JP2018529779A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018529779A5 JP2018529779A5 JP2018536704A JP2018536704A JP2018529779A5 JP 2018529779 A5 JP2018529779 A5 JP 2018529779A5 JP 2018536704 A JP2018536704 A JP 2018536704A JP 2018536704 A JP2018536704 A JP 2018536704A JP 2018529779 A5 JP2018529779 A5 JP 2018529779A5
- Authority
- JP
- Japan
- Prior art keywords
- milligrams
- composition
- therapeutically effective
- effective amount
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- ZQPPMHVWECSIRJ-MDZDMXLPSA-N elaidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(O)=O ZQPPMHVWECSIRJ-MDZDMXLPSA-N 0.000 claims description 11
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 11
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 11
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 7
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 23
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 2
- 102000000018 Chemokine CCL2 Human genes 0.000 claims 2
- 239000007909 solid dosage form Substances 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 6
- 208000020832 chronic kidney disease Diseases 0.000 description 3
- -1 keto fatty acid Chemical class 0.000 description 3
- WRADPCFZZWXOTI-BMRADRMJSA-N (9E)-10-nitrooctadecenoic acid Chemical compound CCCCCCCC\C([N+]([O-])=O)=C/CCCCCCCC(O)=O WRADPCFZZWXOTI-BMRADRMJSA-N 0.000 description 2
- 208000009304 Acute Kidney Injury Diseases 0.000 description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 208000033626 Renal failure acute Diseases 0.000 description 2
- 206010061481 Renal injury Diseases 0.000 description 2
- 201000011040 acute kidney failure Diseases 0.000 description 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 208000037806 kidney injury Diseases 0.000 description 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- CQOAKBVRRVHWKV-SAPNQHFASA-N (9E)-9-nitrooctadecenoic acid Chemical compound CCCCCCCC\C=C([N+]([O-])=O)/CCCCCCCC(O)=O CQOAKBVRRVHWKV-SAPNQHFASA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 208000028004 allergic respiratory disease Diseases 0.000 description 1
- 230000002783 anti-lipogenic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 208000005069 pulmonary fibrosis Diseases 0.000 description 1
- 201000002793 renal fibrosis Diseases 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021139287A JP2021183640A (ja) | 2015-10-02 | 2021-08-27 | 活性化脂肪酸の治療有効量を使用する疾患の予防、処置および逆転 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562236702P | 2015-10-02 | 2015-10-02 | |
| US62/236,702 | 2015-10-02 | ||
| PCT/US2016/055206 WO2017059451A1 (en) | 2015-10-02 | 2016-10-03 | Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139287A Division JP2021183640A (ja) | 2015-10-02 | 2021-08-27 | 活性化脂肪酸の治療有効量を使用する疾患の予防、処置および逆転 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529779A JP2018529779A (ja) | 2018-10-11 |
| JP2018529779A5 true JP2018529779A5 (enExample) | 2019-11-14 |
Family
ID=58428002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536704A Withdrawn JP2018529779A (ja) | 2015-10-02 | 2016-10-03 | 活性化脂肪酸の治療有効量を使用する疾患の予防、処置および逆転 |
| JP2021139287A Pending JP2021183640A (ja) | 2015-10-02 | 2021-08-27 | 活性化脂肪酸の治療有効量を使用する疾患の予防、処置および逆転 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139287A Pending JP2021183640A (ja) | 2015-10-02 | 2021-08-27 | 活性化脂肪酸の治療有効量を使用する疾患の予防、処置および逆転 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10537541B2 (enExample) |
| EP (1) | EP3355879A4 (enExample) |
| JP (2) | JP2018529779A (enExample) |
| KR (1) | KR20180098222A (enExample) |
| CN (2) | CN113440506A (enExample) |
| AU (2) | AU2016331314A1 (enExample) |
