JP2019500848A5 - - Google Patents

Download PDF

Info

Publication number
JP2019500848A5
JP2019500848A5 JP2018520406A JP2018520406A JP2019500848A5 JP 2019500848 A5 JP2019500848 A5 JP 2019500848A5 JP 2018520406 A JP2018520406 A JP 2018520406A JP 2018520406 A JP2018520406 A JP 2018520406A JP 2019500848 A5 JP2019500848 A5 JP 2019500848A5
Authority
JP
Japan
Prior art keywords
tcr
abtcr
domain
tcr subunit
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018520406A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019500848A (ja
JP7316042B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/058305 external-priority patent/WO2017070608A1/en
Publication of JP2019500848A publication Critical patent/JP2019500848A/ja
Publication of JP2019500848A5 publication Critical patent/JP2019500848A5/ja
Priority to JP2021204862A priority Critical patent/JP2022050431A/ja
Application granted granted Critical
Publication of JP7316042B2 publication Critical patent/JP7316042B2/ja
Priority to JP2024015749A priority patent/JP2024062997A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018520406A 2015-10-23 2016-10-21 抗体/t細胞受容体キメラ構築物およびその使用 Active JP7316042B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021204862A JP2022050431A (ja) 2015-10-23 2021-12-17 抗体/t細胞受容体キメラ構築物およびその使用
JP2024015749A JP2024062997A (ja) 2015-10-23 2024-02-05 抗体/t細胞受容体キメラ構築物およびその使用

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562245944P 2015-10-23 2015-10-23
US62/245,944 2015-10-23
US201662304918P 2016-03-07 2016-03-07
US62/304,918 2016-03-07
US201662345649P 2016-06-03 2016-06-03
US62/345,649 2016-06-03
US201662369694P 2016-08-01 2016-08-01
US62/369,694 2016-08-01
PCT/US2016/058305 WO2017070608A1 (en) 2015-10-23 2016-10-21 Antibody/t-cell receptor chimeric constructs and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021204862A Division JP2022050431A (ja) 2015-10-23 2021-12-17 抗体/t細胞受容体キメラ構築物およびその使用

Publications (3)

Publication Number Publication Date
JP2019500848A JP2019500848A (ja) 2019-01-17
JP2019500848A5 true JP2019500848A5 (enExample) 2019-12-05
JP7316042B2 JP7316042B2 (ja) 2023-07-27

Family

ID=58558140

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018520406A Active JP7316042B2 (ja) 2015-10-23 2016-10-21 抗体/t細胞受容体キメラ構築物およびその使用
JP2021204862A Pending JP2022050431A (ja) 2015-10-23 2021-12-17 抗体/t細胞受容体キメラ構築物およびその使用
JP2024015749A Pending JP2024062997A (ja) 2015-10-23 2024-02-05 抗体/t細胞受容体キメラ構築物およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021204862A Pending JP2022050431A (ja) 2015-10-23 2021-12-17 抗体/t細胞受容体キメラ構築物およびその使用
JP2024015749A Pending JP2024062997A (ja) 2015-10-23 2024-02-05 抗体/t細胞受容体キメラ構築物およびその使用

Country Status (17)

