JP2018533363A5 - - Google Patents
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- JP2018533363A5 JP2018533363A5 JP2018521543A JP2018521543A JP2018533363A5 JP 2018533363 A5 JP2018533363 A5 JP 2018533363A5 JP 2018521543 A JP2018521543 A JP 2018521543A JP 2018521543 A JP2018521543 A JP 2018521543A JP 2018533363 A5 JP2018533363 A5 JP 2018533363A5
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- Prior art keywords
- cells
- cell
- hematopoietic
- derived
- pluripotent stem
- Prior art date
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Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016123100A1 (en) | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| SG10202110908WA (en) | 2015-05-04 | 2021-11-29 | Cytomx Therapeutics Inc | Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof |
| KR20180033537A (ko) | 2015-07-21 | 2018-04-03 | 더 칠드런스 메디칼 센터 코포레이션 | Pd-l1 발현 조혈 줄기 세포 및 용도 |
| WO2017078807A1 (en) * | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| CN108368520B (zh) | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| WO2017123806A1 (en) | 2016-01-12 | 2017-07-20 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| EP3405568A4 (en) | 2016-01-20 | 2019-12-04 | Fate Therapeutics, Inc. | COMPOUNDS AND METHODS FOR IMMUNOCELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES |
| SG11201805186VA (en) | 2016-01-20 | 2018-07-30 | Fate Therapeutics Inc | Compositions and methods for immune cell modulation in adoptive immunotherapies |
| GB2564582B (en) | 2016-02-01 | 2021-09-22 | Emulate Inc | Systems and methods for growth of intestinal cells in microfluidic devices |
| ES3039670T3 (en) * | 2016-04-15 | 2025-10-23 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
| JP7215994B2 (ja) | 2016-09-06 | 2023-01-31 | ザ チルドレンズ メディカル センター コーポレーション | 人工多能性幹細胞由来の免疫細胞 |
| JP7098615B2 (ja) | 2016-12-05 | 2022-07-11 | フェイト セラピューティクス,インコーポレイテッド | 養子免疫療法における免疫細胞調節のための組成物および方法 |
| WO2018140647A1 (en) | 2017-01-25 | 2018-08-02 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| JP7092281B2 (ja) * | 2017-02-07 | 2022-06-28 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 多能性幹細胞から模倣自然免疫細胞を生成する方法及びキット |
| CA3052473A1 (en) | 2017-02-09 | 2018-08-16 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| AU2018234827B2 (en) * | 2017-03-15 | 2024-04-04 | Orca Biosystems Inc. | Compositions and methods for hematopoietic stem cell transplants |
| WO2018176001A2 (en) | 2017-03-24 | 2018-09-27 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| US20210102167A1 (en) * | 2017-04-26 | 2021-04-08 | Kyoto University | Hematopoietic progenitor cell marker |
| SG11202000105QA (en) | 2017-07-14 | 2020-02-27 | Cytomx Therapeutics Inc | Anti-cd166 antibodies and uses thereof |
| CA3071683A1 (en) * | 2017-08-08 | 2019-02-14 | Sangamo Therapeutics, Inc. | Chimeric antigen receptor mediated cell targeting |
| KR102167548B1 (ko) | 2017-09-21 | 2020-10-19 | 한국생명공학연구원 | 자연살해세포의 제조방법 및 그의 용도 |
| US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
| US20200308540A1 (en) * | 2017-09-29 | 2020-10-01 | Regents Of The University Of Minnesota | Methods of making, expanding, and using a human progenitor t cell |
