JP2019500848A5 - - Google Patents
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- JP2019500848A5 JP2019500848A5 JP2018520406A JP2018520406A JP2019500848A5 JP 2019500848 A5 JP2019500848 A5 JP 2019500848A5 JP 2018520406 A JP2018520406 A JP 2018520406A JP 2018520406 A JP2018520406 A JP 2018520406A JP 2019500848 A5 JP2019500848 A5 JP 2019500848A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021204862A JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
| JP2024015749A JP2024062997A (ja) | 2015-10-23 | 2024-02-05 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245944P | 2015-10-23 | 2015-10-23 | |
| US62/245,944 | 2015-10-23 | ||
| US201662304918P | 2016-03-07 | 2016-03-07 | |
| US62/304,918 | 2016-03-07 | ||
| US201662345649P | 2016-06-03 | 2016-06-03 | |
| US62/345,649 | 2016-06-03 | ||
| US201662369694P | 2016-08-01 | 2016-08-01 | |
| US62/369,694 | 2016-08-01 | ||
| PCT/US2016/058305 WO2017070608A1 (en) | 2015-10-23 | 2016-10-21 | Antibody/t-cell receptor chimeric constructs and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204862A Division JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500848A JP2019500848A (ja) | 2019-01-17 |
| JP2019500848A5 true JP2019500848A5 (enExample) | 2019-12-05 |
| JP7316042B2 JP7316042B2 (ja) | 2023-07-27 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520406A Active JP7316042B2 (ja) | 2015-10-23 | 2016-10-21 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
| JP2021204862A Pending JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
| JP2024015749A Pending JP2024062997A (ja) | 2015-10-23 | 2024-02-05 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204862A Pending JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
| JP2024015749A Pending JP2024062997A (ja) | 2015-10-23 | 2024-02-05 | 抗体／ｔ細胞受容体キメラ構築物およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US11421013B2 (enExample) |
| EP (2) | EP3365364B1 (enExample) |
| JP (3) | JP7316042B2 (enExample) |
| KR (2) | KR102777395B1 (enExample) |
| CN (4) | CN115925973A (enExample) |
| AU (2) | AU2016342041B2 (enExample) |
| CA (1) | CA3001137A1 (enExample) |
| DK (1) | DK3365364T5 (enExample) |
| ES (1) | ES2979220T3 (enExample) |
| IL (3) | IL314725A (enExample) |
| MX (1) | MX2018004721A (enExample) |
| MY (1) | MY194628A (enExample) |
| PH (1) | PH12018500861A1 (enExample) |
| RU (1) | RU2767209C2 (enExample) |
| SG (3) | SG10201913245UA (enExample) |
| TW (2) | TWI780031B (enExample) |
| WO (1) | WO2017070608A1 (enExample) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3227339T3 (da) | 2014-12-05 | 2022-01-10 | Memorial Sloan Kettering Cancer Center | Kimæriske antigenreceptorer rettet mod g-protein-koblet receptor og anvendelser deraf |
| AU2015357535B2 (en) * | 2014-12-05 | 2020-05-14 | Eureka Therapeutics, Inc. | Antibodies targeting G-protein coupled receptor and methods of use |
| EP3770168A1 (en) | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| MX2018004721A (es) | 2015-10-23 | 2018-07-06 | Eureka Therapeutics Inc | Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas. |
| GB201604458D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| EP3516068B1 (en) | 2016-09-19 | 2025-04-23 | University of Southern California | Non-radioactive cytotoxicity assays |
