CN102612561A - 使用tlr7和tlr9的免疫调节寡核苷酸(iro)拮抗剂强化自身免疫性及炎症性疾病治疗 - Google Patents

使用tlr7和tlr9的免疫调节寡核苷酸(iro)拮抗剂强化自身免疫性及炎症性疾病治疗 Download PDF

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CN102612561A
CN102612561A CN2010800243380A CN201080024338A CN102612561A CN 102612561 A CN102612561 A CN 102612561A CN 2010800243380 A CN2010800243380 A CN 2010800243380A CN 201080024338 A CN201080024338 A CN 201080024338A CN 102612561 A CN102612561 A CN 102612561A
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nucleotide
tnf
iro
inflammatory
disease
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朱富刚
埃卡姆巴·R·坎迪马拉
萨迪尔·阿格拉瓦尔
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Aceragen Inc
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Idera Pharmaceuticals Inc
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CN2010800243380A 2009-06-01 2010-06-01 使用tlr7和tlr9的免疫调节寡核苷酸(iro)拮抗剂强化自身免疫性及炎症性疾病治疗 Pending CN102612561A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18292809P 2009-06-01 2009-06-01
US61/182,928 2009-06-01
PCT/US2010/036923 WO2010141483A2 (en) 2009-06-01 2010-06-01 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9

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Publication Number Publication Date
CN102612561A true CN102612561A (zh) 2012-07-25

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CN2010800243380A Pending CN102612561A (zh) 2009-06-01 2010-06-01 使用tlr7和tlr9的免疫调节寡核苷酸(iro)拮抗剂强化自身免疫性及炎症性疾病治疗

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US (1) US8987221B2 (enExample)
EP (1) EP2437791B1 (enExample)
JP (1) JP6275380B2 (enExample)
CN (1) CN102612561A (enExample)
CA (1) CA2762206C (enExample)
ES (1) ES2624767T3 (enExample)
WO (1) WO2010141483A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014082254A1 (en) * 2012-11-29 2014-06-05 Changchun Huapu Biotechnology Co., Ltd Inhibitory oligonucleotide and use thereof
CN105051194A (zh) * 2013-01-14 2015-11-11 萨勒普塔医疗公司 抑制性寡核苷酸及其在治疗中的用途

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US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
US8486908B2 (en) 2010-11-19 2013-07-16 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
DE202012013155U1 (de) * 2011-10-10 2015-02-06 Abbvie Biotechnology Ltd. System zur Verwaltung von Gesundheitsdiensten
EP2852388A4 (en) * 2012-05-23 2016-01-13 Univ Johns Hopkins COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
EP2943251B1 (en) * 2013-01-08 2018-10-10 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
EP3220895B1 (en) 2014-11-21 2022-08-31 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
WO2017173334A1 (en) 2016-04-01 2017-10-05 Checkmate Pharmaceuticals, Inc. Fc receptor-mediated drug delivery
KR20190017872A (ko) 2016-06-08 2019-02-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 염증 및 면역 반응 유도를 감소시키는 조작된 바이러스 벡터
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
KR20200085812A (ko) 2017-11-08 2020-07-15 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 바이러스 벡터-유도된 염증 반응을 억제하기 위한 조성물 및 방법
EP3752194A4 (en) 2018-02-13 2022-03-16 Checkmate Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
IL277680B2 (en) 2018-04-09 2025-08-01 Checkmate Pharmaceuticals Inc Packaging oligonucleotides into virus-like particles

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US20090087388A1 (en) * 2005-10-12 2009-04-02 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

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US7973016B2 (en) * 2004-01-23 2011-07-05 Joslin Diebetes Center Methods of treating, reducing, or preventing autoimmune conditions
AU2006294528A1 (en) * 2005-09-27 2007-04-05 Coley Pharmaceutical Gmbh Modulation of TLR-mediated immune responses using adaptor oligonucleotides
EP2341059A1 (en) * 2005-10-12 2011-07-06 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8383598B2 (en) * 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
PT2154144E (pt) * 2008-08-06 2014-07-18 Changchun Huapu Biotechnology Co Ltd Oligonucleotídeos e utilização dos mesmos

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US20040097719A1 (en) * 2002-10-24 2004-05-20 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
US20090087388A1 (en) * 2005-10-12 2009-04-02 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014082254A1 (en) * 2012-11-29 2014-06-05 Changchun Huapu Biotechnology Co., Ltd Inhibitory oligonucleotide and use thereof
US9688992B2 (en) 2012-11-29 2017-06-27 Sbi Biotech Co., Ltd. Inhibitory oligonucleotide and use thereof
US10190122B2 (en) 2012-11-29 2019-01-29 Sbi Biotech Co., Ltd. Inhibitory oligonucleotide and use thereof
CN105051194A (zh) * 2013-01-14 2015-11-11 萨勒普塔医疗公司 抑制性寡核苷酸及其在治疗中的用途

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JP6275380B2 (ja) 2018-02-07
US20110171209A1 (en) 2011-07-14
EP2437791A2 (en) 2012-04-11
EP2437791B1 (en) 2017-03-22
JP2012528867A (ja) 2012-11-15
CA2762206C (en) 2017-06-27
US8987221B2 (en) 2015-03-24
ES2624767T3 (es) 2017-07-17
WO2010141483A2 (en) 2010-12-09
CA2762206A1 (en) 2010-12-09
WO2010141483A3 (en) 2012-03-01

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Application publication date: 20120725