JP2019511482A5 - - Google Patents

Download PDF

Info

Publication number
JP2019511482A5
JP2019511482A5 JP2018545668A JP2018545668A JP2019511482A5 JP 2019511482 A5 JP2019511482 A5 JP 2019511482A5 JP 2018545668 A JP2018545668 A JP 2018545668A JP 2018545668 A JP2018545668 A JP 2018545668A JP 2019511482 A5 JP2019511482 A5 JP 2019511482A5
Authority
JP
Japan
Prior art keywords
methyl
pyridine
pyrrolo
carboxamide
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018545668A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019511482A (ja
JP6978424B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2017/080511 external-priority patent/WO2017177955A1/en
Publication of JP2019511482A publication Critical patent/JP2019511482A/ja
Publication of JP2019511482A5 publication Critical patent/JP2019511482A5/ja
Priority to JP2021183089A priority Critical patent/JP2022024026A/ja
Application granted granted Critical
Publication of JP6978424B2 publication Critical patent/JP6978424B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018545668A 2016-04-15 2017-04-14 ブロモドメイン阻害剤 Expired - Fee Related JP6978424B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021183089A JP2022024026A (ja) 2016-04-15 2021-11-10 ブロモドメイン阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/079362 2016-04-15
CN2016079362 2016-04-15
PCT/CN2017/080511 WO2017177955A1 (en) 2016-04-15 2017-04-14 Bromodomain inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021183089A Division JP2022024026A (ja) 2016-04-15 2021-11-10 ブロモドメイン阻害剤

Publications (3)

Publication Number Publication Date
JP2019511482A JP2019511482A (ja) 2019-04-25
JP2019511482A5 true JP2019511482A5 (enExample) 2020-03-19
JP6978424B2 JP6978424B2 (ja) 2021-12-08

Family

ID=60042835

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018545668A Expired - Fee Related JP6978424B2 (ja) 2016-04-15 2017-04-14 ブロモドメイン阻害剤
JP2021183089A Ceased JP2022024026A (ja) 2016-04-15 2021-11-10 ブロモドメイン阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021183089A Ceased JP2022024026A (ja) 2016-04-15 2021-11-10 ブロモドメイン阻害剤

Country Status (39)