| CN110352068A (zh) * | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| WO2018200582A1 (en) * | 2017-04-26 | 2018-11-01 | Eureka Therapeutics, Inc. | Chimeric antibody/t-cell receptor constructs and uses thereof |
| EP3615574B1 (en) | 2017-04-26 | 2026-06-24 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
| US20190016802A1 (en) * | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Dual specificity polypeptide molecule |
| CN111315769A (zh) | 2017-09-06 | 2020-06-19 | 加州理工学院 | 信号传导和抗原呈递双功能受体(sabr) |
| CN117843810A (zh) | 2017-09-22 | 2024-04-09 | 上海药明生物技术有限公司 | 新型双特异性多肽复合物 |
| CN109535257B (zh) | 2017-09-22 | 2021-05-28 | 同润生物医药(上海)有限公司 | 新型双特异性cd3/cd19多肽复合物 |
| BR112020005938A2 (pt) * | 2017-09-27 | 2020-11-17 | University Of Southern California | célula imune ou população de células imunes da mesma, célula efetora imune ou célula-tronco, célula que apresenta antígeno, polinucleotídeo recombinante, vetor, composição que compreende uma célula imune efetora ou uma célula-tronco, métodos para produzir uma célula efetora imune que expressa receptor imune de ocorrência não natural, para gerar uma população de células manipuladas por rna, para fornecer imunidade antidoença em um indivíduo, para tratar ou prevenir uma doença associada à expressão de um antígeno, e, uso |
| GB201718088D0 (en) * | 2017-11-01 | 2017-12-13 | Autolus Ltd | Vectors |
| US11066475B2 (en) | 2017-11-01 | 2021-07-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides |
| CN109971715A (zh) * | 2017-12-28 | 2019-07-05 | 深圳华大生命科学研究院 | 一种扩增特异性car-t细胞的培养方法 |
| JPWO2019151392A1 (ja) * | 2018-01-31 | 2021-02-04 | 国立大学法人東北大学 | 抗原特異的ｍｈｃ発現調節法 |
| GB201801920D0 (en) * | 2018-02-06 | 2018-03-21 | Autolus Ltd | Polypeptides and methods |
| SG11202007622SA (en) * | 2018-02-11 | 2020-09-29 | Memorial Sloan Kettering Cancer Center | Non-hla restricted t cell receptors and uses thereof |
| CN112041432A (zh) | 2018-02-15 | 2020-12-04 | 纪念斯隆-凯特林癌症中心 | Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法 |
| SG11202008568WA (en) | 2018-03-09 | 2020-10-29 | Sorrento Therapeutics Inc | Dimeric antigen receptors (dar) |
| AU2019240370B2 (en) * | 2018-03-23 | 2024-03-07 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed Tregs expressing membrane-bound IL-10 |
| CN112888709B (zh) * | 2018-03-30 | 2024-10-29 | 优瑞科生物技术公司 | 标靶cd22的构建体和其用途 |
| CN110407927B (zh) * | 2018-04-26 | 2022-09-09 | 香雪生命科学技术（广东）有限公司 | 一种识别afp抗原的tcr |
| JP7599205B2 (ja) * | 2018-06-01 | 2024-12-13 | アンヘレス セラピューティクス インコーポレイテッド | 細胞療法のための多様な抗原結合ドメイン、新規プラットフォームおよびその他の強化 |
| CN112469440B (zh) | 2018-06-18 | 2024-09-06 | 优瑞科生物技术公司 | 靶向前列腺特异性膜抗原(psma)的构建体和其用途 |
| US12435137B2 (en) * | 2018-08-03 | 2025-10-07 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing two antigen-binding domains that are linked to each other |
| CN110818802B (zh) * | 2018-08-08 | 2022-02-08 | 华夏英泰（北京）生物技术有限公司 | 一种嵌合t细胞受体star及其应用 |
| JP2022501325A (ja) * | 2018-09-28 | 2022-01-06 | 中外製薬株式会社 | 改変された抗体可変領域を含む抗原結合分子 |
| US12473345B2 (en) | 2018-11-01 | 2025-11-18 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| JP7627216B2 (ja) | 2018-11-16 | 2025-02-05 | メモリアル スローン ケタリング キャンサー センター | ムチン－１６に対する抗体およびそれを使用する方法 |
