|
US5948786A
(en)
|
1996-04-12 |
1999-09-07 |
Sumitomo Pharmaceuticals Company, Limited |
Piperidinylpyrimidine derivatives
|
|
ATE395058T1
(de)
|
2000-03-24 |
2008-05-15 |
Asterand Uk Ltd |
Verwendung von prostanoid-ep4-rezeptor- antagonisten zur behandlung von kopfschmerzen und nachweisverfahren für solche antagonisten
|
|
HN2001000224A
(es)
|
2000-10-19 |
2002-06-13 |
Pfizer |
Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
|
|
GB0031302D0
(en)
|
2000-12-21 |
2001-01-31 |
Glaxo Group Ltd |
Napthalene derivatives
|
|
GB0031295D0
(en)
|
2000-12-21 |
2001-01-31 |
Glaxo Group Ltd |
Naphthalene derivatives
|
|
GB0103269D0
(en)
|
2001-02-09 |
2001-03-28 |
Glaxo Group Ltd |
Napthalene derivatives
|
|
CA2482382A1
(en)
|
2002-04-12 |
2003-10-23 |
Pfizer Inc. |
Pyrazole compounds as anti-inflammatory and analgesic agents
|
|
MXPA04009961A
(es)
|
2002-04-12 |
2004-12-13 |
Pfizer |
Compuestos de imidazol como agentes anti-inflamatorios y analgesicos.
|
|
AU2003233297A1
(en)
|
2002-05-23 |
2003-12-12 |
Theratechnologies Inc |
Antagonistic peptides of prostaglandin e2 receptor subtype ep4
|
|
DE602004013938D1
(de)
|
2003-01-29 |
2008-07-03 |
Asterand Uk Ltd |
Hemmstoffe des ep4-rezeptors
|
|
CA2536887C
(en)
|
2003-08-26 |
2012-03-06 |
Teijin Pharma Limited |
Pyrrolopyrimidinone derivatives
|
|
WO2005021508A1
(en)
|
2003-09-03 |
2005-03-10 |
Pfizer Inc. |
Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists
|
|
US8084457B2
(en)
|
2003-09-15 |
2011-12-27 |
Lead Discovery Center Gmbh |
Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
|
|
GB0324269D0
(en)
|
2003-10-16 |
2003-11-19 |
Pharmagene Lab Ltd |
EP4 receptor antagonists
|
|
WO2005080367A1
(en)
|
2004-02-12 |
2005-09-01 |
Pharmagene Laboratories Limited |
Ep2 receptor agonists
|
|
AU2005238291A1
(en)
|
2004-05-04 |
2005-11-10 |
Pfizer Inc. |
Substituted methyl aryl or heteroaryl amide compounds
|
|
BRPI0510598A
(pt)
|
2004-05-04 |
2007-11-20 |
Pfizer |
compostos de amida de aril ou heteroaril substituìdos
|
|
GT200500284A
(es)
*
|
2004-10-15 |
2006-03-27 |
Aventis Pharma Inc |
Pirimidinas como antagonistas del receptor de prostaglandina d2
|
|
AU2006246930C1
(en)
|
2005-05-19 |
2012-01-19 |
Merck Canada Inc. |
Quinoline derivatives as EP4 antagonists
|
|
WO2006128129A2
(en)
|
2005-05-26 |
2006-11-30 |
Synta Pharmaceuticals Corp. |
Method for treating cancer
|
|
DOP2007000068A
(es)
|
2006-04-12 |
2007-10-31 |
Sanofi Aventis Us Llc |
Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2
|
|
EP2013169B1
(en)
|
2006-04-24 |
2012-08-22 |
Merck Canada Inc. |
Indole amide derivatives as ep4 receptor antagonists
|
|
EP2035376B1
(en)
|
2006-06-12 |
2014-08-27 |
Merck Canada Inc. |
Indoline amide derivatives as ep4 receptor ligands
|
|
US20080280891A1
(en)
|
2006-06-27 |
2008-11-13 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents and uses thereof
|
|
WO2008008059A1
(en)
|
2006-07-12 |
2008-01-17 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents ans uses thereof
|
|
ES2393932T3
(es)
|
2006-07-14 |
2013-01-02 |
Novartis Ag |
Derivados de Pirimidina como inhibidores de ALK-5
|
|
CN101541778B
(zh)
|
2006-08-11 |
2014-10-08 |
默克加拿大有限公司 |
作为ep4受体配体的噻吩甲酰胺衍生物
|
|
WO2008039882A1
(en)
|
2006-09-30 |
2008-04-03 |
Sanofi-Aventis U.S. Llc |
A combination of niacin and a prostaglandin d2 receptor antagonist
|
|
US8158671B2
(en)
|
2007-02-26 |
2012-04-17 |
Merck Canada Inc. |
Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
|
|
JP2010522218A
(ja)
|
2007-03-26 |
2010-07-01 |
メルク フロスト カナダ リミテツド |
Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体
|
|
CA2681861A1
(en)
|
2007-03-26 |
2008-10-16 |
Astellas Pharma Inc. |
Ornithine derivative
|
|
EP2014657A1
(de)
*
|
2007-06-21 |
2009-01-14 |
Bayer Schering Pharma Aktiengesellschaft |
Diaminopyrimidine als Modulatoren des EP2-Rezeptors
|
|
US20110028463A1
(en)
|
2007-07-03 |
2011-02-03 |
Astellas Pharma Inc. |
Amide compounds
|
|
AU2008309517B2
(en)
|
2007-10-12 |
2013-03-14 |
Astrazeneca Ab |
Inhibitors of protein kinases
|
|
CA2714743C
(en)
|
2008-02-19 |
2017-01-17 |
Janssen Pharmaceutica N.V. |
Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase
|
|
SI2565191T1
(sl)
|
2008-05-14 |
2014-12-31 |
Astellas Pharma Inc. |
Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije
|
|
US20130225528A1
(en)
|
2008-05-21 |
2013-08-29 |
Ariad Pharmaceuticals, Inc. |
Phosphorus Derivatives as Kinase Inhibitors
|
|
CN102149384B
(zh)
|
2008-08-14 |
2014-08-20 |
南京奥昭生物科技有限公司 |
作为ep4受体拮抗剂的杂环酰胺衍生物
|
|
US9029414B2
(en)
|
2008-09-19 |
2015-05-12 |
Biotechnology Research Corporation |
Triterpenoid compounds and methods of use thereof
|
|
CN102224154A
(zh)
|
2008-09-25 |
2011-10-19 |
默克弗罗斯特加拿大有限公司 |
作为EP4受体拮抗剂的β-咔啉磺酰脲衍生物
|
|
WO2011022348A1
(en)
|
2009-08-18 |
2011-02-24 |
Janssen Pharmaceutica Nv |
Ethylene diamine modulators of fatty acid amide hydrolase
|
|
US20110124667A1
(en)
|
2009-11-23 |
2011-05-26 |
Philip Manton Brown |
Methods for the treatment of irritable bowel syndrome
|
|
BR112012029647A2
(pt)
|
2010-05-21 |
2016-08-02 |
Chemilia Ab |
novos derivados de pirimidinas
|
|
HRP20170042T1
(hr)
|
2010-09-21 |
2017-03-10 |
Eisai R&D Management Co., Ltd. |
Farmaceutski pripravak
|
|
CN106046158A
(zh)
|
2010-09-29 |
2016-10-26 |
株式会社Nb健康研究所 |
针对人前列腺素e2 受体ep4 的抗体
|
|
WO2012066065A1
(en)
|
2010-11-17 |
2012-05-24 |
Novartis Ag |
Phenyl-heteroaryl amine compounds and their uses
|
|
WO2012066070A1
(en)
|
2010-11-17 |
2012-05-24 |
Novartis Ag |
3-(aminoaryl)-pyridine compounds
|
|
CA2820109C
(en)
|
2010-12-10 |
2018-01-09 |
Rottapharm S.P.A. |
Pyridine amide derivatives as ep4 receptor antagonists
|
|
WO2012103071A2
(en)
|
2011-01-25 |
2012-08-02 |
Eisai R&D Management Co., Ltd. |
Compounds and compositions
|
|
BR112013024378A2
(pt)
|
2011-03-24 |
2016-12-13 |
Chemilia Ab |
novos derivados de pirimidina
|
|
WO2012149528A1
(en)
|
2011-04-29 |
2012-11-01 |
Exelixis, Inc. |
Inhibitors of inducible form of 6-phosphofructose-2-kinase
|
|
US9518044B2
(en)
|
2011-06-20 |
2016-12-13 |
Emory University |
Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto
|
|
CN103702980B
(zh)
|
2011-07-04 |
2016-10-05 |
罗达制药生物技术有限责任公司 |
环胺衍生物作为ep4受体拮抗剂
|
|
EP2554662A1
(en)
|
2011-08-05 |
2013-02-06 |
M Maria Pia Cosma |
Methods of treatment of retinal degeneration diseases
|
|
WO2013090552A1
(en)
|
2011-12-13 |
2013-06-20 |
Yale University |
Compositions and methods for reducing ctl exhaustion
|
|
US9296701B2
(en)
|
2012-04-24 |
2016-03-29 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
|
JO3296B1
(ar)
|
2012-06-29 |
2018-09-16 |
Lilly Co Eli |
مركبات فينوكسي إيثيل بيبريدين
|
|
TWI572597B
(zh)
|
2012-06-29 |
2017-03-01 |
美國禮來大藥廠 |
二甲基－苯甲酸化合物
|
|
EP2711364A1
(en)
*
|
2012-09-21 |
2014-03-26 |
Chemilia AB |
4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer
|
