JP2012528867A5 - - Google Patents

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Publication number
JP2012528867A5
JP2012528867A5 JP2012514047A JP2012514047A JP2012528867A5 JP 2012528867 A5 JP2012528867 A5 JP 2012528867A5 JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012528867 A5 JP2012528867 A5 JP 2012528867A5
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JP
Japan
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substituted
nucleotide
guanosine
deaza
cytosine
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JP2012514047A
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English (en)
Japanese (ja)
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JP2012528867A (ja
JP6275380B2 (ja
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Priority claimed from PCT/US2010/036923 external-priority patent/WO2010141483A2/en
Publication of JP2012528867A publication Critical patent/JP2012528867A/ja
Publication of JP2012528867A5 publication Critical patent/JP2012528867A5/ja
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Publication of JP6275380B2 publication Critical patent/JP6275380B2/ja
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JP2012514047A 2009-06-01 2010-06-01 Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 Expired - Fee Related JP6275380B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18292809P 2009-06-01 2009-06-01
US61/182,928 2009-06-01
PCT/US2010/036923 WO2010141483A2 (en) 2009-06-01 2010-06-01 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9

Publications (3)

Publication Number Publication Date
JP2012528867A JP2012528867A (ja) 2012-11-15
JP2012528867A5 true JP2012528867A5 (enExample) 2017-09-07
JP6275380B2 JP6275380B2 (ja) 2018-02-07

Family

ID=43298446

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012514047A Expired - Fee Related JP6275380B2 (ja) 2009-06-01 2010-06-01 Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化

Country Status (7)

Country Link
US (1) US8987221B2 (enExample)
EP (1) EP2437791B1 (enExample)
JP (1) JP6275380B2 (enExample)
CN (1) CN102612561A (enExample)
CA (1) CA2762206C (enExample)
ES (1) ES2624767T3 (enExample)
WO (1) WO2010141483A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
JP5813778B2 (ja) 2010-11-19 2015-11-17 イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
US20130096938A1 (en) * 2011-10-10 2013-04-18 Abbott Biotechnology Ltd. Managing healthcare services
EP2852388A4 (en) * 2012-05-23 2016-01-13 Univ Johns Hopkins COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
WO2014082254A1 (en) * 2012-11-29 2014-06-05 Changchun Huapu Biotechnology Co., Ltd Inhibitory oligonucleotide and use thereof
KR101898177B1 (ko) * 2013-01-08 2018-09-12 이데라 파마슈티칼즈, 인코포레이티드 톨－유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 （ｉｒｏ） 화합물
EP2754714A1 (en) * 2013-01-14 2014-07-16 Sarepta Therapeutics, Inc. Inhibitory oligonucleotides and their use in therapy
US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
US20190046638A1 (en) 2016-04-01 2019-02-14 Checkmate Pharmaceuticals, Inc. Fc RECEPTOR-MEDIATED DRUG DELIVERY
EP3468605A4 (en) 2016-06-08 2020-01-08 President and Fellows of Harvard College MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
AU2018364542A1 (en) 2017-11-08 2020-04-16 President And Fellows Of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses
EP3752194A4 (en) 2018-02-13 2022-03-16 Checkmate Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
SG11202009647VA (en) 2018-04-09 2020-10-29 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US6096722A (en) * 1990-08-14 2000-08-01 Isis Pharmaceuticals Inc. Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases
US7276489B2 (en) 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
WO2005072290A2 (en) * 2004-01-23 2005-08-11 Joslin Diabetes Center Methods of treating, reducing, or preventing autoimmune conditions
CN101340931A (zh) * 2005-09-27 2009-01-07 科利制药公司 使用连接寡核苷酸调节tlr介导的免疫应答
US8383598B2 (en) * 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
CN101287742B (zh) * 2005-10-12 2016-01-06 艾德拉药物股份有限公司 基于变异应答调制Toll样受体的免疫调节寡核苷酸(IRO)化合物
US8426375B2 (en) * 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
PL2154144T3 (pl) * 2008-08-06 2015-04-30 Changchun Huapu Biotechnology Co Ltd Oligonukleotydy i ich zastosowanie

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