SI2565191T1 - Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije - Google Patents

Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije

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Publication number
SI2565191T1
SI2565191T1 SI200931064T SI200931064T SI2565191T1 SI 2565191 T1 SI2565191 T1 SI 2565191T1 SI 200931064 T SI200931064 T SI 200931064T SI 200931064 T SI200931064 T SI 200931064T SI 2565191 T1 SI2565191 T1 SI 2565191T1
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Slovenia
Prior art keywords
ylcarbonylaminomethyl
indol
treatment
acid derivatives
receptor antagonists
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SI200931064T
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English (en)
Inventor
Eisuke Nozawa
Ryotaro Ibuka
Kazuhiro Ikegai
Keisuke Matsuura
Tatsuya Zenkoh
Ryushi Seo
Susumu Watanuki
Michihito Kageyama
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Astellas Pharma Inc.
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Publication of SI2565191T1 publication Critical patent/SI2565191T1/sl

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20131343A1 (es) * 2010-09-21 2013-11-18 Eisai Randd Man Co Ltd Derivados de acido benzoico
EP2649061B1 (en) 2010-12-10 2015-05-13 Rottapharm Biotech S.r.l. Pyridine amide derivatives as ep4 receptor antagonists
US20120225846A1 (en) 2011-03-02 2012-09-06 Bioenergenix Heterocyclic compounds for the inhibition of pask
BR112014000087B1 (pt) * 2011-07-04 2021-08-17 Rottapharm Biotech S.R.L. Derivados de amina cíclica como antagonistas do receptor ep4
TW201326154A (zh) * 2011-11-28 2013-07-01 拜耳知識產權公司 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
TWI570124B (zh) 2011-12-21 2017-02-11 Ｈ 朗德貝克公司 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物
KR20150005936A (ko) 2012-04-25 2015-01-15 다케다 야쿠힌 고교 가부시키가이샤 질소화 헤테로시클릭 화합물
JO3296B1 (ar) 2012-06-29 2018-09-16 Lilly Co Eli مركبات فينوكسي إيثيل بيبريدين
JP6309519B2 (ja) * 2012-07-06 2018-04-11 ジェネンテック， インコーポレイテッド Ｎ置換ベンズアミド及びその使用方法
EP2873669A4 (en) 2012-07-13 2015-11-25 Takeda Pharmaceutical HETEROCYCLIC COMPOUND
US9556117B2 (en) * 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
US9834520B2 (en) 2013-03-14 2017-12-05 Takeda Pharmaceutical Company Limited Heterocyclic compound
TWI636046B (zh) * 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
CN105431416B (zh) 2013-06-12 2019-01-08 科研制药株式会社 4-炔基咪唑衍生物和含有其作为有效成分的药物
US10053468B2 (en) 2013-07-03 2018-08-21 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6411342B2 (ja) 2013-07-03 2018-10-24 武田薬品工業株式会社 アミド化合物
LT3083562T (lt) * 2013-12-17 2018-01-10 Eli Lilly & Company Fenoksietilo cikliniai amino dariniai ir jų aktyvumas kaip ep4 receptoriaus moduliatorių
KR101585605B1 (ko) * 2014-03-20 2016-01-21 현대약품 주식회사 Pparg에 결합하되 증진제로 작용하지 않는 화합물 및 이를 유효성분으로 함유하는 pparg 관련 질병의 치료용 약학적 조성물
TW201623277A (zh) 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
CA2993312A1 (en) * 2015-07-23 2017-01-26 Takeda Pharmaceutical Company Limited 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CN106478606B (zh) * 2016-09-21 2019-05-10 沈阳药科大学 N-取代吲哚类衍生物及其应用
US11066405B2 (en) 2017-04-18 2021-07-20 Tempest Therapeutics, Inc. Bicyclic compounds and their use in the treatment of cancer
US11738009B2 (en) 2017-04-18 2023-08-29 Tempest Therapeutics, Inc. Bicyclic compounds and their use in the treatment of cancer
WO2018200674A1 (en) * 2017-04-26 2018-11-01 Mitobridge, Inc. Dynamin-1-like protein inhibitors
RS62398B1 (sr) 2017-05-18 2021-10-29 Idorsia Pharmaceuticals Ltd Derivati pirimidina kao modulatori receptora pge2
RS62440B1 (sr) 2017-05-18 2021-11-30 Idorsia Pharmaceuticals Ltd Derivati fenila kao modulatori receptora pge2
WO2018210992A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
ES2929309T3 (es) 2017-05-18 2022-11-28 Idorsia Pharmaceuticals Ltd Derivados de benzofurano y benzotiofeno como moduladores del receptor PGE2
AU2018269667B2 (en) 2017-05-18 2022-02-03 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
CN109836434B (zh) * 2017-11-27 2020-09-25 上海宇耀生物科技有限公司 噻吩并环类化合物及其合成方法和应用
EP3759114A4 (en) * 2018-03-02 2021-12-15 Shenzhen Ionova Life Science Co., Ltd. HETEROBICYCLIC CARBOXYLIC ACIDS AND THEIR SALTS
BR112020021042A2 (pt) * 2018-04-17 2021-01-19 Tempest Therapeutics, Inc. Carboxamidas bicíclicas e métodos de uso das mesmas
KR20210117280A (ko) * 2019-01-22 2021-09-28 키테라 (쑤저우) 파마슈티컬스 컴퍼니 리미티드 Pge2/ep4 신호 전달을 억제하기 위한 화합물, 이의 제조 방법, 및 이의 의약적 용도
WO2020199683A1 (zh) * 2019-04-04 2020-10-08 上海海雁医药科技有限公司 氮杂环取代的磺酰基苯甲酰胺衍生物、其制法与医药上的用途
WO2020251957A1 (en) * 2019-06-11 2020-12-17 Teon Therapeutics, Inc. Prostaglandin e2 receptor 4 antagonists and uses thereof
CN110386941A (zh) * 2019-08-15 2019-10-29 上海邦耀生物科技有限公司 Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗
CN113087719B (zh) * 2020-02-05 2024-01-26 上海宇耀生物科技有限公司 一种ep4受体拮抗剂的多晶型物及其制备方法与用途
WO2022102731A1 (ja) 2020-11-13 2022-05-19 小野薬品工業株式会社 Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療
WO2022161423A1 (zh) * 2021-01-28 2022-08-04 深圳晶泰科技有限公司 环胺衍生物及其制备方法和应用
CN115448913A (zh) * 2021-06-08 2022-12-09 武汉人福创新药物研发中心有限公司 用于治疗ep2、ep4受体介导的疾病的双环化合物
WO2023287241A1 (ko) * 2021-07-15 2023-01-19 주식회사 휴사이온 신규한 벤즈옥사졸아민 유도체 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
WO2023160569A1 (en) * 2022-02-24 2023-08-31 Guangdong Newopp Biopharmaceuticals Co., Ltd. Carboxamide compounds as pge2 receptor antagonists