Country Link
US (4) US10633379B2 (enExample)
EP (2) EP3693369A3 (enExample)
JP (2) JP6978424B2 (enExample)
KR (1) KR102250415B1 (enExample)
CN (1) CN109071534B (enExample)
AR (1) AR108207A1 (enExample)
AU (2) AU2017251537B2 (enExample)
BR (1) BR112018071216A2 (enExample)
CA (1) CA3018802A1 (enExample)
CL (1) CL2018002924A1 (enExample)
CO (1) CO2018011064A2 (enExample)
CR (1) CR20180541A (enExample)
CY (1) CY1123025T1 (enExample)
DK (1) DK3442972T3 (enExample)
DO (1) DOP2018000227A (enExample)
EC (1) ECSP18083519A (enExample)
ES (1) ES2793239T3 (enExample)
HR (1) HRP20200728T1 (enExample)
HU (1) HUE050217T2 (enExample)
IL (1) IL261586B (enExample)
LT (1) LT3442972T (enExample)
MA (2) MA44674B1 (enExample)
MD (1) MD3442972T2 (enExample)
ME (1) ME03759B (enExample)
MX (1) MX379459B (enExample)
MY (1) MY190795A (enExample)
PE (1) PE20190472A1 (enExample)
PH (1) PH12018501920B1 (enExample)
PL (1) PL3442972T3 (enExample)
PT (1) PT3442972T (enExample)
RS (1) RS60302B1 (enExample)
RU (1) RU2741808C2 (enExample)
SG (1) SG11201808003RA (enExample)
SI (1) SI3442972T1 (enExample)
SM (1) SMT202000312T1 (enExample)
TW (3) TWI764237B (enExample)
UA (1) UA124764C2 (enExample)
UY (1) UY37205A (enExample)
WO (1) WO2017177955A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018071216A2 (pt) * 2016-04-15 2019-02-05 Abbvie Inc inibidores de bromodomínios
AU2016426480A1 (en) * 2016-10-14 2019-04-18 Abbvie Inc. Bromodomain inhibitors
EP3612181A4 (en) 2017-04-21 2021-01-06 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
CN112424200B (zh) 2018-07-25 2022-09-20 正大天晴药业集团股份有限公司 作为溴区结构域蛋白抑制剂的亚氨基砜类化合物、药物组合物及其医药用途
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
WO2020063976A1 (zh) * 2018-09-29 2020-04-02 如东凌达生物医药科技有限公司 一类稠杂环联芳基苄醇类化合物、制备方法和用途
CN113226322A (zh) 2018-10-30 2021-08-06 诺维逊生物股份有限公司 作为bet抑制剂的杂环化合物
JP7579580B2 (ja) * 2019-03-17 2024-11-08 シャンハイ リンジーン バイオファーマ カンパニー リミテッド ピロールアミドピリドン系化合物、製造方法及び使用
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2020232214A1 (en) * 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
EP3997070A4 (en) 2019-07-02 2023-07-26 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AS BET INHIBITORS
WO2021022078A1 (en) * 2019-07-30 2021-02-04 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CN112625036A (zh) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 一类具有brd4抑制活性的化合物、其制备方法及用途
CN115667254A (zh) * 2020-05-21 2023-01-31 贝达药业股份有限公司 作为溴结构域蛋白质抑制剂的化合物和组合物
GB202016977D0 (en) 2020-10-26 2020-12-09 In4Derm Ltd Compounds
WO2022116968A1 (zh) * 2020-12-01 2022-06-09 成都苑东生物制药股份有限公司 一种新型n-杂环bet溴结构域抑制剂、其制备方法及医药用途
JP2024502469A (ja) * 2021-01-08 2024-01-19 デザイン セラピューティクス,インク. フリードライヒ運動失調症を治療するための方法及び化合物
CN115232131A (zh) * 2021-04-23 2022-10-25 江苏恒瑞医药股份有限公司 含氮杂环类化合物、其制备方法及其在医药上的应用
WO2022228421A1 (zh) * 2021-04-30 2022-11-03 成都苑东生物制药股份有限公司 一种新型brd4溴结构域protac蛋白降解剂、其制备方法及医药用途
AU2022303310A1 (en) 2021-06-29 2024-02-08 Tay Therapeutics Limited Pyrrolopyridone derivatives useful in the treatment of cancer
CN115611890B (zh) * 2021-07-15 2024-05-31 成都硕德药业有限公司 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途
WO2025006827A1 (en) 2023-06-30 2025-01-02 Genzyme Corporation Substituted cyclic compounds and methods of treating phenylketonuria and other amino acidurias

