JP2019131609A5 - - Google Patents
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- JP2019131609A5 JP2019131609A5 JP2019077828A JP2019077828A JP2019131609A5 JP 2019131609 A5 JP2019131609 A5 JP 2019131609A5 JP 2019077828 A JP2019077828 A JP 2019077828A JP 2019077828 A JP2019077828 A JP 2019077828A JP 2019131609 A5 JP2019131609 A5 JP 2019131609A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- chemotherapeutic agent
- composition according
- cancer
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 88
- 239000002246 antineoplastic agent Substances 0.000 claims 58
- 229940127089 cytotoxic agent Drugs 0.000 claims 58
- 150000001875 compounds Chemical class 0.000 claims 11
- 206010006187 Breast cancer Diseases 0.000 claims 9
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 8
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 4
- 201000000582 Retinoblastoma Diseases 0.000 claims 4
- 229960002932 anastrozole Drugs 0.000 claims 4
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 4
- 229960003881 letrozole Drugs 0.000 claims 4
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical group C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229960001603 tamoxifen Drugs 0.000 claims 4
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 3
- 102000015694 estrogen receptors Human genes 0.000 claims 3
- 108010038795 estrogen receptors Proteins 0.000 claims 3
- 229960000575 trastuzumab Drugs 0.000 claims 3
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical group C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims 2
- 229940122531 Anaplastic lymphoma kinase inhibitor Drugs 0.000 claims 2
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 2
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 2
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical group C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 claims 2
- 108010069236 Goserelin Proteins 0.000 claims 2
- 229940124647 MEK inhibitor Drugs 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 229940116355 PI3 kinase inhibitor Drugs 0.000 claims 2
- 239000012828 PI3K inhibitor Substances 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 229940078123 Ras inhibitor Drugs 0.000 claims 2
- 229960000997 bicalutamide Drugs 0.000 claims 2
- 229960004117 capecitabine Drugs 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 230000009977 dual effect Effects 0.000 claims 2
- 229960005167 everolimus Drugs 0.000 claims 2
- 229960002074 flutamide Drugs 0.000 claims 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 229960002913 goserelin Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229940124302 mTOR inhibitor Drugs 0.000 claims 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 2
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 2
- 229960001156 mitoxantrone Drugs 0.000 claims 2
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical group O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 2
- 229960002653 nilutamide Drugs 0.000 claims 2
- XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical group O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 2
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 2
- 229960004618 prednisone Drugs 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229960005026 toremifene Drugs 0.000 claims 2
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 208000017891 HER2 positive breast carcinoma Diseases 0.000 claims 1
- 229960005558 mertansine Drugs 0.000 claims 1
- PDGKHKMBHVFCMG-UHFFFAOYSA-N CN(CC1)CCN1c(cc1)cnc1Nc1ncc(cc2[n]3C4(CCCCC4)CNC2=O)c3n1 Chemical compound CN(CC1)CCN1c(cc1)cnc1Nc1ncc(cc2[n]3C4(CCCCC4)CNC2=O)c3n1 PDGKHKMBHVFCMG-UHFFFAOYSA-N 0.000 description 5
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798772P | 2013-03-15 | 2013-03-15 | |