| BR112020007228A2 (pt) | 2017-10-11 | 2020-10-13 | Fate Therapeutics, Inc. | reprogramação celular usando sistema de expressão de vetor plasmídeo temporal e transitório |
| KR20250048610A (ko) | 2017-12-22 | 2025-04-09 | 페이트 세러퓨틱스, 인코포레이티드 | 향상된 면역 효과기 세포 및 이의 용도 |
| CN112041428B (zh) * | 2018-01-18 | 2024-05-24 | 新加坡科技研究局 | 用于在悬浮培养物中分化人多能干细胞系的方法 |
| US12161676B2 (en) | 2018-03-23 | 2024-12-10 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| JP7464532B2 (ja) | 2018-04-06 | 2024-04-09 | シーダーズ-サイナイ メディカル センター | マイクロ流体チップ上のヒト多能性幹細胞由来の神経変性疾患モデル |
| WO2019195800A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| US20210033628A1 (en) * | 2018-04-30 | 2021-02-04 | Cedars-Sinai Medical Center | Diagnostic and drug screening for molecular signatures of early onset sporadic parkinson's disease |
| EP3831936A4 (en) * | 2018-07-31 | 2022-04-13 | Thyas Co. Ltd. | METHOD FOR PRODUCING A REGENERATED T LYMPHOCYTE POPULATION USING IPS CELLS |
| AU2019336221B2 (en) | 2018-09-07 | 2025-05-15 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| JP7716976B2 (ja) * | 2018-09-19 | 2025-08-01 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | キメラ抗原受容体改変免疫細胞の活性化及び拡大培養のためのプロテインl |
| US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
| TW202028237A (zh) | 2018-09-27 | 2020-08-01 | 美商西建公司 | SIRPα結合蛋白及其使用方法 |
| CN109266618B (zh) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | 能够靶向肿瘤细胞的巨噬细胞及其制备方法 |
| US12410402B2 (en) | 2018-11-21 | 2025-09-09 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (NK) cell subset and related compositions and methods |
| SG11202105480WA (en) | 2018-12-02 | 2021-06-29 | Fate Therapeutics Inc | IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS |
| CA3127593A1 (en) * | 2019-01-22 | 2020-07-30 | Washington University | Compositions and methods for generating hematopoietic stem cells (hscs) |
| EP3924467A1 (en) | 2019-02-15 | 2021-12-22 | Editas Medicine, Inc. | Modified natural killer (nk) cells for immunotherapy |
| KR20220004126A (ko) * | 2019-04-26 | 2022-01-11 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 유도 다능성 줄기 세포로부터 생체내에서 기능적이고 환자-특이적인 흉선 조직의 생성 |
| WO2020227677A1 (en) * | 2019-05-09 | 2020-11-12 | Figene, Llc | Fibroblast generated patient-specific vaccines |
| CN110106144B (zh) * | 2019-05-17 | 2021-10-08 | 苏州大学 | 一种诱导造血干细胞向前t系细胞分化的方法和试剂盒 |
| WO2021024170A1 (en) * | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| GB201911953D0 (en) * | 2019-08-20 | 2019-10-02 | Adaptimmune Ltd | T cell production fram RAG inacivated iPSCs |
| MX2022001961A (es) * | 2019-08-20 | 2022-03-11 | Adaptimmune Ltd | Medio de cultivo para induccion de hematopoyesis. |
| GB201911957D0 (en) * | 2019-08-20 | 2019-10-02 | Adaptimmune Ltd | Methods of producing haemogenic progenitor cells from pluripotent stem cells |
| IL291924A (en) * | 2019-10-07 | 2022-06-01 | Fate Therapeutics Inc | Enhanced chimeric antigen receptor for immune effector cell engineering and use thereof |
| JP7664913B2 (ja) * | 2019-10-17 | 2025-04-18 | フェイト セラピューティクス,インコーポレイテッド | 免疫のための増強されたキメラ抗原受容体エフェクター細胞操作およびその使用 |
| WO2021096218A1 (ko) * | 2019-11-13 | 2021-05-20 | 연세대학교 산학협력단 | 혈관 내피세포 순수 분리 방법, 혈관 내피세포 특성 유지 배지 및 이를 포함하는 배양 방법 |