Family Cites Families (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1507957A (en) 1975-03-25 1978-04-19 Byk Gulden Lomberg Chem Fab Nitrofuryl-pyrazole derivatives methods for producing them and medicaments comprising them
US4004012A (en) 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
US4072746A (en) 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
DE2845456A1 (de) 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
US4298609A (en) 1979-08-30 1981-11-03 Sterling Drug Inc. 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their preparation and use as blood pressure lowering agents
FR2478640A1 (fr) 1980-03-24 1981-09-25 Sanofi Sa Nouvelles thieno (2,3-d) pyridazinones-4 et thieno (2,3-d) pyridazinones-7, leur procede de preparation et leur therapeutique
US4305943A (en) 1980-04-28 1981-12-15 Sterling Drug Inc. 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics
US4346221A (en) 1980-04-28 1982-08-24 Sterling Drug Inc. Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones
US4486431A (en) 1981-01-14 1984-12-04 Sterling Drug Inc. Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinones
US4338446A (en) 1980-04-28 1982-07-06 Sterling Drug Inc. Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates
US4304776A (en) 1980-04-28 1981-12-08 Sterling Drug Inc. 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics
US4337253A (en) 1980-04-28 1982-06-29 Sterling Drug Inc. 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic
US4559352A (en) 1981-03-30 1985-12-17 Sterling Drug Inc. 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof
US4397854A (en) 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4404203A (en) 1981-05-14 1983-09-13 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4465686A (en) 1981-09-08 1984-08-14 Sterling Drug Inc. 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
US4515797A (en) 1981-09-08 1985-05-07 Sterling Drug Inc. 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof
US4353905A (en) 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
US4599423A (en) 1982-04-26 1986-07-08 Sterling Drug Inc. Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones
US4734415A (en) 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
DE3241102A1 (de) 1982-11-06 1984-05-10 A. Nattermann & Cie GmbH, 5000 Köln Imidazolylalkylthienyl-tetrahydropyridazine und verfahren zu ihrer herstellung
DE3321012A1 (de) 1983-06-10 1984-12-13 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-(thien-2-yl)-3(2h)-pyridazinone und 6-(thien-2-yl)-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
US4666902A (en) 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
GB8323553D0 (en) 1983-09-02 1983-10-05 Smith Kline French Lab Pharmaceutical compositions
US4816454A (en) 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US5221543A (en) 1986-10-22 1993-06-22 Firma Wilhelm Fette Gmbh Method of making a fast release stabilized aspartame ingredient for chewing gum
US4863745A (en) 1986-10-22 1989-09-05 Wm. Wrigley Jr. Company Chewing gum containing zein coated high-potency sweetener and method
US5192563A (en) 1986-10-22 1993-03-09 Wm. Wrigley, Jr. Company Strongly mint-flavored chewing gums with reduced bitterness and harshness
US5217735A (en) 1986-10-22 1993-06-08 Wm. Wrigley Jr. Company Method of making chewing gum with delayed release ingredients
US5112625A (en) 1989-02-15 1992-05-12 Wm. Wrigley Jr. Company Aqueous zein coated sweeteners and other ingredients for chewing gum
US4908371A (en) 1987-11-10 1990-03-13 Ciba-Geigy Corporation Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload
US4919941A (en) 1987-12-18 1990-04-24 Wm. Wrigley Jr. Company Chewing gum containing delayed release protein sweetener and method
DE4134467A1 (de) 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1991012251A1 (fr) 1990-02-19 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Nouveau compose heterocyclique condense et agent anti-asthme prepare a partir de ce compose
DE4023369A1 (de) 1990-07-23 1992-01-30 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE69131268T2 (de) 1990-09-21 1999-12-30 Rohm And Haas Co., Philadelphia Dihydropyridazinone und Pyridazinone als Fungizide
WO1992006087A1 (en) 1990-10-02 1992-04-16 Kaken Pharmaceutical Co., Ltd. Pyridazinone-substituted ethynylphenyl derivative and remedy for circulatory organ disease containing the same as active ingredient
