JP6516743B2 - オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 - Google Patents
オクタヒドロ縮合アザデカリン糖質コルチコイドレセプター調節因子 Download PDFInfo
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- JP6516743B2 JP6516743B2 JP2016533614A JP2016533614A JP6516743B2 JP 6516743 B2 JP6516743 B2 JP 6516743B2 JP 2016533614 A JP2016533614 A JP 2016533614A JP 2016533614 A JP2016533614 A JP 2016533614A JP 6516743 B2 JP6516743 B2 JP 6516743B2
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- Prior art keywords
- fluorophenyl
- sulfonyl
- pyrazolo
- octahydro
- isoquinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| US9943505B2 (en) * | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
| WO2018165460A1 (en) | 2017-03-09 | 2018-09-13 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor modulators in the treatment of catecholamine-secreting tumors |
| CN110520121B (zh) * | 2017-03-31 | 2023-07-04 | 科赛普特治疗学股份有限公司 | 糖皮质激素受体调节剂治疗宫颈癌 |
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| IL263184A (en) | 2018-11-21 | 2020-05-31 | Yarden Yosef | Method of treating cancer and compositions for same |
| KR102657097B1 (ko) | 2018-12-19 | 2024-04-15 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 헤테로아릴-케톤 융합 아자데칼린 화합물인 렐라코릴란트를 함유하는 약학적 제제 |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| BR112021015129A2 (pt) | 2019-02-22 | 2021-09-28 | Corcept Therapeutics Incorporated | Método para tratar um paciente que sofre de hipercortisolemia e um sintoma ou comorbidade da mesma |
| KR102845522B1 (ko) | 2019-10-16 | 2025-08-12 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 선택적 글루코코르티코이드 수용체 길항제로 암 환자의 호중구 대 림프구 비율을 정상화시키는 방법 |
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| CA3162636A1 (en) | 2019-12-21 | 2021-06-24 | Andreas G. MORAITIS | Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome |
| JP2023516885A (ja) | 2020-01-29 | 2023-04-21 | コーセプト セラピューティクス， インコーポレイテッド | 選択的グルココルチコイド受容体モジュレーター（ｓｇｒｍ）及び抗体チェックポイント阻害剤による副腎皮質がん腫の処置 |
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| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| WO2022166810A1 (zh) * | 2021-02-03 | 2022-08-11 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
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