JP2016537394A5 - - Google Patents
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- Publication number
- JP2016537394A5 JP2016537394A5 JP2016533614A JP2016533614A JP2016537394A5 JP 2016537394 A5 JP2016537394 A5 JP 2016537394A5 JP 2016533614 A JP2016533614 A JP 2016533614A JP 2016533614 A JP2016533614 A JP 2016533614A JP 2016537394 A5 JP2016537394 A5 JP 2016537394A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorophenyl
- pyrazolo
- sulfonyl
- isoquinolin
- octahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 34
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 33
- 229910052739 hydrogen Inorganic materials 0.000 claims description 27
- 239000001257 hydrogen Substances 0.000 claims description 27
- CSDSSGBPEUDDEE-UHFFFAOYSA-N 2-formylpyridine Chemical compound O=CC1=CC=CC=N1 CSDSSGBPEUDDEE-UHFFFAOYSA-N 0.000 claims description 26
- FKNSTSIMTSEJOD-UHFFFAOYSA-N 4-(trifluoromethyl)pyridine-2-carbaldehyde Chemical compound FC(F)(F)C1=CC=NC(C=O)=C1 FKNSTSIMTSEJOD-UHFFFAOYSA-N 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 24
- 150000002431 hydrogen Chemical class 0.000 claims description 23
- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
- 125000005842 heteroatom Chemical group 0.000 claims description 22
- 229910052717 sulfur Inorganic materials 0.000 claims description 22
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 20
- 229910052736 halogen Inorganic materials 0.000 claims description 20
- 150000002367 halogens Chemical class 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
- ZGTFNNUASMWGTM-UHFFFAOYSA-N 1,3-thiazole-2-carbaldehyde Chemical compound O=CC1=NC=CS1 ZGTFNNUASMWGTM-UHFFFAOYSA-N 0.000 claims description 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 12
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 10
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 9
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 8
- WRFKSVINLIQRKF-UHFFFAOYSA-N 1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC=N1 WRFKSVINLIQRKF-UHFFFAOYSA-N 0.000 claims description 8
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims description 8
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- -1 5-thiazole Chemical compound 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 150000003852 triazoles Chemical class 0.000 claims description 7
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000006413 ring segment Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- YTQQIHUQLOZOJI-UHFFFAOYSA-N 2,3-dihydro-1,2-thiazole Chemical compound C1NSC=C1 YTQQIHUQLOZOJI-UHFFFAOYSA-N 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000001359 1,2,3-triazol-4-yl group Chemical group [H]N1N=NC([*])=C1[H] 0.000 claims description 2
- 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 claims description 2
- UAKMHSRHDUBNJR-UHFFFAOYSA-N 4-methylpyridine-2-carbaldehyde Chemical compound CC1=CC=NC(C=O)=C1 UAKMHSRHDUBNJR-UHFFFAOYSA-N 0.000 claims description 2
- 150000001204 N-oxides Chemical class 0.000 claims description 2
- XOABHRHUHPEGKJ-KMRXNPHXSA-N [(4aR,8aS)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone Chemical compound Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CC[C@H]3Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1ccccn1 XOABHRHUHPEGKJ-KMRXNPHXSA-N 0.000 claims description 2
- CABSVADZAWZSLR-DCFHFQCYSA-N [(4ar,8as)-1-(4-fluorophenyl)-6-(2-propyltriazol-4-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone Chemical compound CCCN1N=CC(S(=O)(=O)N2C[C@]3(CC4=C(N(N=C4)C=4C=CC(F)=CC=4)C[C@@H]3CC2)C(=O)C=2N=CC=CC=2)=N1 CABSVADZAWZSLR-DCFHFQCYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 2
- 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 208000028017 Psychotic disease Diseases 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000030507 AIDS Diseases 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000003569 Central serous chorioretinopathy Diseases 0.000 claims 1
- 208000033379 Chorioretinopathy Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000014311 Cushing syndrome Diseases 0.000 claims 1