| EP4058564A1 (en) * | 2019-11-14 | 2022-09-21 | Amgen Inc. | Hematopoietic precursor cell production |
| KR20220113422A (ko) * | 2019-11-28 | 2022-08-12 | 암니오틱스 아베 | 내피에서 조혈로의 이행 동안 최종 계통 선별화를 유도하는 대사작용 |
| CA3171960A1 (en) * | 2020-02-28 | 2021-09-02 | Purdue Research Foundation | Generating aorta-gonad-mesonephros-like hematopoietic cells from human pluripotent stem cells under a defined condition |
| CN115427555A (zh) * | 2020-02-28 | 2022-12-02 | 武田药品工业株式会社 | 由多能干细胞产生自然杀伤细胞的方法 |
| EP4133058A4 (en) * | 2020-04-06 | 2024-05-08 | The Board of Trustees of the Leland Stanford Junior University | GENERATING POPULATIONS OF HUMAN BLOOD AND BLOOD VESSEL PROGENITORS FROM PLURIPOTENT STEM CELLS |
| CA3176416A1 (en) * | 2020-04-21 | 2021-10-28 | Modassir CHOUDHRY | Cellular vaccine platform and methods of use |
| MX2022015863A (es) | 2020-06-19 | 2023-03-23 | Fate Therapeutics Inc | Combinación de tipos de células efectoras derivadas de células madre pluripotentes inducidas (ipsc) para uso en inmunoterapia. |
| CN111808812B (zh) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | 一种用于多能干细胞向造血干细胞分化的材料和方法 |
| CN116507346A (zh) * | 2020-09-24 | 2023-07-28 | 广州辑因医疗科技有限公司 | 化合物用于提高人造血干细胞移植效率的用途 |
| CN112119977B (zh) * | 2020-10-15 | 2021-10-19 | 中国人民解放军军事科学院军事医学研究院 | Cd317诱导的抑郁和记忆损伤的小鼠模型的构建方法及其应用 |
| US20250262301A1 (en) | 2020-10-26 | 2025-08-21 | Shoreline Biosciences, Inc. | Methods of inducing antibody-dependent cellular cytotoxicity (adcc) using modified natural killer (nk) cells |
| CN114525257A (zh) * | 2020-10-30 | 2022-05-24 | 未来智人再生医学研究院(广州)有限公司 | 一种表达Tim-3阻断物的多能干细胞或其衍生物及应用 |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| TW202237827A (zh) | 2020-12-03 | 2022-10-01 | 美商世紀治療股份有限公司 | 經基因工程改造之細胞及其用途 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| KR102681869B1 (ko) * | 2020-12-18 | 2024-07-05 | 차의과학대학교 산학협력단 | 줄기 세포를 모니터링하기 위한 조성물, 키트, 및 이를 이용한 줄기 세포를 모니터링하는 방법 |
| US11473060B2 (en) | 2020-12-30 | 2022-10-18 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into NK cells |
| MX2023008809A (es) | 2021-01-29 | 2023-08-04 | Allogene Therapeutics Inc | ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS. |
| KR102766602B1 (ko) * | 2021-02-05 | 2025-02-13 | 의료법인 성광의료재단 | 다능성 줄기세포 유래 조혈 내피세포를 이용한 유전자 편집된 세포의 제조방법 |
| EP4293107A4 (en) * | 2021-02-05 | 2025-10-08 | Sungkwang Medical Found | METHOD FOR DIFFERENTIATING HEMOGENIC ENDOTHELIAL CELLS DERIVED FROM PLURIPOTENT STEM CELLS INTO LYMPHOID LINEAGE CELLS |
| GB202102297D0 (en) * | 2021-02-18 | 2021-04-07 | Adaptimmune Ltd | Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells |
| CN112831461B (zh) * | 2021-02-26 | 2023-08-08 | 澳门大学 | 一种诱导干细胞分化成中胚层谱系或滋养细胞谱系的方法及药物 |
| AU2022257812A1 (en) * | 2021-04-12 | 2023-10-12 | Medgene Therapeutics, Inc. | Method for activating and proliferating cd8 t cells exposed to antigen, cd8 t cells, prepared thereby, having enhanced anticancer activity, and use thereof |
| US12617864B2 (en) | 2021-04-12 | 2026-05-05 | Medgene Therapeutics, Inc. | Methods of activating and proliferating exhausted CD8 T cells, CD8 T cells with enhanced activity prepared by the same, and uses thereof |
| EP4326852A4 (en) * | 2021-04-22 | 2025-04-23 | Artec Biotech, Inc. | Method for producing hematopoietic cells from stem cells using vascular organoids |