| US61/798,772 | 2013-03-15 | ||
| US201361861374P | 2013-08-01 | 2013-08-01 | |
| US61/861,374 | 2013-08-01 | ||
| US201361911354P | 2013-12-03 | 2013-12-03 | |
| US61/911,354 | 2013-12-03 | ||
| US201461949786P | 2014-03-07 | 2014-03-07 | |
| US61/949,786 | 2014-03-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089382A Division JP6517401B2 (ja) | 2013-03-15 | 2018-05-07 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020123189A Division JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019131609A JP2019131609A (ja) | 2019-08-08 |
| JP2019131609A5 true JP2019131609A5 (enExample) | 2019-10-10 |
| JP6738933B2 JP6738933B2 (ja) | 2020-08-12 |
| JP6738933B6 JP6738933B6 (ja) | 2020-09-09 |
Family
ID=51527871
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503092A Active JP6337083B2 (ja) | 2013-03-15 | 2014-03-14 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2016502870A Active JP6430483B2 (ja) | 2013-03-15 | 2014-03-14 | 化学療法の間の正常細胞の一時的な保護 |
| JP2018089382A Active JP6517401B2 (ja) | 2013-03-15 | 2018-05-07 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018204234A Active JP6767456B2 (ja) | 2013-03-15 | 2018-10-30 | 化学療法の間の正常細胞の一時的な保護 |
| JP2019077828A Active JP6738933B6 (ja) | 2013-03-15 | 2019-04-16 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020123189A Active JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020155691A Active JP7213854B2 (ja) | 2013-03-15 | 2020-09-16 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023005413A Ceased JP2023052449A (ja) | 2013-03-15 | 2023-01-17 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023044746A Withdrawn JP2023078341A (ja) | 2013-03-15 | 2023-03-20 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503092A Active JP6337083B2 (ja) | 2013-03-15 | 2014-03-14 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2016502870A Active JP6430483B2 (ja) | 2013-03-15 | 2014-03-14 | 化学療法の間の正常細胞の一時的な保護 |
| JP2018089382A Active JP6517401B2 (ja) | 2013-03-15 | 2018-05-07 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018204234A Active JP6767456B2 (ja) | 2013-03-15 | 2018-10-30 | 化学療法の間の正常細胞の一時的な保護 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020123189A Active JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020155691A Active JP7213854B2 (ja) | 2013-03-15 | 2020-09-16 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023005413A Ceased JP2023052449A (ja) | 2013-03-15 | 2023-01-17 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023044746A Withdrawn JP2023078341A (ja) | 2013-03-15 | 2023-03-20 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Country Status (18)
| Country | Link |
|---|---|
| US (15) | US9487530B2 (enExample) |
| EP (4) | EP4596051A3 (enExample) |
| JP (9) | JP6337083B2 (enExample) |
| CN (4) | CN105473140B (enExample) |
| CA (2) | CA2906156C (enExample) |
| CY (1) | CY1122434T1 (enExample) |
| DK (1) | DK2968290T3 (enExample) |
| ES (2) | ES2761406T3 (enExample) |
| HR (1) | HRP20192168T1 (enExample) |
| HU (1) | HUE046653T2 (enExample) |
| LT (1) | LT2968290T (enExample) |
| ME (1) | ME03557B (enExample) |
| PL (1) | PL2968290T3 (enExample) |
| PT (1) | PT2968290T (enExample) |
| RS (1) | RS59790B1 (enExample) |
| SI (1) | SI2968290T1 (enExample) |
| SM (1) | SMT201900681T1 (enExample) |
| WO (2) | WO2014144326A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9259399B2 (en) | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
| US8691830B2 (en) * | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| CA2868966C (en) | 2012-03-29 | 2021-01-26 | Francis Xavier Tavares | Lactam kinase inhibitors |
| US10202392B2 (en) | 2012-04-26 | 2019-02-12 | Francis Xavier Tavares | Synthesis of lactams |
| WO2014144326A1 (en) | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Transient protection of normal cells during chemotherapy |
