JP2010536787A - Ｔｏｌｌ様受容体モジュレータ - Google Patents

Ｔｏｌｌ様受容体モジュレータ Download PDF

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Publication number
JP2010536787A
JP2010536787A JP2010521194A JP2010521194A JP2010536787A JP 2010536787 A JP2010536787 A JP 2010536787A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010536787 A JP2010536787 A JP 2010536787A
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Prior art keywords
disease
nucleotide
tlr9
tlr
disorder
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JP2010521194A
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Japanese (ja)
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JP2010536787A5 (enExample
Inventor
カンディマラ，エカンバー，アール．
バガット，ラクシュミ
プッタ，マリカージュナ
ワン，ダキン
アグラワル，サディール
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Aceragen Inc
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Idera Pharmaceuticals Inc
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Publication of JP2010536787A publication Critical patent/JP2010536787A/ja
Publication of JP2010536787A5 publication Critical patent/JP2010536787A5/ja
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
JP2010521194A 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ Withdrawn JP2010536787A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95589507P 2007-08-15 2007-08-15
PCT/US2008/073280 WO2009023819A2 (en) 2007-08-15 2008-08-15 Toll like receptor modulators

Publications (2)

Publication Number Publication Date
JP2010536787A true JP2010536787A (ja) 2010-12-02
JP2010536787A5 JP2010536787A5 (enExample) 2011-09-29

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JP2010521194A Withdrawn JP2010536787A (ja) 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ

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Country Link
US (1) US8853375B2 (enExample)
EP (1) EP2179061B1 (enExample)
JP (1) JP2010536787A (enExample)
KR (1) KR20100066512A (enExample)
CN (1) CN101821412A (enExample)
AU (1) AU2008286735A1 (enExample)
CA (1) CA2694973A1 (enExample)
MX (1) MX2010001785A (enExample)
WO (1) WO2009023819A2 (enExample)

Cited By (4)

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JP2013507905A (ja) * 2009-08-27 2013-03-07 イデラ ファーマシューティカルズ インコーポレイテッド 遺伝子発現を阻害する組成物およびその使用
JP2014527819A (ja) * 2011-09-14 2014-10-23 ラナ セラピューティクス インコーポレイテッド 多量体オリゴヌクレオチド化合物
JP2016510213A (ja) * 2013-01-08 2016-04-07 イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
US9790494B2 (en) 2012-09-14 2017-10-17 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers

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CN104278037B (zh) 2005-10-12 2020-09-15 艾德拉药物股份有限公司 基于变异应答调制Toll样受体的免疫调节寡核苷酸(IRO)化合物
CN101801401A (zh) * 2007-03-16 2010-08-11 佛罗里达大学研究基金会 激酶蛋白质结合抑制剂
EP2349271A2 (en) * 2008-10-06 2011-08-03 Idera Pharmaceuticals, Inc. Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
WO2010088395A2 (en) * 2009-01-30 2010-08-05 Idera Pharmaceuticals, Inc. Novel synthetic agonists of tlr9
CN103800906B (zh) 2009-03-25 2017-09-22 德克萨斯大学系统董事会 用于刺激哺乳动物对病原体的先天免疫抵抗力的组合物
US9744183B2 (en) 2009-07-06 2017-08-29 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
US20110009477A1 (en) * 2009-07-08 2011-01-13 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
CA2768236C (en) * 2009-07-16 2018-05-22 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2011041311A2 (en) * 2009-09-29 2011-04-07 Yale University Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
JP2011084517A (ja) * 2009-10-15 2011-04-28 Koreaki Taniguchi 核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法
US20130079505A1 (en) * 2010-03-24 2013-03-28 Mirrx Therapeutics A/S Bivalent antisense oligonucleotides
WO2012008984A1 (en) 2010-07-16 2012-01-19 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
GB201014026D0 (en) * 2010-08-20 2010-10-06 Ucl Business Plc Treatment
EP2617426B1 (en) 2010-09-17 2016-08-10 Japan Science and Technology Agency Inhibitor of hmgb protein-mediated immune response activation
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
EP2640420B1 (en) 2010-11-19 2018-08-15 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
GB201022049D0 (en) * 2010-12-29 2011-02-02 Imp Innovations Ltd Methods
US8877722B2 (en) 2011-03-25 2014-11-04 Idera Pharmaceuticals, Inc. Compositions for inhibiting gene expression and uses thereof
CN108853403A (zh) * 2011-05-16 2018-11-23 豪斯生物药业公司 特定草药制剂的治疗性组合物及其用途
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
BR112015000723A2 (pt) * 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
PT2872485T (pt) 2012-07-13 2021-03-05 Wave Life Sciences Ltd Grupo auxiliar assimétrico
KR102712879B1 (ko) 2012-07-13 2024-10-04 웨이브 라이프 사이언시스 리미티드 키랄 제어
CN103845731B (zh) * 2012-12-05 2015-12-02 复旦大学 抗st2/il-1r4抗体在制备防治瘙痒药物中的应用
CN103845730B (zh) * 2012-12-05 2015-12-09 复旦大学 抗st2/il-1 r4抗体在制备镇痛药物中的用途
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