- 206010012218 Delirium Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 206010017076 Fracture Diseases 0.000 claims 1
- 208000036119 Frailty Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000010428 Muscle Weakness Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000009916 Postpartum depression Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000013200 Stress disease Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000021017 Weight Gain Diseases 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000000561 anti-psychotic effect Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003549 asthenia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 230000006999 cognitive decline Effects 0.000 claims 1
- 230000037410 cognitive enhancement Effects 0.000 claims 1
- 231100000867 compulsive behavior Toxicity 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 230000036457 multidrug resistance Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 208000021011 postpartum psychosis Diseases 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 125000001414 1,2,4-triazol-5-yl group Chemical group [H]N1N=C([H])N=C1[*] 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361908333P | 2013-11-25 | 2013-11-25 | |
| US61/908,333 | 2013-11-25 | ||
| US201461985035P | 2014-04-28 | 2014-04-28 | |
| US61/985,035 | 2014-04-28 | ||
| PCT/US2014/066759 WO2015077530A1 (en) | 2013-11-25 | 2014-11-21 | Octahydro fused azadecalin glucocorticoid receptor modulators |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017206081A Division JP2018012734A (ja) | 2013-11-25 | 2017-10-25 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2019063279A Division JP2019094355A (ja) | 2013-11-25 | 2019-03-28 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537394A JP2016537394A (ja) | 2016-12-01 |
| JP2016537394A5 true JP2016537394A5 (enExample) | 2017-12-07 |
| JP6516743B2 JP6516743B2 (ja) | 2019-05-22 |
Family
ID=53180165
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533614A Active JP6516743B2 (ja) | 2013-11-25 | 2014-11-21 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2017206081A Pending JP2018012734A (ja) | 2013-11-25 | 2017-10-25 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2019063279A Withdrawn JP2019094355A (ja) | 2013-11-25 | 2019-03-28 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2021021630A Withdrawn JP2021073315A (ja) | 2013-11-25 | 2021-02-15 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2022189246A Withdrawn JP2023011052A (ja) | 2013-11-25 | 2022-11-28 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2024148322A Pending JP2024170470A (ja) | 2013-11-25 | 2024-08-30 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017206081A Pending JP2018012734A (ja) | 2013-11-25 | 2017-10-25 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2019063279A Withdrawn JP2019094355A (ja) | 2013-11-25 | 2019-03-28 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2021021630A Withdrawn JP2021073315A (ja) | 2013-11-25 | 2021-02-15 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2022189246A Withdrawn JP2023011052A (ja) | 2013-11-25 | 2022-11-28 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
| JP2024148322A Pending JP2024170470A (ja) | 2013-11-25 | 2024-08-30 | オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US10047082B2 (enExample) |
| EP (4) | EP3848027B1 (enExample) |
| JP (6) | JP6516743B2 (enExample) |
| KR (1) | KR102352737B1 (enExample) |
| CN (2) | CN109761976B (enExample) |
| AU (1) | AU2014352915B2 (enExample) |
| BR (1) | BR112016011826B1 (enExample) |
| CA (1) | CA2931302C (enExample) |
| DK (2) | DK3848027T3 (enExample) |
| ES (3) | ES2943542T3 (enExample) |
| FI (1) | FI3848027T3 (enExample) |
| IL (1) | IL245848B (enExample) |
| MX (1) | MX368167B (enExample) |
| MY (1) | MY180141A (enExample) |
| PH (1) | PH12016500968B1 (enExample) |
| PL (3) | PL3560493T3 (enExample) |
| PT (2) | PT3848027T (enExample) |
| RU (1) | RU2674983C1 (enExample) |
| WO (1) | WO2015077530A1 (enExample) |
| ZA (1) | ZA201604026B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| RU2674983C1 (ru) * | 2013-11-25 | 2018-12-14 | Корсепт Терапеутикс, Инк. | Октагидро конденсированные азадекалиновые модуляторы глюкокортикоидного рецептора |