| BR (1) | BR112018006687A2 (enExample) |
| CA (1) | CA3000842A1 (enExample) |
| CL (1) | CL2018000835A1 (enExample) |
| CO (1) | CO2018004576A2 (enExample) |
| CR (1) | CR20180246A (enExample) |
| EA (1) | EA201890859A1 (enExample) |
| HK (1) | HK1259031A1 (enExample) |
| IL (2) | IL258476B2 (enExample) |
| MX (1) | MX2018004043A (enExample) |
| SG (1) | SG10201913953UA (enExample) |
| WO (1) | WO2017059451A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102083787A (zh) * | 2008-05-01 | 2011-06-01 | 康普雷克萨公司 | 乙烯基取代的脂肪酸 |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| BR112018000254A2 (pt) | 2015-07-07 | 2018-09-04 | H Lundbeck As | inibidores de pde9 com cadeia principal de imidazotriazinona e cadeia principal de imidazopirazinona para o tratamento de doenças periféricas |
| IL258476B2 (en) * | 2015-10-02 | 2023-04-01 | Complexa Inc | Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids |
| HUE065709T2 (hu) | 2018-05-25 | 2024-06-28 | Cardurion Pharmaceuticals Inc | 6-[(3S,4S)-4-metil-1-(pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetrahidropirán-4-il-7H-imidazo[1,5-a] pirazin-8-on vegyület monohidrát és kristályos formái |
| MA53501A (fr) | 2018-08-31 | 2021-07-07 | Imara Inc | Inhibiteurs de pde9 pour le traitement de la drépanocytose |
| CN111229117B (zh) * | 2018-11-29 | 2022-01-04 | 中国石油化工股份有限公司 | 含脂肪酸型表面活性剂的混合体系及其制备方法 |
| CN111229120B (zh) * | 2018-11-29 | 2022-01-07 | 中国石油化工股份有限公司 | 含脂肪酸型表面活性剂的混合体系及其制备方法 |
| FR3092968B1 (fr) * | 2019-02-22 | 2021-05-21 | Microphyt | Complement alimentaire |
| CN110157792A (zh) * | 2019-04-22 | 2019-08-23 | 中山大学孙逸仙纪念医院 | 血清外泌体has_circ_0004771在制备酒精依赖综合征诊断试剂中的应用 |
| WO2021242758A1 (en) * | 2020-05-26 | 2021-12-02 | Imara Inc. | Improved nitro-fatty acid oral dose regimens |
| WO2023014748A1 (en) * | 2021-08-03 | 2023-02-09 | Imara Inc. | Nitrated fatty acids for the treatment of sickle cell disorders |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB587992A (en) | 1944-12-11 | 1947-05-12 | Charles William Scaife | Improvements in and relating to the production of organic nitrogen compounds |
| US3578687A (en) | 1968-01-30 | 1971-05-11 | Texaco Inc | Process for producing 4-nitroalkanoic acids |
| US3819561A (en) | 1970-10-23 | 1974-06-25 | Aerojet General Co | Wetting agents for non-aqueous dispersions |
| JPS5313608B2 (enExample) | 1972-06-16 | 1978-05-11 | ||
| JPS5318013B2 (enExample) | 1973-03-19 | 1978-06-13 | ||
| US4599430A (en) | 1981-12-21 | 1986-07-08 | The Standard Oil Company | Nitrogenation of hydrocarbons, including the production of maleimide |
| JPS62132804A (ja) | 1985-12-05 | 1987-06-16 | Aguro Kanesho Kk | 植物生長調節剤 |
| US5412137A (en) | 1993-06-07 | 1995-05-02 | Sandoz Ltd. | Process for preparing phosphinyloxy propanaminium inner salt derivatives |
| CN1088058C (zh) | 1994-10-13 | 2002-07-24 | 肽技术有限公司 | 经修饰的多不饱和脂肪酸 |
| US5919816A (en) | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| US5741211A (en) | 1995-10-26 | 1998-04-21 | Medtronic, Inc. | System and method for continuous monitoring of diabetes-related blood constituents |
| GB9618420D0 (en) | 1996-09-04 | 1996-10-16 | Scotia Holdings Plc | Fatty acid treatment |
| US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
| KR100569319B1 (ko) | 1997-10-30 | 2006-04-07 | 모리시타 진탄 가부시키가이샤 | 불포화 지방산 또는 이들의 유도체를 내용물로 하는 캡슐제제 및 그의 제조방법 |
| AU5565599A (en) | 1998-08-14 | 2000-03-06 | Dante J. Marciani | Chemically modified saponins and the use thereof as adjuvants |
| CN1329359C (zh) | 1999-04-01 | 2007-08-01 | 埃斯佩里安医疗公司 | 醚化合物,及其组合物和用途 |
