JP2017506659A5 - - Google Patents
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- Publication number
- JP2017506659A5 JP2017506659A5 JP2016554471A JP2016554471A JP2017506659A5 JP 2017506659 A5 JP2017506659 A5 JP 2017506659A5 JP 2016554471 A JP2016554471 A JP 2016554471A JP 2016554471 A JP2016554471 A JP 2016554471A JP 2017506659 A5 JP2017506659 A5 JP 2017506659A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolo
- pyrimidin
- pyrazol
- trifluoromethyl
- acetonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 20
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 13
- -1 7H-pyrrolo [2,3-d] pyrimidin-4-yl Chemical group 0.000 claims 12
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 12
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 6
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 claims 3
- 208000009527 Refractory anemia Diseases 0.000 claims 3
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 3
- 229940124639 Selective inhibitor Drugs 0.000 claims 3
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 claims 3
- 229940126190 DNA methyltransferase inhibitor Drugs 0.000 claims 2
- 206010058314 Dysplasia Diseases 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 206010033661 Pancytopenia Diseases 0.000 claims 2
- 208000024389 cytopenia Diseases 0.000 claims 2
- 239000003968 dna methyltransferase inhibitor Substances 0.000 claims 2
- 230000010437 erythropoiesis Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000011987 methylation Effects 0.000 claims 2
- 238000007069 methylation reaction Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 2
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
- KTBSXLIQKWEBRB-UHFFFAOYSA-N 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile Chemical compound C1=CN=C(C(F)(F)F)C(F)=C1C(=O)N1CCC(N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CC1 KTBSXLIQKWEBRB-UHFFFAOYSA-N 0.000 claims 1
- GDLFDECNYGKCOB-UHFFFAOYSA-N 2-[1-[4-[4-(ethylaminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxycyclohexyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile Chemical compound FC(F)(F)C1=CC(CNCC)=CC(OC2CCC(CC2)N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 GDLFDECNYGKCOB-UHFFFAOYSA-N 0.000 claims 1
- UMIFYBHMXIAHSA-NSQNTRMNSA-N 2-[1-[4-[4-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]-6-(trifluoromethyl)pyridin-2-yl]oxycyclohexyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile Chemical compound C1[C@H](O)CCN1CC1=CC(OC2CCC(CC2)N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=NC(C(F)(F)F)=C1 UMIFYBHMXIAHSA-NSQNTRMNSA-N 0.000 claims 1
- RXXCVKTUMMDIRR-UHFFFAOYSA-N 2-[1-[4-[6-(2-hydroxyethyl)-2-(trifluoromethyl)pyrimidin-4-yl]oxycyclohexyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile Chemical compound FC(F)(F)C1=NC(CCO)=CC(OC2CCC(CC2)N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 RXXCVKTUMMDIRR-UHFFFAOYSA-N 0.000 claims 1
- QFPGZAJRDFHPCE-UHFFFAOYSA-N 2-[3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-1-[1-[2-(trifluoromethyl)pyrimidine-4-carbonyl]piperidin-4-yl]azetidin-3-yl]acetonitrile Chemical compound FC(F)(F)C1=NC=CC(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 QFPGZAJRDFHPCE-UHFFFAOYSA-N 0.000 claims 1
- UHPOZFYNJIMRCT-UHFFFAOYSA-N 3-[1-(6-chloropyridin-2-yl)pyrrolidin-3-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical group ClC1=CC=CC(N2CC(CC2)C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 UHPOZFYNJIMRCT-UHFFFAOYSA-N 0.000 claims 1
- HTGGWBJDPLPEPS-UHFFFAOYSA-N 3-[1-([1,3]oxazolo[5,4-b]pyridin-2-yl)pyrrolidin-3-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1CN(C=2OC3=NC=CC=C3N=2)CC1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 HTGGWBJDPLPEPS-UHFFFAOYSA-N 0.000 claims 1
- UHEIPWYAZVECGS-ZDUSSCGKSA-N 4-[3-(cyanomethyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-n-[(2s)-1,1,1-trifluoropropan-2-yl]benzamide Chemical compound C1=C(F)C(C(=O)N[C@@H](C)C(F)(F)F)=CC(F)=C1N1CC(CC#N)(N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)C1 UHEIPWYAZVECGS-ZDUSSCGKSA-N 0.000 claims 1