| AU2022272317A1 (en) * | 2021-05-14 | 2023-11-30 | Appia Bio, Inc. | Production of engineered t cells from stem cells |
| WO2022264033A1 (en) * | 2021-06-15 | 2022-12-22 | Takeda Pharmaceutical Company Limited | Method for producing natural killer cells from pluripotent stem cells |
| CN117836405A (zh) * | 2021-08-13 | 2024-04-05 | 先声创新公司 | 三维培养多能干细胞产生造血干细胞 |
| JP2024529729A (ja) * | 2021-08-19 | 2024-08-08 | シーダーズ-サイナイ メディカル センター | 加齢関連疾患および神経変性疾患の予防および処置におけるiPSC由来免疫細胞 |
| WO2023038436A1 (ko) * | 2021-09-10 | 2023-03-16 | 의료법인 성광의료재단 | 전분화능 줄기세포 유래 조혈모세포 제조방법 및 상기 제조된 조혈모세포를 이용한 인간화 마우스 모델 제작방법 |
| CN113801846B (zh) * | 2021-09-22 | 2024-06-04 | 南京艾尔普再生医学科技有限公司 | 一种从人诱导多能干细胞分化为自然杀伤细胞的方法 |
| WO2023102119A1 (en) * | 2021-12-01 | 2023-06-08 | The Brigham And Women's Hospital, Inc. | Multispecific t cell engager polypeptides in combination with t cells for cancer therapy |
| CN118829724A (zh) * | 2022-01-20 | 2024-10-22 | 科济生物医药(上海)有限公司 | 诱导细胞分化的方法 |
| CN114350608B (zh) * | 2022-01-27 | 2024-05-28 | 昭泰英基生物医药(香港)有限公司 | 一种诱导t细胞重编程为类nk细胞的组合物及其应用 |
| AU2023241513A1 (en) * | 2022-04-01 | 2024-10-17 | Therabest Co.,Ltd | Natural killer cells produced from induced pluripotent stem cells, method for producing same, and use thereof |
| JP7707304B2 (ja) | 2022-04-08 | 2025-07-14 | フェイト セラピューティクス,インコーポレイティド | 腫瘍標的化のためのキメラ抗原受容体 |
| KR20250005097A (ko) | 2022-04-08 | 2025-01-09 | 페이트 세러퓨틱스, 인코포레이티드 | 고형 종양 표적화 골격을 갖는 세포 및 이의 용도 |
| CN114702591B (zh) * | 2022-05-17 | 2022-09-23 | 诺赛联合(北京)生物医学科技有限公司 | 成体细胞衍生的类器官制备技术 |
| KR102759886B1 (ko) | 2022-06-16 | 2025-02-05 | 대한민국 | Dusp6가 결핍된 줄기세포 및 이의 용도 |
| CN114774365B (zh) * | 2022-06-16 | 2022-08-23 | 呈诺再生医学科技(北京)有限公司 | 一种诱导iPSC分化获得CD34+细胞和NK细胞的方法及其应用 |
| CN119053690A (zh) * | 2022-06-20 | 2024-11-29 | 上海优替济生生物医药有限公司 | 体外诱导干细胞样记忆细胞的化合物及其应用 |
| WO2023247722A1 (en) * | 2022-06-22 | 2023-12-28 | Fondazione Telethon Ets | Method for isolating hemogenic endothelial cells |
| CN114958771B (zh) * | 2022-06-27 | 2023-12-05 | 广东康盾创新产业集团股份公司 | 一种ipsc-car-nk细胞的制备方法 |
| WO2024020587A2 (en) | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
| WO2024036105A2 (en) * | 2022-08-11 | 2024-02-15 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Method for generating cells of the t cell lineage with engineering broadly reactive human notch ligand |
| KR20250069893A (ko) * | 2022-09-13 | 2025-05-20 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 만능성 줄기 세포를 조혈 전구 세포 및 줄기 세포로 분화시키는 방법 |
| CA3267211A1 (en) * | 2022-09-14 | 2024-03-21 | Fate Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR INDUCING HEMATOPOIETIC CELL DIFFERENTIATION |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| KR20240069648A (ko) * | 2022-11-10 | 2024-05-20 | 의료법인 성광의료재단 | 전분화능 줄기세포에서 자연살해세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법 |
| WO2024127335A1 (en) * | 2022-12-15 | 2024-06-20 | Janssen Biotech, Inc. | Materials, methods and systems for cellular redifferentiation and expansion |
| KR20250160941A (ko) * | 2023-02-16 | 2025-11-14 | 신택스 바이오, 인크. | 조혈 계통으로의 세포 프로그래밍을 위한 시스템 및 이의 방법 |
| WO2024220222A1 (en) * | 2023-04-21 | 2024-10-24 | The Regents Of The University Of California | Media and methods for differentiating t cells from hematopoietic stem cells |
