CN101821412A - Toll样受体调控剂 - Google Patents

Toll样受体调控剂 Download PDF

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Publication number
CN101821412A
CN101821412A CN200880111523A CN200880111523A CN101821412A CN 101821412 A CN101821412 A CN 101821412A CN 200880111523 A CN200880111523 A CN 200880111523A CN 200880111523 A CN200880111523 A CN 200880111523A CN 101821412 A CN101821412 A CN 101821412A
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China
Prior art keywords
disease
tlr9
nucleotide
tlr
nucleotides
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Pending
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CN200880111523A
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English (en)
Chinese (zh)
Inventor
艾卡姆巴·R·坎迪马拉
拉克施米·巴加特
马利卡朱纳·普塔
王大庆
萨迪尔·阿格拉沃尔
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Aceragen Inc
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Idera Pharmaceuticals Inc
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Publication date
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Publication of CN101821412A publication Critical patent/CN101821412A/zh
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    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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CN200880111523A 2007-08-15 2008-08-15 Toll样受体调控剂 Pending CN101821412A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95589507P 2007-08-15 2007-08-15
US60/955,895 2007-08-15
PCT/US2008/073280 WO2009023819A2 (en) 2007-08-15 2008-08-15 Toll like receptor modulators

Publications (1)

Publication Number Publication Date
CN101821412A true CN101821412A (zh) 2010-09-01

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Application Number Title Priority Date Filing Date
CN200880111523A Pending CN101821412A (zh) 2007-08-15 2008-08-15 Toll样受体调控剂

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US (1) US8853375B2 (enExample)
EP (1) EP2179061B1 (enExample)
JP (1) JP2010536787A (enExample)
KR (1) KR20100066512A (enExample)
CN (1) CN101821412A (enExample)
AU (1) AU2008286735A1 (enExample)
CA (1) CA2694973A1 (enExample)
MX (1) MX2010001785A (enExample)
WO (1) WO2009023819A2 (enExample)

Cited By (6)

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CN103845730A (zh) * 2012-12-05 2014-06-11 复旦大学 抗st2/il-1 r4抗体在制备镇痛药物中的用途
CN103845731A (zh) * 2012-12-05 2014-06-11 复旦大学 抗st2/il-1r4抗体在制备防治瘙痒药物中的应用
CN103961697A (zh) * 2013-02-05 2014-08-06 日东电工株式会社 粘膜给予用疫苗组合物
CN105541947A (zh) * 2016-01-11 2016-05-04 中国人民解放军第三军医大学第一附属医院 拮抗tlr7/8及tlr9活化的药物分子及用途
CN105597079A (zh) * 2016-01-11 2016-05-25 中国人民解放军第三军医大学第一附属医院 用于治疗银屑病的药物
CN108853403A (zh) * 2011-05-16 2018-11-23 豪斯生物药业公司 特定草药制剂的治疗性组合物及其用途

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EP2349271A2 (en) * 2008-10-06 2011-08-03 Idera Pharmaceuticals, Inc. Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
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EP2391718A2 (en) * 2009-01-30 2011-12-07 Idera Pharmaceuticals, Inc. Novel synthetic agonists of tlr9
AU2010229835B2 (en) 2009-03-25 2015-01-15 The Board Of Regents Of The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
WO2011005942A2 (en) * 2009-07-08 2011-01-13 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
US9562014B2 (en) 2009-07-16 2017-02-07 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
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US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
EP2470656B1 (en) * 2009-08-27 2015-05-06 Idera Pharmaceuticals, Inc. Composition for inhibiting gene expression and uses thereof
WO2011041311A2 (en) * 2009-09-29 2011-04-07 Yale University Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
JP2011084517A (ja) * 2009-10-15 2011-04-28 Koreaki Taniguchi 核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法
EP2550360B1 (en) * 2010-03-24 2017-08-30 Mirrx Therapeutics A/s Bivalent antisense oligonucleotides
GB201014026D0 (en) * 2010-08-20 2010-10-06 Ucl Business Plc Treatment
JP5686814B2 (ja) 2010-09-17 2015-03-18 独立行政法人科学技術振興機構 Ｈｍｇｂタンパクによって仲介される免疫応答の活性化の抑制剤及びスクリーニング方法
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
US8486908B2 (en) 2010-11-19 2013-07-16 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
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US8877722B2 (en) * 2011-03-25 2014-11-04 Idera Pharmaceuticals, Inc. Compositions for inhibiting gene expression and uses thereof
BR112014001244A2 (pt) 2011-07-19 2017-02-21 Wave Life Sciences Pte Ltd métodos para a síntese de ácidos nucléicos funcionalizados
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BR112015000723A2 (pt) * 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
CN112007045A (zh) 2012-07-13 2020-12-01 波涛生命科学有限公司 手性控制
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
WO2014043544A1 (en) 2012-09-14 2014-03-20 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
EP2943251B1 (en) * 2013-01-08 2018-10-10 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
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