- RZUCZMLSGAQMJN-UHFFFAOYSA-N 4-[3-(cyanomethyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-1-yl]-n-[4-fluoro-2-(trifluoromethyl)phenyl]piperidine-1-carboxamide Chemical compound FC(F)(F)C1=CC(F)=CC=C1NC(=O)N1CCC(N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CC1 RZUCZMLSGAQMJN-UHFFFAOYSA-N 0.000 claims 1
- VCJFOLMEZCAWFO-UHFFFAOYSA-N 4-[4-(2-fluoro-4-isocyanobenzoyl)piperazin-1-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]butanenitrile Chemical compound FC1=CC([N+]#[C-])=CC=C1C(=O)N1CCN(CC(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CC1 VCJFOLMEZCAWFO-UHFFFAOYSA-N 0.000 claims 1
- CEIFLXZQZIUBTK-UHFFFAOYSA-N 4-[4-[3-[(dimethylamino)methyl]-5-fluorophenoxy]piperidin-1-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]butanenitrile Chemical compound CN(C)CC1=CC(F)=CC(OC2CCN(CC(CC#N)N3N=CC(=C3)C=3C=4C=CNC=4N=CN=3)CC2)=C1 CEIFLXZQZIUBTK-UHFFFAOYSA-N 0.000 claims 1
- VQDFOOLMNPPTBD-UHFFFAOYSA-N 4-[4-[3-cyano-2-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propyl]piperazine-1-carbonyl]-3-fluorobenzonitrile Chemical compound FC1=CC(C#N)=CC=C1C(=O)N1CCN(CC(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CC1 VQDFOOLMNPPTBD-UHFFFAOYSA-N 0.000 claims 1
- MDDZCYJCJQHUCB-UHFFFAOYSA-N 5-[3-(cyanomethyl)-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]azetidin-1-yl]-n-propan-2-ylpyrazine-2-carboxamide Chemical compound C1=NC(C(=O)NC(C)C)=CN=C1N1CC(CC#N)(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)C1 MDDZCYJCJQHUCB-UHFFFAOYSA-N 0.000 claims 1
- NQSJETFQTIKWPX-UHFFFAOYSA-N 5-[3-(cyanomethyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-1-yl]-n-propan-2-ylpyrazine-2-carboxamide Chemical compound C1=NC(C(=O)NC(C)C)=CN=C1N1CC(CC#N)(N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)C1 NQSJETFQTIKWPX-UHFFFAOYSA-N 0.000 claims 1
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical group O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 1
- UMIFYBHMXIAHSA-KMDXXIMOSA-N C1[C@@H](O)CCN1CC1=CC(O[C@@H]2CC[C@@H](CC2)N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=NC(C(F)(F)F)=C1 Chemical compound C1[C@@H](O)CCN1CC1=CC(O[C@@H]2CC[C@@H](CC2)N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=NC(C(F)(F)F)=C1 UMIFYBHMXIAHSA-KMDXXIMOSA-N 0.000 claims 1
- RUJXSBAUCVPXQZ-UHFFFAOYSA-N CC(C)(O)c1cc(OC2CCC(CC2)N2C[N+](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F Chemical compound CC(C)(O)c1cc(OC2CCC(CC2)N2C[N+](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F RUJXSBAUCVPXQZ-UHFFFAOYSA-N 0.000 claims 1
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 108010008165 Etanercept Proteins 0.000 claims 1
- CMKBSHGTPCCVOM-UHFFFAOYSA-N FC(F)(F)C1=CC(CCO)=CC(OC2CCN(CC2)C2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 Chemical compound FC(F)(F)C1=CC(CCO)=CC(OC2CCN(CC2)C2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 CMKBSHGTPCCVOM-UHFFFAOYSA-N 0.000 claims 1
- FHTRVONXSDSHCU-SPCUYXFBSA-N FC(F)(F)C1=CC(CNC[C@H](O)C)=CC(OC2CCN(CC2)C2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 Chemical compound FC(F)(F)C1=CC(CNC[C@H](O)C)=CC(OC2CCN(CC2)C2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 FHTRVONXSDSHCU-SPCUYXFBSA-N 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 claims 1
- 101000844245 Homo sapiens Non-receptor tyrosine-protein kinase TYK2 Proteins 0.000 claims 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 1
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims 1
- 102100032028 Non-receptor tyrosine-protein kinase TYK2 Human genes 0.000 claims 1
- 208000034442 Refractory anemia with excess blasts type 1 Diseases 0.000 claims 1
- 208000034432 Refractory anemia with excess blasts type 2 Diseases 0.000 claims 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 1
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims 1
- 230000001494 anti-thymocyte effect Effects 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 229960003603 decitabine Drugs 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229960004942 lenalidomide Drugs 0.000 claims 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 208000012846 myelodysplastic syndrome with excess blasts-1 Diseases 0.000 claims 1
- 208000012847 myelodysplastic syndrome with excess blasts-2 Diseases 0.000 claims 1