| CN116445408B (zh) * | 2023-05-22 | 2024-02-02 | 呈诺再生医学科技(北京)有限公司 | LSD1抑制剂在促进iPSC向HSC分化和HSC干性维持中的应用 |
| JPWO2024248141A1 (enExample) * | 2023-06-02 | 2024-12-05 | ||
| CN116574672B (zh) * | 2023-07-11 | 2023-10-20 | 北京北启生物医药有限公司 | 一种诱导化学诱导多能干细胞向生血内皮细胞分化的培养基及方法 |
| WO2025062293A1 (en) * | 2023-09-22 | 2025-03-27 | Janssen Biotech, Inc. | Methods and materials for scalable 3d cellular redifferentiation |
| CN117050940B (zh) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | 一种制备自然杀伤细胞的方法 |
| CN117106714B (zh) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | 一种制备b细胞的方法 |
| CN117050941B (zh) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | 一种制备自然杀伤细胞的方法 |
| CN117448269B (zh) * | 2023-10-25 | 2025-06-17 | 中国科学院香港创新研究院再生医学与健康创新中心 | 一种诱导人多能干细胞快速分化为巨噬细胞的方法及应用 |
| AU2024368655A1 (en) * | 2023-10-26 | 2026-04-02 | Amgen Inc. | Pluripotent cell differentiation |
| CN117736988B (zh) * | 2023-12-25 | 2024-06-21 | 深圳泽医细胞治疗集团有限公司 | 用于诱导Tscm细胞的培养基、培养方法及其应用 |
| WO2025210582A1 (en) * | 2024-04-04 | 2025-10-09 | Janssen Biotech, Inc. | Materials, methods and systems for cellular redifferentiation and expansion |
| GB202405750D0 (en) * | 2024-04-24 | 2024-06-05 | Plasticell Ltd | Therapy |
| WO2025235862A1 (en) | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
| WO2025238202A1 (en) * | 2024-05-16 | 2025-11-20 | Novo Nordisk A/S | Production of cryonoids and blood cells derived therefrom. |
| CN118325837B (zh) * | 2024-06-12 | 2024-09-03 | 深圳市中佳生物医疗科技有限公司 | 中性粒细胞的无血清无基质细胞培养方法 |
| WO2026062399A1 (en) * | 2024-09-19 | 2026-03-26 | Lift Biosciences Ltd | Granulocytes and granulocyte precursors |
| GB202413831D0 (en) * | 2024-09-19 | 2024-11-06 | Lift Biosciences Ltd | Therapeutic cells |
Family Cites Families (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| JP3626206B2 (ja) | 1997-06-13 | 2005-03-02 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Smad6及びその使用 |
| AU757046B2 (en) | 1997-07-01 | 2003-01-30 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| BR0108545A (pt) | 2000-02-24 | 2004-06-29 | Xcyte Therapies Inc | Estimulação e concentração simultâneas das células |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| WO2002006213A2 (en) | 2000-07-19 | 2002-01-24 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| US6689744B2 (en) | 2000-09-22 | 2004-02-10 | Genentech, Inc. | Notch receptor agonists and uses |
| WO2002059285A1 (en) | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| WO2003016496A2 (en) | 2001-08-20 | 2003-02-27 | The Scripps Research Institute | Zinc finger binding domains for cnn |
| EP1456380B1 (en) | 2001-11-02 | 2012-04-18 | Giuliani International Limited | Smad7 inhibitors for the treatment of cns diseases |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| TWI343377B (en) | 2002-03-13 | 2011-06-11 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| US7575925B2 (en) | 2002-12-10 | 2009-08-18 | Sunnybrook Health Sciences Centre | Cell preparations comprising cells of the T cell lineage and methods of making and using them |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| NZ547481A (en) | 2003-11-19 | 2009-12-24 | Array Biopharma Inc | Heterocyclic inhibitors of mek and methods of use thereof |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| CA2568344C (en) | 2004-05-27 | 2016-01-19 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| US20070036769A9 (en) | 2004-06-03 | 2007-02-15 | Linheng Li | BMP pathway methods and compositions |
