JP2019507111A - 代謝抵抗性フェンフルラミン類縁体およびその使用法 - Google Patents
代謝抵抗性フェンフルラミン類縁体およびその使用法 Download PDFInfo
- Publication number
- JP2019507111A JP2019507111A JP2018532741A JP2018532741A JP2019507111A JP 2019507111 A JP2019507111 A JP 2019507111A JP 2018532741 A JP2018532741 A JP 2018532741A JP 2018532741 A JP2018532741 A JP 2018532741A JP 2019507111 A JP2019507111 A JP 2019507111A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- formula
- aryl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(*)(*)N(*)C1(*)C(*)(*I)c2cc(*)ccc2C1(*)* Chemical compound *C(*)(*)N(*)C1(*)C(*)(*I)c2cc(*)ccc2C1(*)* 0.000 description 7
- OXOBKZZXZVFOBB-UHFFFAOYSA-N C(C1)CNC1C(c1ccccc1)c1ccccc1 Chemical compound C(C1)CNC1C(c1ccccc1)c1ccccc1 OXOBKZZXZVFOBB-UHFFFAOYSA-N 0.000 description 1
- RWTNXJXZVGHMGI-UHFFFAOYSA-N C1CC(C(c2ccccc2)c2ccccc2)NCC1 Chemical compound C1CC(C(c2ccccc2)c2ccccc2)NCC1 RWTNXJXZVGHMGI-UHFFFAOYSA-N 0.000 description 1
- MUCGWXLYVIUWGS-UHFFFAOYSA-N CC(Cc1cc(C(F)(F)F)ccc1)NC(C(F)(F)F)(F)F Chemical compound CC(Cc1cc(C(F)(F)F)ccc1)NC(C(F)(F)F)(F)F MUCGWXLYVIUWGS-UHFFFAOYSA-N 0.000 description 1
- XGVGRJLWFJDRPN-UHFFFAOYSA-N CC(Cc1cc(C(F)(F)F)ccc1)NC(C(F)(F)F)F Chemical compound CC(Cc1cc(C(F)(F)F)ccc1)NC(C(F)(F)F)F XGVGRJLWFJDRPN-UHFFFAOYSA-N 0.000 description 1
- VWFTXBQOXGEASH-UHFFFAOYSA-N CC(Cc1cc(C(F)(F)F)ccc1)NCCF Chemical compound CC(Cc1cc(C(F)(F)F)ccc1)NCCF VWFTXBQOXGEASH-UHFFFAOYSA-N 0.000 description 1
- XSWHNYGMWWVAIE-UHFFFAOYSA-N OC(C1NCCCC1)(c1ccccc1)c1ccccc1 Chemical compound OC(C1NCCCC1)(c1ccccc1)c1ccccc1 XSWHNYGMWWVAIE-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562271168P | 2015-12-22 | 2015-12-22 | |
| US62/271,168 | 2015-12-22 | ||
| PCT/US2016/067852 WO2017112701A1 (en) | 2015-12-22 | 2016-12-20 | Metabolism resistant fenfluramine analogs and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019507111A true JP2019507111A (ja) | 2019-03-14 |
| JP2019507111A5 JP2019507111A5 (https=) | 2020-01-30 |
Family
ID=59065966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532741A Pending JP2019507111A (ja) | 2015-12-22 | 2016-12-20 | 代謝抵抗性フェンフルラミン類縁体およびその使用法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10689324B2 (https=) |
| EP (1) | EP3393470B1 (https=) |
| JP (1) | JP2019507111A (https=) |
| KR (1) | KR20180095674A (https=) |
| AU (1) | AU2016379345B2 (https=) |
| CA (1) | CA3007673A1 (https=) |
| WO (1) | WO2017112701A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| ES3024232T3 (en) | 2015-12-22 | 2025-06-04 | Zogenix International Ltd | Fenfluramine compositions and methods of preparing the same |
| WO2017112701A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| SG11201900975XA (en) | 2016-08-24 | 2019-03-28 | Zogenix International Ltd | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| WO2019216919A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| EA202191079A1 (ru) | 2018-11-19 | 2021-09-20 | Зодженикс Интернэшнл Лимитед | Способы лечения синдрома ретта с применением фенфлурамина |
| EP3931178B1 (en) * | 2019-03-01 | 2025-06-25 | Abrexa Pharmaceuticals, Inc. | Compounds for prevention and treatment of post-operative cognitive dysfunction |
| EP3931179B1 (en) * | 2019-03-01 | 2025-12-10 | Abrexa Pharmaceuticals, Inc. | Compounds for prevention and treatment of obesity and related disorders |
| WO2020243349A1 (en) * | 2019-05-29 | 2020-12-03 | The Regents Of The University Of California | Methods and compositions for treating epilepsy |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| EP4392027A4 (en) | 2021-08-23 | 2025-07-23 | Alexander Shulgin Res Institute Inc | FLUORINATED EMPATHOGENS |
| US20230165810A1 (en) * | 2021-12-01 | 2023-06-01 | Zogenix International Limited | Fenfluramine for treatment of conditions associated with spreading depolarization |
| WO2026013310A1 (en) * | 2024-07-11 | 2026-01-15 | Biocodex | Liquid pharmaceutical composition based on stiripentol |
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| JPH10501230A (ja) * | 1994-05-27 | 1998-02-03 | シンテックス（ユー・エス・エイ）インコーポレイテッド | １−ブチル−２−［２’−（２ｈ−テトラゾル−５−イル）−ビフェニル−４−イルメチル］−１ｈ−インドール−３−カルボン酸の製法 |
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- 2016-12-20 KR KR1020187020704A patent/KR20180095674A/ko not_active Withdrawn
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| AU2016379345B2 (en) | 2020-09-17 |
| US20200331844A1 (en) | 2020-10-22 |
| US20170174614A1 (en) | 2017-06-22 |
| US11673852B2 (en) | 2023-06-13 |
| EP3393470B1 (en) | 2021-01-20 |
| KR20180095674A (ko) | 2018-08-27 |
| US11325882B2 (en) | 2022-05-10 |
| US20190002391A1 (en) | 2019-01-03 |
| US20220289663A1 (en) | 2022-09-15 |
| EP3393470A4 (en) | 2019-05-08 |
| EP3393470A1 (en) | 2018-10-31 |
| US10689324B2 (en) | 2020-06-23 |
| CA3007673A1 (en) | 2017-06-29 |
| AU2016379345A1 (en) | 2018-06-14 |
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