RS60302B1 - Inhibitori bromodomena - Google Patents

Inhibitori bromodomena

Info

Publication number
RS60302B1
RS60302B1 RS20200588A RSP20200588A RS60302B1 RS 60302 B1 RS60302 B1 RS 60302B1 RS 20200588 A RS20200588 A RS 20200588A RS P20200588 A RSP20200588 A RS P20200588A RS 60302 B1 RS60302 B1 RS 60302B1
Authority
RS
Serbia
Prior art keywords
process according
ion exchange
exchange chromatography
column
reverse phase
Prior art date
Application number
RS20200588A
Other languages
English (en)
Serbian (sr)
Inventor
Steven D Fidanze
Lisa A Hasvold
Dachun Liu
Keith F Mcdaniel
John PRATT
Michael Schrimpf
George S Sheppard
Le Wang
Bing Li
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of RS60302B1 publication Critical patent/RS60302B1/sr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Oncology (AREA)
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  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
RS20200588A 2016-04-15 2017-04-14 Inhibitori bromodomena RS60302B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016079362 2016-04-15
EP17781931.5A EP3442972B1 (en) 2016-04-15 2017-04-14 Bromodomain inhibitors
PCT/CN2017/080511 WO2017177955A1 (en) 2016-04-15 2017-04-14 Bromodomain inhibitors

Publications (1)

Publication Number Publication Date
RS60302B1 true RS60302B1 (sr) 2020-07-31

Family

ID=60042835

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20200588A RS60302B1 (sr) 2016-04-15 2017-04-14 Inhibitori bromodomena

Country Status (39)

Country Link
US (4) US10633379B2 (enExample)
EP (2) EP3693369A3 (enExample)
JP (2) JP6978424B2 (enExample)
KR (1) KR102250415B1 (enExample)
CN (1) CN109071534B (enExample)
AR (1) AR108207A1 (enExample)
AU (2) AU2017251537B2 (enExample)
BR (1) BR112018071216A2 (enExample)
CA (1) CA3018802A1 (enExample)
CL (1) CL2018002924A1 (enExample)
CO (1) CO2018011064A2 (enExample)
CR (1) CR20180541A (enExample)
CY (1) CY1123025T1 (enExample)
DK (1) DK3442972T3 (enExample)
DO (1) DOP2018000227A (enExample)
EC (1) ECSP18083519A (enExample)
ES (1) ES2793239T3 (enExample)
HR (1) HRP20200728T1 (enExample)
HU (1) HUE050217T2 (enExample)
IL (1) IL261586B (enExample)
LT (1) LT3442972T (enExample)
MA (2) MA44674B1 (enExample)
MD (1) MD3442972T2 (enExample)
ME (1) ME03759B (enExample)
MX (1) MX379459B (enExample)
MY (1) MY190795A (enExample)
PE (1) PE20190472A1 (enExample)
PH (1) PH12018501920B1 (enExample)
PL (1) PL3442972T3 (enExample)
PT (1) PT3442972T (enExample)
RS (1) RS60302B1 (enExample)
RU (1) RU2741808C2 (enExample)
SG (1) SG11201808003RA (enExample)
SI (1) SI3442972T1 (enExample)
SM (1) SMT202000312T1 (enExample)
TW (3) TWI764237B (enExample)
UA (1) UA124764C2 (enExample)
UY (1) UY37205A (enExample)
WO (1) WO2017177955A1 (enExample)

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ES2793239T3 (es) * 2016-04-15 2020-11-13 Abbvie Inc Inhibidores del bromodominio
CN110049979A (zh) * 2016-10-14 2019-07-23 艾伯维公司 布罗莫结构域抑制剂
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
KR102954013B1 (ko) * 2018-07-25 2026-04-16 치아타이 티안큉 파마수티컬 그룹 주식회사 브로모도메인 단백질 억제제로서의 설폭시민 화합물과 약학적 조성물 및 이의 의학적 용도
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
CN110964012B (zh) * 2018-09-29 2021-08-13 上海凌达生物医药有限公司 一类稠杂环联芳基苄醇类化合物、制备方法和用途
AU2019372121A1 (en) 2018-10-30 2021-05-27 Nuvation Bio Inc. Heterocyclic compounds as BET inhibitors
CN111704610B (zh) * 2019-03-17 2022-03-22 上海凌达生物医药有限公司 一类吡咯酰胺并吡啶酮类化合物、制备方法和用途
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2020232214A1 (en) * 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
AU2020299592A1 (en) 2019-07-02 2022-02-17 Nuvation Bio Inc. Heterocyclic compounds as BET inhibitors
EP4003345B1 (en) * 2019-07-30 2024-12-04 XRad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CN112625036A (zh) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 一类具有brd4抑制活性的化合物、其制备方法及用途
CN115667254A (zh) * 2020-05-21 2023-01-31 贝达药业股份有限公司 作为溴结构域蛋白质抑制剂的化合物和组合物
GB202016977D0 (en) 2020-10-26 2020-12-09 In4Derm Ltd Compounds
AU2021392700B2 (en) * 2020-12-01 2023-11-23 Chengdu Easton Biopharmaceuticals Co., Ltd. Novel n-heterocyclic bet bromodomain inhibitor, and preparation method therefor and medical use thereof
CN117241805A (zh) * 2021-01-08 2023-12-15 设计治疗公司 用于治疗弗里德希氏共济失调的方法和化合物
CN115232131A (zh) * 2021-04-23 2022-10-25 江苏恒瑞医药股份有限公司 含氮杂环类化合物、其制备方法及其在医药上的应用
CN115551861B (zh) * 2021-04-30 2024-05-28 成都硕德药业有限公司 一种新型brd4溴结构域protac蛋白降解剂、其制备方法及医药用途
WO2023275542A1 (en) 2021-06-29 2023-01-05 Tay Therapeutics Limited Pyrrolopyridone derivatives useful in the treatment of cancer
CN115611890B (zh) * 2021-07-15 2024-05-31 成都硕德药业有限公司 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途
EP4735422A1 (en) 2023-06-30 2026-05-06 Sanofi Substituted cyclic compounds and methods of treating phenylketonuria and other amino acidurias

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