| CN102898364A (zh) | 2005-05-18 | 2013-01-30 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
| US20090186076A1 (en) | 2006-02-01 | 2009-07-23 | Kazunori Kataoka | Combined Use of TGF-Beta Signaling Inhibitor and Antitumor Agent |
| MX373998B (es) | 2006-03-24 | 2020-07-22 | Childrens Medical Center | Uso de un modulador de células madre hematopoyeticas (hsc) para promover el crecimiento de hsc. |
| EP2044056B1 (en) | 2006-07-14 | 2012-08-22 | Novartis AG | Pyrimidine derivatives as alk-5 inhibitors |
| WO2008094597A2 (en) | 2007-01-30 | 2008-08-07 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
| PL2856876T3 (pl) | 2007-03-30 | 2018-06-29 | Memorial Sloan-Kettering Cancer Center | Konstytutywna ekspresja ligandów kostymulujących na limfocytach T poddanych transferowi adoptywnemu |
| WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| WO2009097140A1 (en) | 2008-01-30 | 2009-08-06 | Memorial Sloan-Kettering Cancer Center | Methods for off -the -shelf tumor immunotherapy using allogeneic t-cell precursors |
| WO2009104825A1 (en) * | 2008-02-18 | 2009-08-27 | Kaist | Method for inducing the defferentiation of embryonic stem cells into hemangioblast |
| EP2712921B1 (en) | 2008-05-06 | 2018-07-11 | Astellas Institute for Regenerative Medicine | Hemangio colony forming cells and non-engrafting hemangio cells |
| ES2489040T3 (es) | 2008-12-03 | 2014-09-01 | The Scripps Research Institute | Cultivos de células madre |
| US8993343B2 (en) | 2009-01-28 | 2015-03-31 | Korea Research Institute Of Bioscience And Biotechnology | CD93 or use of soluble fragment thereof |
| EP2398897B1 (en) * | 2009-02-20 | 2017-06-28 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| CN102388130B (zh) | 2009-02-27 | 2014-08-27 | 细胞动力国际有限公司 | 多能细胞的分化 |
| CA2756833C (en) | 2009-04-09 | 2019-11-19 | Sangamo Therapeutics, Inc. | Targeted integration into stem cells |
| US9005968B2 (en) | 2009-10-16 | 2015-04-14 | The Scripps Research Institute | Induction of pluripotent cells |
| NO2510096T3 (enExample) | 2009-12-10 | 2015-03-21 | ||
| US9206394B2 (en) | 2010-02-03 | 2015-12-08 | The University Of Tokyo | Method for reconstructing immune function using pluripotent stem cells |
| JPWO2011096482A1 (ja) | 2010-02-03 | 2013-06-13 | 国立大学法人 東京大学 | 多能性幹細胞を用いた免疫機能再建法 |
| JP5777115B2 (ja) * | 2010-03-18 | 2015-09-09 | 国立大学法人京都大学 | 多能性幹細胞から中胚葉細胞への分化誘導法 |
| EP3399026B1 (en) | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| WO2011159684A2 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| CA3157027A1 (en) | 2010-07-21 | 2012-01-26 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a t-cell receptor gene |
| CN103180434A (zh) | 2010-08-05 | 2013-06-26 | 威斯康星校友研究基金会 | 用于人多能细胞培养的简化基础培养基 |
| EP2603227B1 (en) | 2010-08-12 | 2017-10-04 | Fate Therapeutics, Inc. | Improved hematopoietic stem and progenitor cell therapy |
