JP2018529743A5 - - Google Patents
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- Publication number
- JP2018529743A5 JP2018529743A5 JP2018517444A JP2018517444A JP2018529743A5 JP 2018529743 A5 JP2018529743 A5 JP 2018529743A5 JP 2018517444 A JP2018517444 A JP 2018517444A JP 2018517444 A JP2018517444 A JP 2018517444A JP 2018529743 A5 JP2018529743 A5 JP 2018529743A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazolo
- pyridine
- carboxamide
- phenyl
- cyclobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239647P | 2015-10-09 | 2015-10-09 | |
| US62/239,647 | 2015-10-09 | ||
| US201662309794P | 2016-03-17 | 2016-03-17 | |
| US62/309,794 | 2016-03-17 | ||
| PCT/IB2016/056029 WO2017060874A1 (en) | 2015-10-09 | 2016-10-07 | N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529743A JP2018529743A (ja) | 2018-10-11 |
| JP2018529743A5 true JP2018529743A5 (https=) | 2019-11-14 |
| JP6779992B2 JP6779992B2 (ja) | 2020-11-04 |
Family
ID=57209654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517444A Active JP6779992B2 (ja) | 2015-10-09 | 2016-10-07 | Ｎ−スルホニル化ピラゾロ［３，４−ｂ］ピリジン−６−カルボキサミドおよび使用法 |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US9890158B2 (https=) |
| EP (1) | EP3359541B1 (https=) |
| JP (1) | JP6779992B2 (https=) |
| KR (1) | KR20180083323A (https=) |
| CN (1) | CN108513574B (https=) |
| AU (1) | AU2016333856C1 (https=) |
| BR (1) | BR112018007161B1 (https=) |
| CA (1) | CA3001096A1 (https=) |
| CL (1) | CL2018000911A1 (https=) |
| CO (1) | CO2018003716A2 (https=) |
| CR (1) | CR20180215A (https=) |
| CY (1) | CY1123545T1 (https=) |
| DK (1) | DK3359541T3 (https=) |
| EC (1) | ECSP18032223A (https=) |
| ES (1) | ES2829636T3 (https=) |
| HR (1) | HRP20201618T1 (https=) |
| HU (1) | HUE051067T2 (https=) |
| IL (1) | IL258553A (https=) |
| LT (1) | LT3359541T (https=) |
| MX (1) | MX379276B (https=) |
| NZ (1) | NZ741223A (https=) |
| PE (1) | PE20181348A1 (https=) |
| PH (1) | PH12018500765B1 (https=) |
| PL (1) | PL3359541T3 (https=) |
| PT (1) | PT3359541T (https=) |
| RU (1) | RU2724345C2 (https=) |
| SG (1) | SG11201802932VA (https=) |
| SI (1) | SI3359541T1 (https=) |
| TW (1) | TWI720032B (https=) |
| UY (1) | UY36943A (https=) |
| WO (1) | WO2017060874A1 (https=) |
| ZA (1) | ZA201802976B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2956129C (en) | 2014-08-21 | 2022-10-25 | Boehringer Ingelheim International Gmbh | New spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors |
| PL3359542T3 (pl) | 2015-10-09 | 2021-09-20 | Boehringer Ingelheim International Gmbh | Związki i pochodne spiro[3h-indolo-3,2’-pirolidyno]-2(1h)-onowe jako inhibitory mdm2-p53 |
| BR112018007161B1 (pt) | 2015-10-09 | 2024-01-16 | Galapagos Nv | COMPOSTOS PIRAZOLO[3,4-b]PIRIDIN-6-CARBOXAMIDA N-SULFONILADA, COMPOSIÇÃO FARMACÊUTICA CONTENDO OS DITOS COMPOSTOS E USOS DOS MESMOS PARA TRATAR FIBROSE CÍSTICA |
| US10138227B2 (en) | 2016-06-03 | 2018-11-27 | Abbvie S.Á.R.L. | Heteroaryl substituted pyridines and methods of use |
| US9981910B2 (en) | 2016-10-07 | 2018-05-29 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| US10399940B2 (en) | 2016-10-07 | 2019-09-03 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| EP3558982A1 (en) | 2016-12-20 | 2019-10-30 | AbbVie S.À.R.L. | Deuterated cftr modulators and methods of use |
| TW201831471A (zh) | 2017-02-24 | 2018-09-01 | 盧森堡商艾伯維公司 | 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法 |
| US10988454B2 (en) * | 2017-09-14 | 2021-04-27 | Abbvie Overseas S.À.R.L. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| WO2019193062A1 (en) | 2018-04-03 | 2019-10-10 | Abbvie S.Á.R.L | Substituted pyrrolidines and their use |
| GB201905711D0 (en) * | 2019-04-24 | 2019-06-05 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of kidney diseases |
| US11345691B2 (en) | 2019-06-03 | 2022-05-31 | AbbVie Global Enterprises Ltd. | Prodrug modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| EP3983388A1 (en) * | 2019-06-12 | 2022-04-20 | Nodthera Limited | Sulfonamide derivatives and uses thereof |
