CA2694973A1 - Toll like receptor modulators - Google Patents
Toll like receptor modulators Download PDFInfo
- Publication number
- CA2694973A1 CA2694973A1 CA2694973A CA2694973A CA2694973A1 CA 2694973 A1 CA2694973 A1 CA 2694973A1 CA 2694973 A CA2694973 A CA 2694973A CA 2694973 A CA2694973 A CA 2694973A CA 2694973 A1 CA2694973 A1 CA 2694973A1
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- Prior art keywords
- disease
- nucleotide
- tlr9
- disorder
- independently
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| JP2010522697A (ja) * | 2007-03-16 | 2010-07-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション | キナーゼタンパク質結合阻害剤 |
| CN102281880A (zh) * | 2008-10-06 | 2011-12-14 | 艾德拉药物股份有限公司 | 类Toll受体抑制剂在高胆固醇血症和高脂血症及相关疾病的预防和治疗中的用途 |
| US9394333B2 (en) | 2008-12-02 | 2016-07-19 | Wave Life Sciences Japan | Method for the synthesis of phosphorus atom modified nucleic acids |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| RU2011135993A (ru) * | 2009-01-30 | 2013-03-10 | Идера Фармасьютикалз, Инк. | Новые синтетические агонисты tlr9 |
| ES2534947T3 (es) | 2009-03-25 | 2015-04-30 | The Board Of Regents Of The University Of Texas System | Composiciones para la estimulación de resistencia inmunitaria innata de mamíferos a patógenos |
| MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| WO2011005942A2 (en) * | 2009-07-08 | 2011-01-13 | Idera Pharmaceuticals, Inc. | Oligonucleotide-based compounds as inhibitors of toll-like receptors |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| US20110015219A1 (en) * | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof |
| HRP20150566T1 (hr) * | 2009-08-27 | 2015-07-17 | Idera Pharmaceuticals, Inc. | Kompozicija za inhibiciju ekspresije gena i njegova upotreba |
| WO2011041311A2 (en) * | 2009-09-29 | 2011-04-07 | Yale University | Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods |
| JP2011084517A (ja) * | 2009-10-15 | 2011-04-28 | Koreaki Taniguchi | 核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法 |
| WO2011117353A1 (en) * | 2010-03-24 | 2011-09-29 | Mirrx Therapeutics A/S | Bivalent antisense oligonucleotides |
| PL2593095T3 (pl) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
| GB201014026D0 (en) * | 2010-08-20 | 2010-10-06 | Ucl Business Plc | Treatment |
| WO2012036215A1 (ja) | 2010-09-17 | 2012-03-22 | Taniguchi Tadatsugu | Ｈｍｇｂタンパクによって仲介される免疫応答の活性化の抑制剤及びスクリーニング方法 |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| EP3213770B1 (en) | 2010-11-19 | 2021-02-24 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| GB201022049D0 (en) * | 2010-12-29 | 2011-02-02 | Imp Innovations Ltd | Methods |
| US8877722B2 (en) | 2011-03-25 | 2014-11-04 | Idera Pharmaceuticals, Inc. | Compositions for inhibiting gene expression and uses thereof |
| US9050359B2 (en) * | 2011-05-16 | 2015-06-09 | Haus Bioceuticals Inc. | Compositions of herbal formulations and uses thereof |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US9580708B2 (en) | 2011-09-14 | 2017-02-28 | Rana Therapeutics, Inc. | Multimeric oligonucleotides compounds |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| KR20240148947A (ko) | 2012-07-13 | 2024-10-11 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| SG11201500243WA (en) * | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| EP2895200B1 (en) | 2012-09-14 | 2019-11-06 | Translate Bio MA, Inc. | Multimeric oligonucleotide compounds |
| CN103845731B (zh) * | 2012-12-05 | 2015-12-02 | 复旦大学 | 抗st2/il-1r4抗体在制备防治瘙痒药物中的应用 |
| CN103845730B (zh) * | 2012-12-05 | 2015-12-09 | 复旦大学 | 抗st2/il-1 r4抗体在制备镇痛药物中的用途 |
| WO2014110081A1 (en) * | 2013-01-08 | 2014-07-17 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| JP2014169275A (ja) * | 2013-02-05 | 2014-09-18 | Nitto Denko Corp | 粘膜投与用ワクチン組成物 |
| GB2514591A (en) * | 2013-05-30 | 2014-12-03 | Mologen Ag | Predictive biomarker for cancer therapy |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| SK500652015A3 (sk) | 2015-10-15 | 2017-05-03 | Ústav Polymérov Sav | Spôsob úpravy funkčného stavu ľubovoľnej mRNA umožňujúci jej selektívne a špecifické rozpoznanie |
| CN105541947A (zh) * | 2016-01-11 | 2016-05-04 | 中国人民解放军第三军医大学第一附属医院 | 拮抗tlr7/8及tlr9活化的药物分子及用途 |
| CN105597079A (zh) * | 2016-01-11 | 2016-05-25 | 中国人民解放军第三军医大学第一附属医院 | 用于治疗银屑病的药物 |
| CN114807152A (zh) | 2016-06-08 | 2022-07-29 | 哈佛学院院长及董事 | 工程化病毒载体减少了炎症和免疫反应的诱导 |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| US11370794B2 (en) | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
| WO2018095697A1 (en) | 2016-11-23 | 2018-05-31 | Berlin Cures Holding Ag | Aptamers for use in inhibition and/or suppression of tlr9 activation |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
| ES2910974T3 (es) | 2017-07-27 | 2022-05-17 | Inst Nat Sante Rech Med | Métodos para determinar si un paciente que padece rabdomiólisis logra una respuesta con un antagonista de TLR9 |
| EP3707262A1 (en) | 2017-11-08 | 2020-09-16 | President and Fellows of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| US11059824B2 (en) | 2018-05-25 | 2021-07-13 | Primmune Therapeutics, Inc. | Substituted purines as TLR7 agonists |
| IL293293A (en) | 2019-11-26 | 2022-07-01 | Primmune Therapeutics Inc | Tlr7 agonists |
| CN114981436A (zh) * | 2020-01-10 | 2022-08-30 | Sbi生物技术有限公司 | 新tlr9激动剂 |
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| JPH08501928A (ja) * | 1992-07-02 | 1996-03-05 | ハイブライドン インコーポレイテッド | 治療剤としての自己安定化オリゴヌクレオチド |
| US5912332A (en) | 1996-07-26 | 1999-06-15 | Hybridon, Inc. | Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| JP5268214B2 (ja) * | 1999-08-13 | 2013-08-21 | イデラ ファーマシューティカルズ インコーポレイテッド | ヌクレオシドの位置的修飾によるオリゴヌクレオチドＣｐＧ−媒体免疫刺激の変調 |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
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| MX2010001785A (es) | 2010-03-10 |
| US20090053148A1 (en) | 2009-02-26 |
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| US8853375B2 (en) | 2014-10-07 |
| AU2008286735A1 (en) | 2009-02-19 |
| WO2009023819A2 (en) | 2009-02-19 |
| JP2010536787A (ja) | 2010-12-02 |
| WO2009023819A3 (en) | 2009-04-09 |
| EP2179061B1 (en) | 2012-10-03 |
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