MX2009010297A - Derivado de ornitina. - Google Patents

Derivado de ornitina.

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Publication number
MX2009010297A
MX2009010297A MX2009010297A MX2009010297A MX2009010297A MX 2009010297 A MX2009010297 A MX 2009010297A MX 2009010297 A MX2009010297 A MX 2009010297A MX 2009010297 A MX2009010297 A MX 2009010297A MX 2009010297 A MX2009010297 A MX 2009010297A
Authority
MX
Mexico
Prior art keywords
compound
ornithine
useful
renal failure
therapeutic agent
Prior art date
Application number
MX2009010297A
Other languages
English (en)
Inventor
Keisuke Matsuura
Ryushi Seo
Eisuke Nozawa
Tatsuya Zenkoh
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2009010297A publication Critical patent/MX2009010297A/es

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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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Abstract

Se proporciona un compuesto útil como un agente terapéutico para insuficiencia renal crónica y un agente terapéutico para neuropatía diabética. Se describe un derivado de ornitina que tiene una actividad antagonista del receptor EP4. En el compuesto, se introduce un cicloalcanodiilo en el término C de la porción ornitina, mediante lo cual las propiedades fisicoquímicas (por ejemplo, solubilidad) del compuesto pueden ser mejoradas grandemente y al compuesto se le imparten propiedades apropiadas como un agente medicinal. El compuesto tiene una buena acción antagonista contra un receptor de EP4, y por lo tanto es útil como un agente terapéutico para insuficiencia renal crónica o neuropatía diabética.
MX2009010297A 2007-03-26 2008-03-25 Derivado de ornitina. MX2009010297A (es)

Applications Claiming Priority (2)

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JP2007078315 2007-03-26
PCT/JP2008/055474 WO2008123207A1 (ja) 2007-03-26 2008-03-25 オルニチン誘導体

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MX2009010297A true MX2009010297A (es) 2009-10-12

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AU2008266228A1 (en) * 2007-06-13 2008-12-24 Bristol-Myers Squibb Company Dipeptide analogs as coagulation factor inhibitors
PT2565191E (pt) 2008-05-14 2014-12-04 Astellas Pharma Inc Derivados do ácido 4-(indol-7- ilcarbonilaminometil)ciclo-hexanocarboxílico como antagonistas de receptores ep4, úteis no tratamento de insuficiência renal crónica ou de nefropatia diabética
JP5859010B2 (ja) * 2010-09-27 2016-02-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ ２−アミノ−ｎ−（２，２，２−トリフルオロエチル）アセトアミドの調製方法
TWI572597B (zh) * 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基－苯甲酸化合物
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
MX2018009870A (es) * 2016-02-15 2018-11-29 Cemm Forschungszentrum Fuer Molekulare Medizin Gmbh Inhibidores de taf1 para la terapia del cancer.
WO2018210987A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as pge2 receptor modulators
DK3625228T3 (da) 2017-05-18 2021-10-11 Idorsia Pharmaceuticals Ltd Pyrimidinderivater som pge2-receptormodulatorer
UA124748C2 (uk) 2017-05-18 2021-11-10 Ідорсія Фармасьютікалз Лтд N-заміщені індольні похідні
AR111941A1 (es) 2017-05-18 2019-09-04 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
CA3063788A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
EP3771711A1 (en) 2019-07-29 2021-02-03 Bayer Animal Health GmbH Pyrazole derivatives for controlling arthropods
CN113512025B (zh) * 2020-07-31 2023-01-06 四川大学 一种吲唑酯类化合物及其制药用途
JPWO2022102731A1 (es) 2020-11-13 2022-05-19

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KR20090122931A (ko) 2009-12-01
WO2008123207A1 (ja) 2008-10-16
CN101641325A (zh) 2010-02-03
CA2681861A1 (en) 2008-10-16
EP2141147A1 (en) 2010-01-06
US8030489B2 (en) 2011-10-04
US20100216803A1 (en) 2010-08-26

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