JP2010536787A - Ｔｏｌｌ様受容体モジュレータ - Google Patents

Ｔｏｌｌ様受容体モジュレータ Download PDF

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Publication number
JP2010536787A
JP2010536787A JP2010521194A JP2010521194A JP2010536787A JP 2010536787 A JP2010536787 A JP 2010536787A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010536787 A JP2010536787 A JP 2010536787A
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Prior art keywords
disease
nucleotide
tlr9
tlr
disorder
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JP2010521194A
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Japanese (ja)
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JP2010536787A5 (enExample
Inventor
カンディマラ，エカンバー，アール．
バガット，ラクシュミ
プッタ，マリカージュナ
ワン，ダキン
アグラワル，サディール
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Aceragen Inc
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Idera Pharmaceuticals Inc
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Publication of JP2010536787A publication Critical patent/JP2010536787A/ja
Publication of JP2010536787A5 publication Critical patent/JP2010536787A5/ja
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
JP2010521194A 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ Withdrawn JP2010536787A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95589507P 2007-08-15 2007-08-15
PCT/US2008/073280 WO2009023819A2 (en) 2007-08-15 2008-08-15 Toll like receptor modulators

Publications (2)

Publication Number Publication Date
JP2010536787A true JP2010536787A (ja) 2010-12-02
JP2010536787A5 JP2010536787A5 (enExample) 2011-09-29

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Application Number Title Priority Date Filing Date
JP2010521194A Withdrawn JP2010536787A (ja) 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ

Country Status (9)

Country Link
US (1) US8853375B2 (enExample)
EP (1) EP2179061B1 (enExample)
JP (1) JP2010536787A (enExample)
KR (1) KR20100066512A (enExample)
CN (1) CN101821412A (enExample)
AU (1) AU2008286735A1 (enExample)
CA (1) CA2694973A1 (enExample)
MX (1) MX2010001785A (enExample)
WO (1) WO2009023819A2 (enExample)

Cited By (4)

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JP2013507905A (ja) * 2009-08-27 2013-03-07 イデラ ファーマシューティカルズ インコーポレイテッド 遺伝子発現を阻害する組成物およびその使用
JP2014527819A (ja) * 2011-09-14 2014-10-23 ラナ セラピューティクス インコーポレイテッド 多量体オリゴヌクレオチド化合物
JP2016510213A (ja) * 2013-01-08 2016-04-07 イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
US9790494B2 (en) 2012-09-14 2017-10-17 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers

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ES2542989T3 (es) 2005-10-12 2015-08-13 Idera Pharmaceuticals, Inc. Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
EP2136829A4 (en) * 2007-03-16 2012-07-18 Univ Florida KINASE PROTEIN BINDING INHIBITORS
KR20110071108A (ko) * 2008-10-06 2011-06-28 이데라 파마슈티칼즈, 인코포레이티드 고콜레스테롤혈증 및 고지혈증 및 이에 관련된 질병의 예방 및 치료에서 톨-유사 수용체의 저해제의 용도
RU2015151857A (ru) 2008-12-02 2019-01-15 Уэйв Лайф Сайенсес Джапан, Инк. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
BRPI1008063A2 (pt) * 2009-01-30 2015-08-25 Idera Pharmaceuticals Inc Agonistas sinteticas de tlr9
MX2011010050A (es) 2009-03-25 2011-12-14 Univ Texas Composiciones para estimulación de resistencia inmune innata de mamiferos a patógenos.
MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
EP2451974A2 (en) * 2009-07-08 2012-05-16 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
WO2011009015A1 (en) * 2009-07-16 2011-01-20 Mallinckrodt Inc. (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US9415046B2 (en) 2009-09-29 2016-08-16 Yale University Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
JP2011084517A (ja) * 2009-10-15 2011-04-28 Koreaki Taniguchi 核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法
WO2011117353A1 (en) * 2010-03-24 2011-09-29 Mirrx Therapeutics A/S Bivalent antisense oligonucleotides
EP2593095B1 (en) 2010-07-16 2019-03-27 Mallinckrodt LLC (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
GB201014026D0 (en) * 2010-08-20 2010-10-06 Ucl Business Plc Treatment
JP5686814B2 (ja) 2010-09-17 2015-03-18 独立行政法人科学技術振興機構 Ｈｍｇｂタンパクによって仲介される免疫応答の活性化の抑制剤及びスクリーニング方法
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
US8486908B2 (en) 2010-11-19 2013-07-16 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
GB201022049D0 (en) * 2010-12-29 2011-02-02 Imp Innovations Ltd Methods
US8877722B2 (en) * 2011-03-25 2014-11-04 Idera Pharmaceuticals, Inc. Compositions for inhibiting gene expression and uses thereof
WO2013106068A2 (en) * 2011-05-16 2013-07-18 Haus Bioceuticals, Inc. Therapeutic compositions of specified herbal formulations and uses thereof
EP3248982A1 (en) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Thiosulfonate reagents for the synthesis of functionalized nucleic acids
CA2879066C (en) * 2012-07-13 2019-08-13 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
CA2879023C (en) 2012-07-13 2017-03-28 Wave Life Sciences Japan Asymmetric auxiliary group
CN104661664B (zh) 2012-07-13 2020-07-03 波涛生命科学有限公司 手性控制
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