Country Link
US (7) US11421013B2 (enExample)
EP (2) EP3842450A1 (enExample)
JP (3) JP7316042B2 (enExample)
KR (2) KR102777395B1 (enExample)
CN (4) CN115927191A (enExample)
AU (2) AU2016342041B2 (enExample)
CA (1) CA3001137A1 (enExample)
DK (1) DK3365364T5 (enExample)
ES (1) ES2979220T3 (enExample)
IL (3) IL314725A (enExample)
MX (1) MX2018004721A (enExample)
MY (1) MY194628A (enExample)
PH (1) PH12018500861A1 (enExample)
RU (2) RU2022103665A (enExample)
SG (3) SG10201913245UA (enExample)
TW (2) TWI856368B (enExample)
WO (1) WO2017070608A1 (enExample)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2899779T3 (es) 2014-12-05 2022-03-14 Memorial Sloan Kettering Cancer Center Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos
JP6753851B2 (ja) * 2014-12-05 2020-09-09 メモリアル スローン ケタリング キャンサー センター Gタンパク質共役受容体を標的化する抗体および使用の方法
JP2018515123A (ja) 2015-05-18 2018-06-14 ティーシーアール2 セラピューティクス インク. 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法
JP7316042B2 (ja) 2015-10-23 2023-07-27 ユーリカ セラピューティックス, インコーポレイテッド 抗体/t細胞受容体キメラ構築物およびその使用
GB201604458D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
WO2018053542A1 (en) 2016-09-19 2018-03-22 University Of Southern California Non-radioactive cytotoxicity assays
CN110352068A (zh) * 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
CA3059753A1 (en) * 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Chimeric antibody/t-cell receptor constructs and uses thereof
MX420947B (es) 2017-04-26 2025-02-10 Eureka Therapeutics Inc Constructos que reconocen específicamente glipicano 3 y usos de estos.
SG11202000027WA (en) 2017-07-14 2020-02-27 Immatics Biotechnologies Gmbh Improved dual specificity polypeptide molecule
WO2019051001A1 (en) * 2017-09-06 2019-03-14 California Institute Of Technology SIGNALING AND BIFUNCTIONAL RECEPTORS HAVING ANTIGENS (SABR)
KR102820804B1 (ko) 2017-09-22 2025-06-16 우시 바이올로직스 아일랜드 리미티드 신규한 이중특이적 cd3/cd19 폴리펩티드 복합체
BR112020005676A2 (pt) * 2017-09-22 2020-10-20 WuXi Biologics Ireland Limited novos complexos polipeptídicos biespecíficos
CN111629734A (zh) * 2017-09-27 2020-09-04 南加利福尼亚大学 用于共刺激的新型平台、新型car设计以及过继性细胞疗法的其他增强
US11066475B2 (en) 2017-11-01 2021-07-20 Juno Therapeutics, Inc. Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides
GB201718088D0 (en) * 2017-11-01 2017-12-13 Autolus Ltd Vectors
CN109971715A (zh) * 2017-12-28 2019-07-05 深圳华大生命科学研究院 一种扩增特异性car-t细胞的培养方法
JPWO2019151392A1 (ja) * 2018-01-31 2021-02-04 国立大学法人東北大学 抗原特異的mhc発現調節法
GB201801920D0 (en) * 2018-02-06 2018-03-21 Autolus Ltd Polypeptides and methods
WO2019157454A1 (en) * 2018-02-11 2019-08-15 Memorial Sloan-Kettering Cancer Center Non-hla restricted t cell receptors and uses thereof
CN112041432A (zh) 2018-02-15 2020-12-04 纪念斯隆-凯特林癌症中心 Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法
CA3092993A1 (en) * 2018-03-09 2019-09-12 Sorrento Therapeutics, Inc. Dimeric antigen receptors (dar)
CA3094927A1 (en) * 2018-03-23 2019-09-26 Gavish-Galilee Bio Applications Ltd. Genetically reprogrammed tregs expressing membrane-bound il-10
CN112888709B (zh) * 2018-03-30 2024-10-29 优瑞科生物技术公司 标靶cd22的构建体和其用途
CN110407927B (zh) * 2018-04-26 2022-09-09 香雪生命科学技术(广东)有限公司 一种识别afp抗原的tcr
SG11202011837UA (en) 2018-06-01 2020-12-30 Univ Southern California Diverse antigen binding domains, novel platforms and other enhancements for cellular therapy
CN112469440B (zh) 2018-06-18 2024-09-06 优瑞科生物技术公司 靶向前列腺特异性膜抗原(psma)的构建体和其用途
CN113286824A (zh) * 2018-08-03 2021-08-20 中外制药株式会社 包含两个彼此连接的抗原结合结构域的抗原结合分子
CN110818802B (zh) * 2018-08-08 2022-02-08 华夏英泰(北京)生物技术有限公司 一种嵌合t细胞受体star及其应用
SG11202102882YA (en) * 2018-09-28 2021-04-29 Chugai Pharmaceutical Co Ltd Antigen-binding molecule comprising altered antibody variable region
BR112021008289A2 (pt) 2018-11-01 2021-10-26 Juno Therapeutics, Inc. Métodos para tratamento utilizando receptores de antígeno quimérico específico para antígeno de maturação de célula b
MX2021005751A (es) 2018-11-16 2021-10-01 Memorial Sloan Kettering Cancer Center Anticuerpos contra mucina 16 y métodos de uso de los mismos.
JP7630832B2 (ja) * 2018-11-19 2025-02-18 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム Carおよびtcr形質導入用のモジュール式ポリシストロニックベクター
US12325734B2 (en) 2019-01-15 2025-06-10 Altor Bioscience Llc Human immunodeficiency virus-specific T cell receptors
CN110006724B (zh) * 2019-04-17 2021-06-04 郑州安图生物工程股份有限公司 采用巴氏和革兰氏染色方法检测滴虫用试剂
