MX372939B - Inhibidores de cinasa janus 1 (jak1) para el tratamiento de sindromes mielodisplasicos. - Google Patents

Inhibidores de cinasa janus 1 (jak1) para el tratamiento de sindromes mielodisplasicos.

Info

Publication number
MX372939B
MX372939B MX2016011103A MX2016011103A MX372939B MX 372939 B MX372939 B MX 372939B MX 2016011103 A MX2016011103 A MX 2016011103A MX 2016011103 A MX2016011103 A MX 2016011103A MX 372939 B MX372939 B MX 372939B
Authority
MX
Mexico
Prior art keywords
jak1
inhibitors
treatment
myelodysplastic syndromes
janus kinase
Prior art date
Application number
MX2016011103A
Other languages
English (en)
Other versions
MX2016011103A (es
Inventor
Krishna Vaddi
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of MX2016011103A publication Critical patent/MX2016011103A/es
Publication of MX372939B publication Critical patent/MX372939B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Esta invención se refiere a inhibidores selectivos de la JAK1, particularmente, pirrolo[2,3-d]pirimidina y derivados de pirrolo[2,3-b]piridina, así como su uso en el tratamiento de síndromes mielodisplásicos (MDS).
MX2016011103A 2014-02-28 2015-02-27 Inhibidores de cinasa janus 1 (jak1) para el tratamiento de sindromes mielodisplasicos. MX372939B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461946124P 2014-02-28 2014-02-28
PCT/US2015/017963 WO2015131031A1 (en) 2014-02-28 2015-02-27 Jak1 inhibitors for the treatment of myelodysplastic syndromes

Publications (2)

Publication Number Publication Date
MX2016011103A MX2016011103A (es) 2017-02-28
MX372939B true MX372939B (es) 2020-04-03

Family

ID=52693052

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011103A MX372939B (es) 2014-02-28 2015-02-27 Inhibidores de cinasa janus 1 (jak1) para el tratamiento de sindromes mielodisplasicos.

Country Status (29)

Country Link
US (4) US20150246046A1 (es)
EP (1) EP3110409B1 (es)
JP (1) JP6576941B2 (es)
KR (1) KR20160136323A (es)
CN (2) CN106456773A (es)
AU (1) AU2015222913B2 (es)
CA (1) CA2940659C (es)
CL (1) CL2016002144A1 (es)
CR (1) CR20160449A (es)
CY (1) CY1120857T1 (es)
DK (1) DK3110409T3 (es)
EA (1) EA201691745A1 (es)
ES (1) ES2688553T3 (es)
HR (1) HRP20181661T1 (es)
HU (1) HUE041456T2 (es)
IL (1) IL247475B (es)
LT (1) LT3110409T (es)
MX (1) MX372939B (es)
MY (1) MY185392A (es)
PE (1) PE20161388A1 (es)
PL (1) PL3110409T3 (es)
PT (1) PT3110409T (es)
RS (1) RS57723B1 (es)
SG (2) SG10201807952PA (es)
SI (1) SI3110409T1 (es)
SM (1) SMT201800551T1 (es)
UA (1) UA121857C2 (es)
WO (1) WO2015131031A1 (es)
ZA (1) ZA201606610B (es)

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Also Published As

Publication number Publication date
JP6576941B2 (ja) 2019-09-18
US20190111058A1 (en) 2019-04-18
ES2688553T3 (es) 2018-11-05
DK3110409T3 (en) 2018-10-22
EP3110409B1 (en) 2018-08-15
MX2016011103A (es) 2017-02-28
US20150246046A1 (en) 2015-09-03
US20220378791A1 (en) 2022-12-01
MY185392A (en) 2021-05-17
IL247475B (en) 2020-05-31
CN106456773A (zh) 2017-02-22
SG10201807952PA (en) 2018-10-30
CA2940659C (en) 2023-01-03
ZA201606610B (en) 2020-08-26
PE20161388A1 (es) 2016-12-28
NZ724464A (en) 2021-01-29
CY1120857T1 (el) 2019-12-11
SMT201800551T1 (it) 2019-01-11
PL3110409T3 (pl) 2018-12-31
PT3110409T (pt) 2018-11-07
CA2940659A1 (en) 2015-09-03
HRP20181661T1 (hr) 2018-12-14
UA121857C2 (uk) 2020-08-10
KR20160136323A (ko) 2016-11-29
CL2016002144A1 (es) 2016-12-16
SI3110409T1 (sl) 2018-11-30
BR112016019511A2 (es) 2017-08-15
AU2015222913A1 (en) 2016-09-29
LT3110409T (lt) 2019-01-25
CN112494652A (zh) 2021-03-16
RS57723B1 (sr) 2018-12-31
BR112016019511A8 (pt) 2023-01-24
US20210069193A1 (en) 2021-03-11
JP2017506659A (ja) 2017-03-09
SG11201607083VA (en) 2016-09-29
EA201691745A1 (ru) 2016-12-30
AU2015222913B2 (en) 2019-12-12
EP3110409A1 (en) 2017-01-04
HUE041456T2 (hu) 2019-05-28
CR20160449A (es) 2016-12-20
IL247475A0 (en) 2016-11-30
WO2015131031A1 (en) 2015-09-03

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