|
ES2544877T3
(es)
|
2005-10-12 |
2015-09-04 |
Idera Pharmaceuticals |
Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
|
|
CA2681038A1
(en)
*
|
2007-03-16 |
2008-09-25 |
University Of Florida Research Foundation |
Kinase protein binding inhibitors
|
|
EP3087988A3
(en)
*
|
2008-10-06 |
2017-03-01 |
Idera Pharmaceuticals, Inc. |
Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
|
|
BRPI0923225A2
(pt)
|
2008-12-02 |
2016-10-04 |
Chiralgen Ltd |
metodo para sintese de acidos nucleicos modificados no atomo de fosforo
|
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
|
JP2012516352A
(ja)
*
|
2009-01-30 |
2012-07-19 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Tlr9の合成アゴニスト
|
|
KR101856462B1
(ko)
|
2009-03-25 |
2018-05-10 |
보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 |
병원체에 대한 포유동물의 선천성 면역 저항성의 자극을 위한 조성물
|
|
EP2451461A4
(en)
|
2009-07-06 |
2013-05-29 |
Ontorii Inc |
NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
|
|
EP2451974A2
(en)
*
|
2009-07-08 |
2012-05-16 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
|
US10363251B2
(en)
|
2009-07-16 |
2019-07-30 |
Mallinckrodt Llc |
(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
|
|
PL2453895T3
(pl)
*
|
2009-07-16 |
2018-10-31 |
Mallinckrodt Llc |
(+)-morfinany jako antagonisty receptora toll-like 9 i ich zastosowania terapeutyczne
|
|
HUE026020T2
(en)
*
|
2009-08-27 |
2016-05-30 |
Idera Pharmaceuticals Inc |
Preparation for inhibiting gene expression and its uses
|
|
US9415046B2
(en)
|
2009-09-29 |
2016-08-16 |
Yale University |
Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
|
|
JP2011084517A
(ja)
*
|
2009-10-15 |
2011-04-28 |
Koreaki Taniguchi |
核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法
|
|
WO2011117353A1
(en)
*
|
2010-03-24 |
2011-09-29 |
Mirrx Therapeutics A/S |
Bivalent antisense oligonucleotides
|
|
WO2012008984A1
(en)
|
2010-07-16 |
2012-01-19 |
Mallinckrodt Llc |
(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
|
|
GB201014026D0
(en)
*
|
2010-08-20 |
2010-10-06 |
Ucl Business Plc |
Treatment
|
|
EP2617426B1
(en)
|
2010-09-17 |
2016-08-10 |
Japan Science and Technology Agency |
Inhibitor of hmgb protein-mediated immune response activation
|
|
DK2620428T3
(da)
|
2010-09-24 |
2019-07-01 |
Wave Life Sciences Ltd |
Asymmetrisk hjælpegruppe
|
|
CN107012149A
(zh)
|
2010-11-19 |
2017-08-04 |
艾德拉药物股份有限公司 |
调控基于toll‑样受体的免疫应答的免疫调节寡核苷酸(iro)化合物
|
|
GB201022049D0
(en)
*
|
2010-12-29 |
2011-02-02 |
Imp Innovations Ltd |
Methods
|
|
US8877722B2
(en)
|
2011-03-25 |
2014-11-04 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting gene expression and uses thereof
|
|
EP2709642A4
(en)
*
|
2011-05-16 |
2015-08-26 |
Haus Bioceuticals Inc |
THERAPEUTIC COMPOSITIONS OF CERTAIN HERBAL FORMULATIONS AND USES THEREOF
|
|
CN107365339A
(zh)
|
2011-07-19 |
2017-11-21 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
|
HK1200484A1
(zh)
|
2011-09-14 |
2015-08-07 |
Translate Bio Ma, Inc. |
多聚寡核苷酸化合物
|
|
DK2872147T3
(da)
|
2012-07-13 |
2023-02-20 |
Wave Life Sciences Ltd |
