JP6275380B2 - Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 - Google Patents

Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 Download PDF

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JP6275380B2
JP6275380B2 JP2012514047A JP2012514047A JP6275380B2 JP 6275380 B2 JP6275380 B2 JP 6275380B2 JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012514047 A JP2012514047 A JP 2012514047A JP 6275380 B2 JP6275380 B2 JP 6275380B2
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substituted
nucleotide
guanosine
deaza
cytosine
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JP2012528867A (ja
JP2012528867A5 (enExample
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フ−ガン・チュ
エカムバー・アール・カンディマラ
スディール・アグラワル
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Aceragen Inc
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JP2012514047A 2009-06-01 2010-06-01 Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 Expired - Fee Related JP6275380B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18292809P 2009-06-01 2009-06-01
US61/182,928 2009-06-01
PCT/US2010/036923 WO2010141483A2 (en) 2009-06-01 2010-06-01 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9

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JP2012528867A JP2012528867A (ja) 2012-11-15
JP2012528867A5 JP2012528867A5 (enExample) 2017-09-07
JP6275380B2 true JP6275380B2 (ja) 2018-02-07

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US (1) US8987221B2 (enExample)
EP (1) EP2437791B1 (enExample)
JP (1) JP6275380B2 (enExample)
CN (1) CN102612561A (enExample)
CA (1) CA2762206C (enExample)
ES (1) ES2624767T3 (enExample)
WO (1) WO2010141483A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
US8486908B2 (en) 2010-11-19 2013-07-16 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
EP2766832A1 (en) * 2011-10-10 2014-08-20 AbbVie Biotechnology Ltd Managing healthcare services
WO2013177367A2 (en) * 2012-05-23 2013-11-28 The Johns Hopkins University Compounds and methods of use thereof for treating neurodegenerative disorders
US9688992B2 (en) 2012-11-29 2017-06-27 Sbi Biotech Co., Ltd. Inhibitory oligonucleotide and use thereof
WO2014110081A1 (en) * 2013-01-08 2014-07-17 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
EP2754714A1 (en) * 2013-01-14 2014-07-16 Sarepta Therapeutics, Inc. Inhibitory oligonucleotides and their use in therapy
CA2968531A1 (en) 2014-11-21 2016-05-26 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
EP3436066A1 (en) 2016-04-01 2019-02-06 Checkmate Pharmaceuticals, Inc. Fc receptor-mediated drug delivery
EP3468605A4 (en) 2016-06-08 2020-01-08 President and Fellows of Harvard College MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
JP2021502381A (ja) 2017-11-08 2021-01-28 プレジデント アンド フェローズ オブ ハーバード カレッジ ウイルスベクター誘発性炎症反応を阻害するための組成物および方法
EP3752194A4 (en) 2018-02-13 2022-03-16 Checkmate Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
EP3775218A1 (en) 2018-04-09 2021-02-17 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US6096722A (en) * 1990-08-14 2000-08-01 Isis Pharmaceuticals Inc. Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
US7973016B2 (en) 2004-01-23 2011-07-05 Joslin Diebetes Center Methods of treating, reducing, or preventing autoimmune conditions
AU2006294528A1 (en) * 2005-09-27 2007-04-05 Coley Pharmaceutical Gmbh Modulation of TLR-mediated immune responses using adaptor oligonucleotides
ES2542989T3 (es) * 2005-10-12 2015-08-13 Idera Pharmaceuticals, Inc. Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
US8383598B2 (en) * 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8426375B2 (en) * 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
ES2478012T3 (es) 2008-08-06 2014-07-18 Changchun Huapu Biotechnology Co., Ltd. Oligonucleótidos y uso de los mismos

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EP2437791B1 (en) 2017-03-22
WO2010141483A2 (en) 2010-12-09
JP2012528867A (ja) 2012-11-15
WO2010141483A3 (en) 2012-03-01
CA2762206A1 (en) 2010-12-09
CA2762206C (en) 2017-06-27
ES2624767T3 (es) 2017-07-17
US8987221B2 (en) 2015-03-24
US20110171209A1 (en) 2011-07-14
CN102612561A (zh) 2012-07-25
EP2437791A2 (en) 2012-04-11

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