DE4127404A1 (de) 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CN1038249C (zh) 1991-08-28 1998-05-06 罗姆和哈斯公司 含有二氢哒嗪酮及其相关化合物的杀菌组合物
US5716954A (en) 1991-10-09 1998-02-10 Syntex U.S.A. Inc. Benzopyridazinone and pyridopyridazinone compounds
NZ244660A (en) 1991-10-09 1995-05-26 Syntex Inc Pyridopyridazine derivatives and medicaments
DE4237656A1 (de) 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
WO1994010151A1 (en) 1992-11-02 1994-05-11 Merck & Co., Inc. Substituted phthalazinones as nerotensin antagonists
US5814651A (en) 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
GB9314412D0 (en) 1993-07-13 1993-08-25 Rhone Poulenc Agriculture New compositions of matter
EP0634404A1 (en) 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
TW263498B (enExample) 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd
JP3247540B2 (ja) 1994-05-12 2002-01-15 株式会社日立製作所 パケット化通信装置および切替え装置
US5466697A (en) 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
AU691673B2 (en) 1994-11-14 1998-05-21 Dow Agrosciences Llc Pyridazinones and their use as fungicides
JPH08337583A (ja) 1995-04-13 1996-12-24 Takeda Chem Ind Ltd 複素環化合物およびその製造法
US5635494A (en) 1995-04-21 1997-06-03 Rohm And Haas Company Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides
WO1997001551A1 (en) 1995-06-26 1997-01-16 Fujisawa Pharmaceutical Co., Ltd. Pyrazole compounds and pharmaceutical compositions
IL118631A (en) 1995-06-27 2002-05-23 Tanabe Seiyaku Co History of pyridazinone and processes for their preparation
AU723064B2 (en) 1995-08-25 2000-08-17 Dow Agrosciences Llc Compositions having synergistic fungitoxic effects
AU716490B2 (en) 1996-09-13 2000-02-24 Mitsubishi Tanabe Pharma Corporation Thienotriazolodiazepine compounds and pharmaceutical use thereof
US5855654A (en) 1997-01-30 1999-01-05 Rohm And Haas Company Pyridazinones as marine antifouling agents
PL335884A1 (en) 1997-04-01 2000-05-22 Astra Pharma Prod Novel derivatives of pyridine and pharmaceutic compositions containing them
US6245804B1 (en) 1997-05-30 2001-06-12 Schering Aktiengesellschaft Nonsteroidal gestagens
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
ID24166A (id) 1997-11-19 2000-07-13 Kowa Co Turunan piridazin baru dan obat-obatan yang mengandung hal yang sama sebagai ramuan efektif
PL340836A1 (en) 1997-12-05 2001-02-26 Astrazeneca Uk Ltd Novel compounds
EP0934933A1 (en) 1998-02-06 1999-08-11 Byk Gulden Lomberg Chemische Fabrik GmbH Phthalazinones
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
HK1040400A1 (zh) 1998-07-16 2002-06-07 盐野义制药株式会社 具有抗肿瘤活性的嘧啶衍生物
US6271380B1 (en) 1998-12-30 2001-08-07 Dupont Pharmaceuticals Company 1H-imidazo[4,5-d]pyridazin-7-ones, 3H-imidazo-[4,5-c]pyridin-4-ones and corresponding thiones as corticotropin releasing factor (CRF) receptor ligands
CN1297916A (zh) 1999-11-26 2001-06-06 上海博容基因开发有限公司 一种新的多肽——人含溴基结构域的蛋白95和编码这种多肽的多核苷酸
DE10010423A1 (de) 2000-03-03 2001-09-06 Bayer Ag Substituierte 2,5-Dimethyldihydropyridazinone und ihre Verwendung
CN1315397A (zh) 2000-03-28 2001-10-03 上海博德基因开发有限公司 一种新的多肽——人溴基结构域10和编码这种多肽的多核苷酸
WO2002001935A1 (en) 2000-07-04 2002-01-10 Robert John Eyre Harvesting machine
US20030114448A1 (en) 2001-05-31 2003-06-19 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
JP2003313169A (ja) 2002-04-19 2003-11-06 Otsuka Chemical Holdings Co Ltd 4,4−ジフルオロ−3−ブテニル化合物及び農園芸用殺虫・殺ダニ剤
ES2195785B1 (es) 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
AU2003249539A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors
BR0313459A (pt) 2002-08-13 2005-06-21 Warner Lambert Co Derivados monocìclicos como inibidores de metaloproteinases de matriz
CN1812981A (zh) 2003-06-27 2006-08-02 万有制药株式会社 杂芳氧基含氮饱和杂环衍生物
WO2005000818A1 (en) 2003-06-27 2005-01-06 Warner-Lambert Company Llc 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
DE602004025258D1 (de) 2003-08-06 2010-03-11 Vertex Pharma Aminotriazol-verbindungen als proteinkinase-hemmer
TWI339206B (en) * 2003-09-04 2011-03-21 Vertex Pharma Compositions useful as inhibitors of protein kinases
EP1677599A4 (en) 2003-10-20 2008-10-22 Merck & Co Inc HYDROXYPYRIDOPYRROLOPYRAZINDION COMPOUNDS AS HIV INTEGRASE INHIBITORS
CN1739788A (zh) 2004-03-31 2006-03-01 新加坡国立大学 Trip-br功能的调节和治疗增殖性紊乱的方法
BRPI0514925A (pt) * 2004-09-03 2008-07-01 Yuhan Corp derivados de pirrol[2,3-c]piridina e processos para a preparação destes
