JP2019518759A5 - - Google Patents
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- Publication number
- JP2019518759A5 JP2019518759A5 JP2018565677A JP2018565677A JP2019518759A5 JP 2019518759 A5 JP2019518759 A5 JP 2019518759A5 JP 2018565677 A JP2018565677 A JP 2018565677A JP 2018565677 A JP2018565677 A JP 2018565677A JP 2019518759 A5 JP2019518759 A5 JP 2019518759A5
- Authority
- JP
- Japan
- Prior art keywords
- target oligonucleotide
- product
- impurity
- mixture
- hydrophobic adsorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662349970P | 2016-06-14 | 2016-06-14 | |
| US62/349,970 | 2016-06-14 | ||
| US201762492402P | 2017-05-01 | 2017-05-01 | |
| US62/492,402 | 2017-05-01 | ||
| PCT/US2017/037126 WO2017218454A1 (en) | 2016-06-14 | 2017-06-13 | Hydrophobic interaction chromatography for purification of oligonucleotides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518759A JP2019518759A (ja) | 2019-07-04 |
| JP2019518759A5 true JP2019518759A5 (enExample) | 2022-04-07 |
| JP7075359B2 JP7075359B2 (ja) | 2022-05-25 |
Family
ID=59216016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565677A Active JP7075359B2 (ja) | 2016-06-14 | 2017-06-13 | オリゴヌクレオチドの精製のための疎水性相互作用クロマトグラフィー |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10947262B2 (enExample) |
| EP (1) | EP3468981B1 (enExample) |
| JP (1) | JP7075359B2 (enExample) |
| KR (1) | KR102461234B1 (enExample) |
| CN (1) | CN109641928B (enExample) |
| AU (1) | AU2017284202B2 (enExample) |
| BR (1) | BR112018075667B1 (enExample) |
| ES (1) | ES2988362T3 (enExample) |
| IL (1) | IL263639B (enExample) |
| MX (1) | MX2018015654A (enExample) |
| NZ (1) | NZ749360A (enExample) |
| WO (1) | WO2017218454A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10436802B2 (en) | 2014-09-12 | 2019-10-08 | Biogen Ma Inc. | Methods for treating spinal muscular atrophy |
| AR102198A1 (es) | 2014-10-09 | 2017-02-08 | Regeneron Pharma | Proceso para reducir partículas subvisibles en una formulación farmacéutica |
| US11020686B2 (en) | 2016-08-16 | 2021-06-01 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| JP7102401B2 (ja) | 2016-10-25 | 2022-07-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | クロマトグラフィーデータ解析のための方法およびシステム |
| CA3073935A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals, Inc. | Methods of reducing particle formation and compositions formed thereby |
| TWI853823B (zh) | 2018-07-02 | 2024-09-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| WO2020072062A1 (en) * | 2018-10-04 | 2020-04-09 | Gsw Creative Corporation | Portable charging case |
| EA202192422A1 (ru) | 2019-03-05 | 2021-12-09 | Ридженерон Фармасьютикалз, Инк. | Человеческий сывороточный альбумин в составах |
| CN110066789B (zh) * | 2019-05-17 | 2021-04-20 | 通用生物系统（安徽）有限公司 | 一种长链dna引物的hplc纯化改进的方法 |
| CN119874910A (zh) * | 2019-06-07 | 2025-04-25 | 达因疗法公司 | 制备蛋白质-寡核苷酸复合物的方法 |
| CN120505310A (zh) | 2020-02-28 | 2025-08-19 | Ionis制药公司 | 用于调节smn2的化合物和方法 |
| EP4301766A4 (en) * | 2021-03-02 | 2024-12-25 | Ionis Pharmaceuticals, Inc. | PURIFICATION PROCESSES FOR OLIGOMERIC COMPOUNDS |
| CN119855824A (zh) | 2022-09-07 | 2025-04-18 | 株式会社日本触媒 | 核酸的制造方法、杂质的去除方法以及杂质少的核酸 |
| CN117050120A (zh) * | 2022-12-09 | 2023-11-14 | 苏州赛分科技股份有限公司 | 一种纯化小干扰rna的柱层析法 |
| WO2024175051A1 (zh) * | 2023-02-23 | 2024-08-29 | 奥安医药（苏州）有限公司 | 一种疏水层析制备寡核苷酸的方法 |
| WO2025149349A1 (en) | 2024-01-09 | 2025-07-17 | Cytiva Bioprocess R&D Ab | Method for separating nucleic acid molecules |