DE102019121007A1 (de) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigenbindende Proteine, die spezifisch an MAGE-A binden
WO2021026266A1 (en) * 2019-08-05 2021-02-11 Distributed Bio, Inc. Antigen binding molecules and methods of screening thereof
WO2021030153A2 (en) * 2019-08-09 2021-02-18 A2 Biotherapeutics, Inc. Engineered t cell receptors and uses thereof
MX2022002723A (es) * 2019-09-05 2022-03-22 Sorrento Therapeutics Inc Receptores de antigeno dimerico (dar) que se enlazan a bcma.
JP2022548866A (ja) * 2019-09-12 2022-11-22 ティーシーアール2 セラピューティクス インク. 融合タンパク質を用いたtcrリプログラミングのための組成物及び方法
EP4086281A4 (en) * 2019-12-30 2024-02-14 China Immunotech (Beijing) Biotechnology Co., Ltd IMPROVED STAR T CELL RECEPTOR AND ITS APPLICATION
CN115427084A (zh) * 2020-01-10 2022-12-02 T细胞受体治疗公司 用于自身免疫调节的组合物和方法
CN111320703A (zh) * 2020-03-11 2020-06-23 北京双赢科创生物科技有限公司 靶向cd22的嵌合抗原受体及其应用
US20230212319A1 (en) 2020-03-16 2023-07-06 University Of Southern California Novel antigen binding domains and synthetic antigen receptors incorporating the same
AU2021239360A1 (en) 2020-03-20 2022-11-10 Lyell Immunopharma, Inc. Novel recombinant cell surface markers
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
US20240148869A1 (en) * 2020-05-07 2024-05-09 China Immunotech (Beijing) Biotechnology Co., Ltd Improved T cell receptor-costimulatory molecule chimera
CN115715299A (zh) * 2020-05-25 2023-02-24 华夏英泰(北京)生物技术有限公司 增强型合成t细胞受体抗原受体
EP4281473A4 (en) * 2021-01-19 2024-12-18 Wuxi Biologics Ireland Limited POLYPEPTIDE COMPLEXES WITH ENHANCED STABILITY AND EXPRESSION
WO2022164959A1 (en) 2021-01-27 2022-08-04 Lyell Immunopharma, Inc. Improved immune cell therapy
JP2024509095A (ja) 2021-02-25 2024-02-29 ライエル・イミュノファーマ・インコーポレイテッド 細胞の培養方法
WO2022187591A1 (en) 2021-03-05 2022-09-09 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
MX2023012902A (es) 2021-05-05 2023-11-08 Immatics Biotechnologies Gmbh Proteinas de union a antigenos que se unen especificamente a prame.
CA3217739A1 (en) 2021-05-05 2022-11-10 Sebastian Bunk Bma031 antigen binding polypeptides
EP4377336A4 (en) * 2021-07-29 2025-07-16 Nantcell Inc MODIFIED T CELL RECEPTORS FOR THE PREVENTION AND TREATMENT OF VIRAL INFECTIONS AND CANCER
JP2024531915A (ja) 2021-08-05 2024-09-03 ジーオー セラピューティクス,インコーポレイテッド 抗グリコmuc抗体およびその使用
AU2022339819A1 (en) 2021-09-03 2024-04-11 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
TW202328188A (zh) 2021-09-03 2023-07-16 美商Go治療公司 抗醣化-cmet抗體及其用途
WO2023070041A1 (en) 2021-10-21 2023-04-27 Lyell Immunopharma, Inc. Enhanced immune cell therapy
AU2022378579A1 (en) 2021-10-28 2024-05-02 Lyell Immunopharma, Inc. Methods of generating cells
EP4423145A1 (en) 2021-10-28 2024-09-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
KR20240112376A (ko) 2021-10-28 2024-07-18 라이엘 이뮤노파마, 인크. c-Jun을 발현하는 세포를 배양하는 방법
WO2023133540A1 (en) 2022-01-07 2023-07-13 Lyell Immunopharma, Inc. Il-12 affinity variants
WO2024020429A1 (en) 2022-07-22 2024-01-25 Lyell Immunopharma, Inc. Immune cell therapy
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024062138A1 (en) 2022-09-23 2024-03-28 Mnemo Therapeutics Immune cells comprising a modified suv39h1 gene
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024100136A1 (en) * 2022-11-08 2024-05-16 Gadeta B.V. Novel method for obtaining gamma t-cell (or delta t-cell) receptor chains (or gamma delta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response
CN120187751A (zh) * 2022-11-15 2025-06-20 原启生物科技(上海)有限责任公司 抗afp/hla02 tcr样抗体及其用途
KR20250133399A (ko) * 2023-01-05 2025-09-05 앤젤레스 테라퓨틱스, 인코포레이티드 유전자 전달 및 합성 및 면역 수용체의 활성을 제어하기 위한 방법 및 조성물
WO2024148369A1 (en) 2023-01-07 2024-07-11 Lyell Immunopharma, Inc. Targeted il-12 affinity variants
WO2024182539A1 (en) 2023-02-28 2024-09-06 Lyell Immunopharma, Inc. Methods of culturing reprogrammed cells
WO2025006797A1 (en) 2023-06-27 2025-01-02 Lyell Immunopharma, Inc. Il-12 stability variants
WO2025024559A1 (en) 2023-07-24 2025-01-30 Strand Therapeutics Inc. Rna-based synthetic circuit for producing engineered immune cells for an extracorporeal cell therapy
WO2025047925A1 (ja) * 2023-08-31 2025-03-06 国立大学法人三重大学 ハイブリッドt細胞受容体
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium
WO2026006604A1 (en) 2024-06-26 2026-01-02 Lyell Immunopharma, Inc. Feeder cell replacement