| AU5319499A (en) | 1999-07-22 | 2001-02-13 | Ivan L. Cameron | Fatty acids to minimize cancer therapy side effects |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| AUPQ291499A0 (en) | 1999-09-17 | 1999-10-07 | Women's And Children's Hospital Adelaide | Novel nitro and sulphur containing compounds |
| US6346231B1 (en) | 1999-10-06 | 2002-02-12 | Joar Opheim | Flavored gelatin capsule and method of manufacture |
| US20010037598A1 (en) | 1999-12-14 | 2001-11-08 | Suppes Galen J. | Process for producing cetane improvers from triglycerides |
| IL151299A0 (en) | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| AR034120A1 (es) | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
| AR030416A1 (es) | 2000-04-13 | 2003-08-20 | Pharmacia Corp | COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA |
| AR032318A1 (es) | 2000-04-13 | 2003-11-05 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa |
| DK1294658T3 (da) | 2000-06-28 | 2005-06-27 | Zambon Spa | Fremgangsmåde til fremstilling af nitroalkener |
| AR031129A1 (es) | 2000-09-15 | 2003-09-10 | Pharmacia Corp | Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa |
| CA2444463C (en) | 2001-04-18 | 2012-03-20 | Prometic Biosciences Inc. | Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors |
| US7105556B2 (en) | 2001-05-30 | 2006-09-12 | Bristol-Myers Squibb Company | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method |
| JPWO2002102364A1 (ja) | 2001-06-18 | 2004-09-30 | 山田 幸子 | ＰＰＡＲγ作動性医薬組成物 |
| AU2002331618B2 (en) | 2001-08-17 | 2007-11-01 | University Of Pittsburgh | Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders |
| GB0123961D0 (en) | 2001-10-05 | 2001-11-28 | Astrazeneca Ab | Process and intermediates |
| WO2003039533A1 (en) | 2001-11-06 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| AU2003258909B2 (en) | 2002-08-20 | 2010-07-08 | Philera New Zealand Limited | Dosage forms and related therapies |
| EP2384750A1 (en) | 2002-09-27 | 2011-11-09 | Martek Biosciences Corporation | Improved Glycemic Control for Prediabetes and/or Diabetes Type II using Docohexaenoic Acid |
| US7166575B2 (en) | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| WO2005016864A1 (en) | 2003-07-29 | 2005-02-24 | The Arizona Disease Control Research Commission | Conjugated nitro alkene anticancer agents based on isoprenoid metabolism |
| US20050136103A1 (en) | 2003-09-17 | 2005-06-23 | Ben-Sasson Shmuel A. | Compositions capable of facilitating penetration across a biological barrier |
| US7935365B2 (en) | 2003-10-22 | 2011-05-03 | Enzymotec, Ltd. | Glycerophospholipids for the improvement of cognitive functions |
| AU2005209331A1 (en) | 2004-01-30 | 2005-08-11 | Peplin Biolipids Pty Ltd | Therapeutic and carrier molecules |
| US20050232981A1 (en) | 2004-04-15 | 2005-10-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| US7776916B2 (en) * | 2004-04-28 | 2010-08-17 | The Uab Research Foundation | Nitrated lipids and methods of making and using thereof |
| WO2006014673A2 (en) | 2004-07-19 | 2006-02-09 | Nobex Corporation | Insulin-oligomer conjugates, formulations and uses thereof |
| WO2006011397A1 (ja) | 2004-07-27 | 2006-02-02 | Kowa Company., Ltd. | 糖尿病の予防または治療のための薬剤 |
| KR20070090928A (ko) | 2004-11-19 | 2007-09-06 | 마텍 바이오싸이언스스 코포레이션 | 장쇄 다가불포화 지방산으로부터의 옥시리핀, 및 이의 제조방법 및 사용 방법 |
| WO2006086727A2 (en) | 2005-02-09 | 2006-08-17 | Entelos, Inc. | Treating diabetes with glucagon-like peptide-1 secretagogues |
| US9274129B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Methods and reagents for detecting bioactive lipids |
| US20090264483A1 (en) | 2006-07-14 | 2009-10-22 | Cedars-Sinai Medical Center | METHODS OF USING PPAR-gamma AGONISTS AND CASPASE-DEPENDENT CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER |
