CY1115944T1 - Παραγωγα 4-(ινδολ-7-υλοκαρβονυλαμινομεθυλο)κυκλοεξανοκαρβοξυλικου οξεος ως ανταγωνιστες του ερ4 υποδοχεα χρησιμοι για την αντιμετωπιση χρονιας νεφρικης ανεπαρκειας ή διαβητικης νεφροπαθειας - Google Patents
Παραγωγα 4-(ινδολ-7-υλοκαρβονυλαμινομεθυλο)κυκλοεξανοκαρβοξυλικου οξεος ως ανταγωνιστες του ερ4 υποδοχεα χρησιμοι για την αντιμετωπιση χρονιας νεφρικης ανεπαρκειας ή διαβητικης νεφροπαθειαςInfo
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- CY1115944T1 CY1115944T1 CY20141100866T CY141100866T CY1115944T1 CY 1115944 T1 CY1115944 T1 CY 1115944T1 CY 20141100866 T CY20141100866 T CY 20141100866T CY 141100866 T CY141100866 T CY 141100866T CY 1115944 T1 CY1115944 T1 CY 1115944T1
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- antagonists
- receptor
- ylocarbonylaminomethyl
- indol
- derivative
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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Abstract
Η παρούσα εφεύρεση σχετίζεται με ενώσεις αμιδίου του τύπου I οι οποίες είναι ανταγωνιστές του ΕΡ4 υποδοχέα και χρήσιμες για αντιμετώπιση χρόνιας νεφρικής ανεπάρκειας και/ή διαβητικής νεφροπάθειας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2008127424 | 2008-05-14 | ||
EP12194789.9A EP2565191B1 (en) | 2008-05-14 | 2009-05-12 | 4-(Indol-7-ylcarbonylaminomethyl)cyclohexanecarboxylic acid derivatives as EP4 receptor antagonists useful for the treatment of chronic renal failure or diabetic nephropathy |
Publications (1)
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CY1115944T1 true CY1115944T1 (el) | 2017-01-25 |
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ID=41318740
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CY20141100866T CY1115944T1 (el) | 2008-05-14 | 2014-10-22 | Παραγωγα 4-(ινδολ-7-υλοκαρβονυλαμινομεθυλο)κυκλοεξανοκαρβοξυλικου οξεος ως ανταγωνιστες του ερ4 υποδοχεα χρησιμοι για την αντιμετωπιση χρονιας νεφρικης ανεπαρκειας ή διαβητικης νεφροπαθειας |
Country Status (21)
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US (1) | US8598355B2 (el) |
EP (2) | EP2565191B1 (el) |
JP (1) | JP5375824B2 (el) |
KR (1) | KR101612971B1 (el) |
CN (1) | CN102026961B (el) |
AU (1) | AU2009247262B2 (el) |
BR (1) | BRPI0912778B1 (el) |
CA (1) | CA2724077C (el) |
CY (1) | CY1115944T1 (el) |
DK (1) | DK2565191T3 (el) |
ES (1) | ES2518919T3 (el) |
HR (1) | HRP20141248T1 (el) |
IL (1) | IL208955A0 (el) |
MX (1) | MX2010012357A (el) |
PL (1) | PL2565191T3 (el) |
PT (1) | PT2565191E (el) |
RU (1) | RU2479576C9 (el) |
SI (1) | SI2565191T1 (el) |
TW (1) | TW201000460A (el) |
WO (1) | WO2009139373A1 (el) |
ZA (1) | ZA201007686B (el) |
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KR102588955B1 (ko) * | 2017-04-18 | 2023-10-13 | 템페스트 테라퓨틱스, 인크. | 이환식 화합물 및 암의 치료에서의 이의 용도 |
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IL208955A0 (en) | 2011-01-31 |
AU2009247262A1 (en) | 2009-11-19 |
ES2518919T3 (es) | 2014-11-05 |
EP2277858A1 (en) | 2011-01-26 |
EP2565191B1 (en) | 2014-10-08 |
KR20110006654A (ko) | 2011-01-20 |
SI2565191T1 (sl) | 2014-12-31 |
RU2479576C9 (ru) | 2014-03-10 |
JPWO2009139373A1 (ja) | 2011-09-22 |
JP5375824B2 (ja) | 2013-12-25 |
BRPI0912778A2 (pt) | 2015-10-13 |
CA2724077A1 (en) | 2009-11-19 |
AU2009247262B2 (en) | 2013-01-31 |
KR101612971B1 (ko) | 2016-04-15 |
BRPI0912778B1 (pt) | 2019-04-30 |
PL2565191T3 (pl) | 2015-03-31 |
RU2010150911A (ru) | 2012-06-20 |
MX2010012357A (es) | 2010-12-07 |
PT2565191E (pt) | 2014-12-04 |
EP2277858A4 (en) | 2012-06-13 |
TW201000460A (en) | 2010-01-01 |
ZA201007686B (en) | 2012-02-29 |
US20110144153A1 (en) | 2011-06-16 |
CN102026961A (zh) | 2011-04-20 |
WO2009139373A1 (ja) | 2009-11-19 |
HRP20141248T1 (en) | 2015-03-13 |
US8598355B2 (en) | 2013-12-03 |
CN102026961B (zh) | 2014-04-09 |
CA2724077C (en) | 2016-04-26 |
RU2479576C2 (ru) | 2013-04-20 |
DK2565191T3 (da) | 2014-11-10 |
EP2565191A1 (en) | 2013-03-06 |
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