Family Cites Families (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753357A (en) 1970-12-14 1973-08-21 Ovitron Res Corp Method and apparatus for the preservation of cells and tissues
US4199022A (en) 1978-12-08 1980-04-22 The United States Of America As Represented By The Department Of Energy Method of freezing living cells and tissues with improved subsequent survival
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL86278A (en) * 1988-05-04 2003-06-24 Yeda Res & Dev Endowing cells with antibody specificity using chimeric t cell receptor
US5906936A (en) 1988-05-04 1999-05-25 Yeda Research And Development Co. Ltd. Endowing lymphocytes with antibody specificity
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69127627T2 (de) 1990-08-29 1998-02-19 Genpharm Int Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
ATE164395T1 (de) 1990-12-03 1998-04-15 Genentech Inc Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US8211422B2 (en) 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
US5585358A (en) 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
EP0835306A1 (en) 1995-06-30 1998-04-15 Kobenhavns Universitet Recombinant antibodies from a phage display library, directed against a peptide-mhc complex
DE19544393A1 (de) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistische herbizide Mischungen
AU757961B2 (en) * 1998-09-30 2003-03-13 Sankyo Company Limited Anti-Fas antibodies
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
EP1240319A1 (en) 1999-12-15 2002-09-18 Genentech, Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
ES2302726T3 (es) 2000-02-24 2008-08-01 Invitrogen Corporation Estimulacion y concentracion simultanea de celulas.
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
HUP0300369A2 (hu) 2000-04-11 2003-06-28 Genentech, Inc. Többértékű antitestek és alkalmazásuk
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
AU2001297703B2 (en) 2000-11-07 2006-10-19 City Of Hope CD19-specific redirected immune cells
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
AU2002357060A1 (en) 2001-12-03 2003-06-17 Abgenix, Inc. Antibody categorization based on binding characteristics
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
EP1485075A4 (en) * 2002-02-20 2006-04-26 Dyax Corp MHC-PEPTIDE COMPLEX BINDING LIGANDS
CN1662556B (zh) 2002-05-22 2013-05-01 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法
JP4753578B2 (ja) 2002-06-03 2011-08-24 ジェネンテック, インコーポレイテッド 合成抗体ファージライブラリー
WO2004065416A2 (en) 2003-01-16 2004-08-05 Genentech, Inc. Synthetic antibody phage libraries
WO2004106380A2 (en) 2003-05-31 2004-12-09 Micromet Ag Human-anti-human cd3 binding molecules
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
US20060034850A1 (en) 2004-05-27 2006-02-16 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
AU2006232287B2 (en) 2005-03-31 2011-10-06 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
WO2006130458A2 (en) * 2005-06-02 2006-12-07 Astrazeneca Ab Antibodies directed to cd20 and uses thereof
KR20080032097A (ko) 2005-06-20 2008-04-14 메다렉스, 인코포레이티드 씨디19 항체 및 그의 용도
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US9078843B2 (en) 2005-09-22 2015-07-14 Irun R. Cohen Immunogenic fragments of T-cell receptor constant domains and peptides derived therefrom
US8679490B2 (en) 2005-11-07 2014-03-25 Genentech, Inc. Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
US20070237764A1 (en) 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