| WO2021011327A1 (en) | 2019-07-12 | 2021-01-21 | Orphomed, Inc. | Compound for treating cystic fibrosis |
| EP4010348B1 (en) * | 2019-08-09 | 2023-12-20 | Idorsia Pharmaceuticals Ltd | (2-acetamidyl)thio-beta-d-galactopyranoside derivatives |
| PL4073065T3 (pl) | 2019-12-10 | 2025-05-19 | F. Hoffmann-La Roche Ag | Nowe pochodne metylochinazolinonu |
| ES2991366T3 (es) | 2020-05-08 | 2024-12-03 | Halia Therapeutics Inc | Inhibidores de NEK7 cinasa |
| MX2022015495A (es) | 2020-06-08 | 2023-03-14 | Halia Therapeutics Inc | Inhibidores de cinasa relacionada con el gen a nunca en mitosis (nek7). |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| WO2022040447A2 (en) | 2020-08-20 | 2022-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating respiratory diseases characterized by mucus hypersecretion |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| EP4274828A1 (en) | 2021-01-06 | 2023-11-15 | AbbVie Global Enterprises Ltd. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| US20220213041A1 (en) | 2021-01-06 | 2022-07-07 | AbbVie Global Enterprises Ltd. | Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use |
| JP2025506382A (ja) | 2022-02-03 | 2025-03-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症の治療方法 |
| CA3249865A1 (en) | 2022-02-03 | 2023-08-10 | Vertex Pharmaceuticals Incorporated | PROCESSES FOR PREPARATION AND CRYSTALLINE FORMS OF (6A,12A)-17-AMINO-12-METHYL-6,15-BIS(TRIFLUOROMETHYL)-13,19-DIOXA-3,4,18-TRIAZATRICYCLO[12,3,1,12,5]NONADECA-1(18),2,4,14,16-PENTAEN-6-OL |
| JP2025505643A (ja) | 2022-02-08 | 2025-02-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子の調節因子 |
| WO2023224931A1 (en) | 2022-05-16 | 2023-11-23 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| CN115806532A (zh) * | 2022-08-31 | 2023-03-17 | 大连百傲化学股份有限公司 | 一种mit中杂质的制备方法 |
| US20240158394A1 (en) | 2022-09-14 | 2024-05-16 | Halia Therapeutics, Inc. | Nek7 inhibitors |
| CN115960100B (zh) * | 2022-12-28 | 2023-08-18 | 北京康立生医药技术开发有限公司 | 一种治疗胃肠道间质瘤药物皮咪特昔布的合成方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3833598A (en) * | 1972-12-29 | 1974-09-03 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine-6-carboxylic acids and esters |
| GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| US20080275078A1 (en) * | 2004-03-16 | 2008-11-06 | Glaxo Group Limited | Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors |
| CA2569402A1 (en) | 2004-06-04 | 2005-12-22 | The Regents Of The University Of California | Compounds having activity in increasing ion transport by mutant-cftr and uses thereof |
| RS56037B1 (sr) | 2004-06-24 | 2017-09-29 | Vertex Pharma | Modulatori atp-vezujućih kasetnih transportera |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| KR20070042164A (ko) * | 2004-07-05 | 2007-04-20 | 아스텔라스세이야쿠 가부시키가이샤 | 피라졸로피리딘 유도체 |
| US8362031B2 (en) * | 2004-08-20 | 2013-01-29 | University Of Kansas | Lonidamine analogues and treatment of polycystic kidney disease |
| JP5686596B2 (ja) | 2007-05-25 | 2015-03-18 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜貫通コンダクタンス制御因子の調節因子 |
| US20100331297A1 (en) * | 2007-11-07 | 2010-12-30 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| MX2010006421A (es) | 2007-12-10 | 2010-06-25 | Novartis Ag | Compuestos organicos. |
| JP5637859B2 (ja) | 2007-12-13 | 2014-12-10 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンスレギュレーターのモジュレーター |
| CN102224141B (zh) | 2008-10-23 | 2014-10-08 | 沃泰克斯药物股份有限公司 | N-(4-(7-氮杂双环[2.2.1]庚-7-基)-2-(三氟甲基)苯基)-4-氧代-5-(三氟甲基)-1,4-二氢喹啉-3-甲酰胺的固体形式 |
| EP2382197B1 (en) | 2008-12-30 | 2016-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| MX2013002895A (es) * | 2010-09-14 | 2013-06-05 | Inst Biochemii I Biofizyki Pan | Compuestos como moduladores de una proteina cftr mutante y su uso para tratar enfermedades asociadas con las deficiencias de la proteina cftr. |
| KR101886459B1 (ko) | 2010-10-08 | 2018-08-07 | 니발리스 테라퓨틱스, 인코포레이티드 | S-나이트로소글루타티온 리덕타제 억제제로서의 신규한 치환된 퀴놀린 화합물 |
| WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| US9056867B2 (en) | 2011-09-16 | 2015-06-16 | Novartis Ag | N-substituted heterocyclyl carboxamides |
| WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| CN103946221B (zh) | 2011-09-16 | 2016-08-03 | 诺华股份有限公司 | 用于治疗囊性纤维化的杂环化合物 |
| AU2012312520A1 (en) | 2011-09-20 | 2014-05-08 | The University Of North Carolina At Chapel Hill | Regulation of sodium channels by PLUNC proteins |
| RU2014121984A (ru) * | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
| EP2922852A4 (en) * | 2012-11-20 | 2016-05-25 | Discoverybiomed Inc | SMALL MOLECULAR CFTR CORRECTORS |
| WO2014180562A1 (en) | 2013-05-07 | 2014-11-13 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis |
| PT3030568T (pt) | 2013-08-08 | 2018-12-24 | Galapagos Nv | Tieno[2,3-c]piranos como moduladores de cftr |
| EP3102569A1 (en) * | 2014-02-06 | 2016-12-14 | AbbVie Inc. | 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof |
| WO2015138909A1 (en) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| US9745292B2 (en) | 2014-03-13 | 2017-08-29 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
| DK3212189T3 (da) | 2014-10-31 | 2020-10-26 | Abbvie Overseas Sarl | Substituerede chromaner og fremgangsmåde til anvendelse deraf |
| MX2017005663A (es) | 2014-10-31 | 2018-03-01 | Abbvie Sarl | Tetrahidropiranos sustituidos y metodo de uso. |
| JP2018529707A (ja) * | 2015-10-09 | 2018-10-11 | アッヴィ・エス・ア・エール・エル | 嚢胞性線維症の処置のための新規な化合物 |
| BR112018007161B1 (pt) * | 2015-10-09 | 2024-01-16 | Galapagos Nv | COMPOSTOS PIRAZOLO[3,4-b]PIRIDIN-6-CARBOXAMIDA N-SULFONILADA, COMPOSIÇÃO FARMACÊUTICA CONTENDO OS DITOS COMPOSTOS E USOS DOS MESMOS PARA TRATAR FIBROSE CÍSTICA |
-
2016
- 2016-10-07 BR BR112018007161-7A patent/BR112018007161B1/pt active IP Right Grant
- 2016-10-07 CR CR20180215A patent/CR20180215A/es unknown
- 2016-10-07 LT LTEP16788232.3T patent/LT3359541T/lt unknown
- 2016-10-07 WO PCT/IB2016/056029 patent/WO2017060874A1/en not_active Ceased
- 2016-10-07 AU AU2016333856A patent/AU2016333856C1/en not_active Ceased
- 2016-10-07 ES ES16788232T patent/ES2829636T3/es active Active
- 2016-10-07 MX MX2018004359A patent/MX379276B/es unknown
- 2016-10-07 PL PL16788232T patent/PL3359541T3/pl unknown
- 2016-10-07 KR KR1020187012937A patent/KR20180083323A/ko not_active Ceased
- 2016-10-07 RU RU2018115722A patent/RU2724345C2/ru active
- 2016-10-07 DK DK16788232.3T patent/DK3359541T3/da active
- 2016-10-07 SG SG11201802932VA patent/SG11201802932VA/en unknown
- 2016-10-07 HU HUE16788232A patent/HUE051067T2/hu unknown
- 2016-10-07 HR HRP20201618TT patent/HRP20201618T1/hr unknown
- 2016-10-07 US US15/287,911 patent/US9890158B2/en not_active Expired - Fee Related
- 2016-10-07 SI SI201630965T patent/SI3359541T1/sl unknown
- 2016-10-07 CN CN201680069459.4A patent/CN108513574B/zh active Active
- 2016-10-07 PE PE2018000521A patent/PE20181348A1/es unknown
- 2016-10-07 CA CA3001096A patent/CA3001096A1/en active Pending
- 2016-10-07 NZ NZ741223A patent/NZ741223A/en unknown
- 2016-10-07 EP EP16788232.3A patent/EP3359541B1/en active Active
- 2016-10-07 PT PT167882323T patent/PT3359541T/pt unknown
- 2016-10-07 TW TW105132676A patent/TWI720032B/zh not_active IP Right Cessation
- 2016-10-07 JP JP2018517444A patent/JP6779992B2/ja active Active
- 2016-10-11 UY UY0001036943A patent/UY36943A/es not_active Application Discontinuation
-
2017
- 2017-12-15 US US15/843,917 patent/US10259810B2/en active Active
-
2018
- 2018-04-06 PH PH12018500765A patent/PH12018500765B1/en unknown
- 2018-04-06 CO CONC2018/0003716A patent/CO2018003716A2/es unknown
- 2018-04-08 IL IL258553A patent/IL258553A/en active IP Right Grant
- 2018-04-09 CL CL2018000911A patent/CL2018000911A1/es unknown
- 2018-04-26 EC ECIEPI201832223A patent/ECSP18032223A/es unknown
- 2018-05-07 ZA ZA2018/02976A patent/ZA201802976B/en unknown
-
2019
- 2019-03-06 US US16/293,973 patent/US20190202823A1/en not_active Abandoned
- 2019-06-18 US US16/444,495 patent/US10647717B2/en active Active
-
2020
- 2020-11-03 CY CY20201101034T patent/CY1123545T1/el unknown
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