| US20220033848A1 (en) * | 2018-11-19 | 2022-02-03 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
| WO2020150364A1 (en) * | 2019-01-15 | 2020-07-23 | Altor Bioscience, Llc | Human immunodeficiency virus-specific t cell receptors |
| CN110006724B (zh) * | 2019-04-17 | 2021-06-04 | 郑州安图生物工程股份有限公司 | 采用巴氏和革兰氏染色方法检测滴虫用试剂 |
| DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
| EP4010697A4 (en) * | 2019-08-05 | 2022-10-12 | Charles River Laboratories, Inc. | ANTIGEN-BINDING MOLECULES AND THEIR SCREENING METHODS |
| WO2021030153A2 (en) * | 2019-08-09 | 2021-02-18 | A2 Biotherapeutics, Inc. | Engineered t cell receptors and uses thereof |
| CN114650829A (zh) * | 2019-09-05 | 2022-06-21 | 索伦托药业有限公司 | 结合bcma的二聚体抗原受体(dar) |
| KR20220078607A (ko) * | 2019-09-12 | 2022-06-10 | 티씨알2 테라퓨틱스 인크. | 융합 단백질들을 이용한 tcr 재프로그래밍을 위한 조성물 및 방법들 |
| WO2021113780A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods |
| EP4086281A4 (en) * | 2019-12-30 | 2024-02-14 | China Immunotech (Beijing) Biotechnology Co., Ltd | IMPROVED STAR T CELL RECEPTOR AND ITS APPLICATION |
| US20230338421A1 (en) * | 2020-01-10 | 2023-10-26 | TCR2 Therapeutics Inc. | Compositions and methods for autoimmunity regulation |
| CN111320703A (zh) * | 2020-03-11 | 2020-06-23 | 北京双赢科创生物科技有限公司 | 靶向cd22的嵌合抗原受体及其应用 |
| WO2021188599A1 (en) | 2020-03-16 | 2021-09-23 | University Of Southern California | Novel antigen binding domains and synthetic antigen receptors incorporating the same |
| EP4121447A1 (en) | 2020-03-20 | 2023-01-25 | Lyell Immunopharma, Inc. | Novel recombinant cell surface markers |
| WO2021222479A1 (en) | 2020-04-28 | 2021-11-04 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| JP7645500B2 (ja) * | 2020-05-07 | 2025-03-14 | ブリスター イムノテック リミテッド | 改善されたｔ細胞受容体共刺激分子キメラ |
| EP4159768A4 (en) * | 2020-05-25 | 2024-11-20 | Bristar Immunotech Limited | Enhanced synthetic t-cell receptor and antigen receptor |
| WO2022156687A1 (en) * | 2021-01-19 | 2022-07-28 | Wuxi Biologics (Shanghai) Co., Ltd. | Polypeptide complexes with improved stability and expression |
| WO2022164959A1 (en) | 2021-01-27 | 2022-08-04 | Lyell Immunopharma, Inc. | Improved immune cell therapy |
| AU2022226660A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| EP4301782A1 (en) | 2021-03-05 | 2024-01-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| WO2022233956A1 (en) | 2021-05-05 | 2022-11-10 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
| KR20240004937A (ko) | 2021-05-05 | 2024-01-11 | 이매틱스 바이오테크놀로지스 게엠베하 | Bma031 항원 결합 폴리펩타이드 |
| US20240327492A1 (en) * | 2021-07-29 | 2024-10-03 | Nantcell, Inc. | Modified T Cell Receptors For The Prevention And Treatment Of Viral Infections And Cancer |
| JP2024531915A (ja) | 2021-08-05 | 2024-09-03 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｍｕｃ抗体およびその使用 |
| JP2024534910A (ja) | 2021-09-03 | 2024-09-26 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｌａｍｐ１抗体およびその使用 |
| WO2023034569A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
| US20250228939A1 (en) | 2021-10-21 | 2025-07-17 | Lyell Immunopharma, Inc. | Enhanced immune cell therapy |
| JP2024540099A (ja) | 2021-10-28 | 2024-10-31 | ライエル・イミュノファーマ・インコーポレイテッド | Ｒｏｒ１結合タンパク質を発現する細胞を培養する方法 |
| US20230313138A1 (en) | 2021-10-28 | 2023-10-05 | Lyell Immunopharma, Inc. | Methods for culturing cells expressing c-jun |