JP5431920B2 (ja) 2006-04-28 2014-03-05 デリネックス・セラピューティクス・アーゲー 受容体チロシンキナーゼalkの細胞外ドメインに結合する抗体
ES2382777T3 (es) * 2006-05-03 2012-06-13 Government Of The United States Of America,As Represented By The Secretary, Department Of Health And Human Services Receptor de células T quimérico y materiales relacionados y métodos de uso
CA2651567A1 (en) 2006-05-09 2007-11-22 Genentech, Inc. Binding polypeptides with optimized scaffolds
EP2026837A4 (en) 2006-06-01 2010-06-02 Receptor Logic Inc ANTIBODIES AS T-CELL RECEPTOR MIMICS, METHOD OF MANUFACTURE AND ITS USES
AU2007294575B2 (en) 2006-09-08 2013-06-27 Viela Bio, Inc. Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
CA2685675C (en) 2007-05-01 2016-02-16 Research Development Foundation Immunoglobulin fc libraries
CN100592373C (zh) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 液晶显示面板驱动装置及其驱动方法
EP2727933B1 (en) 2008-06-25 2019-01-09 Athenix Corporation Toxin genes and methods for their use
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
WO2010059543A1 (en) 2008-11-20 2010-05-27 Merck Sharp & Dohme Corp. Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
US20100153133A1 (en) 2008-12-16 2010-06-17 International Business Machines Corporation Generating Never-Event Cohorts from Patient Care Data
WO2010091637A1 (en) 2009-02-10 2010-08-19 Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
EP2459181A2 (en) 2009-07-30 2012-06-06 Helmholtz-Zentrum für Infektionsforschung GmbH Compositions for generating an antigen specific immune response
CA2778533A1 (en) 2009-10-22 2011-04-28 Ricardo J. Moro Peptides that bind the alpha-fetoprotein (afp) receptor and uses thereof
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
PL2552959T3 (pl) 2010-03-26 2017-08-31 Memorial Sloan-Kettering Cancer Center Przeciwciała przeciwko MUC16 i metody stosowania
WO2012050374A2 (en) 2010-10-13 2012-04-19 Innocell, Inc. Immunotherapy for solid tumors
EA201391449A1 (ru) 2011-04-01 2014-03-31 Мемориал Слоан-Кеттеринг Кэнсер Сентер Антитела против пептидов цитозоля
US10239952B2 (en) 2011-04-01 2019-03-26 Memorial Sloan Kettering Cancer Center Anti-WT1/HLA bi-specific antibody
UY34317A (es) * 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
US20130280220A1 (en) 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
AU2013253581B2 (en) 2012-04-23 2019-05-16 Genefrontier Corporation Anti-human CD69 antibody, and use thereof for medical purposes
CN103319595B (zh) 2012-07-04 2016-12-28 中国药科大学 抗人afp单链抗体以及融合抗原肽的制备方法和应用
MX2015000426A (es) 2012-07-13 2015-07-14 Univ Pennsylvania Incremento de actividad de celulas t car mediante cointroduccion de un anticuerpo biespecifico.
WO2014014796A1 (en) * 2012-07-18 2014-01-23 Eli Lilly And Company Multi-specific igg-(fab)2 constructs containing t-cell receptor constant domains
CN104769103B (zh) 2012-09-04 2018-06-08 塞勒克提斯公司 多链嵌合抗原受体和其用途
SG11201502598SA (en) 2012-10-02 2015-05-28 Sloan Kettering Inst Cancer Compositions and methods for immunotherapy
CN102993305B (zh) 2012-11-16 2015-05-13 上海赛伦生物技术有限公司 人源抗人表皮生长因子受体抗体及其编码基因与应用
EP3756687A3 (en) 2012-12-13 2021-03-24 University Of Virginia Patent Foundation Target peptides for ovarian cancer therapy and diagnostics
CN103965362B (zh) 2013-02-06 2019-02-01 上海细胞治疗集团有限公司 一种可使t细胞趋向肿瘤部位的嵌合趋化因子受体
JPWO2014123165A1 (ja) 2013-02-06 2017-02-02 旭硝子株式会社 透明面材およびそれを用いた表示装置
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
