JP6275380B2 - Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 - Google Patents

Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 Download PDF

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JP6275380B2
JP6275380B2 JP2012514047A JP2012514047A JP6275380B2 JP 6275380 B2 JP6275380 B2 JP 6275380B2 JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012514047 A JP2012514047 A JP 2012514047A JP 6275380 B2 JP6275380 B2 JP 6275380B2
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substituted
nucleotide
guanosine
deaza
cytosine
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JP2012528867A (ja
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フ−ガン・チュ
エカムバー・アール・カンディマラ
スディール・アグラワル
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Aceragen Inc
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JP2012514047A 2009-06-01 2010-06-01 Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 Expired - Fee Related JP6275380B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18292809P 2009-06-01 2009-06-01
US61/182,928 2009-06-01
PCT/US2010/036923 WO2010141483A2 (en) 2009-06-01 2010-06-01 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9

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JP2012528867A JP2012528867A (ja) 2012-11-15
JP2012528867A5 JP2012528867A5 (enExample) 2017-09-07
JP6275380B2 true JP6275380B2 (ja) 2018-02-07

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US (1) US8987221B2 (enExample)
EP (1) EP2437791B1 (enExample)
JP (1) JP6275380B2 (enExample)
CN (1) CN102612561A (enExample)
CA (1) CA2762206C (enExample)
ES (1) ES2624767T3 (enExample)
WO (1) WO2010141483A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
CN107012149A (zh) 2010-11-19 2017-08-04 艾德拉药物股份有限公司 调控基于toll‑样受体的免疫应答的免疫调节寡核苷酸(iro)化合物
US20130096938A1 (en) * 2011-10-10 2013-04-18 Abbott Biotechnology Ltd. Managing healthcare services
EP2852388A4 (en) * 2012-05-23 2016-01-13 Univ Johns Hopkins COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
JP6106280B2 (ja) * 2012-11-29 2017-03-29 Ｓｂｉバイオテック株式会社 阻害性オリゴヌクレオチド及びその使用
AU2014205544B2 (en) * 2013-01-08 2018-07-12 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
EP2754714A1 (en) * 2013-01-14 2014-07-16 Sarepta Therapeutics, Inc. Inhibitory oligonucleotides and their use in therapy
WO2016081911A2 (en) 2014-11-21 2016-05-26 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
US20190046638A1 (en) 2016-04-01 2019-02-14 Checkmate Pharmaceuticals, Inc. Fc RECEPTOR-MEDIATED DRUG DELIVERY
EP3468605A4 (en) 2016-06-08 2020-01-08 President and Fellows of Harvard College MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
JP2021502381A (ja) 2017-11-08 2021-01-28 プレジデント アンド フェローズ オブ ハーバード カレッジ ウイルスベクター誘発性炎症反応を阻害するための組成物および方法
WO2019160866A2 (en) 2018-02-13 2019-08-22 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
BR112020020479A2 (pt) 2018-04-09 2021-01-12 Checkmate Pharmaceuticals Empacotamento de oligonucleotídeos em partículas similares a vírus

Family Cites Families (9)

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US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US6096722A (en) * 1990-08-14 2000-08-01 Isis Pharmaceuticals Inc. Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
WO2005072290A2 (en) * 2004-01-23 2005-08-11 Joslin Diabetes Center Methods of treating, reducing, or preventing autoimmune conditions
WO2007038720A2 (en) 2005-09-27 2007-04-05 Coley Pharmaceutical Gmbh Modulation of tlr-mediated immune responses using adaptor oligonucleotides
ES2544877T3 (es) * 2005-10-12 2015-09-04 Idera Pharmaceuticals Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
US8426375B2 (en) * 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8383598B2 (en) * 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
EP2154144B1 (en) * 2008-08-06 2014-05-07 Changchun Huapu Biotechnology Co., Ltd. Oligonucleotides and use thereof

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WO2010141483A2 (en) 2010-12-09
ES2624767T3 (es) 2017-07-17
US20110171209A1 (en) 2011-07-14
WO2010141483A3 (en) 2012-03-01
CA2762206A1 (en) 2010-12-09
CN102612561A (zh) 2012-07-25
US8987221B2 (en) 2015-03-24
CA2762206C (en) 2017-06-27
JP2012528867A (ja) 2012-11-15
EP2437791B1 (en) 2017-03-22
EP2437791A2 (en) 2012-04-11

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