Fremgangsmåde til fremstilling af kirale oligonukleotider
|
|
SG11201500243WA
(en)
*
|
2012-07-13 |
2015-04-29 |
Shin Nippon Biomedical Lab Ltd |
Chiral nucleic acid adjuvant
|
|
WO2014010250A1
(en)
|
2012-07-13 |
2014-01-16 |
Chiralgen, Ltd. |
Asymmetric auxiliary group
|
|
US20150247141A1
(en)
*
|
2012-09-14 |
2015-09-03 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
CN103845731B
(zh)
*
|
2012-12-05 |
2015-12-02 |
复旦大学 |
抗st2/il-1r4抗体在制备防治瘙痒药物中的应用
|
|
CN103845730B
(zh)
*
|
2012-12-05 |
2015-12-09 |
复旦大学 |
抗st2/il-1 r4抗体在制备镇痛药物中的用途
|
|
AU2014205544B2
(en)
*
|
2013-01-08 |
2018-07-12 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
CN103961697A
(zh)
*
|
2013-02-05 |
2014-08-06 |
日东电工株式会社 |
粘膜给予用疫苗组合物
|
|
GB2514591A
(en)
*
|
2013-05-30 |
2014-12-03 |
Mologen Ag |
Predictive biomarker for cancer therapy
|
|
EP3095461A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3095459A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
WO2015108046A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
EP3094728B1
(en)
|
2014-01-16 |
2022-03-09 |
Wave Life Sciences Ltd. |
Chiral design
|
|
AU2015269412B2
(en)
|
2014-06-04 |
2020-03-12 |
Exicure Operating Company |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
|
WO2016044839A2
(en)
|
2014-09-19 |
2016-03-24 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
|
|
WO2016081911A2
(en)
|
2014-11-21 |
2016-05-26 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
|
SK500652015A3
(sk)
|
2015-10-15 |
2017-05-03 |
Ústav Polymérov Sav |
Spôsob úpravy funkčného stavu ľubovoľnej mRNA umožňujúci jej selektívne a špecifické rozpoznanie
|
|
CN105541947A
(zh)
*
|
2016-01-11 |
2016-05-04 |
中国人民解放军第三军医大学第一附属医院 |
拮抗tlr7/8及tlr9活化的药物分子及用途
|
|
CN105597079A
(zh)
*
|
2016-01-11 |
2016-05-25 |
中国人民解放军第三军医大学第一附属医院 |
用于治疗银屑病的药物
|
|
EP3468605A4
(en)
|
2016-06-08 |
2020-01-08 |
President and Fellows of Harvard College |
MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS
|
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
|
US11370794B2
(en)
|
2016-11-11 |
2022-06-28 |
Dynavax Technologies Corporation |
Toll-like receptor antagonist compounds and methods of use
|
|
KR102596343B1
(ko)
*
|
2016-11-23 |
2023-10-31 |
베를린 큐어스 게엠베하 |
TLR9 활성화의 저해 및/또는 억제에 사용되는 압타머(aptamer)
|
|
WO2018209270A1
(en)
|
2017-05-11 |
2018-11-15 |
Northwestern University |
Adoptive cell therapy using spherical nucleic acids (snas)
|
|
US11473145B2
(en)
|
2017-07-27 |
2022-10-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for determining whether a patient suffering from rhabdomyolysis achieves a response with a TLR9 antagonist
|
|
JP2021502381A
(ja)
|
2017-11-08 |
2021-01-28 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ウイルスベクター誘発性炎症反応を阻害するための組成物および方法
|
|
CR20200649A
(es)
*
|
2018-05-25 |
2021-05-11 |
Primmune Therapeutics Inc |
Agosnistas de tlr7
|
|
PH12022551280A1
(en)
|
2019-11-26 |
2024-01-08 |
Primmune Therapeutics Inc |
Tlr7 agonists
|
|
US12686870B2
(en)
|
2020-01-10 |
2026-07-21 |
Sbi Biotech Co., Ltd. |
TLR9 agonists
|