EP2975942B1 (en) 2013-03-21 2018-08-08 Sangamo Therapeutics, Inc. Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
KR101536668B1 (ko) 2013-06-18 2015-07-15 사회복지법인 삼성생명공익재단 인간 및 마우스 c-Met에 교차결합하는 항체 및 그의 용도
GB201313377D0 (en) 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
WO2015063069A1 (en) 2013-10-28 2015-05-07 Benjamin Felder Chimeric antigen receptors with antigen binding domains derived from gamma delta t cell receptors
JP6553069B2 (ja) 2013-11-07 2019-07-31 メモリアル スローン ケタリング キャンサー センター 抗wt1/hla二重特異性抗体
CN104087592B (zh) 2014-05-13 2016-01-27 天津医科大学总医院 Afp158-166特异性tcr基因及其转基因t细胞及体外增殖方法及用途
SMT202100221T1 (it) 2014-12-05 2021-07-12 Memorial Sloan Kettering Cancer Center Anticorpi bersaglianti l'antigene di maturazione delle cellule e metodi d'uso
JP6753851B2 (ja) 2014-12-05 2020-09-09 メモリアル スローン ケタリング キャンサー センター Gタンパク質共役受容体を標的化する抗体および使用の方法
US11673957B2 (en) 2015-03-10 2023-06-13 Eureka Therapeutics, Inc. Anti-ROR2 antibodies
US11066480B2 (en) 2015-03-17 2021-07-20 Memorial Sloan Kettering Cancer Center Anti-MUC16 antibodies and uses thereof
JP6903587B2 (ja) 2015-04-03 2021-07-14 ユーリカ セラピューティックス, インコーポレイテッド Afpペプチド/mhc複合体を標的化する構築物およびその使用
WO2016182957A1 (en) 2015-05-08 2016-11-17 Eureka Therapeutics, Inc. Constructs targeting hpv16-e7 peptide/mhc complexes and uses thereof
JP2018515123A (ja) 2015-05-18 2018-06-14 ティーシーアール2 セラピューティクス インク. 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法
EP3842072A1 (en) 2015-05-18 2021-06-30 Eureka Therapeutics, Inc. Anti-ror1 antibodies
TW201702272A (zh) 2015-05-22 2017-01-16 美國紀念斯隆 凱特琳癌症中心 Prame肽專一性類t細胞受體抗體
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
HK1252653A1 (zh) 2015-06-09 2019-05-31 Memorial Sloan Kettering Cancer Center 特异於人hla呈递的ebv潜伏膜蛋白2a肽的t细胞受体样抗体药剂
EP3313873A4 (en) 2015-06-24 2019-04-24 Eureka Therapeutics, Inc. AGAINST NY-ESO-1 PEPTIDE / MHC COMPLEX DRAWINGS AND USES THEREOF
WO2017004252A1 (en) 2015-06-30 2017-01-05 The Arizona Board Of Regents On Behalf Of The University Of Arizona Redirected cells with mhc chimeric receptors and methods of use in immunotherapy
WO2017015634A2 (en) 2015-07-22 2017-01-26 Eureka Therapeutics, Inc. Constructs targeting psa peptide/mhc complexes and uses thereof
MY196631A (en) 2015-10-13 2023-04-24 Eureka Therapeutics Inc Antibody Agents Specific for Human Cd19 and uses Thereof
JP7316042B2 (ja) 2015-10-23 2023-07-27 ユーリカ セラピューティックス, インコーポレイテッド 抗体/t細胞受容体キメラ構築物およびその使用
CN105331585A (zh) 2015-11-13 2016-02-17 科济生物医药(上海)有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
PH12018501177B1 (en) 2015-12-04 2024-01-24 Eureka Therapeutics Inc Antibodies targeting fc receptor-like 5 and methods of use
US11505599B2 (en) 2016-01-14 2022-11-22 Memorial Sloan-Kettering Cancer Center T cell receptor-like antibodies specific for Foxp3-derived peptides
WO2018057967A2 (en) 2016-09-23 2018-03-29 Eureka Therapeutics, Inc. Constructs targeting hiv peptide/mhc complexes and uses thereof
MX420947B (es) 2017-04-26 2025-02-10 Eureka Therapeutics Inc Constructos que reconocen específicamente glipicano 3 y usos de estos.
CN112888709B (zh) 2018-03-30 2024-10-29 优瑞科生物技术公司 标靶cd22的构建体和其用途
CN112469440B (zh) 2018-06-18 2024-09-06 优瑞科生物技术公司 靶向前列腺特异性膜抗原(psma)的构建体和其用途
MX2021005751A (es) 2018-11-16 2021-10-01 Memorial Sloan Kettering Cancer Center Anticuerpos contra mucina 16 y métodos de uso de los mismos.
US20220235143A1 (en) 2019-05-08 2022-07-28 Memorial Sloan Kettering Cancer Center Humanized antibodies to mucin-16 and methods of use thereof