| CN105407723A (zh) | 2013-03-15 | 2016-03-16 | G1治疗公司 | 高效的抗赘生剂和抗增生剂 |
| US20150297606A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic Lactams for Use in the Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation |
| WO2016040858A1 (en) * | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| US20160220569A1 (en) * | 2015-02-03 | 2016-08-04 | G1 Therapeutics, Inc. | CDK4/6 Inhibitor Dosage Formulations For The Protection Of Hematopoietic Stem And Progenitor Cells During Chemotherapy |
| MX389753B (es) | 2015-06-17 | 2025-03-20 | Pfizer | Compuestos triciclicos y su uso como inhibidores de la fosfodiesterasa |
| CN108348514A (zh) * | 2015-08-28 | 2018-07-31 | 诺华股份有限公司 | 含pi3k抑制剂alpelisib和cdk4/6抑制剂ribociclib的药物组合以及其在治疗/预防癌症中的应用 |
| JP6635374B2 (ja) * | 2015-12-18 | 2020-01-22 | 京都府公立大学法人 | 癌におけるリン酸化ｒｂタンパク質を指標としたイリノテカン感受性予測法 |
| US11077110B2 (en) * | 2016-03-18 | 2021-08-03 | Tufts Medical Center | Compositions and methods for treating and preventing metabolic disorders |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| WO2018005863A1 (en) * | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| EA201990189A1 (ru) * | 2016-07-01 | 2019-06-28 | Г1 Терапьютикс, Инк. | Синтез n-(гетероарил)пирроло[3,2-d]пиримидин-2-аминов |
| WO2018005533A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Antiproliferative pyrimidine-based compounds |
| KR20190025943A (ko) | 2016-07-01 | 2019-03-12 | 쥐원 쎄라퓨틱스, 인크. | 피리미딘-기재 항증식제 |
| IL264950B2 (en) | 2016-08-23 | 2024-01-01 | Eisai R&D Man Co Ltd | Combined treatments for the treatment of malignant liver cell carcinoma |
| AU2017359333B2 (en) | 2016-11-08 | 2024-03-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods of modulating anti-tumor immunity |
| WO2018106729A1 (en) | 2016-12-05 | 2018-06-14 | G1 Therapeutics, Inc. | Preservation of immune response during chemotherapy regimens |
| EP3565558B1 (en) | 2017-01-06 | 2023-12-06 | G1 Therapeutics, Inc. | Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer |
| WO2018156812A1 (en) | 2017-02-22 | 2018-08-30 | G1 Therapeutics, Inc. | Treatment of egfr-driven cancer with fewer side effects |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| CN110636862A (zh) | 2017-03-16 | 2019-12-31 | 卫材 R&D 管理有限公司 | 用于治疗乳腺癌的组合疗法 |
| KR102317480B1 (ko) | 2017-03-23 | 2021-10-25 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| WO2019006393A1 (en) * | 2017-06-29 | 2019-01-03 | G1 Therapeutics, Inc. | Morphic forms of git38 and methods of manufacture thereof |
| KR102464677B1 (ko) | 2017-08-11 | 2022-11-10 | 셍커 파마슈티컬스 (지앙수) 엘티디. | 단백질 인산화효소 억제제로 작용하는 1h-피라졸로[4,3-h]퀴나졸린 화합물 |
| WO2019136451A1 (en) | 2018-01-08 | 2019-07-11 | G1 Therapeutics, Inc. | G1t38 superior dosage regimes |
| BR112020015431A2 (pt) | 2018-02-15 | 2020-12-08 | Nuvation Bio Inc. | Compostos heterocíclicos como inibidores de quinase |
| AU2019253706A1 (en) * | 2018-04-09 | 2020-11-26 | G1 Therapeutics, Inc. | Treatment of cancers having driving oncogenic mutations |
| SG11202100429TA (en) * | 2018-07-27 | 2021-02-25 | California Inst Of Techn | Cdk inhibitors and uses thereof |
| KR20210049847A (ko) | 2018-08-24 | 2021-05-06 | 쥐원 쎄라퓨틱스, 인크. | 1,4-디아자스피로[5.5]운데칸-3-온의 개선된 합성 |
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| JP2022536854A (ja) * | 2019-06-18 | 2022-08-19 | ジー１、セラピューティクス、インコーポレイテッド | 癌患者における抗腫瘍免疫の増強のための患者選択 |
| TW202128174A (zh) * | 2019-10-09 | 2021-08-01 | 美商G1治療公司 | 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療 |
| AU2021273744A1 (en) | 2020-05-19 | 2022-12-08 | Pharmacosmos Holding A/S | Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders |
| KR20230023661A (ko) * | 2020-06-11 | 2023-02-17 | 루넬라 바이오테크 인코포레이티드 | 선택적 cdk4/6 억제제 암 치료제 |
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