JP2012528867A5 - - Google Patents
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- JP2012528867A5 JP2012528867A5 JP2012514047A JP2012514047A JP2012528867A5 JP 2012528867 A5 JP2012528867 A5 JP 2012528867A5 JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012528867 A5 JP2012528867 A5 JP 2012528867A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- nucleotide
- guanosine
- deaza
- cytosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18292809P | 2009-06-01 | 2009-06-01 | |
| US61/182,928 | 2009-06-01 | ||
| PCT/US2010/036923 WO2010141483A2 (en) | 2009-06-01 | 2010-06-01 | Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528867A JP2012528867A (ja) | 2012-11-15 |
| JP2012528867A5 true JP2012528867A5 (enExample) | 2017-09-07 |
| JP6275380B2 JP6275380B2 (ja) | 2018-02-07 |
Family
ID=43298446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514047A Expired - Fee Related JP6275380B2 (ja) | 2009-06-01 | 2010-06-01 | Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8987221B2 (enExample) |
| EP (1) | EP2437791B1 (enExample) |
| JP (1) | JP6275380B2 (enExample) |
| CN (1) | CN102612561A (enExample) |
| CA (1) | CA2762206C (enExample) |
| ES (1) | ES2624767T3 (enExample) |
| WO (1) | WO2010141483A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| CN107012149A (zh) | 2010-11-19 | 2017-08-04 | 艾德拉药物股份有限公司 | 调控基于toll‑样受体的免疫应答的免疫调节寡核苷酸(iro)化合物 |
| US20130096938A1 (en) * | 2011-10-10 | 2013-04-18 | Abbott Biotechnology Ltd. | Managing healthcare services |
| EP2852388A4 (en) * | 2012-05-23 | 2016-01-13 | Univ Johns Hopkins | COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| JP6106280B2 (ja) * | 2012-11-29 | 2017-03-29 | Ｓｂｉバイオテック株式会社 | 阻害性オリゴヌクレオチド及びその使用 |
| AU2014205544B2 (en) * | 2013-01-08 | 2018-07-12 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| EP2754714A1 (en) * | 2013-01-14 | 2014-07-16 | Sarepta Therapeutics, Inc. | Inhibitory oligonucleotides and their use in therapy |
| WO2016081911A2 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| US20190046638A1 (en) | 2016-04-01 | 2019-02-14 | Checkmate Pharmaceuticals, Inc. | Fc RECEPTOR-MEDIATED DRUG DELIVERY |
| EP3468605A4 (en) | 2016-06-08 | 2020-01-08 | President and Fellows of Harvard College | MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| JP2021502381A (ja) | 2017-11-08 | 2021-01-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ウイルスベクター誘発性炎症反応を阻害するための組成物および方法 |
| WO2019160866A2 (en) | 2018-02-13 | 2019-08-22 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| BR112020020479A2 (pt) | 2018-04-09 | 2021-01-12 | Checkmate Pharmaceuticals | Empacotamento de oligonucleotídeos em partículas similares a vírus |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399676A (en) * | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
| US6096722A (en) * | 1990-08-14 | 2000-08-01 | Isis Pharmaceuticals Inc. | Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| WO2005072290A2 (en) * | 2004-01-23 | 2005-08-11 | Joslin Diabetes Center | Methods of treating, reducing, or preventing autoimmune conditions |
| WO2007038720A2 (en) | 2005-09-27 | 2007-04-05 | Coley Pharmaceutical Gmbh | Modulation of tlr-mediated immune responses using adaptor oligonucleotides |
| ES2544877T3 (es) * | 2005-10-12 | 2015-09-04 | Idera Pharmaceuticals | Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll |
| US8426375B2 (en) * | 2005-10-12 | 2013-04-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| US8383598B2 (en) * | 2005-10-12 | 2013-02-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| EP2154144B1 (en) * | 2008-08-06 | 2014-05-07 | Changchun Huapu Biotechnology Co., Ltd. | Oligonucleotides and use thereof |
-
2010
- 2010-06-01 US US12/791,636 patent/US8987221B2/en active Active
- 2010-06-01 WO PCT/US2010/036923 patent/WO2010141483A2/en not_active Ceased
- 2010-06-01 CN CN2010800243380A patent/CN102612561A/zh active Pending
- 2010-06-01 CA CA2762206A patent/CA2762206C/en active Active
- 2010-06-01 ES ES10783933.4T patent/ES2624767T3/es active Active
- 2010-06-01 JP JP2012514047A patent/JP6275380B2/ja not_active Expired - Fee Related
- 2010-06-01 EP EP10783933.4A patent/EP2437791B1/en not_active Not-in-force
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