Similar Documents

Publication Publication Date Title
JP2019500848A5 (enExample)
RU2018118652A (ru) Химерные конструкции антитело/т-клеточный рецептор и их применения
US20250188145A1 (en) Tcr and peptides
CN108135998B (zh) 高亲合力hpv t细胞受体
JP2023021396A (ja) キメラ抗原受容体
JP6985934B2 (ja) 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用
US20190177746A1 (en) Retroviral And Lentiviral Vectors
KR20190016960A (ko) γδ T-세포 집단의 선택적 확장을 위한 방법 및 그의 조성물
JP2016505635A (ja) Mage−a1を認識する高結合活性結合分子
US20180223255A1 (en) Activation and Expansion of T Cells
US20220177524A1 (en) Nef-containing t cells and methods of producing thereof
KR20230013257A (ko) 종양 미세환경의 역전을 위한 융합 단백질 및 이의 응용
JP7606510B2 (ja) Ebv-由来抗原に特異的なtcr構築物
JP7747724B2 (ja) マウス定常領域を伴うtcrを発現する細胞を選択的に増幅するための方法
CN110776562A (zh) 一种识别afp抗原的t细胞受体
Lyu et al. A novel and simple method to produce large amounts of recombinant soluble peptide/major histocompatibility complex monomers for analysis of antigen-specific human T cell receptors
AU2019370618C1 (en) Bispecific polypeptides for engagement of CAR expressing immune cells with antigen presenting cells and uses thereof
Merhavi-Shoham et al. Genetically modulating T-cell function to target cancer
WO2021022447A1 (zh) 识别afp抗原短肽的t细胞受体
ES2877820T3 (es) Composiciones y métodos para la clonación rápida de receptores de células T
CN112041432A (zh) Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法
CN119613563A (zh) 编码car的核酸分子和含其的载体、car、含car的免疫细胞及其制造方法和含该细胞的医药组合物及提升细胞损伤活性的方法
CN107129537A (zh) 抗乙型肝炎病毒的免疫反应性细胞
JP7518915B2 (ja) Cd3融合タンパク質およびその使用
GB2641580A (en) Tumour-transforming multispecific proteins