
| IL290457B2 (en) | 2015-12-30 | 2025-02-01 | Kodiak Sciences Inc | Antibodies and their conjugates |
| WO2019043096A1 (en) * | 2017-08-30 | 2019-03-07 | Fresenius Kabi Deutschland Gmbh | METHOD FOR PURIFYING IL-6 ANTI-RECEPTOR ANTIBODIES |
| US11945839B2 (en) | 2017-12-22 | 2024-04-02 | Hoffmann-La Roche Inc. | Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography |
| WO2019149691A1 (en) * | 2018-01-30 | 2019-08-08 | Univercells S.A. | Protein purification process |
| WO2019149693A1 (en) * | 2018-01-30 | 2019-08-08 | Univercells S.A. | Protein purification process and platform |
| CN111699004A (zh) | 2018-02-06 | 2020-09-22 | 豪夫迈·罗氏有限公司 | 眼科疾病的治疗 |
| CA3092588A1 (en) | 2018-03-02 | 2019-09-06 | Kodiak Sciences Inc. | Il-6 antibodies and fusion constructs and conjugates thereof |
| US20230182041A1 (en) * | 2018-04-25 | 2023-06-15 | Medimmune, Llc | Purification of antibodies |
| CN119033684A (zh) | 2018-10-29 | 2024-11-29 | 豪夫迈·罗氏有限公司 | 抗体制剂 |
| CN111423512B (zh) * | 2019-01-10 | 2024-01-05 | 北京比洋生物技术有限公司 | 阻断血管内皮细胞生长且活化t细胞的多靶向融合蛋白和包含其的药物组合物 |
| TWI871300B (zh) * | 2019-01-28 | 2025-02-01 | 美商安進公司 | 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程 |
| KR20210121137A (ko) | 2019-01-29 | 2021-10-07 | 샤이어-엔피에스 파마슈티칼즈, 인크. | 부갑상선 호르몬 변이체 |
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| CN114026108B (zh) * | 2019-06-28 | 2024-09-10 | 夏尔巴生物技术(苏州)有限公司 | 无缝连续流层析方法 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| JP2022554283A (ja) * | 2019-11-07 | 2022-12-28 | アムジエン・インコーポレーテツド | 生成物関連不純物を除去するためのカチオン交換クロマトグラフィー中の高塩分洗浄 |
| WO2021099536A1 (en) * | 2019-11-22 | 2021-05-27 | Morphosys Ag | Method to increase antibody yield during ion exchange chromatography |
| AU2021208515A1 (en) * | 2020-01-15 | 2022-08-04 | F. Hoffmann-La Roche Ag | Methods to decrease impurities from recombinant protein manufacturing processes |
| KR102154952B1 (ko) * | 2020-02-21 | 2020-09-10 | 프레스티지바이오로직스 주식회사 | 아달리무맙의 Non-Protein A 정제방법 |
| WO2021170060A1 (en) * | 2020-02-28 | 2021-09-02 | Wuxi Biologics (Shanghai) Co., Ltd. | Purification of bispeciifc antibodies |
| WO2021181417A1 (en) * | 2020-03-11 | 2021-09-16 | Dr. Reddy's Laboratories Limited | METHOD OF PURIFYING AN Fc-FUSION PROTEIN |
| CN115734969A (zh) * | 2020-04-13 | 2023-03-03 | 上海药明生物技术有限公司 | 双特异性抗体的纯化 |
| US20230143066A1 (en) * | 2020-04-17 | 2023-05-11 | Ono Pharmaceutical Co., Ltd. | Method for removing color from drug substance of protein preparation |
| CN113563469A (zh) * | 2020-04-28 | 2021-10-29 | 江苏中新医药有限公司 | 高回收率纯化阿达木单抗的方法 |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| AU2021265346A1 (en) * | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of affinity chromatography |
| CA3182314A1 (en) * | 2020-05-01 | 2021-11-04 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| WO2021220500A1 (ja) * | 2020-05-01 | 2021-11-04 | ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 | 帯電物質の精製方法 |
| CN114014906B (zh) * | 2020-06-24 | 2024-01-12 | 夏尔巴生物技术(苏州)有限公司 | 一种利用阳离子交换层析纯化疏水性蛋白的方法 |
| WO2022061214A1 (en) * | 2020-09-21 | 2022-03-24 | Genentech, Inc. | Purification of multispecific antibodies |
| CN114539416B (zh) * | 2020-11-26 | 2024-11-08 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体的层析纯化工艺 |
| SMT202500333T1 (it) | 2020-12-18 | 2025-11-10 | Richter Gedeon Nyrt | Metodi per la purificazione di proteina di fusione fc-peptide |
| MX2023007028A (es) * | 2020-12-18 | 2023-09-21 | Kiniksa Pharmaceuticals Ltd | Composiciones de proteínas y métodos para producir y usar las mismas. |
| BR112023018268A2 (pt) * | 2021-03-09 | 2023-10-31 | Japan Chem Res | Método para produzir uma proteína de fusão |
| US20240191179A1 (en) * | 2021-04-23 | 2024-06-13 | Kyowa Kirin Co., Ltd. | Method for suppressing production of degradation products |
| CN117242095A (zh) * | 2021-04-23 | 2023-12-15 | 和铂医药(上海)有限责任公司 | 一种双特异性抗体的纯化方法 |
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| EP4421089A4 (en) * | 2021-10-19 | 2026-01-07 | Alteogen Inc | METHOD FOR PURIFYING A FUSION PROTEIN HAVING AN IGG FC DOMAIN |
| WO2024076990A1 (en) * | 2022-10-03 | 2024-04-11 | Therini Bio, Inc. | Multi-specific antigen binding proteins which bind human fibrin or fibrinogen ?c domain and vascular endothelial growth factor and methods of use |
| CN117990807B (zh) * | 2022-11-07 | 2024-09-24 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp单克隆抗体电荷异质性的检测方法 |
| CN119264256B (zh) * | 2023-07-07 | 2026-01-02 | 齐鲁制药有限公司 | 一种单克隆抗体的纯化方法 |
| CN116769044A (zh) * | 2023-07-11 | 2023-09-19 | 康日百奥生物科技(苏州)有限公司 | 抗cd3和cd19双特异性抗体蛋白及其层析纯化方法 |
| WO2025029614A1 (en) * | 2023-07-28 | 2025-02-06 | Amgen Inc. | A method for equilibrating a chromatography medium |
| WO2025088516A1 (en) * | 2023-10-26 | 2025-05-01 | Pfizer Inc. | Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained |
| WO2025155751A1 (en) * | 2024-01-17 | 2025-07-24 | Nutcracker Therapeutics, Inc. | Improved method for isolating and characterizing proteins |
| CN122060072A (zh) * | 2026-03-16 | 2026-05-19 | 齐鲁制药有限公司 | 一种法瑞西单抗的纯化方法 |
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2017
- 2017-06-16 CA CA3026518A patent/CA3026518A1/en active Pending
- 2017-06-16 EP EP24193902.4A patent/EP4549463A3/en active Pending
- 2017-06-16 ES ES17751870T patent/ES2988363T3/es active Active
- 2017-06-16 WO PCT/US2017/038007 patent/WO2017218977A2/en not_active Ceased
- 2017-06-16 SG SG11201810777WA patent/SG11201810777WA/en unknown
- 2017-06-16 KR KR1020237025000A patent/KR102826635B1/ko active Active
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