GB0420970D0 (en) 2004-09-21 2004-10-20 Smithkline Beecham Corp Novel triazoloquinoline compounds
WO2006038734A1 (en) 2004-10-08 2006-04-13 Astellas Pharma Inc. Pyridazinone derivatives cytokines inhibitors
CA2588949A1 (en) 2004-11-30 2006-06-08 Artesian Therapeutics, Inc. Compounds with mixed pde-inhibitory and .beta.-adrenergic antagonist or partial agonist activity for treatment of heart failure
WO2006059778A1 (ja) 2004-12-01 2006-06-08 Banyu Pharmaceutical Co., Ltd. 置換ピリドン誘導体
CA2599925A1 (en) 2005-03-14 2006-09-21 Merck & Co., Inc. Cgrp receptor antagonists
US20060276496A1 (en) 2005-03-17 2006-12-07 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-Cytokine Heterocyclic Compounds
JPWO2006112331A1 (ja) 2005-04-13 2008-12-11 大日本住友製薬株式会社 新規縮合ピロール誘導体
EP1887008B1 (en) 2005-05-30 2021-04-21 Mitsubishi Tanabe Pharma Corporation Thienotriazolodiazepine compound and a medicinal use thereof
WO2007008145A1 (en) 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008144A1 (en) 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
EP1953148B1 (en) 2005-10-28 2012-02-29 Takeda Pharmaceutical Company Limited Heterocyclic amide compound and use thereof
AU2006325746A1 (en) 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
US20070142414A1 (en) 2005-12-16 2007-06-21 Pharmacia Italia S.P.A. N-substituted pyrrolopyridinones active as kinase inhibitors
AU2007277163B2 (en) 2006-07-25 2012-06-21 Cephalon, Inc. Pyridizinone derivatives
US20080119457A1 (en) 2006-08-24 2008-05-22 Serenex, Inc. Benzene, Pyridine, and Pyridazine Derivatives
US7838523B2 (en) 2006-09-11 2010-11-23 Cgi Pharmaceuticals, Inc. Certain substituted amides, method of making, and method of use thereof
EP2097422A4 (en) 2006-11-13 2010-04-14 Lilly Co Eli THIENOPYRIMIDINONE FOR THE TREATMENT OF INFLAMMATORY DISEASES AND CARCINOMAS
AU2007352397B2 (en) 2006-12-14 2013-09-26 Gilead Sciences, Inc. Viral inhibitors
JP2008156311A (ja) 2006-12-26 2008-07-10 Institute Of Physical & Chemical Research Brd2ブロモドメイン結合剤
WO2008148034A1 (en) 2007-05-25 2008-12-04 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors
CA2697168A1 (en) 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CL2008002793A1 (es) 2007-09-20 2009-09-04 Cgi Pharmaceuticals Inc Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras
ES2444144T3 (es) 2007-10-23 2014-02-24 F. Hoffmann-La Roche Ag Nuevos inhibidores de quinasa
WO2009054790A1 (en) 2007-10-26 2009-04-30 Astrazeneca Ab Amide linked heteroaromatic derivatives as modulators of mglur5
JP2011507910A (ja) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
CA2710740C (en) 2007-12-28 2016-07-19 Shinji Miyoshi Thienotriazolodiazepine compound as antitumor agent
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
CA2722427A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134384A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009142732A2 (en) 2008-05-20 2009-11-26 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
ES2432150T3 (es) 2008-07-25 2013-12-02 Boehringer Ingelheim International Gmbh Inhibidores cíclicos de la 11 beta-hidroxiesteroide deshidrogenasa 1
CA2737219C (en) 2008-08-11 2017-02-28 Tracy Keller Halofuginone analogs for inhibition of trna synthetases and uses thereof
PE20120031A1 (es) 2008-11-20 2012-02-05 Merck Sharp & Dohme Compuestos aril metil benzoquinazolinona como moduladores alostericos positivos del receptor m1
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
US20100331320A1 (en) 2009-04-30 2010-12-30 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
BR112012010705A2 (pt) 2009-11-05 2016-03-29 Glaxosmithkline Llc composto, composição farmacêutica, produto farmacêutico combinado, uso de um composto, e, métodos para tratar uma doença ou condição, e para inibir um bromodomínio
ES2539964T3 (es) 2009-11-05 2015-07-07 Glaxosmithkline Llc Procedimiento novedoso
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB0919426D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB0919432D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Use
ME02360B (me) 2009-11-05 2016-06-20 Glaxosmithkline Llc Inhibitor bromodomena benzodiazepina
GB0919434D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
US20130061612A1 (en) 2009-11-11 2013-03-14 E.I. Du Pont De Nemours And Company Refrigerant storage in secondary loop refrigeration systems
BR112012026641A2 (pt) 2010-04-23 2016-07-12 Kineta Inc compostos antivirais