| WO2023076511A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods of generating cells |
| WO2023133540A1 (en) | 2022-01-07 | 2023-07-13 | Lyell Immunopharma, Inc. | Il-12 affinity variants |
| CN116063458A (zh) * | 2022-04-27 | 2023-05-05 | 恒瑞源正(广州)生物科技有限公司 | Mage-a1特异性t细胞受体及其用途 |
| WO2024020429A1 (en) | 2022-07-22 | 2024-01-25 | Lyell Immunopharma, Inc. | Immune cell therapy |
| WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
| WO2024062138A1 (en) | 2022-09-23 | 2024-03-28 | Mnemo Therapeutics | Immune cells comprising a modified suv39h1 gene |
| WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024100136A1 (en) * | 2022-11-08 | 2024-05-16 | Gadeta B.V. | Novel method for obtaining gamma t-cell (or delta t-cell) receptor chains (or gamma delta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response |
| EP4620974A1 (en) * | 2022-11-15 | 2025-09-24 | Oricell Therapeutics Co., Ltd. | Anti-afp/hla02 tcr-like antibody and use thereof |
| JP2026501516A (ja) * | 2023-01-05 | 2026-01-16 | アンヘレス セラピューティクス インコーポレイテッド | 遺伝子導入および合成および免疫受容体の活性を制御するための方法および組成物 |
| WO2024148369A1 (en) | 2023-01-07 | 2024-07-11 | Lyell Immunopharma, Inc. | Targeted il-12 affinity variants |
| WO2024182539A1 (en) | 2023-02-28 | 2024-09-06 | Lyell Immunopharma, Inc. | Methods of culturing reprogrammed cells |
| JP2026524181A (ja) | 2023-06-27 | 2026-07-21 | ライエル・イミュノファーマ・インコーポレイテッド | Ｉｌ－１２安定性バリアント |
| KR20260042228A (ko) | 2023-07-24 | 2026-03-30 | 스트랜드 세러퓨틱스 인코포레이티드 | 체외 세포 요법을 위한 조작된 면역 세포를 생산하기 위한 rna 기반 합성 회로 |
| WO2025047925A1 (ja) * | 2023-08-31 | 2025-03-06 | 国立大学法人三重大学 | ハイブリッドｔ細胞受容体 |
| WO2025217398A1 (en) | 2024-04-10 | 2025-10-16 | Lyell Immunopharma, Inc. | Methods for culturing cells with improved culture medium |
| WO2026006604A1 (en) | 2024-06-26 | 2026-01-02 | Lyell Immunopharma, Inc. | Feeder cell replacement |
Family Cites Families (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL86278A (en) * | 1988-05-04 | 2003-06-24 | Yeda Res & Dev | Endowing cells with antibody specificity using chimeric t cell receptor |
| US5906936A (en) | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US5585358A (en) | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| JPH11510375A (ja) | 1995-06-30 | 1999-09-14 | コベンハブンズ ユニバーサイテッド | ペプチド−ｍｈｃ複合体を指向するファージディスプレイライブラリーからの組換え抗体 |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| AU757961B2 (en) * | 1998-09-30 | 2003-03-13 | Sankyo Company Limited | Anti-Fas antibodies |
| EP1235842A4 (en) | 1999-10-15 | 2003-04-23 | Univ Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| JP2003516755A (ja) | 1999-12-15 | 2003-05-20 | ジェネンテック・インコーポレーテッド | ショットガン走査、すなわち機能性タンパク質エピトープをマッピングするための組み合わせ方法 |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| HK1052372A1 (zh) | 2000-02-24 | 2003-09-11 | Xcyte Therapies, Inc. | 细胞的同步刺激和富集 |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| PT2857516T (pt) | 2000-04-11 | 2017-08-28 | Genentech Inc | Anticorpos multivalentes e utilizações dos mesmos |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| US7446179B2 (en) | 2000-11-07 | 2008-11-04 | City Of Hope | CD19-specific chimeric T cell receptor |
