CN101821412A - Toll样受体调控剂 - Google Patents

Toll样受体调控剂 Download PDF

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Publication number
CN101821412A
CN101821412A CN200880111523A CN200880111523A CN101821412A CN 101821412 A CN101821412 A CN 101821412A CN 200880111523 A CN200880111523 A CN 200880111523A CN 200880111523 A CN200880111523 A CN 200880111523A CN 101821412 A CN101821412 A CN 101821412A
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China
Prior art keywords
disease
tlr9
nucleotide
tlr
nucleotides
Prior art date
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Pending
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CN200880111523A
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English (en)
Chinese (zh)
Inventor
艾卡姆巴·R·坎迪马拉
拉克施米·巴加特
马利卡朱纳·普塔
王大庆
萨迪尔·阿格拉沃尔
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Aceragen Inc
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Idera Pharmaceuticals Inc
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Publication date
Application filed by Idera Pharmaceuticals Inc filed Critical Idera Pharmaceuticals Inc
Publication of CN101821412A publication Critical patent/CN101821412A/zh
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    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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CN200880111523A 2007-08-15 2008-08-15 Toll样受体调控剂 Pending CN101821412A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95589507P 2007-08-15 2007-08-15
US60/955,895 2007-08-15
PCT/US2008/073280 WO2009023819A2 (en) 2007-08-15 2008-08-15 Toll like receptor modulators

Publications (1)

Publication Number Publication Date
CN101821412A true CN101821412A (zh) 2010-09-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880111523A Pending CN101821412A (zh) 2007-08-15 2008-08-15 Toll样受体调控剂

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US (1) US8853375B2 (enExample)
EP (1) EP2179061B1 (enExample)
JP (1) JP2010536787A (enExample)
KR (1) KR20100066512A (enExample)
CN (1) CN101821412A (enExample)
AU (1) AU2008286735A1 (enExample)
CA (1) CA2694973A1 (enExample)
MX (1) MX2010001785A (enExample)
WO (1) WO2009023819A2 (enExample)

Cited By (6)

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CN103845731A (zh) * 2012-12-05 2014-06-11 复旦大学 抗st2/il-1r4抗体在制备防治瘙痒药物中的应用
CN103845730A (zh) * 2012-12-05 2014-06-11 复旦大学 抗st2/il-1 r4抗体在制备镇痛药物中的用途
CN103961697A (zh) * 2013-02-05 2014-08-06 日东电工株式会社 粘膜给予用疫苗组合物
CN105541947A (zh) * 2016-01-11 2016-05-04 中国人民解放军第三军医大学第一附属医院 拮抗tlr7/8及tlr9活化的药物分子及用途
CN105597079A (zh) * 2016-01-11 2016-05-25 中国人民解放军第三军医大学第一附属医院 用于治疗银屑病的药物
CN108853403A (zh) * 2011-05-16 2018-11-23 豪斯生物药业公司 特定草药制剂的治疗性组合物及其用途

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CN102281880A (zh) * 2008-10-06 2011-12-14 艾德拉药物股份有限公司 类Toll受体抑制剂在高胆固醇血症和高脂血症及相关疾病的预防和治疗中的用途
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RU2011135993A (ru) * 2009-01-30 2013-03-10 Идера Фармасьютикалз, Инк. Новые синтетические агонисты tlr9
ES2534947T3 (es) 2009-03-25 2015-04-30 The Board Of Regents Of The University Of Texas System Composiciones para la estimulación de resistencia inmunitaria innata de mamíferos a patógenos
MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
WO2011005942A2 (en) * 2009-07-08 2011-01-13 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
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US20110015219A1 (en) * 2009-07-16 2011-01-20 Mallinckrodt Inc. (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof
HRP20150566T1 (hr) * 2009-08-27 2015-07-17 Idera Pharmaceuticals, Inc. Kompozicija za inhibiciju ekspresije gena i njegova upotreba
WO2011041311A2 (en) * 2009-09-29 2011-04-07 Yale University Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
JP2011084517A (ja) * 2009-10-15 2011-04-28 Koreaki Taniguchi 核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法
WO2011117353A1 (en) * 2010-03-24 2011-09-29 Mirrx Therapeutics A/S Bivalent antisense oligonucleotides
PL2593095T3 (pl) 2010-07-16 2019-12-31 Mallinckrodt Llc (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania
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WO2012036215A1 (ja) 2010-09-17 2012-03-22 Taniguchi Tadatsugu Ｈｍｇｂタンパクによって仲介される免疫応答の活性化の抑制剤及びスクリーニング方法
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
EP3213770B1 (en) 2010-11-19 2021-02-24 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
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KR20240148947A (ko) 2012-07-13 2024-10-11 웨이브 라이프 사이언시스 리미티드 키랄 제어
SG11201500243WA (en) * 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
EP2895200B1 (en) 2012-09-14 2019-11-06 Translate Bio MA, Inc. Multimeric oligonucleotide compounds
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