PL2571503T3 (pl) 2010-05-14 2015-06-30 Dana Farber Cancer Inst Inc Kompozycje i sposoby leczenia nowotworu, choroby zapalnej i innych zaburzeń
US9085582B2 (en) 2010-06-22 2015-07-21 Glaxosmithkline Llc Benzotriazolodiazepine compounds inhibitors of bromodomains
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
CN104054099A (zh) 2011-12-07 2014-09-17 阿弗科迪瓦公司 广告有效性的基于影响的评估
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
US20130188311A1 (en) 2012-01-23 2013-07-25 International Business Machines Corporation Cooling and noise-reduction apparatus
EP2838881B1 (en) 2012-04-20 2018-08-08 AbbVie Inc. Isoindolone derivatives
WO2013185284A1 (en) 2012-06-12 2013-12-19 Abbott Laboratories Pyridinone and pyridazinone derivatives
KR102008733B1 (ko) 2012-06-15 2019-08-09 소프트 머신즈, 인크. 스토어 상위 서열에 기초하여 상이한 스레드들로부터의 포워딩을 구현하는 스레드에 무관한 로드 스토어 버퍼
US20140094456A1 (en) 2012-10-02 2014-04-03 Intermune, Inc. Anti-fibrotic pyridinones
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
WO2014125408A2 (en) 2013-02-12 2014-08-21 Aurigene Discovery Technologies Limited Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors
WO2014164780A1 (en) 2013-03-11 2014-10-09 Abbvie Inc. Fused tetracyclic bromodomain inhibitors
MX2015012005A (es) 2013-03-11 2016-04-04 Abbvie Inc Inhibidores de bromodominio.
CN105164113B (zh) 2013-03-12 2018-03-02 艾伯维公司 吡咯酰胺抑制剂
CA2905071A1 (en) * 2013-03-12 2014-10-09 Abbvie Inc. Dihydro-pyrrolopyridinone bromodomain inhibitors
EP2970330B1 (en) 2013-03-12 2019-04-17 AbbVie Inc. Tetracyclic bromodomain inhibitors
AR096758A1 (es) 2013-06-28 2016-02-03 Abbvie Inc Inhibidores cristalinos de bromodominios
JP2016525503A (ja) 2013-06-28 2016-08-25 アッヴィ・インコーポレイテッド ブロモドメイン阻害剤
CN103387576A (zh) * 2013-08-09 2013-11-13 中国药科大学 基于嘌呤结构的芳酰胺类Raf激酶抑制剂及其制备方法和用途
HRP20221389T1 (hr) * 2013-10-18 2023-01-06 Celgene Quanticel Research, Inc. Inhibitori bromodomena
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
WO2015081246A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
WO2015081280A1 (en) 2013-11-26 2015-06-04 Coferon, Inc. Bromodomain ligands capable of dimerizing in an aqueous solution
CN105939996A (zh) 2013-12-09 2016-09-14 艾伯维公司 用作布罗莫结构域抑制剂的二氢吡啶酮和二氢哒嗪酮衍生物
CA2932040A1 (en) 2013-12-10 2015-06-18 Abbvie Inc. Bromodomain inhibitors
DK3674302T3 (da) 2014-04-23 2023-04-03 Incyte Holdings Corp 1h-pyrrolo[2,3-c]pyridin-7(6h)-oner og pyrazolo[3,4-c]pyridin-7(6h)-oner som inhibitorer af bet-proteiner
MA40940A (fr) 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
ES2815683T3 (es) 2015-05-11 2021-03-30 Bristol Myers Squibb Co Compuestos tricíclicos como agentes antineoplásicos
US10174024B2 (en) 2015-05-12 2019-01-08 Bristol-Myers Squibb Company 5H-pyrido[3,2-B]indole compounds as anticancer agents
JP6606444B2 (ja) 2016-03-10 2019-11-13 株式会社Subaru 車両用制御装置
HUE064145T2 (hu) 2016-04-15 2024-03-28 Epizyme Inc Amin-szubsztituált aril- vagy heteroaril vegyületek, mint EHMT1 és EHMT2 inhibitorok
JP6855504B2 (ja) 2016-04-15 2021-04-07 シンジェンタ パーティシペーションズ アーゲー 除草性ピリダジノン化合物
BR112018071216A2 (pt) * 2016-04-15 2019-02-05 Abbvie Inc inibidores de bromodomínios
AU2017251155B2 (en) 2016-04-15 2021-08-05 Elanco Animal Health Gmbh Pyrazolopyrimidine derivatives
SG11201808907PA (en) 2016-04-15 2018-11-29 Blueprint Medicines Corp Inhibitors of activin receptor-like kinase
ES2973875T3 (es) 2016-06-09 2024-06-24 Dana Farber Cancer Inst Inc Métodos de uso y combinaciones farmacéuticas de inhibidores de HDAC con inhibidores de BET
WO2017216772A2 (en) 2016-06-16 2017-12-21 The University Of Chicago Methods and compositions for treating breast and prostate cancer
WO2017223268A1 (en) 2016-06-22 2017-12-28 Yale University COMPOSITIONS AND METHODS OF RESENSITIZING CELLS TO BROMODOMAIN AND EXTRATERMINAL DOMAIN PROTEIN INHIBITORS (BETi)
MX2019004187A (es) 2016-10-14 2019-06-12 Abbvie Inc Inhibidores de bromodominios.
AU2016426480A1 (en) 2016-10-14 2019-04-18 Abbvie Inc. Bromodomain inhibitors
WO2018095933A1 (en) 2016-11-22 2018-05-31 Université D'aix-Marseille (Amu) Method of prognosticating, or for determining the efficiency of a compound for treating cancer
TW201825490A (zh) 2017-01-11 2018-07-16 大陸商江蘇豪森藥業集團有限公司 吡咯並[2,3-c]吡啶類衍生物、其製備方法及其在醫藥上的應用
WO2018188047A1 (en) 2017-04-14 2018-10-18 Abbvie Inc. Bromodomain inhibitors
CN108976278B (zh) 2017-06-05 2021-04-06 海创药业股份有限公司 一种嵌合分子及其制备和应用
CN108690020A (zh) 2018-07-04 2018-10-23 清华大学 一种靶向降解bet蛋白的化合物及其应用

