MD3442972T2 - Inhibitori ai bromodomeniului - Google Patents
Inhibitori ai bromodomeniului Download PDFInfo
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- MD3442972T2 MD3442972T2 MDE20190228T MDE20190228T MD3442972T2 MD 3442972 T2 MD3442972 T2 MD 3442972T2 MD E20190228 T MDE20190228 T MD E20190228T MD E20190228 T MDE20190228 T MD E20190228T MD 3442972 T2 MD3442972 T2 MD 3442972T2
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- MD
- Moldova
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- mmol
- mixture
- added
- ethyl acetate
- stirred
- Prior art date
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- 102000001805 Bromodomains Human genes 0.000 title description 12
- 108050009021 Bromodomains Proteins 0.000 title description 11
- 239000003112 inhibitor Substances 0.000 title description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- OEDSFMUSNZDJFD-UHFFFAOYSA-N abbv-744 Chemical compound C(C)NC(=O)C1=CC2=C(C(N(C=C2C2=C(C=CC(=C2)C(C)(C)O)OC2=C(C=C(C=C2C)F)C)C)=O)N1 OEDSFMUSNZDJFD-UHFFFAOYSA-N 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 abstract description 82
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 17
- 201000010099 disease Diseases 0.000 abstract description 12
- 206010028980 Neoplasm Diseases 0.000 abstract description 8
- 201000011510 cancer Diseases 0.000 abstract description 4
- 208000027866 inflammatory disease Diseases 0.000 abstract description 2
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- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- 2017-04-18 UY UY0001037205A patent/UY37205A/es not_active Application Discontinuation
-
2018
- 2018-09-04 IL IL261586A patent/IL261586B/en active IP Right Grant
- 2018-09-07 PH PH12018501920A patent/PH12018501920B1/en unknown
- 2018-10-12 DO DO2018000227A patent/DOP2018000227A/es unknown
- 2018-10-12 CL CL2018002924A patent/CL2018002924A1/es unknown
- 2018-10-16 CO CONC2018/0011064A patent/CO2018011064A2/es unknown
- 2018-11-08 EC ECSENADI201883519A patent/ECSP18083519A/es unknown
-
2020
- 2020-04-27 US US16/858,930 patent/US20200255426A1/en not_active Abandoned
- 2020-05-22 CY CY20201100494T patent/CY1123025T1/el unknown
- 2020-12-14 ME MEP-2020-128A patent/ME03759B/me unknown
-
2021
- 2021-01-08 AU AU2021200101A patent/AU2021200101A1/en not_active Abandoned
- 2021-02-24 US US17/183,832 patent/US20220017511A1/en not_active Abandoned
- 2021-11-10 JP JP2021183089A patent/JP2022024026A/ja not_active Ceased
-
2023
- 2023-11-21 US US18/516,230 patent/US20240360124A1/en not_active Abandoned
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