| US7070995B2 (en) * | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7771951B2 (en) | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| AU2003216341A1 (en) | 2002-02-20 | 2003-09-09 | Dyax Corporation | Mhc-peptide complex binding ligands |
| CN102093477B (zh) | 2002-05-22 | 2014-02-26 | 艾斯巴技术-诺华有限责任公司 | 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法 |
| EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
| AU2004205631A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| AU2004242845B2 (en) | 2003-05-31 | 2011-06-02 | Amgen Research (Munich) Gmbh | Human-anti-human CD3 binding molecules |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| US20060034850A1 (en) | 2004-05-27 | 2006-02-16 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| KR101374454B1 (ko) | 2005-03-31 | 2014-03-17 | 추가이 세이야쿠 가부시키가이샤 | 회합제어에 의한 폴리펩티드 제조방법 |
| EP1891113A2 (en) * | 2005-06-02 | 2008-02-27 | AstraZeneca AB | Antibodies directed to cd20 and uses thereof |
| WO2007002223A2 (en) | 2005-06-20 | 2007-01-04 | Medarex, Inc. | Cd19 antibodies and their uses |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US9078843B2 (en) | 2005-09-22 | 2015-07-14 | Irun R. Cohen | Immunogenic fragments of T-cell receptor constant domains and peptides derived therefrom |
| EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| WO2007064919A2 (en) | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| CA2650822C (en) | 2006-04-28 | 2017-03-14 | Esbatech Ag | Antibodies binding to the extracellular domain of the receptor tyrosine kinase alk |
| US20090304657A1 (en) * | 2006-05-03 | 2009-12-10 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Chimeric t cell receptors and related materials and methods of use |
| EP2016101A2 (en) | 2006-05-09 | 2009-01-21 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
| WO2007143104A2 (en) | 2006-06-01 | 2007-12-13 | Receptor Logic, Ltd. | Antibodies as t cell receptor mimics, methods of production and uses thereof |
| US8323653B2 (en) | 2006-09-08 | 2012-12-04 | Medimmune, Llc | Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| US8629245B2 (en) | 2007-05-01 | 2014-01-14 | Research Development Foundation | Immunoglobulin Fc libraries |
| CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
| EP2297189A2 (en) | 2008-06-25 | 2011-03-23 | Athenix Corporation | Toxin genes and methods for their use |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| WO2010059543A1 (en) | 2008-11-20 | 2010-05-27 | Merck Sharp & Dohme Corp. | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
| US20100153133A1 (en) | 2008-12-16 | 2010-06-17 | International Business Machines Corporation | Generating Never-Event Cohorts from Patient Care Data |
| US20110311517A1 (en) | 2009-02-10 | 2011-12-22 | Shenogen Pharma Group, Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
| EP2258719A1 (en) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| WO2011012720A2 (en) | 2009-07-30 | 2011-02-03 | Helmholtz-Zentrum für Infektionsforschung GmbH | Compositions for generating an antigen specific immune response |
| WO2011048503A2 (en) | 2009-10-22 | 2011-04-28 | Moro Ricardo J | Peptides that bind the alpha-fetoprotein (afp) receptor and uses thereof |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| CA2793753C (en) | 2010-03-26 | 2018-06-05 | Memorial Sloan-Kettering Cancer Center | Antibodies to muc16 and methods of use thereof |