| WO2008011085A1 (en) | 2006-07-19 | 2008-01-24 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of mucositis |
| US20110190389A1 (en) | 2007-02-20 | 2011-08-04 | Linda Arterburn | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US8324277B2 (en) | 2007-08-01 | 2012-12-04 | University of Pittsburgh—of the Commonwealth System of Higher Education | Nitrated-fatty acids modulation of type II diabetes |
| CA2699483A1 (en) | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| US20110092594A1 (en) | 2008-04-18 | 2011-04-21 | Tianxin Yang | Use of nitrated lipids for treatment of lipid disorders and obesity, and lipid- and obesity-related conditions |
| CN102083787A (zh) | 2008-05-01 | 2011-06-01 | 康普雷克萨公司 | 乙烯基取代的脂肪酸 |
| WO2009149496A1 (en) | 2008-06-10 | 2009-12-17 | Central Northern Adelaide Health Service | Treatment of diabetes and complications thereof and related disorders |
| WO2009155439A2 (en) | 2008-06-19 | 2009-12-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| US20140024713A1 (en) * | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| CN102105152B (zh) | 2008-07-29 | 2012-10-17 | 内尔维阿诺医学科学有限公司 | 包含cdks抑制剂和抗肿瘤剂的治疗组合 |
| WO2010042877A1 (en) | 2008-10-09 | 2010-04-15 | Tekmira Pharmaceuticals Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
| US8933255B2 (en) * | 2008-12-31 | 2015-01-13 | Nitromega Corp. | Nutraceuticals containing nitro fatty acids |
| US8937194B2 (en) * | 2008-12-31 | 2015-01-20 | Nitromega Corp. | Topical compositions containing nitro fatty acids |
| US20100286271A1 (en) | 2009-05-08 | 2010-11-11 | Perricone Nicholas V | Nitro-alkyl Compound Compositions |
| US20100286257A1 (en) | 2009-05-08 | 2010-11-11 | Perricone Nicholas V | Methods Of Use Of Nitroalkane Compositions In Dermatologic Applications To Prevent or Treat Skin Aging |
| US20100286272A1 (en) | 2009-05-08 | 2010-11-11 | Perricone Nicholas V | Methods Of Use Of Nitroalkene Compositions In Dermatologic Applications |
| EP2459510A4 (en) | 2009-07-29 | 2013-08-07 | Phenomenome Discoveries Inc | HYDROXIDE-FATTY ACID COMPOSITIONS AND USES THEREOF FOR ILLNESS TREATMENT AND DIAGNOSIS |
| JP2013500966A (ja) | 2009-07-31 | 2013-01-10 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 抗炎症剤としての脂肪酸 |
| US8686167B2 (en) | 2009-10-02 | 2014-04-01 | Complexa, Inc. | Heteroatom containing substituted fatty acids |
| KR20120130078A (ko) | 2009-11-09 | 2012-11-28 | 메디비르 아베 | 신규한 1,3-옥사졸리딘 화합물 및 이의 레닌 억제제로서의 용도 |
| WO2011098746A1 (en) | 2010-02-09 | 2011-08-18 | Pulmagen Therapeutics (Inflammation) Limited | Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone |
| US20130039956A1 (en) * | 2010-03-15 | 2013-02-14 | Ulrich Dietz | Use of nitrocarboxylic acids for the treatment, diagnosis and prophylaxis of aggressive healing patterns |
| US8563609B2 (en) * | 2010-05-13 | 2013-10-22 | Nitromega Corp. | Nitro fatty acids - neuroprotection and/or inhibition of cognitive decline |
| EP2590643A4 (en) | 2010-06-28 | 2014-01-01 | Complexa Inc | MEDICINAL PRODUCT MADE FROM SEVERAL INGREDIENTS FOR THE TREATMENT OF DIABETES |
| WO2013028501A1 (en) | 2011-08-19 | 2013-02-28 | The University Of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| US9271952B2 (en) | 2011-10-11 | 2016-03-01 | Complexa, Inc. | Compositions and methods for treating nephropathy |
| DE102012008730A1 (de) | 2011-12-02 | 2013-06-06 | Dr. Budz GmbH | Orale Zusammensetzungen mit ungesättigten C18-Fettsäuren und ihre Verwendung |
| US20150018417A1 (en) | 2012-02-03 | 2015-01-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Fatty acids as anti-inflammatory agents |
