JP2019501865A5 - - Google Patents

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JP2019501865A5
JP2019501865A5 JP2018517576A JP2018517576A JP2019501865A5 JP 2019501865 A5 JP2019501865 A5 JP 2019501865A5 JP 2018517576 A JP2018517576 A JP 2018517576A JP 2018517576 A JP2018517576 A JP 2018517576A JP 2019501865 A5 JP2019501865 A5 JP 2019501865A5
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crystalline hemihydrate
crystalline
diffraction pattern
ray powder
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JP6770775B2 (ja
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JP2018517576A 2015-10-16 2016-10-17 （３Ｓ，４Ｒ）−３−エチル−４−（３Ｈ−イミダゾ［１，２−ａ］ピロロ［２，３−ｅ］−ピラジン−８−イル）−Ｎ−（２，２，２−トリフルオロエチル）ピロリジン−１−カルボキサミドおよびそれの固体型の製造方法 Active JP6770775B2 (ja)

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JP2020159855A JP7358317B2 (ja) 2015-10-16 2020-09-24 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562242797P 2015-10-16 2015-10-16
US62/242,797 2015-10-16
US201562267672P 2015-12-15 2015-12-15
US62/267,672 2015-12-15
US201662301537P 2016-02-29 2016-02-29
US62/301,537 2016-02-29
US201662352380P 2016-06-20 2016-06-20
US62/352,380 2016-06-20
PCT/US2016/057372 WO2017066775A1 (en) 2015-10-16 2016-10-17 PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF

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JP2020159855A Division JP7358317B2 (ja) 2015-10-16 2020-09-24 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法

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JP2019501865A JP2019501865A (ja) 2019-01-24
JP2019501865A5 true JP2019501865A5 (enExample) 2019-12-05
JP6770775B2 JP6770775B2 (ja) 2020-10-21

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JP2018517576A Active JP6770775B2 (ja) 2015-10-16 2016-10-17 （３Ｓ，４Ｒ）−３−エチル−４−（３Ｈ−イミダゾ［１，２−ａ］ピロロ［２，３−ｅ］−ピラジン−８−イル）−Ｎ−（２，２，２−トリフルオロエチル）ピロリジン−１−カルボキサミドおよびそれの固体型の製造方法
JP2020159855A Active JP7358317B2 (ja) 2015-10-16 2020-09-24 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2022079226A Pending JP2022107001A (ja) 2015-10-16 2022-05-13 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2023096042A Pending JP2023113917A (ja) 2015-10-16 2023-06-12 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2024041977A Pending JP2024073591A (ja) 2015-10-16 2024-03-18 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2025133177A Pending JP2025166113A (ja) 2015-10-16 2025-08-08 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2025133176A Pending JP2025166112A (ja) 2015-10-16 2025-08-08 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2025165233A Pending JP2026004431A (ja) 2015-10-16 2025-10-01 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法

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JP2020159855A Active JP7358317B2 (ja) 2015-10-16 2020-09-24 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2022079226A Pending JP2022107001A (ja) 2015-10-16 2022-05-13 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2023096042A Pending JP2023113917A (ja) 2015-10-16 2023-06-12 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2024041977A Pending JP2024073591A (ja) 2015-10-16 2024-03-18 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2025133177A Pending JP2025166113A (ja) 2015-10-16 2025-08-08 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2025133176A Pending JP2025166112A (ja) 2015-10-16 2025-08-08 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法
JP2025165233A Pending JP2026004431A (ja) 2015-10-16 2025-10-01 （３Ｓ，４Ｒ）－３－エチル－４－（３Ｈ－イミダゾ［１，２－ａ］ピロロ［２，３－ｅ］－ピラジン－８－イル）－Ｎ－（２，２，２－トリフルオロエチル）ピロリジン－１－カルボキサミドおよびそれの固体型の製造方法

Country Status (13)

Country Link
US (39) US20170129902A1 (enExample)
EP (5) EP4706768A2 (enExample)
JP (8) JP6770775B2 (enExample)
KR (2) KR102753815B1 (enExample)
CN (8) CN120289468A (enExample)
AU (5) AU2016340167B2 (enExample)
BR (1) BR122022024925B1 (enExample)
CA (9) CA3251507C (enExample)
IL (3) IL314468A (enExample)
MX (2) MX387822B (enExample)
RU (1) RU2018117889A (enExample)
SG (8) SG10201913990RA (enExample)
WO (1) WO2017066775A1 (enExample)

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CN117534678B (zh) * 2023-11-08 2026-01-06 浙江宏元药业股份有限公司 一种乌帕替尼的新结晶形式及其制备方法
CN117285537B (zh) * 2023-11-27 2024-02-06 中节能万润股份有限公司 一种乌帕替尼的制备方法
CN117285535B (zh) * 2023-11-27 2024-02-02 中节能万润股份有限公司 一种乌帕替尼中间体及成盐中间体的制备方法
CN117285536B (zh) * 2023-11-27 2024-02-20 中节能万润股份有限公司 一种乌帕替尼中间体的制备方法
CN117447481A (zh) * 2023-12-23 2024-01-26 潍坊医学院 一种乌帕替尼-焦谷氨酸盐的无定形物及其制备方法与应用
WO2025149011A1 (zh) * 2024-01-11 2025-07-17 浙江华海药业股份有限公司 一种乌帕替尼或其水合物的合成工艺
KR20250130961A (ko) 2024-02-26 2025-09-02 주식회사 파마코스텍 신규한 유파다시티닙 결정형 i의 제조방법 및 신규한 유파다시티닙 결정형 i
CN118047785A (zh) * 2024-03-07 2024-05-17 和鼎（南京）医药技术有限公司 制备乌帕替尼及其中间体的方法
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