| WO2012050374A2 (en) | 2010-10-13 | 2012-04-19 | Innocell, Inc. | Immunotherapy for solid tumors |
| ES2785081T3 (es) | 2011-04-01 | 2020-10-05 | Memorial Sloan Kettering Cancer Center | Anticuerpos biespecíficos similares a receptores de células T específicos para un péptido de WT1 presentado por HLA-A2 |
| WO2015070061A1 (en) | 2013-11-07 | 2015-05-14 | Memorial Sloan-Kettering Cancer Center | Anti-wt1/hla bi-specific antibody |
| US10239952B2 (en) | 2011-04-01 | 2019-03-26 | Memorial Sloan Kettering Cancer Center | Anti-WT1/HLA bi-specific antibody |
| UY34317A (es) * | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| US20130280220A1 (en) | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
| EP2843051B1 (en) | 2012-04-23 | 2018-06-06 | GeneFrontier Corporation | Anti-human cd69 antibody, and use thereof for medical purposes |
| CN103319595B (zh) | 2012-07-04 | 2016-12-28 | 中国药科大学 | 抗人afp单链抗体以及融合抗原肽的制备方法和应用 |
| KR20150029714A (ko) | 2012-07-13 | 2015-03-18 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 이중특이적 항체의 공-도입에 의한 ｃａｒ 세포의 활성 증강 |
| US20150183877A1 (en) * | 2012-07-18 | 2015-07-02 | Eli Lilly And Company | Multi-Specific IgG-(Fab)2 Constructs Containing T-Cell Receptor Constant Domains |
| AU2013312838B2 (en) | 2012-09-04 | 2018-11-29 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| RU2729401C2 (ru) | 2012-10-02 | 2020-08-06 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы для иммунотерапии |
| CN102993305B (zh) | 2012-11-16 | 2015-05-13 | 上海赛伦生物技术有限公司 | 人源抗人表皮生长因子受体抗体及其编码基因与应用 |
| WO2014093855A1 (en) | 2012-12-13 | 2014-06-19 | University Of Virginia Patent Foundation | Target peptides for ovarian cancer therapy and diagnostics |
| WO2014123165A1 (ja) | 2013-02-06 | 2014-08-14 | 旭硝子株式会社 | 透明面材およびそれを用いた表示装置 |
| CN103965362B (zh) | 2013-02-06 | 2019-02-01 | 上海细胞治疗集团有限公司 | 一种可使t细胞趋向肿瘤部位的嵌合趋化因子受体 |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| AU2014235968B2 (en) * | 2013-03-21 | 2018-05-24 | Ospedale San Raffaele Srl | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| KR101536668B1 (ko) | 2013-06-18 | 2015-07-15 | 사회복지법인 삼성생명공익재단 | 인간 및 마우스 c-Met에 교차결합하는 항체 및 그의 용도 |
| GB201313377D0 (en) | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| WO2015063069A1 (en) | 2013-10-28 | 2015-05-07 | Benjamin Felder | Chimeric antigen receptors with antigen binding domains derived from gamma delta t cell receptors |
| CN104087592B (zh) | 2014-05-13 | 2016-01-27 | 天津医科大学总医院 | Afp158-166特异性tcr基因及其转基因t细胞及体外增殖方法及用途 |
| HRP20210582T1 (hr) | 2014-12-05 | 2021-09-03 | Memorial Sloan Kettering Cancer Center | Antitijela koja ciljaju antigen sazrijevanja b-stanice i postupci uporabe |
| AU2015357535B2 (en) | 2014-12-05 | 2020-05-14 | Eureka Therapeutics, Inc. | Antibodies targeting G-protein coupled receptor and methods of use |
| WO2016142768A1 (en) | 2015-03-10 | 2016-09-15 | Eureka Therapeutics, Inc. | Ror2 antibody |
| KR102618312B1 (ko) | 2015-03-17 | 2023-12-28 | 메모리얼 슬로안 케터링 캔서 센터 | 항muc16 항체 및 그의 용도 |
| CN114456272A (zh) | 2015-04-03 | 2022-05-10 | 优瑞科生物技术公司 | 靶向afp肽/mhc复合体的构建体及其用途 |
