CY1120857T1 - Jak1 αναστολεις για την αγωγη μυελοδυσπλαστικων συνδρομων - Google Patents

Jak1 αναστολεις για την αγωγη μυελοδυσπλαστικων συνδρομων

Info

Publication number
CY1120857T1
CY1120857T1 CY181101196T CY181101196T CY1120857T1 CY 1120857 T1 CY1120857 T1 CY 1120857T1 CY 181101196 T CY181101196 T CY 181101196T CY 181101196 T CY181101196 T CY 181101196T CY 1120857 T1 CY1120857 T1 CY 1120857T1
Authority
CY
Cyprus
Prior art keywords
treatment
syndroms
myelodyplastic
jak1 inhibitors
jak1
Prior art date
Application number
CY181101196T
Other languages
English (en)
Inventor
Krishna Vaddi
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CY1120857T1 publication Critical patent/CY1120857T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με JAK1 εκλεκτικούς αναστολείς, ιδίως με παράγωγα πυρρολο[2,3-d]πυριμιδίνης και πυρρολο[2,3-b]πυριδίνης, και με τη χρήση αυτών στην αγωγή μυελοδυσπλαστικών συνδρόμων (MDS).
CY181101196T 2014-02-28 2018-11-13 Jak1 αναστολεις για την αγωγη μυελοδυσπλαστικων συνδρομων CY1120857T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461946124P 2014-02-28 2014-02-28
PCT/US2015/017963 WO2015131031A1 (en) 2014-02-28 2015-02-27 Jak1 inhibitors for the treatment of myelodysplastic syndromes

Publications (1)

Publication Number Publication Date
CY1120857T1 true CY1120857T1 (el) 2019-12-11

Family

ID=52693052

Family Applications (1)

Application Number Title Priority Date Filing Date
CY181101196T CY1120857T1 (el) 2014-02-28 2018-11-13 Jak1 αναστολεις για την αγωγη μυελοδυσπλαστικων συνδρομων

Country Status (28)

Country Link
US (4) US20150246046A1 (el)
EP (1) EP3110409B1 (el)
JP (1) JP6576941B2 (el)
KR (1) KR20160136323A (el)
CN (2) CN106456773A (el)
AU (1) AU2015222913B2 (el)
CA (1) CA2940659C (el)
CL (1) CL2016002144A1 (el)
CR (1) CR20160449A (el)
CY (1) CY1120857T1 (el)
DK (1) DK3110409T3 (el)
EA (1) EA201691745A1 (el)
ES (1) ES2688553T3 (el)
HR (1) HRP20181661T1 (el)
HU (1) HUE041456T2 (el)
IL (1) IL247475B (el)
LT (1) LT3110409T (el)
MX (1) MX2016011103A (el)
MY (1) MY185392A (el)
PE (1) PE20161388A1 (el)
PL (1) PL3110409T3 (el)
PT (1) PT3110409T (el)
RS (1) RS57723B1 (el)
SG (2) SG11201607083VA (el)
SI (1) SI3110409T1 (el)
UA (1) UA121857C2 (el)
WO (1) WO2015131031A1 (el)
ZA (1) ZA201606610B (el)

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Also Published As

Publication number Publication date
UA121857C2 (uk) 2020-08-10
CN106456773A (zh) 2017-02-22
WO2015131031A1 (en) 2015-09-03
ES2688553T3 (es) 2018-11-05
SG11201607083VA (en) 2016-09-29
BR112016019511A2 (el) 2017-08-15
SG10201807952PA (en) 2018-10-30
HUE041456T2 (hu) 2019-05-28
SI3110409T1 (sl) 2018-11-30
HRP20181661T1 (hr) 2018-12-14
KR20160136323A (ko) 2016-11-29
US20190111058A1 (en) 2019-04-18
US20210069193A1 (en) 2021-03-11
CN112494652A (zh) 2021-03-16
ZA201606610B (en) 2020-08-26
CA2940659C (en) 2023-01-03
PT3110409T (pt) 2018-11-07
AU2015222913A1 (en) 2016-09-29
US20220378791A1 (en) 2022-12-01
BR112016019511A8 (pt) 2023-01-24
EP3110409A1 (en) 2017-01-04
EP3110409B1 (en) 2018-08-15
JP2017506659A (ja) 2017-03-09
DK3110409T3 (en) 2018-10-22
JP6576941B2 (ja) 2019-09-18
LT3110409T (lt) 2019-01-25
US20150246046A1 (en) 2015-09-03
AU2015222913B2 (en) 2019-12-12
RS57723B1 (sr) 2018-12-31
CR20160449A (es) 2016-12-20
EA201691745A1 (ru) 2016-12-30
MX2016011103A (es) 2017-02-28
MY185392A (en) 2021-05-17
IL247475B (en) 2020-05-31
CA2940659A1 (en) 2015-09-03
CL2016002144A1 (es) 2016-12-16
PL3110409T3 (pl) 2018-12-31
IL247475A0 (en) 2016-11-30
NZ724464A (en) 2021-01-29
PE20161388A1 (es) 2016-12-28

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