| US9181529B2 (en) | 2010-10-19 | 2015-11-10 | Cellular Dynamics International, Inc. | Titration of differentiation medium components |
| PE20170917A1 (es) | 2010-12-20 | 2017-07-12 | Genentech Inc | Anticuerpos anti-mesotelina e inmunoconjugados |
| AU2011349446C1 (en) | 2010-12-22 | 2016-01-21 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
| WO2012089669A1 (en) | 2010-12-31 | 2012-07-05 | Universität Für Bodenkultur Wien | Method of generating induced pluripotent stem cells and differentiated cells |
| US8700106B2 (en) | 2011-03-09 | 2014-04-15 | Universal Electronics Inc. | System and method for provision of infrared signalling in smart phone devices |
| CN102732483B (zh) * | 2011-03-31 | 2014-12-03 | 北京大学 | 造血祖细胞的制备方法及其专用培养基 |
| US20130071414A1 (en) | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| WO2013009825A1 (en) | 2011-07-11 | 2013-01-17 | Cellular Dynamics International, Inc. | Methods for cell reprogramming and genome engineering |
| KR101405437B1 (ko) * | 2011-08-16 | 2014-06-11 | 사회복지법인 삼성생명공익재단 | 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물 |
| WO2013028684A1 (en) * | 2011-08-23 | 2013-02-28 | Wisconsin Alumni Research Foundation | Angiohematopoietic progenitor cells |
| CN102329769B (zh) * | 2011-09-28 | 2013-07-31 | 浙江大学 | 一种获得造血干细胞的方法 |
| WO2013074916A1 (en) | 2011-11-18 | 2013-05-23 | Board Of Regents, The University Of Texas System | Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla |
| WO2013075222A1 (en) * | 2011-11-21 | 2013-05-30 | University Health Network | Populations of hematopoietic progenitors and methods of enriching stem cells therefor |
| PT2785834T (pt) | 2011-12-02 | 2020-11-13 | Fate Therapeutics Inc | Composição de células estaminais melhorada |
| US9428732B2 (en) * | 2011-12-05 | 2016-08-30 | Primorigen Biosciences, Inc. | Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof |
| EP2788476B1 (en) | 2011-12-08 | 2019-05-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2606884A1 (en) | 2011-12-21 | 2013-06-26 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Inhibitors of notch signaling pathway and use thereof in treatment of cancers |
| DK2836226T3 (en) * | 2012-02-24 | 2017-09-18 | Hutchinson Fred Cancer Res | COMPOSITIONS AND PROCEDURES FOR TREATING HEMOGLOBINOPATHY |
| PL2838548T3 (pl) | 2012-04-17 | 2024-02-05 | University Of Washington Through Its Center For Commercialization | Komórki z niedoborem hla klasy ii, komórki z niedoborem hla klasy i, zdolne do ekspresji białek hla klasy ii i ich zastosowania |
| WO2013158309A2 (en) | 2012-04-18 | 2013-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Non-disruptive gene targeting |
| US9260696B2 (en) | 2012-04-24 | 2016-02-16 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
| EP2853590B1 (en) | 2012-05-22 | 2018-11-07 | The University of Tokyo | Method for producing antigen-specific t cells |
| EP4541818A3 (en) | 2012-05-25 | 2025-07-23 | Cellectis | Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy |
| US20150148292A1 (en) | 2012-07-09 | 2015-05-28 | Emory University | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto |
| SG11201502598SA (en) | 2012-10-02 | 2015-05-28 | Sloan Kettering Inst Cancer | Compositions and methods for immunotherapy |