| JP2018516879A (ja) | 2015-05-08 | 2018-06-28 | ユーリカ セラピューティックス， インコーポレイテッド | Ｈｐｖ１６−ｅ７ペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
| EP3770168A1 (en) | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| HK1253507A1 (zh) | 2015-05-18 | 2019-06-21 | Eureka Therapeutics, Inc. | 抗 ror1 抗体 |
| TW201702272A (zh) | 2015-05-22 | 2017-01-16 | 美國紀念斯隆 凱特琳癌症中心 | Ｐｒａｍｅ肽專一性類ｔ細胞受體抗體 |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| IL281396B (en) | 2015-06-09 | 2022-07-01 | Memorial Sloan Kettering Cancer Center | T cell receptor-like antibody agents specific for ebv latent membrane protein 2a peptide presented by human hla |
| RU2018102526A (ru) | 2015-06-24 | 2019-07-25 | Еурека Терапьютикс, Инк. | Конструкции, направленные на комплексы пептида ny-eso-1/мнс, и их применение |
| WO2017004252A1 (en) | 2015-06-30 | 2017-01-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with mhc chimeric receptors and methods of use in immunotherapy |
| KR20180029253A (ko) | 2015-07-22 | 2018-03-20 | 유레카 쎄라퓨틱스, 인코포레이티드 | Psa 펩티드/mhc 복합체를 표적화하는 구축물 및 그의 용도 |
| SG11201803054UA (en) | 2015-10-13 | 2018-05-30 | Eureka Therapeutics Inc | Antibody agents specific for human cd19 and uses thereof |
| MX2018004721A (es) | 2015-10-23 | 2018-07-06 | Eureka Therapeutics Inc | Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas. |
| CN105331585A (zh) | 2015-11-13 | 2016-02-17 | 科济生物医药（上海）有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| PH12018501177B1 (en) | 2015-12-04 | 2024-01-24 | Eureka Therapeutics Inc | Antibodies targeting fc receptor-like 5 and methods of use |
| US11505599B2 (en) | 2016-01-14 | 2022-11-22 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for Foxp3-derived peptides |
| WO2018057967A2 (en) | 2016-09-23 | 2018-03-29 | Eureka Therapeutics, Inc. | Constructs targeting hiv peptide/mhc complexes and uses thereof |
| EP3615574B1 (en) | 2017-04-26 | 2026-06-24 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
| CN112888709B (zh) | 2018-03-30 | 2024-10-29 | 优瑞科生物技术公司 | 标靶cd22的构建体和其用途 |
| CN112469440B (zh) | 2018-06-18 | 2024-09-06 | 优瑞科生物技术公司 | 靶向前列腺特异性膜抗原(psma)的构建体和其用途 |
| JP7627216B2 (ja) | 2018-11-16 | 2025-02-05 | メモリアル スローン ケタリング キャンサー センター | ムチン－１６に対する抗体およびそれを使用する方法 |
| US12617866B2 (en) | 2019-05-08 | 2026-05-05 | Memorial Sloan Kettering Cancer Center | Humanized antibodies to mucin-16 and methods of use thereof |
-
2016
- 2016-10-21 MX MX2018004721A patent/MX2018004721A/es unknown
- 2016-10-21 IL IL314725A patent/IL314725A/en unknown
- 2016-10-21 CN CN202210861652.9A patent/CN115925973A/zh active Pending
- 2016-10-21 CN CN202210862478.XA patent/CN115927191A/zh active Pending
- 2016-10-21 CA CA3001137A patent/CA3001137A1/en active Pending
- 2016-10-21 ES ES16858388T patent/ES2979220T3/es active Active
- 2016-10-21 JP JP2018520406A patent/JP7316042B2/ja active Active
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- 2016-10-21 EP EP16858388.8A patent/EP3365364B1/en active Active
- 2016-10-21 US US15/769,724 patent/US11421013B2/en active Active
- 2016-10-21 KR KR1020187014004A patent/KR102777395B1/ko active Active
- 2016-10-21 CN CN202210865517.1A patent/CN116059316A/zh active Pending
- 2016-10-21 IL IL295398A patent/IL295398B2/en unknown
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