| WO2025234897A1 (ru) * | 2024-05-07 | 2025-11-13 | Акционерное общество "ГЕНЕРИУМ" | Способ получения тиофосфатных олигонуклеотидов для терапевтического применения |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60104097A (ja) * | 1983-11-08 | 1985-06-08 | Sagami Chem Res Center | Ｄνａの精製方法 |
| DE3433649A1 (de) * | 1984-09-13 | 1986-03-20 | Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig | Verfahren zur aufreinigung synthetischer oligonucleotide |
| US6087491A (en) * | 1993-01-08 | 2000-07-11 | Hybridon, Inc. | Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks |
| CN1155887A (zh) * | 1994-07-05 | 1997-07-30 | 海布里顿公司 | 用deae-5pw阴离子-离子交换色谱和疏水作用色谱纯化硫代磷酸寡脱氧核苷酸 |
| CA2194350A1 (en) | 1994-07-05 | 1996-01-18 | Hybridon, Inc. | Purification of oligodeoxynucleotide phosphorothioates using deae 5pw anion ion-exchange chromatography and hydrophobic interaction chromatography |
| JP2001520660A (ja) * | 1997-04-21 | 2001-10-30 | プロリゴ・エルエルシー | オリゴヌクレオチドの溶液相合成方法 |
| JP2000035423A (ja) | 1998-05-11 | 2000-02-02 | Tosoh Corp | 液体クロマトグラフィ―による核酸の分離法 |
| RU2001135838A (ru) * | 1999-05-28 | 2004-01-20 | Камбрекс Байо Сайенс Инк. (Us) | Способы очистки ДНК и очищенная ДНК |
| PT102491B (pt) * | 2000-07-10 | 2003-02-28 | Inst Superior Tecnico | Processo para producao e purificacao de dna plasmidico |
| US7345163B2 (en) | 2002-08-28 | 2008-03-18 | Quiatech Ab | Process for separating and deprotecting oligonucleotides |
| WO2004041889A2 (en) | 2002-11-05 | 2004-05-21 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| US20050019951A1 (en) * | 2003-07-14 | 2005-01-27 | Gjerde Douglas T. | Method and device for extracting an analyte |
| EP1661905B9 (en) | 2003-08-28 | 2012-12-19 | IMANISHI, Takeshi | Novel artificial nucleic acids of n-o bond crosslinkage type |
| NZ549835A (en) * | 2004-04-19 | 2008-12-24 | Centelion | Method for purifying plasmid DNA |
| EP3470072A1 (en) | 2005-06-23 | 2019-04-17 | Biogen MA Inc. | Compositions and methods for modulation of smn2 splicing |
| WO2007090071A2 (en) | 2006-01-27 | 2007-08-09 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
| US8969068B2 (en) * | 2008-04-30 | 2015-03-03 | Gradalis, Inc. | Processes for the preparation of highly pure plasmid compositions by enzymatic digestion of colanic acid |
| ES2699827T3 (es) | 2009-06-17 | 2019-02-13 | Biogen Ma Inc | Composiciones y métodos para la modulación de corte y empalme de SMN2 en un sujeto |
| HUE050704T2 (hu) | 2014-04-01 | 2020-12-28 | Biogen Ma Inc | Összetételek a SOD-1 expressziójának modulálására |
-
2017
- 2017-06-13 BR BR112018075667-9A patent/BR112018075667B1/pt active IP Right Grant
- 2017-06-13 NZ NZ749360A patent/NZ749360A/en unknown
- 2017-06-13 EP EP17733243.4A patent/EP3468981B1/en active Active
- 2017-06-13 JP JP2018565677A patent/JP7075359B2/ja active Active
- 2017-06-13 WO PCT/US2017/037126 patent/WO2017218454A1/en not_active Ceased
- 2017-06-13 ES ES17733243T patent/ES2988362T3/es active Active
- 2017-06-13 MX MX2018015654A patent/MX2018015654A/es unknown
- 2017-06-13 AU AU2017284202A patent/AU2017284202B2/en active Active
- 2017-06-13 KR KR1020197000396A patent/KR102461234B1/ko active Active
- 2017-06-13 US US16/309,622 patent/US10947262B2/en active Active
- 2017-06-13 CN CN201780037028.4A patent/CN109641928B/zh active Active
-
2018
- 2018-12-11 IL IL263639A patent/IL263639B/en unknown
-
2021
- 2021-03-12 US US17/199,921 patent/US20210269467A1/en not_active Abandoned
-
2024
- 2024-06-13 US US18/742,011 patent/US20250011357A1/en active Pending
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