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3030578B2 (ja) 1991-08-12 2000-04-10 コニカ株式会社 高感度・高鮮鋭性で、かつ処理ムラの少ない白黒用ハロゲン化銀写真感光材料
AU7139598A (en) 1997-04-25 1998-11-24 Smithkline Beecham Corporation Protease inhibitors
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
AU9462198A (en) 1997-10-17 1999-05-10 Yamanouchi Pharmaceutical Co., Ltd. Amide derivatives or salts thereof
JP2002145840A (ja) 2000-01-25 2002-05-22 Japan Tobacco Inc Ｎ−アリールヒドラジド化合物及びその医薬用途
GB0031315D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Indole derivatives
BR0211810A (pt) * 2001-08-09 2004-08-24 Ono Pharmaceutical Co Derivados ácido carboxìlico e agente farmacêutico compreendendo os mesmos como ingrediente ativo
WO2003086371A2 (en) 2002-04-12 2003-10-23 Pfizer Japan Inc. Use of ep4 receptor ligands in the treatment of il-6 involved diseases
ES2527185T3 (es) 2003-03-07 2015-01-21 Santen Pharmaceutical Co., Ltd Nuevos compuestos que tienen un grupo 4-piridilalquiltio como sustituyente
JP4496406B2 (ja) 2003-03-07 2010-07-07 参天製薬株式会社 ４−ピリジルアルキルチオ基を置換基として有する新規化合物
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative
EP1663979B1 (en) * 2003-09-03 2013-10-09 RaQualia Pharma Inc. Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
JP2007516950A (ja) * 2003-12-22 2007-06-28 アステラス製薬株式会社 プロスタグランジンｅ２アゴニストまたはアンタゴニストであるオルニチン誘導体
JP2007533723A (ja) * 2004-04-20 2007-11-22 ファイザー・プロダクツ・インク α２δリガンドを含む組合せ
FR2869610B1 (fr) 2004-05-03 2006-07-28 Merck Sante Soc Par Actions Si Derives de l'acide pentenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques
WO2005105732A1 (en) * 2004-05-04 2005-11-10 Pfizer Japan Inc. Substituted methyl aryl or heteroaryl amide compounds
ATE435198T1 (de) * 2004-05-04 2009-07-15 Raqualia Pharma Inc Orthosubstituierte aryl- oder heteroarylamidverbindungen
CA2648729A1 (en) * 2006-04-24 2007-11-01 Merck Frosst Canada Ltd. Indole amide derivatives as ep4 receptor antagonists
CA2654811A1 (en) * 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Indoline amide derivatives as ep4 receptor ligands
CA2660133C (en) * 2006-08-11 2015-10-27 Merck Frosst Canada Ltd. Thiophenecarboxamide derivatives as ep4 receptor ligands
KR20090089868A (ko) * 2006-12-15 2009-08-24 글락소 그룹 리미티드 Ｅｐ４ 수용체 작동제로서 벤즈아미드 유도체
CN101622230B (zh) * 2007-02-26 2012-08-22 默克弗罗斯特加拿大有限公司 作为ep4受体拮抗剂的吲哚和二氢吲哚环丙基酰胺衍生物
WO2008123207A1 (ja) 2007-03-26 2008-10-16 Astellas Pharma Inc. オルニチン誘導体
EP2172447A4 (en) 2007-07-03 2011-08-24 Astellas Pharma Inc amide
GB0721611D0 (en) * 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds

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WO2009139373A1 (ja) 2009-11-19
KR20110006654A (ko) 2011-01-20
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KR101612971B1 (ko) 2016-04-15
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AU2009247262A1 (en) 2009-11-19
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