| US20140271844A1 (en) * | 2013-03-15 | 2014-09-18 | Nitromega Corp. | Compositions containing nitro fatty acids |
| US20160081962A1 (en) | 2013-05-10 | 2016-03-24 | Nitromega Corp. | Nutritional or dietary supplements containing fatty acids and nitrite |
| WO2014204872A2 (en) | 2013-06-14 | 2014-12-24 | Complexa, Inc. | Composition and method for inhibition of pkng from mycobacterium tuberculosis |
| WO2015073527A1 (en) | 2013-11-12 | 2015-05-21 | Complexa, Inc. | Nitroalkene tocopherols and analogs thereof for use in the treatment and prevention of inflammation related conditions |
| WO2016161285A1 (en) * | 2015-04-02 | 2016-10-06 | Aobiome Llc | Production of nitro-fatty acids and nitro-hydrocarbons by ammonia oxidizing bacteria |
| IL258476B2 (en) * | 2015-10-02 | 2023-04-01 | Complexa Inc | Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids |
-
2016
- 2016-10-03 IL IL258476A patent/IL258476B2/en unknown
- 2016-10-03 WO PCT/US2016/055206 patent/WO2017059451A1/en not_active Ceased
- 2016-10-03 JP JP2018536704A patent/JP2018529779A/ja not_active Withdrawn
- 2016-10-03 HK HK19101519.9A patent/HK1259031A1/zh unknown
- 2016-10-03 CR CR20180246A patent/CR20180246A/es unknown
- 2016-10-03 IL IL297844A patent/IL297844A/en unknown
- 2016-10-03 CA CA3000842A patent/CA3000842A1/en not_active Abandoned
- 2016-10-03 BR BR112018006687A patent/BR112018006687A2/pt not_active Application Discontinuation
- 2016-10-03 SG SG10201913953UA patent/SG10201913953UA/en unknown
- 2016-10-03 US US15/283,887 patent/US10537541B2/en not_active Expired - Fee Related
- 2016-10-03 CN CN202110744035.6A patent/CN113440506A/zh active Pending
- 2016-10-03 EA EA201890859A patent/EA201890859A1/ru unknown
- 2016-10-03 CN CN201680070797.XA patent/CN108430466A/zh active Pending
- 2016-10-03 MX MX2018004043A patent/MX2018004043A/es unknown
- 2016-10-03 AU AU2016331314A patent/AU2016331314A1/en not_active Abandoned
- 2016-10-03 KR KR1020187012337A patent/KR20180098222A/ko not_active Ceased
- 2016-10-03 EP EP16852846.1A patent/EP3355879A4/en not_active Withdrawn
-
2018
- 2018-03-29 CL CL2018000835A patent/CL2018000835A1/es unknown
- 2018-04-27 CO CONC2018/0004576A patent/CO2018004576A2/es unknown
-
2019
- 2019-10-18 US US16/657,028 patent/US20200046669A1/en not_active Abandoned
-
2021
- 2021-03-19 US US17/207,380 patent/US20220000824A1/en not_active Abandoned
- 2021-07-14 AU AU2021205027A patent/AU2021205027A1/en not_active Abandoned
- 2021-08-27 JP JP2021139287A patent/JP2021183640A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018529779A5 (enExample) | ||
| IL297844A (en) | Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids | |
| JP2023002662A5 (enExample) | ||
| JP2020073546A5 (enExample) | ||
| JP2020502250A5 (enExample) | ||
| JP2018518537A5 (enExample) | ||
| TW201733583A (zh) | Fxr促效劑之使用方法 | |
| JP2009530413A5 (enExample) | ||
| JP2021119158A5 (enExample) | ||
| JP2013532665A5 (enExample) | ||
| JP2013521303A5 (enExample) | ||
| JP2012520866A5 (enExample) | ||
| JP2019515884A5 (enExample) | ||
| JP2017508817A5 (enExample) | ||
| JP2008533127A5 (enExample) | ||
| JP2015508068A5 (enExample) | ||
| US20230301951A1 (en) | Compositions and methods for the treatment of primary biliary cholangitis | |
| JP2019218379A5 (enExample) | ||
| JP6878596B2 (ja) | Ｆｘｒアゴニストの組合せ | |
| CN116615217A (zh) | 炎症性疾病和/或疼痛性疾病的预防或治疗药 | |
| Chave et al. | Henoch‐Schönlein purpura following hepatitis B vaccination | |
| JP2019507786A5 (enExample) | ||
| KR20210110407A (ko) | Fxr 작용제의 신규 요법 | |
| JP7523691B2 (ja) | 急性膵炎を予防及び治療するための薬物の製造におけるノルハルマンの使用 | |
| EP3681537A1 (en) | Combinations comprising fxr agonists |