- ZBXHNCURDISBRO-UHFFFAOYSA-N n-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]methyl]cyclopropanecarboxamide Chemical compound C1CC1C(=O)NCC(C=1C2=O)=CC=CC=1C(=O)N2C1CCC(=O)NC1=O ZBXHNCURDISBRO-UHFFFAOYSA-N 0.000 claims 1
- 229960000688 pomalidomide Drugs 0.000 claims 1
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims 1
- 229960003433 thalidomide Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461946124P | 2014-02-28 | 2014-02-28 | |
| US61/946,124 | 2014-02-28 | ||
| PCT/US2015/017963 WO2015131031A1 (en) | 2014-02-28 | 2015-02-27 | Jak1 inhibitors for the treatment of myelodysplastic syndromes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506659A JP2017506659A (ja) | 2017-03-09 |
| JP2017506659A5 true JP2017506659A5 (https=) | 2018-04-12 |
| JP6576941B2 JP6576941B2 (ja) | 2019-09-18 |
Family
ID=52693052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554471A Active JP6576941B2 (ja) | 2014-02-28 | 2015-02-27 | 骨髄異形成症候群の治療のためのｊａｋ１阻害剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US20150246046A1 (https=) |
| EP (1) | EP3110409B1 (https=) |
| JP (1) | JP6576941B2 (https=) |
| KR (1) | KR20160136323A (https=) |
| CN (2) | CN106456773A (https=) |
| AU (1) | AU2015222913B2 (https=) |
| CA (1) | CA2940659C (https=) |
| CL (1) | CL2016002144A1 (https=) |
| CR (1) | CR20160449A (https=) |
| CY (1) | CY1120857T1 (https=) |
| DK (1) | DK3110409T3 (https=) |
| EA (1) | EA201691745A1 (https=) |
| ES (1) | ES2688553T3 (https=) |
| HR (1) | HRP20181661T1 (https=) |
| HU (1) | HUE041456T2 (https=) |
| IL (1) | IL247475B (https=) |
| LT (1) | LT3110409T (https=) |
| MX (1) | MX372939B (https=) |
| MY (1) | MY185392A (https=) |
| PE (1) | PE20161388A1 (https=) |
| PL (1) | PL3110409T3 (https=) |
| PT (1) | PT3110409T (https=) |
| RS (1) | RS57723B1 (https=) |
| SG (2) | SG10201807952PA (https=) |
| SI (1) | SI3110409T1 (https=) |
| SM (1) | SMT201800551T1 (https=) |
| UA (1) | UA121857C2 (https=) |
| WO (1) | WO2015131031A1 (https=) |
| ZA (1) | ZA201606610B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2455382B1 (en) | 2005-12-13 | 2016-10-26 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
| EP3070090B1 (en) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| SG176111A1 (en) | 2009-05-22 | 2011-12-29 | Incyte Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| PT3354652T (pt) | 2010-03-10 | 2020-07-20 | Incyte Holdings Corp | Derivados de piperidin-4-ilazetidina como inibidores de jak1 |
| RS54824B1 (sr) | 2010-05-21 | 2016-10-31 | Incyte Holdings Corp | Topikalna formulacija za inhibiciju jak-a |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| CN104918945B (zh) | 2012-11-01 | 2018-01-05 | 因赛特公司 | 作为jak抑制剂的三环稠合噻吩衍生物 |
| CN113384546A (zh) | 2012-11-15 | 2021-09-14 | 因赛特公司 | 鲁索利替尼的缓释剂型 |
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| RS60244B1 (sr) | 2013-01-15 | 2020-06-30 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| WO2014138168A1 (en) | 2013-03-06 | 2014-09-12 | Incyte Corporation | Processes and intermediates for making a jak inhibitor |
| SMT201900223T1 (it) | 2013-05-17 | 2019-07-11 | Incyte Corp | Sale di bipirazolo come inibitore di jak |
| SG10201801069QA (en) | 2013-08-07 | 2018-03-28 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
| CN105658653A (zh) | 2013-08-23 | 2016-06-08 | 因赛特公司 | 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 |
| PH12020552277A1 (en) | 2014-04-08 | 2023-07-17 | Incyte Holdings Corp | Treatment of b-cell malignancies by a combination jak and pi3k inhibitor |
| CN106687462A (zh) | 2014-04-30 | 2017-05-17 | 因赛特公司 | Jak1抑制剂的制备方法以及其新形式 |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Ｐｉｍ激酶抑制劑之鹽 |
| US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| EP3461887A4 (en) * | 2016-03-09 | 2020-01-22 | University Of Ulsan Foundation For Industry Cooperation | COMPOSITION FOR PROLIFERATION, PROMOTION OF DIFFERENTIATION OR SENESCENCE INHIBITION OF STEM CELLS WITH JAK1 INHIBITOR AS AN ACTIVE SUBSTANCE |
| KR101934107B1 (ko) * | 2016-12-15 | 2018-12-31 | 가톨릭대학교산학협력단 | 골수형성이상 증후군 환자의 저메틸화 제제 치료 반응성 및 생존 예후 예측용 조성물 |
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