Similar Documents

Publication Publication Date Title
JP2019511482A5 (enExample)
RU2018140061A (ru) Ингибиторы бромодомена
JP2015514780A5 (enExample)
RU2018137194A (ru) Ингибиторы бромдомена
JP2018519323A5 (enExample)
ME02801B (me) Kristalni inhibitori bromodomena
RU2015143191A (ru) Дигидропирролопиридиновые ингибиторы бромодоменов
RU2015143192A (ru) Тетрациклические ингибиторы бромодоменов
KR102653667B1 (ko) Apj 수용체의 트라이아졸 작용제
RU2500673C2 (ru) Гетероциклические ингибиторы мек и способы их применения
JP2016512515A5 (enExample)
JP2016525136A5 (enExample)
Nishimura et al. Small molecule disruptors of the glucokinase–glucokinase regulatory protein interaction: 3. structure–activity relationships within the aryl carbinol region of the N-Arylsulfonamido-N′-arylpiperazine series
JP2016516724A5 (enExample)
RU2014153628A (ru) Производные пиридинона и пиридазинона
JP2016537394A5 (enExample)
NZ631569A (en) Phenyl alkanoic acid derivatives as gpr agonists
CN112955448A (zh) 芳环或芳杂环类化合物及其制备方法和医药用途
CA3081983A1 (en) Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases
JP2016515562A5 (enExample)
JP2013531055A5 (enExample)
JP2011515341A5 (enExample)
JP2016516026A5 (enExample)
JP2013530240A5 (enExample)
NZ627750A (en) Carbamate compounds and of making and using same