|
BR112015011497B1
(pt)
|
2012-11-27 |
2023-01-10 |
Thomas Helledays Stiftelse För Medicinsk Forskning |
Composto, e, formulação farmacêutica
|
|
UA115576C2
(uk)
|
2012-12-06 |
2017-11-27 |
Байєр Фарма Акцієнгезелльшафт |
Похідні бензимідазолу як антагоністи ер4
|
|
EP2765128A1
(en)
|
2013-02-07 |
2014-08-13 |
Almirall, S.A. |
Substituted benzamides with activity towards EP4 receptors
|
|
TW201443004A
(zh)
|
2013-02-15 |
2014-11-16 |
Lilly Co Eli |
苯氧基乙氧基化合物
|
|
TWI636046B
(zh)
|
2013-05-17 |
2018-09-21 |
美國禮來大藥廠 |
苯氧基乙基二氫－１ｈ－異喹啉化合物
|
|
SG11201510121RA
(en)
|
2013-06-12 |
2016-01-28 |
Kaken Pharma Co Ltd |
4-alkynyl imidazole derivative and medicine comprising same as active ingredient
|
|
WO2015034820A1
(en)
|
2013-09-04 |
2015-03-12 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
ES2675027T3
(es)
|
2013-09-06 |
2018-07-05 |
Aurigene Discovery Technologies Limited |
Derivados de 1,2,4-oxadiazol como inmunomoduladores
|
|
WO2015044900A1
(en)
|
2013-09-27 |
2015-04-02 |
Aurigene Discovery Technologies Limited |
Therapeutic immunomodulating compounds
|
|
JP6374959B2
(ja)
|
2013-10-17 |
2018-08-15 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
Ｄｎａ−ｐｋ阻害剤
|
|
SI3057953T1
(sl)
|
2013-10-17 |
2018-12-31 |
Vertex Pharmaceuticals Incorporated |
Ko-kristali(s)-n-metil-8-(1-((2'-metil-(4,5'-bipimiridin)-6-il)amino) propan-2-il)kinolin-4-karboksamida in njegovi devterirani derivati kot inhibitorji dna-pk
|
|
DK3083554T3
(da)
|
2013-12-17 |
2019-05-13 |
Lilly Co Eli |
Dimethylbenzoesyreforbindelser
|
|
RS56615B1
(sr)
|
2013-12-17 |
2018-02-28 |
Lilly Co Eli |
Derivati fenoksietil cikličnih amina i njihova aktivnost kao modulatora ep4 receptora
|
|
TW201607943A
(zh)
|
2013-12-19 |
2016-03-01 |
拜耳製藥公司 |
作為ｅｐ４配體之新穎苯并咪唑衍生物
|
|
TW201623277A
(zh)
|
2014-03-26 |
2016-07-01 |
安斯泰來製藥股份有限公司 |
醯胺化合物
|
|
WO2015167825A1
(en)
|
2014-04-29 |
2015-11-05 |
Emory University |
Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
|
|
CN110354266A
(zh)
|
2014-05-23 |
2019-10-22 |
卫材 R&D 管理有限公司 |
用于治疗癌症的组合疗法
|
|
JP6635949B2
(ja)
|
2014-06-04 |
2020-01-29 |
トーマス・ヘレデイズ・スティフテルス・フォー・メディシンスク・フォルスクニング |
炎症性および自己免疫性の病気の処置のためのｍｔｈ１阻害剤
|
|
WO2016021742A1
(en)
|
2014-08-07 |
2016-02-11 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compounds as ep4 receptor antagonists
|
|
TWI739666B
(zh)
|
2015-01-09 |
2021-09-11 |
日商小野藥品工業股份有限公司 |
醫藥組成物
|
|
JP6689297B2
(ja)
|
2015-07-23 |
2020-04-28 |
武田薬品工業株式会社 |
複素環化合物
|
|
KR102684436B1
(ko)
|
2015-10-16 |
2024-07-15 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
Ep4 길항제
|
|
CR20180323A
(es)
|
2015-11-20 |
2018-08-06 |
Idorsia Pharmaceuticals Ltd |
Derivados de indol n-sustituídos como moduladores de los receptores de pge2
|
|
EP4219462A1
(en)
|
2016-07-13 |
2023-08-02 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
|
PE20191811A1
(es)
|
2017-05-18 |
2019-12-26 |
Idorsia Pharmaceuticals Ltd |
Derivados de pirimidina como moduladores del receptor de pge2
|
|
PE20191814A1
(es)
|
2017-05-18 |
2019-12-27 |
Idorsia Pharmaceuticals Ltd |
Derivados de pirimidina como moduladores del receptor de pge2
|
|
JP7065117B2
(ja)
|
2017-05-18 |
2022-05-11 |
イドーシア ファーマシューティカルズ リミテッド |
Ｎ－置換インドール誘導体
|
|
CN110621671A
(zh)
|
2017-05-18 |
2019-12-27 |
爱杜西亚药品有限公司 |
作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物
|
|
EP3625223B1
(en)
|
2017-05-18 |
2021-08-11 |
Idorsia Pharmaceuticals Ltd |
Pyrimidine derivatives
|