JP2010536787A - Ｔｏｌｌ様受容体モジュレータ - Google Patents

Ｔｏｌｌ様受容体モジュレータ Download PDF

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Publication number
JP2010536787A
JP2010536787A JP2010521194A JP2010521194A JP2010536787A JP 2010536787 A JP2010536787 A JP 2010536787A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010536787 A JP2010536787 A JP 2010536787A
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Japan
Prior art keywords
disease
nucleotide
tlr9
tlr
disorder
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JP2010521194A
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Japanese (ja)
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JP2010536787A5 (enExample
Inventor
カンディマラ，エカンバー，アール．
バガット，ラクシュミ
プッタ，マリカージュナ
ワン，ダキン
アグラワル，サディール
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Aceragen Inc
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Idera Pharmaceuticals Inc
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Publication of JP2010536787A publication Critical patent/JP2010536787A/ja
Publication of JP2010536787A5 publication Critical patent/JP2010536787A5/ja
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
JP2010521194A 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ Withdrawn JP2010536787A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95589507P 2007-08-15 2007-08-15
PCT/US2008/073280 WO2009023819A2 (en) 2007-08-15 2008-08-15 Toll like receptor modulators

Publications (2)

Publication Number Publication Date
JP2010536787A true JP2010536787A (ja) 2010-12-02
JP2010536787A5 JP2010536787A5 (enExample) 2011-09-29

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JP2010521194A Withdrawn JP2010536787A (ja) 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ

Country Status (9)

Country Link
US (1) US8853375B2 (enExample)
EP (1) EP2179061B1 (enExample)
JP (1) JP2010536787A (enExample)
KR (1) KR20100066512A (enExample)
CN (1) CN101821412A (enExample)
AU (1) AU2008286735A1 (enExample)
CA (1) CA2694973A1 (enExample)
MX (1) MX2010001785A (enExample)
WO (1) WO2009023819A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2013507905A (ja) * 2009-08-27 2013-03-07 イデラ ファーマシューティカルズ インコーポレイテッド 遺伝子発現を阻害する組成物およびその使用
JP2014527819A (ja) * 2011-09-14 2014-10-23 ラナ セラピューティクス インコーポレイテッド 多量体オリゴヌクレオチド化合物
JP2016510213A (ja) * 2013-01-08 2016-04-07 イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
US9790494B2 (en) 2012-09-14 2017-10-17 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers

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CN101287742B (zh) 2005-10-12 2016-01-06 艾德拉药物股份有限公司 基于变异应答调制Toll样受体的免疫调节寡核苷酸(IRO)化合物
JP2010522697A (ja) * 2007-03-16 2010-07-08 ユニバーシティ オブ フロリダ リサーチ ファウンデーション キナーゼタンパク質結合阻害剤
CN102281880A (zh) * 2008-10-06 2011-12-14 艾德拉药物股份有限公司 类Toll受体抑制剂在高胆固醇血症和高脂血症及相关疾病的预防和治疗中的用途
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
RU2011135993A (ru) * 2009-01-30 2013-03-10 Идера Фармасьютикалз, Инк. Новые синтетические агонисты tlr9
AU2010229835B2 (en) 2009-03-25 2015-01-15 The Board Of Regents Of The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
WO2011005942A2 (en) * 2009-07-08 2011-01-13 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
TR201809739T4 (tr) * 2009-07-16 2018-07-23 Mallinckrodt Llc Toll benzeri reseptör 9 antagonistleri olarak (+)-morfinanlar ve bunların terapötik amaçlı kullanımları.
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US9415046B2 (en) 2009-09-29 2016-08-16 Yale University Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
JP2011084517A (ja) * 2009-10-15 2011-04-28 Koreaki Taniguchi 核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法
EP2550360B1 (en) * 2010-03-24 2017-08-30 Mirrx Therapeutics A/s Bivalent antisense oligonucleotides
ES2728701T3 (es) 2010-07-16 2019-10-28 Mallinckrodt Llc (+)-Morfinanos como antagonistas del receptor 9 de tipo Toll y aplicaciones terapéuticas de los mismos
GB201014026D0 (en) * 2010-08-20 2010-10-06 Ucl Business Plc Treatment
US9186371B2 (en) 2010-09-17 2015-11-17 Japan Science And Technology Agency Inhibitor of HMGB protein-mediated immune response activation, and screening method
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
JP5813778B2 (ja) 2010-11-19 2015-11-17 イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
GB201022049D0 (en) * 2010-12-29 2011-02-02 Imp Innovations Ltd Methods
US8877722B2 (en) * 2011-03-25 2014-11-04 Idera Pharmaceuticals, Inc. Compositions for inhibiting gene expression and uses thereof
US9050359B2 (en) * 2011-05-16 2015-06-09 Haus Bioceuticals Inc. Compositions of herbal formulations and uses thereof
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
CN112007045B (zh) 2012-07-13 2026-01-06 波涛生命科学有限公司 手性控制
JP6246121B2 (ja) * 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
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