| SG11201503045YA (en) | 2012-10-19 | 2015-05-28 | Agency Science Tech & Res | Methods of differentiating stem cells into one or more cell lineages |
| US9382531B2 (en) * | 2012-10-22 | 2016-07-05 | Wisconsin Alumni Research Foundation | Induction of hemogenic endothelium from pluripotent stem cells |
| US9255250B2 (en) | 2012-12-05 | 2016-02-09 | Sangamo Bioscience, Inc. | Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene |
| CN114558032B (zh) * | 2012-12-21 | 2025-07-29 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| SG11201507275TA (en) | 2013-03-13 | 2015-10-29 | Wisconsin Alumni Res Found | Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions |
| JP6857028B2 (ja) | 2013-03-15 | 2021-04-14 | メモリアル スローン ケタリング キャンサー センター | 免疫治療のための組成物および方法 |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| WO2014165707A2 (en) | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
| JP2016522679A (ja) * | 2013-04-04 | 2016-08-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | CRISPR/Cas系を用いたゲノム編集の治療的使用 |
| US9381210B2 (en) * | 2013-04-15 | 2016-07-05 | Wisconsin Alumni Research Foundation | Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells |
| US10240126B2 (en) * | 2013-06-12 | 2019-03-26 | Kyoto University | Induced pluripotent stem cell selection method and method for inducing differentiation to blood cells |
| CN103361310B (zh) * | 2013-06-25 | 2015-09-23 | 中国人民解放军军事医学科学院野战输血研究所 | 培养基、试剂盒及其用途 |
| CA2926078C (en) | 2013-10-17 | 2021-11-16 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
| US9932607B2 (en) | 2013-11-15 | 2018-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Site-specific integration of transgenes into human cells |
| SG11201606934SA (en) | 2014-03-04 | 2016-09-29 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| EP3122769B1 (en) | 2014-03-28 | 2023-02-22 | Regents of the University of Minnesota | Polypeptides, cells, and methods involving engineered cd16 |
| WO2015164740A1 (en) | 2014-04-24 | 2015-10-29 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
| CN103937743B (zh) * | 2014-04-27 | 2017-12-01 | 浙江大学 | 一种利用三维诱导系统获得造血干细胞的方法 |
| WO2016123100A1 (en) | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| EP3250682A4 (en) | 2015-01-26 | 2018-08-01 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| CN104745529B (zh) * | 2015-03-13 | 2019-03-05 | 华南生物医药研究院 | 瘦素在诱导胚胎干细胞分化为造血干/祖细胞中的用途及其应用 |
| US20170020922A1 (en) * | 2015-07-16 | 2017-01-26 | Batu Biologics Inc. | Gene editing for immunological destruction of neoplasia |
| EP4108255A1 (en) | 2015-10-05 | 2022-12-28 | Precision Biosciences, Inc. | Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene |
| WO2017078807A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| CN108368520B (zh) | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| WO2017164257A1 (ja) * | 2016-03-23 | 2017-09-28 | 国立大学法人京都大学 | 血球分化能の高い中胚葉誘導方法 |
| ES3039670T3 (en) | 2016-04-15 | 2025-10-23 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
-
2016
- 2016-07-26 WO PCT/US2016/044122 patent/WO2017078807A1/en not_active Ceased
- 2016-07-26 SG SG11201803145RA patent/SG11201803145RA/en unknown
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