| ES2906778T3 (es) | 2015-03-30 | 2022-04-20 | Corcept Therapeutics Inc | Uso de antagonistas del receptor de glucocorticoides en combinación con glucocorticoides para tratar la insuficiencia suprarrenal |
| KR102845317B1 (ko) | 2016-03-01 | 2025-08-13 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 체크포인트 억제제를 강화시키기 위한 글루코코르티코이드 수용체 조정제의 용도 |
| CN106478464B (zh) * | 2016-08-30 | 2018-06-05 | 黄河三角洲京博化工研究院有限公司 | 一种2-氟-6-三氟甲基苯磺酰氯的制备方法 |
| US9943505B2 (en) * | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
| AU2018230429B2 (en) | 2017-03-09 | 2023-06-15 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor modulators in the treatment of catecholamine-secreting tumors |
| KR102342620B1 (ko) | 2017-03-31 | 2021-12-22 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 자궁경부암을 치료하기 위한 글루코코르티코이드 수용체 조정제 |
| US20180325891A1 (en) * | 2017-05-10 | 2018-11-15 | Corcept Therapeutics, Inc. | Octahydro azadecalin formulations |
| US11213526B2 (en) | 2017-06-20 | 2022-01-04 | Corcept Therapeutics, Inc. | Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators |
| WO2019199891A1 (en) * | 2018-04-10 | 2019-10-17 | Duke University | Lasofoxifene treatment of breast cancer |
| CA3098118C (en) | 2018-04-23 | 2023-09-05 | Corcept Therapeutics, Inc. | Methods of preparing regioselective n-alkyl triazoles |
| TWI811400B (zh) * | 2018-07-20 | 2023-08-11 | 德商歌林達有限公司 | 經進一步取代之三唑并喹噁啉衍生物 |
| IL263184A (en) | 2018-11-21 | 2020-05-31 | Yarden Yosef | Method of treating cancer and compositions for same |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| SG11202105770YA (en) | 2018-12-19 | 2021-07-29 | Corcept Therapeutics Inc | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| EP3927345A4 (en) | 2019-02-22 | 2022-12-21 | Corcept Therapeutics Incorporated | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| EP4045045A4 (en) | 2019-10-16 | 2023-11-22 | Corcept Therapeutics Incorporated | METHOD FOR NORMALIZING THE RATIO BETWEEN NEUTROPHILS AND LYMPHOCYTES IN CANCER PATIENTS USING A SELECTIVE GLUCOCORTICOID RECEPTOR ANTAGONIST |
| EP4072556A4 (en) | 2019-12-11 | 2024-01-03 | Corcept Therapeutics Incorporated | METHODS OF TREATING ANTIPSYCHOTIC DRUG-INDUCED WEIGHT GAIN WITH MIRICORILANT |
| EP4076470B1 (en) | 2019-12-21 | 2025-12-03 | Corcept Therapeutics Incorporated | Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome |
| PH12022551938A1 (en) | 2020-01-29 | 2023-10-23 | Corcept Therapeutics Inc | TREATMENT OF ADRENOCORTICAL CARCINOMA WITH SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS (SGRMs) AND ANTIBODY CHECKPOINT INHIBITORS |
| KR20220140567A (ko) * | 2020-02-10 | 2022-10-18 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 선택적 글루코코르티코이드 수용체 조절제를 사용하여 항-종양 반응을 자극하는 방법 |
| KR20230027245A (ko) | 2020-06-22 | 2023-02-27 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 4차 인다졸 글루코코르티코이드 수용체 길항제 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| WO2022166810A1 (zh) * | 2021-02-03 | 2022-08-11 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
| AU2022417485A1 (en) | 2021-12-21 | 2024-07-04 | Corcept Therapeutics Incorporated | Piperazine indazole glucocorticoid receptor antagonists |
| CA3243547A1 (en) | 2021-12-21 | 2023-06-29 | Corcept Therapeutics Inc | INDAZOLE GLUCOCORTICOID RECEPTOR BICYCLIC ANTAGONISTS |
| CN119997939A (zh) | 2022-10-06 | 2025-05-13 | 科赛普特治疗公司 | 糖皮质激素受体调节剂的制剂 |
| CN120202004A (zh) | 2022-10-28 | 2025-06-24 | 科赛普特治疗学股份有限公司 | 使用达祖可兰治疗肌萎缩侧索硬化症 |
| AU2024223250A1 (en) * | 2023-02-17 | 2025-08-14 | Corcept Therapeutics Incorporated | Methods and compositions for treating huntington's disease and its symptoms |
| US20240390341A1 (en) * | 2023-05-22 | 2024-11-28 | Corcept Therapeutics Incorporated | Methods for treating adrenal gland tumors |
| WO2025152964A1 (en) * | 2024-01-15 | 2025-07-24 | Insilico Medicine Ip Limited | Novel compounds as glucocorticoid receptor modulators and uses thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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